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Health benefits of Probiotics by Antioxidant Activity: A review
... The pharmacology research, for the evaluation of the toxicity, is become vital in regards to the neutraceuticals products development [1,[7][8][9][10]. The cytotoxicity studies of the nutraceutical products, especially the lactobacillus (LAB) formulation are gaining importance due to its industrial application [11,12]. ...
... The cytotoxicity studies of the nutraceutical products, especially the lactobacillus (LAB) formulation are gaining importance due to its industrial application [11,12]. The interaction of the probiotics cells with the living host cells may rarely precipitate toxicity [1][2][3]13,14,17,18]. The interaction of the LAB in pathophysiological conditions such as cancer is gaining importance as an alternative source of functional food [14][15][16]. ...
... Although, inflammation is a defensive mechanism in response to foreign bodies but leads to cellular damage due to producing oxidative stress [5] . Under these circumstances, synthetic and natural antioxidants have a major role to protect cells against oxidative stress [6] . Hence, it is obligatory to develop new drugs at minimum cost, which are effective against resistant organisms and also aid in quick healing of infected wounds through free radical scavenging [7] . ...
... The research work was aimed to theoretically validate the binding of the synthesized SMZ derivatives (4a-4f) using molecular docking against COX-2 protein of Mus musculus as depicted in Table 2. The docking score and molecule interactions ( fig. 3) were obtained in least binding energy of the compound 4d and 4f at value -12.980 and -12.386 kcal/mol with 1-picrylhydrazyl (DPPH) assay procedure with some modifications [6] at several concentrations, the absorbance of the test molecules and the standard butylated hydroxy toluene (BHT) was measured at 517 nm on a UV/Vis spectrophotometer and the antioxidant activity was calculated. A mixture of DPPH and methanol was considered as control. ...
... Milk plays vital role in the human daily life [1][2][3] . Because it contains the fat, protein, vitamin, carbohydrates and minerals. ...
Milk plays vital role in the human daily life. Because it contains the fat, protein, vitamin, carbohydrates and minerals. It contains sodium, potassium, vitamin B6, vitamin D, vitamin C, iron, Phosphorous, casein. Most probably calcium is an important content in the milk along with casein which contains highest amount of protein. Sheep and Buffalo milk contains more amount of casein than the human milk. Daily consumption of milk can help in our growth and development. Prevents wear and tear of the body. Daily consumption of milk helps to increases the RBC count in the human body and even it makes muscles strong. It provides the energy to the body due to the presence of phosphorous in it. It controls the weight gain in body. Milk plays important role in children it helps to make their bones strong because of the nutrients present in it.
... Nutrients that are generally present at relatively low concentrations in living tissues and which are needed for optimum performance of a particular function in the living system are designated as 'Micronutrients' [1][2][3] . They include vitamins and minerals. ...
Nutrients that are generally present at relatively low concentrations in living tissues and which are needed for optimum performance of a particular function in the living system are designated as 'Micronutrients'1-3. They include vitamins and minerals. Micronutrients, although do not provide energy themselves unlike macronutrients (carbohydrate, fat and protein), but help in the liberation and utilization of energy from the macronutrients. In addition, they have other specific vital functions in the body. Vitamins are essential for the utilization of the macronutrients and also in the regulation of the body processes-metabolism and circulation, digestion and absorption of nutrients and reproduction. Macrominerals such as calcium and phosphorous are structural components of bones and skeleton; sodium and potassium are elements present in cellular fluids; magnesium is an active constituent of many enzyme systems
... Researchers are working in culturing probiotics in milk of A2 milk from different milking animals. The maximum growth profile observed in the milk of milking animal is considered as prebiotics source [1][2][3][4][5] . Prebiotics are nothing but are source of food for probiotics that is Lactobacillus [6][7][8][9] . ...
The milk of buffalo is consumed mostly in all local areas of Maharashtra. A2 type of milk is found effective in marinating the health profile of consumers. It is assumed that the milk obtained from the different breeds of the buffalo are rich in probiotics especially Lactobacillus. Researchers are working in culturing probiotics in milk of A2 milk from different milking animals. The maximum growth profile observed in the milk of milking animal is considered as prebiotics source.
... Stomach pain and respiratory problems can occur due to consumption of A1 milk. In type 1 diabetes, the production of insulin is in fewer amounts because of intake of A1 milk thus type 1 diabetes is triggered at the end [1][2][3] . Milk also negatively effects on the blood vessel's function and blood pressure rate by controlling the cholesterol content. ...
