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To what extent does cinnamon administration improve the glycemic and lipid profiles?
Abstract
Background & aims:
Cinnamon is a condiment used in cooking and by some in large quantities as a supplement with purported hypoglycemic and lipid-lowering potential. The current literature review aims to discuss the evidence of cinnamon administration regarding its hypoglycemic and lipid-lowering effects, summarizing clinical recommendations.
Methods:
Electronic databases including PubMed, Cochrane library, Science Direct and Web of Science were searched with the scientific name of the plant as well as the common name. The search for articles was based on following keywords: "cinnamon diabetes", "cinnamon diabetes type 2", "cinnamon and diabetes type 2", "Cinnamomum aromaticum", "Cinnamomum cassia", "Cinnamomum verum", "Cinnamomum zeylanicum". We carried out inclusion criteria between 2003 and 2018 focusing on human studies.
Results:
Concerning glycemic profile, in individuals with type II diabetes mellitus the fasting blood glucose reduced from 12.9 to 52.2 mg/dL and HbA1c from 0.27 to 0.83%, whereas serum insulin decreased in few studies. Research papers ranged from 6 to 17 weeks in duration. The lipid lowering potential, in turn, is most controversial compared to anti-hyperglycemic potential. Also cinnamon administration has been claimed to reduce fat mass and raise serum antioxidants, but the studies used inaccurate methods. Two species are most investigated, C. cassia/aromaticum, and C.zeylanicum/verum.
Conclusions:
About 1-6 g of these cinnamon species mainly in powder seems to be an adjunct drug treatment for type 2 diabetes mellitus and other conditions of glycemic impairment. However, more controlled clinical trials are needed.
... The mechanisms of action of cinnamaldehyde involve increase in insulin activity, which increases the expression of the GLUT-4 receptor and its mRNA in skeletal muscle cells. [56][57][58] Cinnamon extract seems to induce GLUT-4 translocation through the AMPK signaling pathway. 58,59 Cinnamtannin B1 enhances insulin sensitivity through various mechanisms, including stimulation of phosphorylation of the insulin receptor b-subunit on adipocytes and other insulin receptors. ...
... 60 Gallic acid increases insulin receptor mRNA and protein expression, enhances the expression of proteins involved in glucose transport, acts as an a-glycosidase inhibitor, and protects b-cells by alleviating hyperglycemia. 57,61 Eugenol alters ghrelin secretion and affects food intake and gastric emptying, while beta caryophyllene plays a supporting role, increasing noradrenaline and thermogenic action. 62 Cinnamic acid seems to inhibit lipase activity, reducing the hydrolysis of dietary triglycerides and stimulating lipolysis via activation of AMPK, leading to the inhibition of fatty acid synthesis. ...
... In addition, cinnamon supplementation increases antioxidant-related proteins, including Nrf2 and HO-1, reducing blood lipids. 57,58 Our subgroup analysis revealed the importance of comparing the different types of cinnamon supplements. Cinnamon in capsules was the type of supplementation that showed an effect on the greatest number of metabolic biomarkers (FBG, postprandial glucose, HbA1c, TC, LDL-C, and TGs). ...
Context
The global prevalence of type 2 diabetes mellitus (DM2) has been rising significantly over the years. Recent studies have shown beneficial effects of cinnamon on metabolic biomarkers.
Objective
The objective of this review was to assess the effect of cinnamon supplementation on metabolic biomarkers in patients with DM2.
Data Sources
The Pubmed/MEDLINE, Cochrane CENTRAL, and Embase databases were searched up to November 10, 2022.
Data Extraction
A systematic search was performed for randomized controlled trials (RCTs) evaluating the effect of cinnamon supplementation on metabolic biomarkers, in adults and the elderly with DM2, and comparing the data for a cinnamon intervention group with that for a placebo group or a control group. The main exclusion criteria were studies (1) with other types of diabetes (ie, gestational diabetes or type 1 diabetes), (2) without cinnamon consumption, (3) that did not evaluate metabolic biomarkers, or (4) in vitro and animal studies. Two researchers independently screened 924 records, evaluated full-text studies, extracted data, and appraised their quality. A third researcher was consulted to resolve any discrepancies. The data were pooled using random-effects models and expressed as the weighted mean difference (WMD) with 95% CI. Heterogeneity was assessed using Cochran’s Q test and quantified using I2 statistics. Risk of bias was assessed using the Joanna Briggs Institute (JBI) instrument. Sensitivity analysis and the GRADE system were used to assess the robustness and certainty of the findings.
Data Analysis
In total, 28 RCTs with a duration ranging from 30 to 120 days and a total enrollment of 3054 patients with DM2 were included. Participants consuming cinnamon showed a significant reduction in fasting blood glucose (FBG) (WMD: −15.26 mg/dL; 95% CI: −22.23 to −8.30; I2 = 88%), postprandial glucose (WMD: −39.22 mg/dL; 95% CI: −63.90 to −14.55; I2 = 100%), HbA1c (WMD: −0.56 mg/dL; 95% CI: −0.99 to −0.13; I2 = 94%), and HOMA-IR (WMD = −0.76, 95% CI: −1.13 to −0.39; I2 = 22%) compared with the control group. An intervention of cinnamon in capsule form reduced FBG (WMD:−18.43 mg/dL, 95% CI: −26.32 to −10.53; I2 = 89%), postprandial glucose (WMD: −44.83 mg/dL, 95% CI: −70.67 to −18.99; I2 = 100%), HbA1c (WMD: −0.56 mg/dL, 95% CI: −1.02 to −0.09; I2 = 94%), total cholesterol (WMD: −13.39 mg/dL; 95% CI: −24.71 to −2.07; I2 = 96%), LDL-C (WMD: −6.49 mg/dL, 95% CI: −12.69 to −0.29; I2 = 92%), and triglycerides (WND: −19.75 mg/dL; 95% CI, −33.71 to −5.80; I2 = 88%). Both doses (≤2 g/day and >2 g/day) reduced FBG and postprandial glucose. Only cinnamon doses of ≤2 g/day reduced HbA1c (WMD: −0.68 mg/dL, 95% CI: −1.16 to −0.1; I2 = 92%), HOMA-IR (WMD: −0.94 mg/dL; 95% CI: −1.21 to −0.67; I2 = 0%), and BMI (WMD: −1.18 kg/m2; 95% CI: −1.97 to −0.39; I2 = 0%).
