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71
Consensus
Statements:
Development
and
Testing
of
the
School
Competency
Assessment
Scale
Audrey
Nelson,
PhD,
RN,
Julia
Challinor,
PhD,
RN,
Ida
(Ki)
Moore,
DNS,
RN,
Robert
B.
Noll,
PhD,
Nancy
Cushen
White,
EdD,
Jill
Brace
O’Neill,
MSN,
RN-CS,
PNP,
and
Laura
Clarke-Steffen,
PhD,
RN
CONSENSUS
STATEMENTS:
Development
and
Testing
of
the
School
Competency
Assessment
Scale
Survival
rate
of
children
under
15 years
of
age
from
acute
lymphoblastic
leukemia
(ALL)
is
approximately
80%
(Greenlee,
Murray,
Bolden,
&
Wingo,
2000).
Treatment
of
ALL
includes
whole-brain
radiation,
intrathecal
chemotherapy,
and
high-dose
systemic
chemotherapy.
These
modalities
are
effective
in
reducing
the
risk
of
central
nervous
system
(CNS)
relapse
(Balis
&
Poplack,
1989).
However,
the
effects
of
CNS
treatment
result
in
declines
of
the
child’s
cognitive
and
academic
skills
(Brown
et
al.,
1996;
Copeland,
Moore,
Francis, Jaffe,
&
Culbert,
1996;
the
MacLean
et
al.,
1995;
Smibert,
Anderson,
Godber,
&
Ekert,
1996).
Moore
and
colleagues
(2000)
reported
preliminary
evidence
that
CNS
injury
may
result
in
differences
in
intellectual
and
academic
outcomes
in
children
with
ALL
receiving
CNS
treatment.
They
identified
other
factors
that
may
also
affect
academic
performance.
These
include
missed
school,
fatigue,
and
availability
of
tutorial
assistance.
Additionally,
it
has
been
recommended
that
the
process
of
developing
and
testing
interventions
through
interdisciplinary
collaboration
needs
to
be
outlined
(Auger
et
al.,
2000).
A
preconference
workshop
at
the
Association
of
Pediatric
Oncology
Nursing’s
24th
Annual
Conference,
held
in
2000,
focused
on
the
development
and
testing
of the
School
Competence
Assessment
Scale
(SCAS).
The
SCAS
is
a
questionnaire
including
forms
for
the
parent
of
children
who
are
newly
diagnosed
with
cancer
as
well
as
their
teacher
and
health
team.
Numerous
factors
related
to
cognitive
and
academic
deficits
for
children
with
ALL
were
identified.
These
included
age
of
the
child
when
ALL
treatment
was
received,
gender,
socioeconomic
status
of
the
family,
school
class
size,
and
interaction
with
others.
After
the
workshop,
the
presenters
and
workshop
planning
committee
members
reviewed
the
notes
from
discussion
and
developed
consensus
statements.
These
consensus
statements
are
as
follows:
1.
A
psychosocial
team
that
includes
nurses,
social
workers,
psychologists,
child
life,
and
educators
contribute
to
the
treatment
plan
of
a
child/adolescent
with
cancer.
2.
Age-appropriate
cognitive
and
readiness
assessments
need
to
be
incorporated
in
the
child’s
treatment
plan.
3.
A
child’s
treatment
plan
needs
to
include
cognitive
and
readiness
assessments
annually
after
the
From
the
University
of Nebraska
Medical
Center,
College
of Nursing,
Omaha,
NE;
University
of
California,
San
Francisco
Division
of
Pediatric
Oncology,
San
Franczsco,
CA;
University
of Arizona
Division
of Pediatric
HematologylOncology,
Tucson,
AZ;
Chzldren’s
Hospital
Medical
Center
Division
of
HematologylOncology,
Cincinnati,
OH;
University
of
California,
San
Francisco,
Department
of Pediatrics,
Division
of Adolescent
Medicine,
San
Francisco,
CA;
Dana
Farber
Cancer
Institute,
Boston,
MA;
and
Phoenix
Children’s
Hospital,
Phoenix,
AZ.
Address
reprint
requests
to
Audrey
Nelson,
PhD,
RN,
Associate
Professor,
University
of
Nebraska Medical
Center,
College
of
Nursing,
985330
Nebraska
Medical
Center,
Omaha,
NE
68198-5330.
©
2003
by
Association
of Pediatric
Oncology
Nurses
1043-4542/03/2002-0005$30.00/0
doz:10.1053!jpon.2003.78
at UNIV ARIZONA LIBRARY on September 1, 2016jpo.sagepub.comDownloaded from
72
initial
evaluation
shortly
after
the
diagnosis
and
6
months
following
completion
of
treatment.
Assessment
tools
will
vary
according
to
the
child’s
age
and
developmental
progress.
4.
