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Abstract

The identification of two new clinical syndrome: “The Post Hexavalent Vaccination Sudden Infant Death Syndrome ”, (PHVSIDS) and the Post Vaccination ASIA Syndrome (PVAS), irrefutably confirmed by the scientific literature and for PHVSIDS from autopsies of newborns died without pathologies inducing a life risk, calls for an urgent revision of the criticized WHO AEFI algorithm for assessing adverse reactions to vaccines. PVAS syndrome , taking in account the delayed auto-immunity reactions, is a risk also for adult population. Moreover a multiple antigens’ inoculation induces depression of the natural and adaptive immunity via the NK cells suppressing antigen presenting cells (APC), inducing the inhibition of TCell effectors priming . In Italy from 1999 to 2004 there has been a slaughter of 52 new-borns after hexavalent vaccination without taking in account 55 (44%) deaths of immunized children for cardiac arrest of 121 SIDS. The PHVSIDS and PVAS call public health for a new person-centered vaccination schedule, submitted to the paediatrician’s clinical evaluation , reducing the vaccines number within the first year of life to the essence with a distanced mono-antigenic inoculation and starting a health policy promoting breast feeding ,natural immunity and a healthy life quality for all.
PREPRINT
The need of a new person-centered vaccination policy after the identification of the Post Hexavalent Vaccination Sudden
Infant Death (PHVSIDS) and the Post Vaccination Asia Syndromes (PVAS).
Copyright Giuseppe R.Brera 2018
The need of a new person-centered vaccination policy after the identification of the Post
Hexavalent Vaccination Sudden Infant Death (PHVSIDS) and the Post Vaccination Asia
Syndromes (PVAS).
Giuseppe R.Brera
A review of the international literature on the hexavalent vaccination adverse effects,
introduces, without a doubt, an irrefutable existence of two new clinical syndromes: “The Post
Hexavalent Vaccination Sudden Infant Death Syndrome ”, (PHVSIDS) and the Post Vaccination
ASIA Syndrome (PVAS). ASIA is the acronym of “Autoimmunity Syndrome Induced by Adjuvants
.
1
The PHVSIDS existence is confirmed by autopsies of 13 newborns died a few hours after the
hexavalent vaccination that evidenced no existence of concurrent pathologies inducing a life
risk:
In none of these victims congenital developmental alterations of the main nervous structures regulating
the vital functions were observed. Only the hypoplasia of the arcuate nucleus was present in 5 cases.In one
case in particular an acquired hyperarcuate encephalitis of the tractus solitarii nucleus was diagnosed in
the brainstem”
2
These children without hexavalent vaccination would be still alive. The increase of infant
mortality and hospital admission rates correlated to the number of vaccines before the first
year of life, confirmed the extreme dangerousness of the hexavalent vaccination.
3
4
(fig. 1-Fig 2)
Many papers before 2014 documented the existence of a life risk derived from hexavalent
vaccination.
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7
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From 1999 to 2004, in Italy, there has been a slaughter of 52 infant deaths
directly associated with hexavalent vaccination , 8 before 24 hours (RR= 1,5, RR= 2,3 with the
Infarix Hexa vaccine( 0,7 with Hexavac ) , 34 within 7 days (RR=1,8- RR 1,5 with Infarix Hexa ; 2,8
with Hexavac, with all the hexavalent products RR =2) 52 within 14 days (RR 1,5, RR= 1,5 with
Infarix Hexa,1,6 with Hexavac); during the same period 55 immunized children aged 31-729
days of life , 44% of 121 SIDS died because of a cardiac arrest, but the authors didn’t apply a RR
epidemiological analysis to data
10
. The hexavalent vaccination appears like a Russian Roulette
in newborns with an unknown vulnerability or immune depressed, probably related to a
cascade of metabolic reaction triggered by an impressive release of inflammatory cytokines by
NK cells after the multiple antigens’ contemporary inoculation induced by the hexavalent
vaccination and/or its boosting. The hypothesized pathway could be the Antigen Presenting Cells
(APC) destruction by the NK inflammatory cytokines causing depression of the T-Cell effectors’
work for adaptive immunity causing a general lowering of the resistance to other also lethal
infections
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12
13
14
. In addition to PHVSIDS, there is the clinical and scientific evidence of auto-
immune diseases,
15
(fig.3) , associated with vaccinations caused by the bio-persistence and
brain translocation of minerals added to vaccines as adjuvants, preservatives and stabilizers, like
PREPRINT
The need of a new person-centered vaccination policy after the identification of the Post Hexavalent Vaccination Sudden
Infant Death (PHVSIDS) and the Post Vaccination Asia Syndromes (PVAS).