Conclusion
The data suggest that cinnamon improves the glycemic and lipid profile and reduces the BMI, particularly in DM2 patients who receive cinnamon supplementation in capsule form and at a dose of ≤2 g/day.
Systematic Review Registration
PROSPERO registration no. CRD42022370332.
... This is mainly attributed to the whole perspective and multiple target approaches of TCM providing distinct benefits in the management of complicated diabetes (Tong et al., 2012). Cinnamon, a spice and/or flavoring ingredient, has emerged as a promising supplement for the treatment of T2DM, obesity, and dyslipidemia (Santos and da Silva, 2018). However, the mechanisms and effectiveness of cinnamon on metabolic diseases remain perplexing because large majority of studies exhibited design limitations, such as short intervention durations, limited sample sizes, and inconsistent efficacy assessments (Gannon et al., 2015). ...
... The majority of studies (Santos and da Silva, 2018) have shown that cinnamon in dosages of 1-6 g/day resulted in a reduction in LDLc, TG, and TC in T2DM individuals, confirming the protective function of cinnamon and cinnamon extracts at various stages of diabetes, which is similar to the current meta-analysis results. Animal investigations, both in vitro and in vivo, have found that cinnamon is an insulin sensitizer (Talpur et al., 2005). ...
... It also boosts the expression of receptor proteins involved in glucose transport, insulin signaling, and dyslipidemia regulation (Subash Babu et al., 2007;Sharma et al., 2020). Santos and da Silva (2018) indicated six pathways by which cinnamon enhances serum parameters and lipid reduction. Based on the aforementioned summary, this review comprehensively introduced and summarized the mechanisms in more detailly in Supplementary Table S4. ...
Background: Cinnamon is a spice used in cooking and in large quantities as a medical complement with hypoglycemic and lipid-lowering properties. The potential pharmacological mechanisms underlying cinnamon’s anti-diabetic properties and its active ingredients have not been adequately determined. The current meta-analysis aims to systematically review the potential pharmacological mechanisms underlying the hypoglycemic and hypolipidemic efficacy of cinnamon administration and summarize clinical recommendations of cinnamon and its active ingredients.
Method: Relevant randomized clinical trials (RCTs) were identified through a literature search that spanned the years January 2005 to April 2022. Retrieve electronic databases including Web of Science, PubMed, Embase, Medline, and the Cochrane Library. To obtain standardized mean differences (SMDs), continuous outcomes were pooled and 95 percent confidence intervals (CIs) were provided. Categorical outcomes were aggregated to calculate relative risks (RRs) and were accompanied by 95% CIs. Heterogeneity was measured using the Cochrane Q-test and I² statistics, with a p < 0.05 considered as substantial heterogeneity. If I² was less than 50%, a fixed effect model was employed; otherwise, a random effect model was used. Subgroup analyses and sensitivity analyses were performed to identify the origins of heterogeneity. Publication bias was retrieved by means of a funnel-plot analysis and Egger’s test. The data were analyzed using revman (V.5.3) and stata (V.15) software packages.
Results: These 16 RCTs included a total of 1,020 patients who were followed for a duration ranging from 40 days to 4 months. According to the current meta-analysis results, glycolipid levels in diabetic individuals who received cinnamon were significantly improved as compared to those who got placebo (All p < 0.05). An adverse effect was only detected in one patient.
Conclusion: These findings imply that cinnamon has a significant influence on lipid and glucose metabolism regulation. An even more pronounced effect was observed in patients with HbA1c of 8%. The results of this study suggested that cinnamon may be utilized as hypoglycemic and lipid-lowering supplement in clinical settings with a guaranteed safety profile.Systematic Review Registration: [PROSPERO], identifier [CRD42022322735].
... It contains manganese, iron, dietary fiber, calcium, their derivatives, and other related compounds (Abraham et al., 2010). Cinnamon is a popular ingredient in cooking, medicine, forage, and is used in many industries (Michiels et al., 2007;Santos and da Silva, 2018). From a clinical viewpoint, it is often used in diabetes treatment because of its hypoglycemic and lipidlowering potential (Santos and da Silva, 2018;Zare et al., 2019). ...
... Cinnamon is a popular ingredient in cooking, medicine, forage, and is used in many industries (Michiels et al., 2007;Santos and da Silva, 2018). From a clinical viewpoint, it is often used in diabetes treatment because of its hypoglycemic and lipidlowering potential (Santos and da Silva, 2018;Zare et al., 2019). It has also been found to be useful in reducing glycated hemoglobin (HbA1c) and fasting blood glucose levels in patients with type 2 diabetes (Pauline and Maddox, 2017). ...
... Numerous studies have reported the advantages of cinnamon when used safely (Ghosh et al., 2015;Pauline and Maddox, 2017;Santos and da Silva, 2018;Zare et al., 2019), for example, in the treatment of diabetes and as a natural antioxidant in foods. Furthermore, the active ingredients of cinnamon have been proven helpful in controlling and preventing the complications of coronavirus disease 2019 (Prasanth et al., 2021;Zareie et al., 2021). ...
Purpose: Many evidence-based studies have indicated that cinnamon has therapeutic effects. However, it may not be entirely safe and its adverse effects may be ignored. The present umbrella review was conducted to elucidate the safety of cinnamon.
Methods: Pertinent meta-analyses and systematic reviews of randomized controlled trials on cinnamon use in humans were identified by searching PubMed, EMBASE, and the Cochrane Library from their inception to September 15, 2021. All meta-analyses and systematic reviews on the safety or adverse effects of cinnamon were considered. PRISMA 2020 was used as the standard of reporting (PRISMA registration ID: 286746).
