In Silico Oncology: Building and validating hypermodels and Oncosimulators as clinical decision support systems in the framework of the EU-US CHIC project

Abstract

Development, clinical adaptation and partial clinical validation of multiscale cancer hypermodels developed by different modelling groups were three of the major tasks of the recently completed large scale EU-US research project CHIC on in silico oncology. The main goal of the project, of which the outcome was rated as “excellent” by the European Commission, was the creation of clinically driven and clinically useable personalized treatment focusing decision support systems based on cancer hypermodels. The latter are able to exploit a range of relevant multiscale data of the individual patient. To this end, clinical medicine, fundamental science and information technology have been both successfully exploited and advanced.