Copyright Giuseppe R.Brera 2018
Aluminium , inoculated in enormous quantities that allowed to assess the existence of PVAS
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. Autoimmunity can derive also from the recombination of the DNA host with that
from human cell lines of aborted foetuses used for the MMRV vaccine production also associated
with autism
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25
. The WHO AEFI algorithm
26
(Causality Assessment of Adverse Event Following
Vaccination) built on an obsolete epistemological mechanistic linear causality , showed a well
explained fallacy.
27
These scientific and clinical observations give evidence to the fact that
children cannot be treated as battery chickens and to the necessity of a person- centered
approach to vaccination according to Person Centered Medicine change of the mechanistic
medical science paradigm and the health concept.
28
The former Italian Health Ministry has
spread in 2017 a 2009 guide to the vaccination contraindications, with ridiculous and dangerous
suggestions , like “ Do not visit healthy children before vaccination nor take temperature and
was informed about the Italian children’s slaughter and serious adverse effects from hexavalent
vaccination (9-20,3 % from 2014-2016) and other children’s deaths from PHVSIDS . The
philosophy “ Let few die for saving much more people, is unacceptable for physicians who risk
to see a newborn’s death caused by their act, within few hours from a preventive vaccination,
and at the same time, parents cannot be obliged to expose their children to a Russian Roulette.
The possible solution is to entrust only to the paediatrician the choice of the vaccination time,
because of the necessary clinical evaluation, taking in account many individual and psychosocial
variables and reducing the number of vaccines to essential, with a health policy that could be
defined as “Person centered vaccination”. Deaths of children, inserted into vaccination
standardized programs without a previous diagnosis of immune system depression and its
existence also in stressed children and adolescents are documented.
29
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Vaccination needs a
person centered approach. Infectious diseases, that can be treated, can be more prevented also
increasing natural and adaptive immunity, with a public health policy promoting breastfeeding, a
strong immune protective factor with also vaccine power,
31
maternal care and psychosocial
environment quality. An updated person centered medical education to treat infectious diseases
and to create immunity conditions for sub-clinical infections increasing individual resources for
resistance, is necessary. Few physicians know that 10.000 units of Vit.A prevent 70% of measles
complications and the relationships between the immune system, quality of maternal care,
children’s nutrition and psychosocial environment. Children and adolescents are persons and the
persons are not chicken battery. An immune stimulating diet, a healthy life quality and sub-
clinical infections are resiliency factors reinforcing natural immunity more powerful than the
adaptive one, triggering a public health oriented to primary prevention and a policy for
improving healthy lifestyles. The best practice for preventing infectious diseases is the welfare
development more than a stock market.
1
Brera G.R The “Russian Roulette” hexavalent vaccination. The hexavalent vaccination risk for children’s and adults
life and health. The Post Hexavalent Vaccination Sudden Death Syndrome (PHVSIDS) and the Post Vaccination Asia
Syndrome( PVAS). (In Italian). Italian Journal of Adolescentology and Adolescence Medicine. 2018 Oct.;3:2-19.
PREPRINT
The need of a new person-centered vaccination policy after the identification of the Post Hexavalent Vaccination Sudden
Infant Death (PHVSIDS) and the Post Vaccination Asia Syndromes (PVAS).