Results: We identified three meta-analyses and one systematic review that described the safety of cinnamon. The quality of the meta-analysis and systematic reviews was evaluated using “Assessing the Methodological Quality of Systematic Reviews.” Their quality was rated as low in two (50%) instances and moderate in two (50%). There were no significant toxic- or side effects between cinnamon group and placebo group regardless of dose and duration.
Conclusion: There is evidence to support that the use of cinnamon has no adverse reactions. It can improve the health status of patients as an adjuvant treatment. Future studies exploring better profile risks and protective factors for cinnamon use-related adverse effect are needed, in order that preventive approaches can be developed.
... galactomannans decrease blood glucose concentration [57] 4hydroxyisoleucine [58] saponins - [59] trigonelline + nicotinic acid + [60] Ceylon cinnamon Cinnamomum zeylanicum J.Presl methylhydroxychal cone polymer elevation in plasma insulin; hypoglycaemic; hypocholesterolemic; stimulate glucose uptake by adipocytes; [61] cinnamaldehyde [62,63] eugenol [64] Ginger Zingiber officinale Rosc. shogaol increase insulin level; decrease fasting glucose level [65,66] gingerol [66,67] ...
... The antioxidative and antibacterial activity of an extract derived from cinnamon has been demonstrated in recent years [127]. Among the best-known herbs and spices in terms of antioxidant content, researchers indicate that cinnamon (77 mM per 100 g of antioxidant) has less antioxidative properties than only several other plants, which include allspice, cloves, and peppermint [63]. Ethanol extracts from cinnamon bark in the ABTS cationic radical test reached the value of 525.85 µM Trolox equivalent per g of dry weight, 87.45%-in the DPPH radical test, and 637.00 µM Trolox equivalent per g of dry weight in the FRAP test [128]. ...
... Studies have also demonstrated that cinnamon bark in doses of 1-6 g per day causes a reduction in TG, TC, and LDL fraction in patients with type 2 diabetes [63]. This is probably caused by the presence of a methylhydroxychalcone polymer (MHCP) stimulating, almost like insulin, glucose uptake by adipocytes [61]. ...
Diabetes is a metabolic disease that affected 9.3% of adults worldwide in 2019. Its co-occurrence is suspected to increase mortality from COVID-19. The treatment of diabetes is mainly based on the long-term use of pharmacological agents, often expensive and causing unpleasant side effects. There is an alarming increase in the number of pharmaceuticals taken in Europe. The aim of this paper is to concisely collect information concerning the few antidiabetic or hypoglycaemic raw plant materials that are present in the consciousness of Europeans and relatively easily accessible to them on the market and sometimes even grown on European plantations. The following raw materials are discussed in this mini-review: Morus alba L., Cinnamomum zeylanicum J.Presl, Trigonella foenum-graecum L., Phaseolus vulgaris L., Zingiber officinale Rosc., and Panax ginseng C.A.Meyer in terms of scientifically tested antidiabetic activity and the presence of characteristic biologically active compounds and their specific properties, including antioxidant properties. The characteristics of these raw materials are based on in vitro as well as in vivo studies: on animals and in clinical studies. In addition, for each plant, the possibility to use certain morphological elements in the light of EFSA legislation is given.
... Споживання кориці у їжу сприяє зниженню рівня загального холестерину, особливо холестерину низької щільності, та підвищує рівень холестерину високої щільності (Heitor, 2018). Виявлено також сприятливі ефекти цієї рослини при переддіабеті і цукровому діабеті (покращання чутливості до інсуліну, зниження інсулінорезистентності), діабетичній нейропатії та нефропатії (Costello, 2016;Heitor, 2018;Przeor, 2022;Seravit, 2019). ...
... Споживання кориці у їжу сприяє зниженню рівня загального холестерину, особливо холестерину низької щільності, та підвищує рівень холестерину високої щільності (Heitor, 2018). Виявлено також сприятливі ефекти цієї рослини при переддіабеті і цукровому діабеті (покращання чутливості до інсуліну, зниження інсулінорезистентності), діабетичній нейропатії та нефропатії (Costello, 2016;Heitor, 2018;Przeor, 2022;Seravit, 2019). ...
... [24][25][26][27] It was reported that cinnamon extract equivalent to doses of 5-14 g of cinnamon powder did not alter alanine aminotransferase (ALT) and aspartate aminotransferase (AST), bilirubin and alkaline phosphatase. 28 The use of 1500 mg/dL of cinnamon powder for 12 weeks improved liver profile markers in patients with non-alcoholic fatty liver disease (NAFLD). ALT decreased by 26.6 IU/L, AST by 25.6 IU/L, gamma-glutamyltransferase (GGT) by 22.8 U/L and high sensitivity C-reactive protein (hs-CRP) by 2.9 mg/dL. ...
... ALT decreased by 26.6 IU/L, AST by 25.6 IU/L, gamma-glutamyltransferase (GGT) by 22.8 U/L and high sensitivity C-reactive protein (hs-CRP) by 2.9 mg/dL. 28,29 It also showed hepatoprotection against liver injury and lower liver fat in animal studies. 30,31 A phase I clinical trial of cinnamon showed no side effect including hepatotoxicity. ...
Background: Cinnamon is a herbal medicine that is supposed to improve the metabolic disorder polycystic ovary syndrome (PCOS), but there is still no data about the effectiveness and efficacy of this herbal medicine for the metabolic parameters of PCOS. This study aims to systematically evaluate the effects of cinnamon extract on improving insulin resistance, lipid profile and regularity of menstruation in PCOS women.
Methods: This is a systematic review and meta-analysis of randomized controlled trials (RCTs) studies. We searched the MEDLINE, Cochrane, Google Scholar, and PubMed databases to identify relevant studies using cinnamon extract effects on insulin resistance, metabolic factors, and menstrual cyclicity of PCOS women.
