Multidrug-resistant infections have created a horror in society as common antibiotics like ampicillin; streptomycin, ciprofloxacin, cefotaxime and azithromycin are no longer useful to cure bacterial infections. G-20 Nations have declared AMR Action Plan to combat MDR calamity and WHO has advised for the development of alternate to antibiotics. Indian medicinal plants have long tradition to cure many diseases as described in Charaka Samhita, Sasruta Samhita and Veda. We have demonstrated here to use heterogenous phyto-antibiotics (MDR-Cure) to combat superbugs. Kolkata Ganga River has been polluted with MDR bacteria and mdr genes like β-lactamases (blaTEM, blaCTX-M, blaOXA and blaNDM-1), acetyl-, phospho-and adenyl-transferases (aacC1/A2, aphA4, aadA2) as well as mcr, tet, acr and mexAB/CD/EF types drug efflux genes. Isolated superbugs are also resistant to advanced drug derivatives like imipenem, colistin, amikacin, linezolid, vancomycin, ceftriaxone and lomofloxacin. Ganga Action Plan has been initiated by Indian Government with estimated > Rs 40000 crores with mission 2020, when all industrial and domestic effluents will be treated before reach river as such contaminants generate multidrug-resistant bacteria. However, no immediate control on MDR bacterial contamination in river possible and many Indian still drink raw Ganga River water and also all bath in Kumbh Mela (Sangam of Allahabad) in religious occasions. We have also proposed that mdr genes are created and transmitted to save 2 × 10 12 diverse species of gut microbiota that synthesize 20 vitamins and other bio-molecules absolutely needed for human metabolosome. We believe, if we continue oral dose of antibiotics, all bacteria will be drug resistant for two reasons: (1) mdr genes combined with conjugative plasmids and (2) a message has generated to protect symbiotic relation between intestinal bacteria and luminal cells for vitamin synthesis which is needed for >30000 enzymatic reactions. Our research indicated that Indian medicinal plants like Suregada multiflora and Cassia fistula were useful and would give a new dimension to combat MDR pathogenesis and may help to prepare cheap effective drugs for poor nations.