Copyright Giuseppe R.Brera 2018
Internet:https://www.researchgate.net/publication/328126924_THE_HEXAVALENT_VACCINATION_RUSSIAN_ROU
LETTE_THE_HEXAVALENT_VACCINATION_RISKS_FOR_CHILDREN_AND_ADULTS'_LIFE_THE_INTRODUCTION_OF_TH
E_POST_HEXAVALENT_VACCINATION_SUDDEN_DEATH_SYNDROME_PHVSIDS_AND_THE_POS
2
Matturri L., Del Corno G.,Lavezzi AM. Sudden Infant Death following hexavalent vaccination. A neuropathological
study. Curr.Med Chem. 2014 Mar; 21(7): 941-6
3
Goldman G.S and Miller NZ. Relative trends in hospitalizations and mortality among infants by the number of
vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 19902010. Hum Exp
Toxicol. 2012 Oct; 31(10): 10121021.Published online 2012 Apr 24. doi: 10.1177/0960327112440111
4
Miller N Z and Goldman G S Infant mortality rates regressed against number of vaccine doses routinely given: Is
there a biochemical or synergistic toxicity? 2011 Sep; 30(9): 14201428.Doi Hum Exp
Toxicol: 10.1177/096032711140764426
5
Von Kries R, Toschke AM, Kundi M, Kalies H, Nennstiel U. et al.. Sudden and unexpected deaths after the
administration of hexavalent vaccines (diphtheria, tetanus, pertussis, poliomyelitis hepatitis B, Haemophilius
influenzae type b): is there a signal? . 2005 Feb; 164(2):61-9. Epub 2004 Dec 16.
6
Zinka B, Rauch E, Buettner A, Ibidem Ruëff F. Penning R. Unexplained cases of sudden infant death shortly after
hexavalent vaccination. Vaccine. 2006 Jul 26;24(31-32):5779-80.
7
Kuhnert R, Hecker H, Poethko-Müller C, Schlaud M, Vennemann M, Whitaker HJ et al. . A modified self-controlled
case series method to examine association between multidose vaccinations and death. Stat Med 2011; 30(6):
666677
8
Ottaviani G, Lavezzi AM, Matturri L. Sudden infant death syndrome (SIDS) shortly after hexavalent vaccination:
another pathology in suspected SIDS ? Virchows Arch. 2006 Jan; 448(1):100-4.
9
Panico MG, Caporale V, Attena F. Adverse events following hexavalent vaccine (Hexavac): knowledge and
informative sources. Vaccine. 2005 Apr 22; 23(22):2841-3
10
Traversa G., Spila-Alegiani S., Salmaso S, Ciofi degli Atti M with the HERA Study Group et al. Sudden
Unexpected Deaths and Vaccinations during the First Two Years of Life in Italy: A Case Serie Study. PloS One.
2011; 6(1): e16363. Published on line 2011 Jan 26. doi: 10.1371/journal.pone.001636
11
Prandota J. Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia,
infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed
infants. Am J Ther. 2004; 11(6): 517546
12
Daniels KA, Brooks TR , Mahl SE, Moran MT , Sutiwisesak L. , Welsh RM et al. Generation of cellular immune
memory and B-cell immunity is impaired by natural killer cells. 2015 Feb 27; 6:6375.doi: 10.1038/ncomms7375
13
Piccioli D., .Sbrana V, Melandri E., Valiante F. Contact-dependent Stimulation and Inhibition of Dendritic Cells
by Natural Killer. J,Exp.Med.2002 Feb.4;195(3):335-341
14
Philipp A, Lang, Karl S, Lang, Haifeng C, Xu, H C et al. Natural killer cell activation enhances immune pathology
and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):
12101215.Published online 2011 Dec 13. doi: 10.1073/pnas.1118834109
15
Guimarães LE, Baker B, Perricone C, Shoenefeld Perricone C, Shoenefeld Y. Vaccines, adjuvants and
autoimmunity. Pharmacol Res. 2015 Oct;100:190-209. doi: 10.1016/j.phrs.2015.08.003. Epub 2015 Aug 12.
PREPRINT
The need of a new person-centered vaccination policy after the identification of the Post Hexavalent Vaccination Sudden
Infant Death (PHVSIDS) and the Post Vaccination Asia Syndromes (PVAS).
Copyright Giuseppe R.Brera 2018
16
Shoenfeld Y, Agmon-Levin N. 'ASIA' Autoimmune/inflammatory Syndrome Induced by Adjuvants. J
Autoimmun. 2011 Feb; 36(1):4-8. doi: 10.1016/j.jaut.2010.07.003. Epub 2010 Aug 13.