Results: Five RCTs consisting of 206 women were included in the meta-analysis. Significant differences were found in fasting blood glucose (FBG) (mean difference (MD)= -4.8 mg/dL, 95% CI: -8.04 to -1.57, p=0.004; 143 participants), High-Density Lipoprotein (HDL-cholesterol, HDL-C) (MD= -27.24 mg/dL, 95% CI: -32.62 to -21.85, p< 0.00001; 143 participants, Insulin level (MD = -2.20 mIU/dL, 95% CI: -4.17 to -0.23, p=0.03; 143 participants), and menstrual cyclicity in six months (MD= 2.28, 95% CI: 1.83 to 2.73, p< 0.00001; 33 participants) were obtained.
Conclusion: Cinnamon can be a potential supplementary therapy agent for PCOS women as it improves fasting blood glucose, insulin level, HDL–cholesterol and menstrual cyclicity in PCOS women.
... They prescribed cinnamon (100 mg/kg body weight) for two weeks and the results indicated that cinnamon had significant antioxidant ability and might be beneficial in reducing the complications of many oxidative stress-related diseases in humans [22]. Another study explained that the consumption of cinnamon (500 mg/kg body weight) in patients with type 2 diabetes for 2 months reduced blood sugar and blood lipid [23]. On the other hand, in a study on the effects of turmeric, chili peppers and cinnamon on blood lipids of patients with CVDs and cancer during an 11-year follow-up, the findings showed that cinnamon, unlike other spices, did not affect CVDs [24]. ...
... In addition to its antioxidant effects, cinnamon plays a role in regulating blood lipids, reducing LDL and TC levels, and improving blood lipids in obese people with high-fat diets and diabetes [46,47]. Many studies reviewed in this article had mentioned the beneficial effects of cinnamon on the heart; however, in the studies conducted by Pender et al. and Santos et al., it was indicated that cinnamon had no beneficial effect in regulating blood lipid factors [20,23]. Moreover, there were conflicting reports about the effect of cinnamon in increasing HDL level, despite many reports about its effect in improving HDL level which may be due to the type of extract, solvent or the dose of cinnamon. ...
Introduction: Herbal medicine is being considered today due to the side effects and high prices of chemical medicines. Cinnamon appears to be effective in the prevention and treatment of a variety of diseases, both as a food spice and in traditional medicine. We attempted to collect the effects of cinnamon on the occurrence of cardiovascular disorders and their related parameters in this review. Methods: In this review study, the English keywords; Cinnamon, Cinnamomum, Cinnamaldehyde, Cardiac, Cardiomyopathy, and Heart, as well as the Persian keywords Cinnamon and Cardiovascular in the title and abstract of the papers, were used to search papers for this analysis report. The Web of Sciences (ISI), PubMed, Science Direct, Scopus, Google Scholar, and SID databases were searched for papers, with no time limit until March 2021. A variety of experimental and clinical human and animal studies were enrolled to investigate the effect of cinnamon on various aspects of cardiovascular disease. Results: Out of a total of 205 articles found at the end of the search, 51 were thoroughly analyzed and their data was included in this review report. In the final papers, the results related to the effects of cinnamon on the risk factors of cardiovascular diseases such as hyperlipidemia, hypertension and oxidative stress were investigated. Conclusion: The majority of human and animal studies showed that cinnamon may prevent and treat cardiovascular disease by lowering oxidative stress, as well as by improving blood pressure and blood lipid parameters.
... In terms of therapeutic potential of polyphenol for metabolic dysregulation, it seems that enhancing acetylation of histones is not the only benefit of consumption. Polyphenols, particularly those found in cinnamon, improve insulin resistance and improve lipid profile [32,33,37,38]. Some clinical studies have demonstrated reductions of 12.9-52.2 ...
... Some clinical studies have demonstrated reductions of 12.9-52.2 mg/dL in blood glucose levels while others have found less robust and potentially null effects [38][39][40]. ...
The chapter summarizes available research on polyphenols and the potential for polyphenol based therapeutics. Polyphenols have the potential to be used in a multi-target fashion therapeutically. The majority of the polyphenol benefits appear to share positive effects across multiple disease states including inflammatory diseases, diseases of metabolic dysregulation and cancer. The reviewed literature includes human, animal and cell culture based studies. Selected mechanisms within each disease state are highlighted including interleukin inflammatory markers, NF-κB, acetyl-CoA concentration regulation of metabolism, and p-glycoprotein multidrug efflux pump associated with cancer treatment failures. Reviewed studies discuss polyphenols inhibiting transcription factors that control expression on inflammatory factors as well as activating other transcription factors that increase expression of enzymes protective of oxidative damage. Levels of metabolic regulatory enzymes are also affected positively by polyphenol addition through epigenetic modifications. Epigenetic modifications affecting cancer development and progression appear positively affected by polyphenol treatment. Additionally, oxidative damage protection of normal cells can be achieved by polyphenol treatment thus limiting chemotherapeutic damage. Upon review of the available literature, a strong case for the potential use of polyphenols in therapeutic situations stands out. Potential risks included are that the purity and specific concentrations required to achieve therapeutic benefits without potential side effects need to be examined prior to the adoption of therapeutics.
... There are several postulated mechanisms of action. Cinnamon can: 1) improve glucose uptake, promoting gastric emptying, and inhibiting alpha-glucosidase; 2) improve insulin receptor phosphorylation, synthesis and translocation of GLUT-4 for glucose uptake, increasing glycogen; 3) improve the enzymatic action for loss of adipose tissue; and 4) have antioxidant and anti-inflammatory actions, which may play a role in reducing insulin resistance and diabetes complications (19). ...
... Other randomized clinical trials that used cinnamon showed that it works by improving glucose uptake and decreasing insulin levels, leading to fewer episodes of hyper/ hypoglycemia, regardless of the type of cinnamon used (19,(22)(23)(24)(25). This might explain why we observed similar results in reductions of HbA1c and in fasting venous blood glucose. ...