Milk is the basic source of food in the country like India and many Asian countries. There are two types of milks-A1 and A2 Milk. Nearly50 samples of Mehsana buffalo milk samples were collected in local areas of Maharashtra. The parameters screened were protein, fat, lactose, total solid content and percentage of casein in the raw milk of Mehsana reported as 5.4 ± 0.62; 6.1 ± 0.66; 6.2 ± 0.65; 18.8 ± 1.54; 11.4 ± 1.02 respectively. Similarly, the parameters screened for pasteurized milk sample were protein, fat, lactose, total solid content and percentage of casein as 5.2 ± 0.21; 6.2 ± 0.22; 6.1 ± 0.71; 18.1 ± 0.54; 10.4 ± 2.02 respectively. Milk is the basic source of food in the country like India and many Asian countries. There are two types of milks-A1 and A2 Milk. A1 Milk is most commonly used milk. It is obtained from cow or some hybrid milking animals. A1 type of milk raises the issues of digestion. Stomach pain and respiratory problems can occur due to consumption of A1 milk. In type 1 diabetes, the production of insulin is in fewer amounts because of intake of A1 milk thus type 1 diabetes is triggered at the end 1-3. Milk also negatively effects on the blood vessel's function and blood pressure rate by controlling the cholesterol content. A1 milk is not good for infants' health. It also contains more amount of fat which is not healthy for human beings 4-7. Similarly, there is another type of milk that is calledA2 milk. This milk is obtained from desi cows in countryside. A2 milk is a great source of vitamin A, Vitamin D, Vitamin B12, Calcium and Potassium. As compared to A1 milk the A2 milk is more beneficial for health concerns. Due to Consumption of A2 milks bones and teeth get stronger. It maintains tissue growth and cell growth in human body. It maintains good nourishment and the well-being in the human body 8-11. Camel's milk contains also contain A2 caseins. It is used as nutrition support for the human who are living in desert area.Buffalo milk is used in the dairy products like Mozzarella cheese. It is most common animal milk used in dairy products. It contains more amounts of fats proteins and minerals.The Cow's milk also known as A2 milk. As we know in the cow's milk is having higher amount of casein which help into whitening of the color of milk. The cows' milks are thick than the other animal's milk. Nearly50 samples of Mehsana buffalo milk samples were collected in local areas of Maharashtra. To conduct the experiment approximately 40 ml quantity of milk was used. Before the study to initiate the milk was processed with ultra-high-temperature (UHT) pasteurizedin cyclic process of 8 s for a period of 1 hour 12-18. To analyse the nutrient content FOSS milk scan TM 120 (calibrated with buffalo standards, Swabhimani dairy, India)
... The amount of drug permeated was determined using a UV Spectrophotometer at 287 nm. The results were compared with permeation of solution of Ivabradine hydrochloride through buccal mucosa [34][35][36]. ...
Thiolation of polymers is one of the most appropriate approaches to impart higher mechanical strength and mucoadhesion. Thiol modification of gum karaya and gum acacia was carried out by esterification with 80% thioglycolic acid. FTIR, DSC and XRD confirmed the completion of thiolation reaction. Anticancer potential of developed thiomer was studied on cervical cancer cell lines (HeLa) and more than 60% of human cervical cell lines (HeLa) were inhibited at concentration of 5 µg/100 µL. Immobilized thiol groups were found to be 0.8511 mmol/g as determined by Ellman’s method. Cytotoxicity studies on L929 fibroblast cell lines indicated thiomers were biocompatible. Bilayered tablets were prepared using Ivabradine hydrochloride as the model drug and synthesized thiolated gums as mucoadhesive polymer. Tablets prepared using thiolated polymers in combination showed more swelling, mucoadhesion and residence time as compared to unmodified gums. Thiol modification controlled the release of the drug for 24 h and enhanced permeation of the drug up to 3 fold through porcine buccal mucosa as compared to tablets with unmodified gums. Thiolated polymer showed increased mucoadhesion and permeation, anticancer potential, controlled release and thus can be utilized as a novel excipient in formulation development.
