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Biotechnologically produced moss active improves skin resilience

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Abstract

Mosses substantially helped changing primitive earth into a green planet before vascular plants even existed. They encode genes and proteins for extraordinary resilience long abandoned by higher plants. Biotechnology offers a sterile production of the moss Physcomitrella patens in a reproducible and sustainable way. MossCellTec™ No. 1 is the first biotechnological mossbased product for cosmetic application. In our research, we have investigated the importance of cell nucleus health as a novel target for anti-aging cosmetics. Interestingly, the moss extract was able to improve the expression of cell nucleus health markers in aged skin cells. Additionally, the active ingredient could improve the hot-humid/cold-dry adaptation of reconstructed skin and improved skin homogeneity, barrier and hydration despite stressful weather conditions in a placebo-controlled clinical study. The moss active may therefore enhance the general resilience of the skin against environmental changes.

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... Furthermore, with the release of the complete P. patens genome sequence (Rensing et al., 2008), precise and efficient genetic manipulation to explore biological functions of genes responsible for the unique features of the moss has become possible (Cove et al., 2009a). Subsequently, several studies have reported the development of powerful bioengineering tools for the production of high-value compounds in mosses, such as terpenoids, biopharmaceuticals, and cosmetic products (Bach et al., 2014;Reski et al., 2015;Wandrey et al., 2018). ...
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