The major aim of this randomized, placebo-controlled, triple-blind clinical trial was to evaluate the efficacy of cinnamon as an adjuvant treatment in reducing glycemic levels in people with type 2 diabetes, compared to a placebo. The study was conducted between August and December 2019, with 160 people with type 2 diabetes, in five Primary Health Units, in Parnaíba, Brazil. Inclusion criteria were: persons of both genders using oral antidiabetic agents, with glycated hemoglobin ≥ 6.0%, and between 18 and 80 years of age. The primary outcome was change in glycated hemoglobin levels after 90 days of intervention. Other biomarkers evaluated were fasting blood glucose, insulin level, and HOMA-IR index. Participants were divided equally into two groups of 80 individuals each, and were given 3 g capsules of either cinnamon or placebo to be taken in combination with their usual oral antidiabetic agents. After 90 days, participants in the cinnamon group had statistically significant reductions of 0.2% of glycated hemoglobin and 0.55 mmol/L of fasting venous glucose, when compared with the placebo group. Cinnamon reduced the glycemic measures of persons with type 2 diabetes, albeit with modest reductions. TRIAL: RBR-2KKB6D.
... The health benefit of long-term cinnamon consumption has been previously evaluated (1)(2)(3)(4)(5)22). In Type 2 diabetes, the glucose lowering effects of long-term cinnamon supplementation has been consistently reported (22,23). ...
... The health benefit of long-term cinnamon consumption has been previously evaluated (1)(2)(3)(4)(5)22). In Type 2 diabetes, the glucose lowering effects of long-term cinnamon supplementation has been consistently reported (22,23). However, current knowledge of cinnamon's acute effect is very limited (17,24). ...
Clinical studies and meta-analyses have supported the notion that consuming cinnamon spice long term can have beneficial effects in individuals with normal glucose homeostasis and varying degrees of glucose intolerance including type 2 diabetes. The objective of this study was to evaluate the acute effect of cinnamon on the post-prandial responses to a typical American breakfast in normal and overweight/obese participants (ClinicalTrials.gov registration No. NCT04686552). The consumption of a single dose of 6 g of cinnamon added to oatmeal prepared with milk resulted in a significant reduction of one of our primary outcomes post-prandial insulin response (niAUC0−180min) in overweight/obese participants compared to control consuming breakfast without cinnamon. We also performed exploratory analysis of secondary outcomes. In normal weight participants, we observed a decrease of post-prandial glucagon response (niAUC0−180min and glucagon levels at 60–120 min) and C-peptide response (30 min) comparing breakfast with to without cinnamon. Cinnamon consumption did not change post-prandial glycemic response in normal weight participants, but increased 60 min post-prandial glucose in overweight/obese participants compared to control. In summary, cinnamon consumption differentially affected post-prandial hormonal responses in normal and overweight/obese participants.
... Another in vivo study demonstrated that administration of cassia bark extracts the intestinal glycosidase activity was reduced, whereas the serum insulin level and HDL-cholesterol level are increased [142]. Compiling the human studies of 2003-2018 concerning the glycemic profiles of individuals with type II diabetes mellitus showed that fasting blood glucose reduced from 12.9 to 52.2 mg/dL and HbA1c from 0.27 to 0.83%, after moderate consumption of cinnamon extract [143]. Some meta-analysis also indicated that cinnamon powder intake decreased fasting blood glucose and HbA1c [144]. ...
Phytotherapy is attracting increased interest for several reasons. It differs from medical procedures in that it uses the whole herb, although there is often only one component of the plant that works effectively to manage the problem. Plants contain many natural chemicals or phytochemicals that interact with the active ingredient and help prevent any side effects. Medicinal herbs and spices are investigated for their suitability in daily diets for maintaining general wellness or preventing disease. In the past decade, natural health products, dietary supplements, foods with added value, or nutraceuticals have emerged due to the increasing demand for non-pharmaceutical healthcare products. Medical herbs and spices are potential sources for developing new, effective, and safe ingredients to capture a rapidly expanding opportunity in global marketplaces. This book presents up-to-date information on the chemical, pharmacological, and nutritional uses of medicinal herbs and spices in folk medicine, pharmaceuticals, the food industry, veterinary practice, and gastronomy.
... The majority of studies (Santos and da Silva, 2018) have shown that cinnamon in dosages of 1-6 g/day resulted in a reduction in LDLc, TG, and TC in T2DM individuals, confirming the protective function of cinnamon and cinnamon extracts at various stages of diabetes, which is similar to the current meta-analysis JCHR (2024) 14(2), 2018-2034 | ISSN:2251-6727 2026 results. Animal investigations, both in vitro and in vivo, have found that cinnamon is an insulin sensitizer (Talpur et al., 2005). ...
... Furthermore, polyphenols such as rutin, catechin, quercetin, kaempferol, and isorhamnetin in cinnamon can diminish insulin activity and improve glycaemic control [8]. The consumption of 500 mg cinnamon /kg body weight in type 2 diabetes patients for 2 months reduced blood sugar and lipids [71]. Also, using cinnamon extract capsules (250 mg/kg body weight) in type 2 diabetes patients for two months reduced total cholesterol, HDL, and LDL. ...
Diseases such as diabetes, atherosclerosis, and hypertension are risk factors for Cardiovascular Diseases (CVDs). About 17.3 million deaths worldwide were due to CVDs in 2013 and is anticipated to be 23.3 million by 2030. Common therapies for CVDs are associated with wide side effects. Thus, herbal medicines have been regarded more due to fewer side effects, availability, cultural beliefs, and being cheap. For thousands of years, herbal medicine has been used for bacterial infections, colds, coughs, and CVDs. Cinnamon bark contains phenolic compounds such as cinnamaldehyde and cinnamic acid with protective properties that can reduce the risk of cardiovascular diseases, cardiac ischemia and hypertrophy, and myocardial infarction. Furthermore, cinnamon has antioxidant and anti-inflammatory properties and exhibits beneficial effects on the complications of diabetes, obesity, hypercholesterolemia, and hypertension which cause CVDs. Although the protective effects of cinnamon on the heart have been reported in many studies, it needs more clinical studies to prove the pharmaceutical and therapeutic efficacy of cinnamon on risk factors of CVDs. This review explains the protective effects of bioactive compounds of cinnamon on the cardiovascular system.