Health
care
providers
need
to
promote
the
parent’s
understanding
of
the
findings
from
these
assessments
and
to
identify
available
resources
for
the
child.
Networking
between
the
health
team
members
and
the
education
experts
at
the
child’s
home
school
and
health
care
facility
is
essential.
5.
The
SCAS
is
a
screening
tool
for
assessing
risk
for
academic
and
progression
problems
by
school
age
children
and
adolescents
receiving
CNS
treatment
for
cancer.
The
screening
tool
focuses
on
mathematics
computational
skills,
reading
and
spelling.
6.
Findings
from
the
SCAS
will
assist
the
health
team
and
educators
to
determine
frequency
of
continued
assessment,
referrals
for
improvement
in
cognitive
function
and
development
of
the
individual
education
plan
(IEP)
when
appropriate.
7.
Future
research
is
needed
to
develop
an
evidence-based
algorithm
to
illustrate
interventions
for
a
child
with
a
cancer
diagnosis
at
risk
for
or
experiencing
cognitive
deficits
that
may
affect
academic
success
and
progress
by
the
young
adult
in
advanced
school
settings.
8.
Additional
research
is
needed
to
evaluate
the
stability
of
the
SCAS
over
time
for
the
individual
child
dealing
with
cognitive
deficits
after
cancer
treatment.
References
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Article
Full-text available
Long-term cognitive and educational sequelae have been inconsistently reported in children who received cranial irradiation (CRT) to prevent central nervous system (CNS) disease in acute lymphoblastic leukaemia (ALL). This study investigates a large and representative sample of survivors of ALL and compares them with non-irradiated survivors of cancer and healthy control children to determine the effect of CRT on cognitive and educational ability. Three groups of children were studied: Group 1 (n=100) survivors of ALL treated with chemotherapy and CRT, group 2 (n=50) children with a variety of malignancies treated with chemotherapy alone, group 3(n=100) healthy children. Cognitive and educational abilities of these groups were evaluated using standardised psychometric techniques. Significant differences in cognitive and educational abilities were found between the children in group 1 (chemotherapy + CRT) and the two control groups, with the children receiving CRT performing less well in a range of tests. Greatest differences were detected for tasks dependent on language function including verbal IQ, reading and spelling. Within group 1 a younger age at treatment (less than 5 years) and a higher dose of CRT (24 Gy vs 18 Gy) were predictive of poor long-term outcome for cognitive and education ability. In contrast, children who received chemotherapy alone, with or without intrathecal methotrexate, performed similarly to healthy controls. No gender differences were detected for these measures.
Article
This prospective study compared the intellectual and academic functioning of two groups of children treated for cancer over the 3 years after their diagnosis. One group consisted of children who received central nervous system (CNS) prophylactic chemotherapy, and the other group consisted of children with cancer who did not receive CNS chemotherapy. The results suggest that the children who received CNS chemotherapy experienced more adverse effects from their treatment in the area of academic functioning than the children who did not receive CNS chemotherapy. Although there were no differences in the academic functioning of the two groups of children immediately after their diagnosis, 3 years postdiagnosis, the CNS-treated children scored more poorly on academic tests of reading, spelling, and arithmetic than the non-CNS-treated children. The results suggest that CNS chemotherapy prophylaxis may impede academic achievement.
Article
Objectives: To determine the relationship between membrane damage and intellectual and academic abilities in children with acute lymphoblastic leukemia (ALL) and pilot test a math intervention for children with ALL who were affected. Data sources: Research studies and review articles. Conclusions: Despite the prophylactic central nervous system (CNS) treatment for long-term disease-free survival, many children with ALL subsequently experience declines in intellectual and academic skills. Implications for nursing practice: Improving academic abilities in children who have received CNS treatment is of high priority and may have longlasting implications on quality of life.
The blood-brain barrier provides a pharmacologic sanctuary for leukemic cells within the central nervous system (CNS), protecting them from the cytotoxic effects of systemic antileukemic therapy. Attempts to overcome this problem have included specific CNS-directed treatment in the form of direct intrathecal drug injection, cranial irradiation, and alteration in the dose and schedule of systemic agents to enhance their CNS penetration. Use of these treatments and strategies has led to the effective prevention and control of meningeal leukemia. Intrathecal therapy, primarily with methotrexate or cytosine arabinoside, is a form of regional chemotherapy that can achieve very high drug concentrations at the target site [i.e., in the meninges and cerebrospinal fluid (CSF)] with a low total dose. Therefore, there is minimal systemic toxicity. The dose and schedules, clinical pharmacology, and toxicities of the commonly used intrathecal agents are discussed in detail in this article. Another approach to overcoming the limited penetration of antileukemic drugs into the CNS has been the use of high-dose systemic therapy. Methotrexate and cytosine arabinoside in high doses have produced favorable clinical responses in patients with overt meningeal disease, and pharmacokinetic studies have documented cytotoxic concentrations of these drugs within the cerebrospinal fluid. A clear understanding of the CNS pharmacology of the antileukemic drugs is required in order to use these agents in the safest and most efficacious manner for the treatment of meningeal leukemia.
