Osteoarthritis (OA), a common joint disease in elderly, is characterized by articular cartilage degeneration, osteophyte formation, and synovitis. which arouses serious social and economic burden in the recent years. Previous studies indicated that some differentially-expressed circRNAs participated in initiation and progression of OA. These findings suggested that circRNAs may act as promising ... [Show full abstract] diagnostic biomarkers and therapeutic targets for OA. In this review, we summarize the biogenesis and biological functions of circRNAs and explore the underlying roles of circRNAs in OA, which may enlighten further studies and contribute to the early diagnosis and intervention of OA.