... Furthermore, polyphenols such as rutin, catechin, quercetin, kaempferol, and isorhamnetin in cinnamon can diminish insulin activity and improve glycemic control [7]. The consumption of 500 mg cinnamon/kg body weight in type 2 diabetes patients for 2 months reduced blood sugar and lipid levels [63]. Also, using cinnamon extract capsules (250 mg/kg body weight) in type 2 diabetes patients for 2 months reduced total cholesterol, HDL, and LDL. ...
Common therapies for cardiovascular diseases (CVDs) are associated with wide side effects. Thus, herbal medicines have been regarded due to fewer side effects, availability, cultural beliefs, and being cheap. For thousand years, herbal medicine has been used for bacterial infections, colds, coughs, and CVDs. Cinnamon bark contains phenolic compounds such as cinnamaldehyde and cinnamic acid with protective properties which can reduce the risk of cardiovascular diseases, cardiac ischemia and hypertrophy, and myocardial infarction. Furthermore, cinnamon has antioxidant and anti-inflammatory properties and exhibits beneficial effects on the complications of diabetes, obesity, hypercholesterolemia, and hypertension which cause CVDs. Although the protective effects of cinnamon on the heart have been reported in many studies, it needs more clinical studies to prove the pharmaceutical and therapeutic efficacy of cinnamon on risk factors of CVDs.
... Furthermore, polyphenols such as rutin, catechin, quercetin, kaempferol, and isorhamnetin in cinnamon can diminish insulin activity and improve glycaemic control [8]. The consumption of 500 mg cinnamon /kg body weight in type 2 diabetes patients for 2 months reduced blood sugar and lipids [71]. Also, using cinnamon extract capsules (250 mg/kg body weight) in type 2 diabetes patients for two months reduced total cholesterol, HDL, and LDL. ...
Diseases such as diabetes, atherosclerosis, and hypertension are risk factors for Cardiovascular Diseases (CVDs). About 17.3 million deaths worldwide were due to CVDs in 2013 and is anticipated to be 23.3 million by 2030. Common therapies for CVDs are associated with wide side effects. Thus, herbal medicines have been regarded more due to fewer side effects, availability, cultural beliefs, and being cheap. For thousands of years, herbal medicine has been used for bacterial infections, colds, coughs, and CVDs. Cinnamon bark contains phenolic compounds such as cinnamaldehyde and cinnamic acid with protective properties that can reduce the risk of cardiovascular diseases, cardiac ischemia and hypertrophy, and myocardial infarction. Furthermore, cinnamon has antioxidant and anti-inflammatory properties and exhibits beneficial effects on the complications of diabetes, obesity, hypercholesterolemia, and hypertension which cause CVDs. Although the protective effects of cinnamon on the heart have been reported in many studies, it needs more clinical studies to prove the pharmaceutical and therapeutic efficacy of cinnamon on risk factors of CVDs. This review explains the protective effects of bioactive compounds of cinnamon on the cardiovascular system.
... B-type procyanidin C1 in the cinnamon extract also induces preadipocyte differentiation and functions as a possible enhancer of insulin action in mature adipocytes via the AKT-eNOS pathway [32]. In our study results, the use of cinnamon supplements did not improve the FBG of the subjects, which is different from the results of previous meta-analyses [10,33,34]. However, we found a noticeable drop in the level of FBG at an intervention dose of cinnamon ≤1200 mg in the sub-group analysis. ...
(1) Background: The effect of cinnamon on the regulation of glycolipid levels in type 2 diabetic patients is still controversial, and there is a lack of research on the dose-response relationship between cinnamon and glycolipid indicators in type 2 diabetic patients. (2) Methods: This dose-response meta-analysis was performed to explore the effect of the cinnamon intervention on glycolipid metabolism. We conducted a comprehensive database search for literature published before November 2022. Nonlinear models were used for dose-response relationship analysis. (3) Results: We identified that a cinnamon intervention was effective in controlling triglyceride (TG) levels (mean difference = -7.31; 95%CI: -12.37, -2.25, p = 0.005) and low-density lipoprotein cholesterol (LDL-C) levels (mean difference = -6.78; 95%CI: -11.35, -2.22, p = 0.004) in type 2 diabetic patients; however, it also was able to increase high-density lipoprotein cholesterol (HDL-C) levels in patients with type 2 diabetes (mean difference = 1.53; 95%CI: 1.01, 2.05, p < 0.001). However, the cinnamon intervention had no significant effect on the level of fasting blood glucose, glycated hemoglobin (HbA1c), or total cholesterol (TC) levels. We found a significant effect of the cinnamon intervention dose on the TG level (p-nonlinearity = 0.016) and LDL-C (p-nonlinearity = 0.019) in the nonlinear dose-response analysis. In the subgroup analysis, we found a hypoglycemic effect with the cinnamon dose ≤1200 mg (mean difference = -11.1, 95%CI: -14.64, -7.58, p < 0.001). (4) Conclusion: Cinnamon intervention may be beneficial in lowering TG and LDL-C levels while enhancing HDL-C levels, and the dosage of the intervention was an important factor in influencing the TG and LDL-C levels.
... In this regard, the anti-diabetic effects of many medicinal herbs have been studied so far [9][10][11][12]. Cinnamomum (cinnamon), is a dietary component and a traditional herbal medicine [1,13,14]. There is evidence for the beneficial health effects of cinnamon such as anti-diabetic, lipid-lowering, anti-tumor, and antioxidant properties [2]. ...
Background:
Several meta-analyses reported glycemic-lowering effects of cinnamon, while others reported conflicting findings. In the present study, we aimed to perform an umbrella meta-analysis of previous interventional meta-analyses on the effects of cinnamon on glycemic control in patients with type 2 diabetes (T2D) or with polycystic ovary syndrome (PCOS).
