The focus of integrative care for the various challenges to the aging immune system starts with comprehensive preventative care: addressing overall gut health (Magrone T, Jirillo E, Immun Ageing 10(1):31, 2013); addressing nutrient deficiencies such as vitamins A, D, and E, zinc, and selenium (Kaur D, Rasane P, Singh J, Kaur S, Kumar V, Mahato DK, et al. Curr Aging Sci 12(1):15–27, 2019); encouraging a nutrient-dense diet void of inflammatory convenience foods such as packaged snacks, fried foods, and sweets; (Kiecolt-Glaser JK, Psychosom Med 72(4):365–369, 2010) and engaging in regular physical activity (Senchina DS, Kohut ML. Immunological outcomes of exercise in older adults. Clin Interv Aging. 2007;2(1):3–16). While this is applicable advice for all of us, the natural decline in immune functioning in the elder population, immunosenescence, which affects both innate and adaptive immunity, makes immune health a weakness in this population that can have dire consequences (Denkinger MD, Leins H, Schirmbeck R, Florian MC, Geiger H, Trends Immunol 36(12):815–824, 2015). Immunosenescence includes impairment of natural killer cell response to circulating cytokines, reduction in naive B- and T-cell production in the bone marrow and thymus, and sluggish maturation of lymphocytes in secondary lymphoid tissue. As a result, the elderly’s response to both novel and previously encountered antigens is ineffective. For example, individuals over 70 years old are at increased risk of influenza, in large part exacerbated by their ineffective response to vaccination (Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K, J Clin Invest 123(3):958–965, 2013). As a consequence, the incidence and prevalence of allergies, autoimmune disease, and acute infections are increased in older adults (Fuentes E, Fuentes M, Alarcón M, Palomo I, An Acad Bras Cienc 89(1):285–299, 2017).