... ese formulation forms may be in tablets, capsules, and oral liquid monophasic single dosage forms. But the most concerning part is its short shelf life, as the formulation will prepare to deteriorate by a change in temperature and various storage conditions [4,[27][28][29][30][31][32]. Many studies revealed that the colony-forming unit (CFU) per gram value above 10 8 counts is found to show the health bene ts [5][6][7][8][9][10]33]. ...
Lactobacillus (LAB) genera are considered important functional food but are found to have a short shelf life. In this study, two LAB, Lactobacillus plantarum (Lp) and Lactobacillus rhamnosus (Lr), were isolated from sheep's milk, and whole-genome sequencing was carried out by using 16s rRNA Illumina Nextseq, the Netherlands. e LAB were encapsulated by the lyo-philisation technique using di erent lyoprotective pharmaceutical excipients. is process was carried out using a freeze dryer (U-TECH, Star Scienti c Instruments, India). Shelf-life determination was carried out by a 12-month study using the viability survival factor (Vsf). e in vitro cell adhesion technique was carried out by using the red snapper sh along with autoaggregation and cell surface hydrophobicity as vital probiotic properties. It was observed that Lp has a signi cantly higher (P < 0.001) Vsf of 7.2, while Lr has a Vsf of 7 (P < 0.05) when both are encapsulated with 10% maltodextrin + 5% sucrose kept at 4°C for 12 months. e result demonstrated that Lp had signi cantly high (P < 0.05) cell adhesion, 96% ± 1.2 autoaggregation, and 6% cell surface hydro-phobicity as compared to Lr. Moreover, this study demonstrated that lyophilised LAB with lyoprotective excipients enhances shelf life without any changes in probiotic properties when kept at 4°C exhibiting all its probiotic properties.
... The scientist found about 4% variability in genomic nucleotides of bat SARS and a bat SARS-CoV-2. Many research is going on to check that use of probiotics or neutraceuticals can prevent the infection by antioxidant mechanism along with existing drugs available in the market [14][15][16][17][18][19][20][21]. ...
The new respiratory disease frequently observed are zoonoses exhibiting positive-stranded RNA viruses called Coronaviruses (CoVs). These groups of the virus are having origin from non-human species such as bats, cows and birds. The transmission of the virus to humans is reported to cause severe acute respiratory infection from cough to pneumonia. The mortality rate is increased from its origin from severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) to newly developed COVID-19. The following review states that the SARS, MERS to newly developed COVID-19 are generally types of coronavirus. The mode of infection and symptoms exhibited by all the corona types are nearly the same but with the difference in its virulence.
The cytotoxicity studies of the nutraceutical products, especially the lactobacillus (LAB) formulation are gaining importance due to its industrial application. To support the claim MTT test was performed on three different strains of Lactobacillus i.e. Lp-Lactobacillus plantarum; Lr-Lactobacillus rhamnosus and La-Lactobacillus acidophilus. The viability study conducted by MTT assay on HCT 115 cell lines shows a decrease in percentage cell viability, an approximately around 40% in case of the Lp for its highest dose of 50 µg/ml and further, showing the strongest anti-proliferative activity as compared to control group. SHORT COMMUNICATION The pharmacology research, for the evaluation of the toxicity, is become vital in regards to the neutraceuticals products development 1-7. The cytotoxicity studies of the nutraceutical products, especially the lactobacillus (LAB) formulation is gaining importance due to its industrial application 11-12. The interaction of the probiotics cells with the living host cells may rarely precipitate toxicity 13-18. The interaction of the LAB in pathophysiological conditions such as cancer is gaining importance as an alternative source of functional food 14-16. To support the claim MTT test was performed on three different strains of Lactobacillus i.e. Lp-Lactobacillus plantarum; Lr-Lactobacillus rhamnosus and La-Lactobacillus acidophilus. The culture of Lp and La were discovered by our team from sheep milk and whole genome
Worm infestation issue is a common health condition observed mostly in Asian countries. The prevalence of worms in children is higher due to the habit of playing in mud or outdoors which is not found in the case of an infant. Very rarely worm infestation is observed in infants. There is a need for an investigation to be carried out for live worms in the stool. Sometimes the change in the diet of the infant, irregular bowel movements, and worm-like things in stool makes an alarming situation. We report the original case of a 6-month-old infant camouflaging for worm infestation due to the presence of the thread-like parasite in stool. The routine stool and chemical analysis of black thread thing from stool revealed solid diet fibers of banana and not any parasitic infection.
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