A number of recent studies in the economics literature have focused on the usefulness of factor models in the context of prediction using " big data " (see Bai and Ng (the references cited therein). We add to this literature by analyzing whether " big data " are useful for modelling low frequency macroeconomic variables such as unemployment, in ‡ation and GDP. In particular, we analyze the predictive bene…ts associated with the use of principal component analysis (PCA), independent component analysis (ICA), and sparse principal component analysis (SPCA). We also evaluate machine learning, variable selection and shrinkage methods, including bagging, boosting, ridge regression, least angle regression, the elastic net, and the non-negative garotte. Our approach is to carry out a forecasting " horse-race " using prediction models constructed using a variety of model speci…cation approaches, factor estimation methods, and data windowing methods, in the context of the prediction of 11 macroeconomic variables relevant for monetary policy assessment. In many instances, we …nd that various of our benchmark models, including autoregressive (AR) models, AR models with exogenous variables, and (Bayesian) model averaging, do not dominate speci…cations based on factor-type dimension reduction combined with various machine learning, variable selection, and shrinkage methods (called " combination " models). We …nd that forecast combination methods are mean square forecast error (MSFE) " best " for only 3 of 11 variables when the forecast horizon, h = 1, and for 4 variables when h = 3 or 12. Additionally, non-PCA type factor estimation methods yield MSFE-best predictions for 9 of 11 variables when h = 1, although PCA dominates at longer horizons. Interestingly, we also …nd evidence of the usefulness of combination models for approximately 1/2 of our variables, when h > 1. Most importantly, we present strong new evidence of the usefulness of factor based dimension reduction, when utilizing " big data " for macroeconometric forecasting.