The Onset of Acne Vulgaris among Adult Women and the Effectiveness of Therapy with Ferulic Acid and D`arsonwal’s Currents

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Volume 5- Issue 4: 2018
1/6
ISSN: 2574-1241
DOI: 10.26717/BJSTR.2018.07.001576
Izabela Zaleska. Biomed J Sci & Tech Res
Research Article
Biomedical Journal of

Open Access
Introduction
Acne vulgaris is a quite common illness of hair follicles and
sebaceous glands, primarily located on the face area (forehead, chin,
    
is chronic and recurring. In its acute stage, it can lead to lasting and
     



In 1964, Loughlin’s research revealed, that the illness can emerge
also in the adulthood. In that age group, because of the occurrence

a) puberty continuation – persistent acne,
 
25- late onset acne [1].
In a subject literature, information can also be found about

inform that it disappears after puberty in order to reactivate in
the period of adulthood [2]. The most characteristic skin changes
    
seldom papules and pustules [3].



Izabela Zaleska*12
1The Section of Professional Cosmetology, The Faculty of Motor Rehabilitation, University of Physical Education in Krakow, Poland
2The Department of Medical Chemistry of Medical University of Gdańsk, Poland
 August 08, 2018;  August 13, 2018
 

Abstract
Acne vulgaris as a skin disease does not only affect young people. It is extremely acute and more common problem among adults,

discomfort, depression and in serious cases it may lead to suicide attempts.


puberty and after the age of 25.
                      
  


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

      




    



 Volume 7- Issue 5: 2018

Izabela Z, Anna K. 
..
DOI 10.26717/ BJSTR.2018.07.001576. 2/6
  
all, excessive sebum production, disorder of follicular xeroderma
and comedo formation in hair follicles and colonization of the


    
       
   
acid is plant originated, it is very often encountered in fruit and
 

countries as a food additive in order to prevent lipid peroxidation.

        
then other antioxidants such as Vitamin C [6]. The researchers
     
neuroprotective and anti-proliferative activity [7]. Positive
  
used by scientists for many years.


 
500 kHz. D’Arsonvalization is used in seborrhoeic skin treatment

       
is one of the strongest antioxidants.It also possesses very high


of microorganisms. The crucial part is that this destructive property
on anaerobic bacteria, that are one of the reasons of deterioration
of acne infected skin [10].


       
high frequency currents in the context of reduction of exanthema


puberty.
Methods and Materials
           
          
   
the period of breastfeeding, violation of continuity of epidermis,
    

last 6 months and around face area, using retinoids up to six months
        
     
     
        
      
using contact method.
         
          
        
        
      
probands voluntarily gave permission to participate in the discussed
          
         
advantages, potential risks and dangers, all inconveniences
          
    
treatment process, could be asked directly by the probands to the
       
the agreement of Independent Bioethics Commission for Research



 

   
       
       


        
 
 

        
t-test, (or in case of lack of homogeneity of variants -Welch test) or
     
applying student’s t-test or variables measured on ordinal scale).




     
        

case of non-compliance the conditions of applying student’s t-test
  


         

variables measured on ordinal scale).Tests of independence A chi-
 
the use of correction according to Yates for the numerousness of
       
         




 Volume 7- Issue 5: 2018
 Izabela Z, Anna K. 
.. DOI
10.26717/ BJSTR.2018.07.001576. 3/6
Results

         


 
        
          
probands marked the time of acne appearance in puberty, and in the



  
exanthema in relation to the onset of illness
Table 1: Characteristics of researched groups regarding the age
and acne onset.








average
(SD) 30,8 (4,8) 30,3 (4,9) 30,6 (4,8) 10,7303
Scope 24,0-42,0 23,0-42,0 23,0-42,0
 30,0 30,0 30,0
95%CI [29,0;32,6] [28,5;32,2] [29,3;31,8]

Puberty 15 (50,0%) 14 (46,7%) 29 (48,3%) 20,7961
maturity 15 (50,0%) 16 (53,3%) 31 (51,7%)
Note: 1t-Student (0,35);2Chi2 (0,07).
       

Table 2: Characteristics of researched groups regarding the
number of inammatory exanthema before the rst treatment
and after the fth treatment for probands who suffered from
acne in the time of puberty.



 
st 
average (SD) 4,6 (4,8) 8,1 (6,1)
Scope 0,0-13,0 1,0-22,0
median 3,0 7,0 10,0887
95%CI [1,9;7,3] [4,5;11,6]
th
average (SD) 1,1 (2,0) 0,6 (1,4)
Scope 0,0-5,0 0,0-4,0
median 0,0 0,0 20,7270
95%CI [0,0;2,2] [-0,2;1,5]
Value p 30,0033 40,0002
Note: 1Mann-Whitney (-1,70); 2Mann-Whitney (0,35); 3Wilcoxon
(2,93); 4t-Student (5,16).
   


         

        
    
  
   
 

 

-

       
       

         

  

   
       
          

      

Table 3: Characteristics of researched groups regarding the
number of inammatory exanthema before the rst treatment
and after the fth treatment for probands who suffered from
acne in the time of maturity.



 
st
average (SD) 3,1 (3,8) 6,1 (3,9)
Scope 0,0-12,0 0,0-11,0
median 1,0 7,0 10,0438
95%CI [1,0;5,2] [4,0;8,1]
th
average (SD) 1,5 (2,3) 0,9 (1,7)
Scope 0,0-6,0 0,0-6,0
median 0,0 0,0 20,7518
95%CI [0,2;2,7] [0,0;1,8]
Value p 30,0160 40,0001
Note: 1Mann-Whitney (-2,02); 2Mann-Whitney (0,32); 3t-Student
(2,74); 4t-Student (6,12).
     