Article
To determine the effects of cranial irradiation on neuropsychological test performance evident 9 months after diagnosis. A companion study to a randomized clinical trial (CCG-105). Institutions participating in Childrens Cancer Group cooperative treatment trials. Seventy-four children aged 3.0 to 6.5 years with average-risk acute lymphoblastic leukemia. Children with central nervous system leukemia at the time of diagnosis, preexisting mental retardation, or Down's syndrome or for whom English was not the primary language were not eligible for study. Children were randomized to receive treatment with one of four systemic chemotherapy regimens and either intrathecal methotrexate sodium during induction and consolidation plus 18 Gy of cranial irradiation or intrathecal methotrexate during induction, consolidation, and maintenance as central nervous system prophylaxis. The groups were comparable with regard to chronologic age, sex, and family socioeconomic status. Children who received cranial irradiation plus intrathecal methotrexate scored significantly lower on the McCarthy Motor Scale (P < .05) and the Token Test (P < .05) than children who received intrathecal methotrexate alone. The groups did not differ significantly on the McCarthy General Cognitive Index, Developmental Test of Visual Motor Integration, or Peabody Picture Vocabulary Test-Revised. Findings suggest that the combined effects of cranial irradiation and intrathecal methotrexate therapy on neuropsychological performance may be evident in young children as early as 9 months after diagnosis. Follow-up assessment of these children will reveal whether these effects remain constant, intensify, or resolve.
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A prospective study was conducted to assess the effects of chemotherapy for cancer on children's long-term neuropsychologic status. Ninety-nine children who received no cranial radiation therapy (CRT) completed four annual neuropsychologic assessments. Fifty-one patients received intrathecal (IT) chemotherapy (ITC); 48 received no CNS treatment. These two groups were compared using repeated-measures analysis of variance on IQ, memory, language, freedom from distractibility, academic achievement, executive functions, and fine-motor, perceptual-motor, and tactile-spatial skills. In addition, 51 of the sample of 99 patients had been examined 5 to 11 years after diagnosis. Their data were analyzed to evaluate the longer-term effects of chemotherapy. The predictability of demographic and medical variables on neuropsychologic outcome at 3-year and long-term follow-up study were assessed using multiple regression techniques. Overall, the effects of chemotherapy in the absence of CRT appear to be slight. Patients who received ITC and intravenous (IV) methotrexate declined slightly on perceptual-motor skills, but were still well within the normal range. Both groups, regardless of treatment, declined on academic achievement tests, although not to a statistically significant degree. Age effects were found on performance IQ (PIQ) and perceptual-motor skills. Socioeconomic status (SES) correlated with a large number of variables. Sex effects were not significant. The present results are largely consistent with previous findings for nonirradiated groups. Treatment effects from ITC are slightly more apparent 5 to 11 years after diagnosis than at 3-year follow-up evaluation but this does not constitute a clinically meaningful difference. More noticeable are academic declines among all groups, regardless of treatment.
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This longitudinal investigation extends our prospective study of the intellectual and academic functioning of children treated for cancer to 4 years after diagnosis. In the longer term, the children who received central nervous system (CNS) chemotherapy experienced greater neurocognitive deficits, particularly in the area of academic achievement, than did the children who did not receive CNS chemotherapy. Specifically, the CNS chemotherapy-treated children scored lower on academic tests of reading at 3 and 4 years after diagnosis. The results suggest that CNS chemotherapy prophylaxis may adversely effect the development of higher-order mental abilities and cognitive skills during the late-effects period and may also impair academic achievement.
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The Surveillance Research Program of the American Cancer Society's Department of Epidemiology and Surveillance Research reports its annual compilation of estimated cancer incidence, mortality, and survival data for the United States in the year 2000. After 70 years of increases, the recorded number of total cancer deaths among men in the US declined for the first time from 1996 to 1997. This decrease in overall male mortality is the result of recent down-turns in lung and bronchus cancer deaths, prostate cancer deaths, and colon and rectum cancer deaths. Despite decreasing numbers of deaths from female breast cancer and colon and rectum cancer, mortality associated with lung and bronchus cancer among women continues to increase. Lung cancer is expected to account for 25% of all female cancer deaths in 2000. This report also includes a summary of global cancer mortality rates using data from the World Health Organization.
  • R T Greenlee
  • T Murray
  • S Bolden
  • P A Wmgo
Greenlee, R.T., Murray, T., Bolden, S, & Wmgo, P.A. (2000) Cancer statistics 2000. CA Cancer Journal Clinical, 50, 7-33.