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Title: HSCRP as a Biomarker of the Capillary Cell Pivot and Swing Dance
Author (s) Name: Robert Buckingham, MD, FACP
Ojai California 93023
HSCRP is an infalmmatory protein, produced in the liver and increased in the blood when there is
chronic interstitial space inflammation invovling one or several end organs. Because of its
sensitivity, it can be increased from any chronic inflammatory process but is elevated in the blood
stream when vascular infalmmatory free radicals are impinging on endothelial and capillary cell
basement membranes. Because of its sensitivity to basement membrane impingement, its elevation
can be indirectly used as an indicator of how well endotheila and capillaries are dancing. If trending
higher or substantially elevated, it can be assumed that interstial spaces are inflamed, basement
membreanes are impinged, and that endothelia and capillaries have stopped their pivot and swing in
favor of funneling immune arsenal into the intersital space to combat the free radical onslaught
while also having their mitochondrial combustion get stuck in energy production to support the
active transport of immune arsneal into the interstitial space. The blocked dance, not only blocks the
rejuvenating nitric oxide production cycle, but also increases toxic superoxide exhaust which
subsequently increases damage to memebrane surfaces it attaches to as well as to both nuclear and
mitochondrial DNA. This severely impacts the cells coding and transcrition apparatus thereby
rendering protein synthesis inadequate and making replacement proteins for mitochondria, outer
membranes and other organelles ineffective. As the capillary cell infrastructure, choreography and
signaling feedback loops diminish, chronic intersital space inflammation escalates, as rogue
immune arsneal, and their bewitched cytokines they release, will seize control interstial space
signaling loops. Disease veneus of all types will follow. HSCRP elevation can becomes an early
flag bearer of this cascading proinflammatory momentum years before cancer, scarring, thrombosis,
autoimmune complexes or infections become serious interstial space players.
Biography
Robert Buckingham, MD, FACP, has had an extensive career in medical practice andmost recently
in theoretical molecular biology. He has pulblished three books on the capillary cell dance and how
it becomes impaired with chronic interstitial space inflammation thereby spawning disease venues
that include cancer, scarring, infections, autoimmune complex diseases and thrombosis. By
establishing the relationship of outer membrane permeability to the swinging of mitochondrial
combustion, known as the pivot and swing, Dr. Buckingham has helped to solve the complex
interactions of fluxing cellular combustion, outer membrane permeability, functioing feedback
loops involving allied cells and the cell’s regeneative capacity.
Presenting author details
Full name: Robert Buckingham,MD, FACP
Contact number:1-805-798-3481
Email id:drrlbuckingham@yahoo.com
Category: (Oral presentation/ Poster presentation)
Session name:
Research interest: Chronic Inflammation and the Capillary Cell Dance
Bibliography:
R. Buckingham,MD, FACP, Hazing Aging, 2015, I Universe
R. Buckingham, MD, FACP, Rejuvenation!, 2017, I Universe
R. Buckingham, MD, FACP, Trafficking, 2018, Litfire Press