Methods:
Relevant studies were searched in PubMed, Scopus, EMBASE, Web of Science, and Google Scholar up to June 2022. Meta-analyses of randomized clinical trials (RCTs) investigating the effects of cinnamon on glycemic indices including fasting plasma glucose (FPG), homeostatic model assessment for insulin resistance (HOMA-IR), insulin, and hemoglobin A1C (HbA1c) were included. Random-effects models were used to perform the umbrella meta-analysis and pool the weighted mean difference (WMD) or standardized mean difference (SMD) and their 95% confidence intervals (CI).
Results:
Overall, 11 meta-analyses of RCTs were included. Cinnamon supplementation was effective in reducing serum FPG (WMD: -10.93 mg/dL; 95%CI: -16.22, -5.65; SMD: -0.86; 95%CI: -1.19, -0.52), insulin (WMD: -2.01 IU/mL; 95%CI: -3.96, -0.07; SMD: -0.61; 95%CI: -0.93, -0.30), HOMA-IR levels (WMD: -0.61; 95%CI: -0.91, -0.31; SMD: -0.78; 95%CI: -1.26, -0.30), and HbA1c (WMD: -0.10%; 95%CI: -0.17, -0.03).
Conclusion:
Cinnamon can be used as an anti-diabetic agent and an add-on treatment to control glycemic indices among patients with T2D or PCOS.
... Another in vivo study demonstrated that administration of cassia bark extracts the intestinal glycosidase activity was reduced, whereas the serum insulin level and HDL-cholesterol level are increased [142]. Compiling the human studies of 2003-2018 concerning the glycemic profiles of individuals with type II diabetes mellitus showed that fasting blood glucose reduced from 12.9 to 52.2 mg/dL and HbA1c from 0.27 to 0.83%, after moderate consumption of cinnamon extract [143]. Some meta-analysis also indicated that cinnamon powder intake decreased fasting blood glucose and HbA1c [144]. ...
Herbs and spices have been used as therapeutic agents in traditional medicine due to the presence of bioactive compounds including flavonoids, polyphenols, alkaloids, carotenoids, organosulfur compounds, glucosinolates etc. As a result, they are associated with various functional properties such as digestive stimulant, antioxidant, anti-inflammatory anticancer, anti-diabetic, cardioprotective, neuroprotective, and antimicrobial activities. However, the bioefficacy of different spices are affected by the bioavailabilties of their bioactive compounds and depends on various factors such bioaccessibility, molecular structures, composition of food matrices, and metabolizing enzymes. In this chapter we discuss on major phytochemical compounds of some selected spices including turmeric, garlic, ginger, onion, cinnamon, chili pepper, and black pepper including their bio accessibilities, bioavailabilities and their health beneficial effects. The knowledge of bioaccessibility and bioavailability of spices bioactive compounds will give a better understanding towards the development of strategies to optimize the positive health benefits of spices.
... A review by Allen et al. have concluded that cinnamon had no significant effect on lipid profile in patients with type II diabetes (Allen, et al., 2013). In 2018, another systematic review was carried out and the added evidence from randomized controlled trials carried out in that 5 year gap were still unsuccessful in showing an overall improvement in lipid profile (Santos and da Silva, 2018). ...
Type II diabetes has been on the rise for the past few decades and the current management plan of diabetes is challenging to individuals in keeping their blood glucose levels within normal limits. There is a constant search of new ways to tackle these challenges. Cinnamon is suggested to have antihyperglycemic and lipid lowering effect and has been proposed to be utilized in type II diabetes. The aim behind this review is to explore the role of cinnamon in improving the glycemic status, lipid profile, and weight status of patients with type II diabetes. PubMed and ScienceDirect databases have been searched for eligible studies conducted until February 2022, the outcomes measured were glycemic markers as primary outcome and lipid profile and weight status as secondary outcomes. A total of ten trials involving 861 patients were included in the study. Five studies have demonstrated reductions in glycemic markers (ranging between −0.56 and −1.9 mmol/L for fasting blood sugar and between −0.21% and −0.93% for glycated hemoglobin) whereas the remaining four did not show any significant reduction. The most improvements in glycemic markers are seen in patients with poorly controlled diabetes and patients with higher body mass index (BMI) values. The majority of the studies did not record improvement in lipid profile. Changes in weight status are only observed in overweight patient category (BMI between 25 and 30). Overall, there is no coherent evidence to decide about antihyperglycemic, lipid lowering, and weight reducing effects of cinnamon in type II diabetes.
... In vitro enzyme inhibition assays revealed that cinnamon has inhibitory effects on digestion enzymes where cinnamon derivates act as α-glycosidase and α-amylase inhibitors (Ercan & EI, 2020;Santos & da Silva, 2018;Hayward et al., 2019). Though enzyme inhibition assay is widely used in screening natural product extracts for potential enzyme inhibitors, it may not accurately estimate the diabetic effect of the bioactive compounds during digestion. ...
Two in vitro digestion methods (static and dynamic) were applied in this study to investigate the effect of cinnamon on starch hydrolysis of rice pudding during in vitro digestion. The dynamic model simulated the major physiological processes including gastric emptying, motility, gastric acidification, and digestive secretions. The INFOGEST static method, which is widely adopted in digestion simulation studies, was conducted as a comparison. Two meals (i.e., rice pudding with and without cinnamon) were digested in oral, gastric, and small intestinal phases in both models. Higher starch hydrolysis was observed in the gastric and intestinal phases in the dynamic model compared to the static model (p < 0.05). Furthermore, a significant inhibitory effect of cinnamon on starch hydrolysis was observed in the dynamic model but no such effect was found in the static model. The difference could be attributed to the distinct gastric conditions including pH profiles, gastric emptying, and gastrointestinal (GI) motility in the two models. Our results indicated that the dynamic model could more closely estimate the effect of cinnamon on starch hydrolysis during digestion by simulating physiologically important GI conditions in humans. Our findings also contribute to the growing body of scientific data suggesting that cinnamon may benefit hyperglycemic management due to its inhibitory effects on digestion enzymes.