        
      

       
       
          

 Volume 7- Issue 5: 2018

Izabela Z, Anna K. 
..
DOI 10.26717/ BJSTR.2018.07.001576. 4/6
       
       




         

      
       
Table 4.
Table 4: Characteristics of researched groups regarding the
number of non-nammatory exanthema before the rst treatment
and after the fth treatment for probands who suffered from
acne in the time of puberty.



 
Before 1st treatment
average (SD) 12,8 (9,4) 11,8 (8,0)
Scope 0,0-37,0 2,0-25,0
median 10,0 10,5 10,7578
95%CI [7,6;18,0] [7,2;16,4]
After 5th treatment
average (SD) 6,4 (7,1) 5,1 (4,0)
Scope 0,0-26,0 0,0-16,0
median 5,0 4,0 20,9652
95%CI [2,5;10,3] [2,9;7,4]
value p 30,0010 40,0007
Note: 1t-Student (0,31); 2Mann-Whitney (0,04); 3t-Student(4,17);
4t-Student (4,41).
      

Table 5: Characteristics of researched groups regarding the
number of non-inammatory exanthema before the rst
treatment and after the fth treatment for probands who suffered
from acne in the time of maturity.



 
st 
average (SD) 11,9 (7,8) 10,9 (6,2)
Scope 0,0-25,0 2,0-24,0
median 12,0 9,5 10,0371
95%CI [7,6;16,3] [7,5;14,2]
th
average (SD) 3,7 (4,7) 6,0 (4,4)
Scope 0,0-18,0 2,0-14,0
median 2,0 3,5 20,0721
95%CI [1,1;6,3] [3,7;8,3]
value p 30,0001 40,0004
Note: 1t-Student (-2,19); 2Mann-Whitney (-1,80); 3t-Student (5,53);
4t-Student (4,53).
       
        
        
         
      
          
         
 
  

        
    

Discussion
          

       
        
          
          
       
features of acne vulgaris progress is the appearance of increased
         
acid on skin stops the production of reactive forms of oxygen that
          
  


no matter the season of the year or the degree of insolation. That

that practically does not cause any irritation. Thanks to that fact,
therapeutic processes can be extended and the operation of other
active substances can be strengthened [16]. One can therefore
venture a statement that introduction of the discussed acid in

        
        
         
near vicinity of condenser electrodes that emit currents, ozone is
produced [17]. The ozone can be potentially dangerous for human
   

a perfect antiseptic resource, that supports healing processes
of skin infections [18]. The highest attention is paid to ozone’s
       
the use of high frequency currents. The excessive colonisation of
anaerobic bacteria Propionibacterium acnes is often mentioned as


form. This fact seems to be highly useful n the context of feasibility
of application of the discussed gas on the skin surface in this exact
state [19].
        
    

 Volume 7- Issue 5: 2018
 Izabela Z, Anna K. 
.. DOI
10.26717/ BJSTR.2018.07.001576. 5/6

   


     
       
quantitative differences in the future. Also Dreno in his studies
         

  
take on other methods of treatment regarding younger skin.

      

   

method.
        

       
        


        

       
      

        
         
          

anaerobic bacteria, involved in pathogenesis of acne vulgaris. The
   
         

       
        

Summary


       
proved the decrease in the number of exanthema no matter the
probands’ onset of an illness. The results gained, demonstrate
that both methods applied on the surface of the skin may be used
interchangeably in a mild stage of acne and they can support
       

if it happened after the age of 25 or from the time of puberty.
         

    
 
        
currents on the surface of the skin. It seems possible to demonstrate
even higher effectiveness over the decrease of exanthema of both
provenance in the process of Acne vulgaris in case of combining
both kinds of treatments in the future. The extension of the research
         

Declarations

All procedures performed in studies involving human
    
       
1964 Helsinki declaration and its later amendments or comparable

consent.

    
person’s data.
References
1.          

2. 

3.         


4.   

5.         


6.          
         

7. 
        


8. Roucayrol PE (1954) Bactericidal effect of d’Arsonval currents in the
male and female genital tracts. J Radiol D’électrologie Arch D’électricité

9. Kasprzak W, Adamski Z, Bia      
Ozonot herapy and application of ozone as disinfectant. Advances in

10.        
        
    

11. 
scale international study enhances understanding of an emerging acne
          

12. 


 Volume 7- Issue 5: 2018

Izabela Z, Anna K. 
..
DOI 10.26717/ BJSTR.2018.07.001576. 6/6
13. 
In vitro and in vivo evaluation of caffeic and ferulic acids as topical

14.             
 
        

15. 
topical antioxidant complex containing vitamins C and E and ferulic acid
against ultraviolet irradiation-induced photodamage in Chinese Women.

16.         

17.            

18. 


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ISSN: 2574-1241
DOI: 10.26717/BJSTR.2018.07.001576
Izabela Zaleska. Biomed J Sci & Tech Res