Article

Xanthine oxidase inhibitory activity of artocarpus blancoi

January 2018
LATIN AMERICAN JOURNAL OF PHARMACY 37(12):2525-2529

Authors:

The bark of Artocarpus blancoi (Elmer) Merr. exhibited xanthine oxidase inhbitory activity at 64.64%. Purification of the active compound using bioassay-guided isolation scheme led to the identification of 5,7,4’-trihydroxyflavanone-3-O-α-L-rhamnopyranoside. Its activity was found to be comparable with the positive control allopurinol. RESUMEN. La corteza de Artocarpus blancoi (Elmer) Merr. exhibió actividad inhibitoria de la xantina oxidasa en un 64.64%. La purificación del compuesto activo utilizando un esquema de aislamiento guiado por bioensayo condujo a la identificación de 5,7,4’-trihidroxiflavanona-3-O-α-L-ramnopiranósido. Se encontró que su actividad era comparable con el control positivo alopurinol. © 2018, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.

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Article

Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase

October 2010 · Journal of Ethnopharmacology

Seed of Semecarpus anacardium L. is widely used in Indian traditional medicine; Ayurveda and Sidha, for treatment of inflammatory disorders and gout. The present study was aimed at isolation of a compound for its potential to inhibit xanthine oxidase (XO), over expression of which lead to inflammation and gout. Activity guided fractionation of S. anacardium seed was conducted using liquid-liquid ... [Show full abstract] partition and preparative HPLC. The fractions were evaluated for their XO inhibition and antioxidant activity. The ethyl acetate fraction with the highest XO activity yielded a biflavonoid compound tetrahydroamentoflavone (THA). Lineweaver-Burk (LB) plot for the XO inhibition of THA and allopurinol was constructed from the kinetic data. IC₅₀ values of THA and allopurinol for XO inhibition were 92 and 100 nM respectively and their corresponding values for K(i) were 0.982 and 0.612 μM respectively. THA was a potent XO inhibitor which could be considered as a drug candidate or chemopreventive agent, after establishing its pharmacological and clinical evaluation. The study results appear to support the claim of the traditional medicine with respect to the efficacy of S. anacardium seed against inflammation and gout.

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A Preliminary Assessment of Certain Heavy Metals on Plants in and Around the Shivamogga City of Karn...

August 2010

Metals are ubiquitous in the modern industrialized environment. Heavy metals like cadmium, iron, molybdenum, lead, nickel, tin and zinc are present in the environment in trace concentrations .These metals are universally present in soil, water, air and biota. Eight plant species were chosen for the study purpose in and around Shivamogga city (Experimental site). Shankarghatta was chosen as a ... [Show full abstract] control site. The selected plant species are Polyalthia longifolia, Bauhinia purpurea, Anacardium occidentale, Artocarpus heterophyllus, Syzygium cumini, Terminalia catappa, Psidium guajava, and Hibiscus rosa-sinensis. The heavy metals analyzed were found to be in extremely high concentration. The industrial areas of Machenahalli and Mandli were found to be severely polluted and hence the concentration of heavy metals in these areas was found to be very high. From the present investigation, it is evident that Shivamogga city (experimental site) is severely polluted, as comparing the data with control site (Shankarghatta).

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Studies on some cauliflorous plants of Bhopal (India)

December 2005

A survey of angiospermic flora of Bhopal and its suburbs carried out during 2004-2005 revealed that quite a handsome number of arboreal species beautify the landscape of by their elegant presence. The present paper, however, pertains to four species of flowering plants belonging to different families which exhibit cauliflory. The species are Artocarpus integrifolia, Couropita guianensis, ... [Show full abstract] Crescentia cujete and Kigelia pinnata, which can be witnessed at various localities of the capital.

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The Foliage of Flemingia (Flemingia macrophylla) or Jackfruit (Artocarpus heterophyllus) as a Substi...

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Ninety lactating goats (Bachthao, Barbary, Beetal and Jamnapary breeds) were used in an experiment to investigate the replacement value of the tree fodders Flemingia (Flemingia macrophylla) and Jackfruit (Artocarpus heterophyllus). The foliages were used to replace the concentrate in diets based on chopped whole sugar cane (Sacharatum sp.), Para grass (Brachiaria mutica) and dried cassava root ... [Show full abstract] (Manihot esculanta). The concentrate was replaced by foliage of Jackfruit or Flemingia at 0%, 20%, 40%, 60% and 80% based on the crude protein (CP) content in the concentrate and foliages, respectively. Average milk yield was 1,617 g/day for goats fed Jackfruit compared to 1,532 g/day for those fed Flemingia. Increasing amounts of Flemingia foliage resulted in reduced dry matter intake and decreased milk yield but milk composition (CP, casein and fat content) was similar up to 60% replacement. Flemingia showed a poor potential as a supplement for lactating goats and replacement levels should not exceed 20% of the protein in the concentrate or 7.5% of the dry matter in the diet. With respect to the combination of milk production and net return over the control a CP replacement rate of 20% was the most promising. For Jackfruit there was similar feed intake and milk yield at a replacement level of 20% of CP in the concentrate (9.2% of DM intake) compared to the control diet. Milk yield at the level of 40% replacement (15% of the DM) in the diet was slightly reduced. Up to a level of CP replacement rate of 60% (21% DM in the diet) can be suggested for on-farm testing as a higher net return over the control was obtained on station.

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N. Haq