17
Kern JK,, Homme KG , Geier MR. A Cross-Sectional Study of the Association between Infant Hepatitis B Vaccine
Exposure in Boys and the Risk of Adverse Effects as Measured by Receipt of Special Education Services. Int J
Environ Res Public Health. 2014 Sep 5;11(9):9156-70. doi: 10.3390/ijerph110909156.
18
Shoenfeld Y. Vaccine-induced autoimmunity: the role of molecular mimicry and immune cross reaction. Cell Mol
Immunol. 2018 Mar 5: 586-594. doi: 10.1038/cmi.2017.151.
19
Kern JK, King PG, Sykes LK, Geier MR. A case-control study evaluating the relationship between thimerosal-
containing haemophilus influenzae type b vaccine administration and the risk for a pervasive developmental
disorder diagnosis in the United States. Biol Trace Elem Res. 2015 Feb; 163(1-2):28-38. doi: 10.1007/s12011-014-
0169-3.
20
Salemi S, D'Amelio R. Could autoimmunity be induced by vaccination? Int Rev Immunol. 2010 Jun; 29(3):247-69.
Doi: 10.3109/08830181003746304.
21
Poddighe D., Laurino C., and Palmieri B, Vadalà M. Vaccination and autoimmune diseases: is prevention of
adverse health effects on the horizon? EPMA J. 2017 Sep; 8(3): 295311.Published online 2017 Jul
20. doi: 10.1007/13167-017-0101-
22
Gherardi RK , Eidi H , Crépeaux G, Authier FJ, Cadusseau J . Biopersistence and Brain Translocation of Aluminum
Adjuvants of Vaccines. Front Neurol. 2015; 6:4.Published online 2015 Feb 5. doi: 10.3389/fneur.2015.00004
23
Dórea JG. Exposure to mercury and aluminum in early life: developmental vulnerability as a modifying factor in
neurologic and immunologic effects .Published online Int J Environ Res Public Health. 2015 Feb; 12(2): 1295
1313.015 Jan 23. doi: 10.3390/ijerph120201295
24
Ratajczak H. Theoretical aspects of autism: Causes. A review. Journal of Immunotoxicology, 2011; 8(1): 6879
Available on line https://www.researchgate.net/publication/49815583_Theoretical_aspects_of_autism_Causes-
A_review
25
Tomljenovic L , Shaw CA . Do aluminum vaccine adjuvants contribute to the rising prevalence of autism? .J Inorg
Biochem. 2011 Nov; 105(11):1489-99. doi: 10.1016/j.jinorgbio.2011.08.008.
26
WHO AEFI Causality_assessement. 2005 available on line http://www.rho.org/files/rbr3 AEFI
27
Pulivel J, and Pathik N. Revised World Health Organization (WHO)’s causality assessment of adverse events
following immunizationa critique. Version 2. F1000Res. 2018; 7: 243. Published online 2018 May
29. doi: 10.12688/f1000research.13694.2
28
Brera G.R Medical science and health paradigm change . Milano; Università Ambrosiana : 2018 available on
Internethttps://www.researchgate.net/publication/324172109_Medical_Science_and_Health_Paradigm_change
29
Bitnun A, Shannon P, Durward A, Rota PA, Bellini WJ et al. Measles inclusion-body encephalitis caused by the
vaccine strain of measles virus. Clin Infect Dis. 1999 Oct;29(4):855-61. DOI:10.1086/520449
30
Caserta MT , O’Connor T, Wyman P A, Wang H, Moynihan J, et al. The Associations between Psychosocial
Stress and the Frequency of Illness, and Innate and Adaptive Immune Function in Children. Brain Behav
Immun. 2008 Aug; 22(6): 933940. Published online 2008 Mar 4. doi: 10.1016/j.bbi.2008.01.007
PREPRINT
The need of a new person-centered vaccination policy after the identification of the Post Hexavalent Vaccination Sudden
Infant Death (PHVSIDS) and the Post Vaccination Asia Syndromes (PVAS).
Copyright Giuseppe R.Brera 2018
31
Verhassel V. Is infant immunization by breastfeeding possible? Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;
370(1671): 20140139. doi: 10.1098/rstb.2014.0139
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