... the mechanisms underlying the effects of oPC extract on the insulin signaling pathway were also investigated. the results revealed that oPC exerted its hypoglycemic effects through the activation of the PI3K/akt pathway and the stimulation of GlUt4 translocation, which in turn enhanced glucose transport and cellular uptake, as well as lipid metabolism in addition to reduced glycogenesis (GSK-3β), which is in line with the findings of previous studies (31)(32)(33). ...
Diabetes mellitus is the most common chronic metabolic disorder worldwide. The present study was designed to investigate the potential role of cinnamon bark extract oligomeric proanthocyanidins (OPCs) in controlling streptozotocin (STZ)-induced hyperglycemia and to clarify the underlying molecular mechanisms underlying its effects. For this purpose, 60 male rats were equally divided into six groups as follows: The normal control group; OPC control group (non-diabetic rats treated with OPC at 300 mg/kg orally for 21 days); the untreated diabetic control group; the wortmannin control group [diabetic rats treated with wortmannin at 1 mg/kg, intraperitoneal (i.p.) on the final day of the experiment]; the OPC diabetic group (diabetic rats treated with OPC at 300 mg/kg orally for 21 days); and the OPC diabetic + wortmannin co-treated group (diabetic rats treated with OPC at 300 mg/kg/day for 21 consecutive days and then 24 h after the final OPC dose treated with a single wortmannin injection at 1 mg/kg, i.p.). The results indicated that OPC ameliorated the diabetic state, as evidenced by a significant decrease in serum glucose levels, and a significant increase in the levels of insulin, amylin, insulin receptor phosphorylation, glycogen and glucose transporter-4 translocation; it also improved the lipid profile in STZ-diabetic rats. On the whole, the findings of the present study provide biochemical evidence that OPC treatment is effective as an anti-diabetic and anti-hyperlipidemic agent by enhancing glucose uptake through the activation of insulin receptor kinase activity and the PI3K/Akt pathway.
... For example, the effects of vitamin D administration on the concentrations of serum lipids remain controversial and should be further investigated, as the correction of dyslipidemia can result in a decrease of cardiovascular risk (Lee et al., 2008;Zittermann et al., 2005). Recent research into the management of dyslipidemia has highlighted that apart from statins and other synthetic compounds, a great deal of natural compounds, e.g., fish oil, tocotrienol, artichoke, cocoa, cinnamon, magnesium and others, exert lipid-lowering effects Santos and da Silva, 2018;Santos and Macedo, 2018a;Santos et al., 2020b;Zuo et al., 2020). ...
Background and aim
The exact effect of vitamin D administration on the lipid profile in postmenopausal women is unknown. However, as dyslipidemia is a recognized risk factor for coronary heart disease (CHD) in this population, the lipid-lowering effects of vitamin D need to be explored Thus, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that evaluated the impact of vitamin D use on triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) as a risk factor for coronary heart disease (CHD) in postmenopausal women.
Methods
We developed a search strategy for multiple databases (PubMed/Medline, Scopus, Embase, and Web of Science) to identify relevant RCTs whose results were published until June 1st, 2021. We combined the results using a random effects model (the DerSimonian and Laird random effects model). Lipid profile outcomes were expressed as weighted mean difference (WMD) and 95% confidence intervals (CIs) between intervention and comparator groups.
Results
Supplementation with vitamin D decreased TG (WMD: −3.55 mg/dL, 95% CI: −5.34 to −1.76, P < 0.001) in postmenopausal females versus controls. In the subgroup analyses, vitamin D increased TC when the treatment duration was ˂26 weeks (WMD: 6.56 mg/dL, 95% CI: 0.78 to 12.35, P = 0.02) as compared to ≥26 weeks (WMD: −2.06 mg/dL, 95% CI: −5.49, 1.36, P = 0.23) and in the participants with a BMI ≥30 kg/m² (WMD: 3.65 mg/dL, 95% CI: 0.09, 7.22, P = 0.044). Moreover, vitamin D increased HDL-C when the treatment duration was ˂26 weeks (WMD: 2.67 mg/dL, 95% CI: 0.66 to 4.68, P = 0.009). In addition, vitamin D decreased LDL-C when the vitamin D dose was ˃400 IU/day (WMD: −1.89 mg/dL, 95% CI: −2.47 to −1.31, P < 0.001) as compared to ≤400 IU/day (WMD: 2.50 mg/dL, 95% CI: −2.50, 7.52, P = 0.327).
Conclusions
Vitamin D administration on the lipid profile as a risk factor for CHD in postmenopausal women reduces TG. Its effects to lower LDL-C and increase HDL-C and TC levels are clinically negligible but should be investigated in future research. In addition, supplementation with vitamin D results in a clinically significant reduction in TG, particularly in postmenopausal females with hypertriglyceridemia at baseline.
... Beyond macronutrients and calories, the intake of antioxidants has gained vast attention to global public health, which are nonenzymatic elements classified primarily as flavonoids, minerals, vitamins, and derivatives [20][21][22][23]. In this sense, several nutraceutical agents (e.g., some herbal medicines and supplements) and functional foods have been proposed in the management of glucose levels due to their antioxidant features [24][25][26][27][28][29]. Nevertheless, the antioxidant potential across the diet overwhelms those adjunctive strategies since long-term adherence is a cornerstone, in which hallmark foodstuffs such as fruits, vegetables, seeds, whole grains, oils, and particular beverages (e.g., coffee and tea) must be endorsed [30,31]. ...
Background:
The overall dietary quality, as well as the dietary total antioxidant capacity (DTAC), deserves central attention in the management of borderline high glucose levels since nonpharmacological strategies are imperative in this regard. Thus, we aimed to investigate the association between prediabetes with dietary quality and DTAC.
Methods:
A case-control study was conducted on 49 patients with prediabetes and 98 controls. Demographics, anthropometric measures, and fasting blood glucose levels of all participants were obtained. Participants completed a validated 80-item food frequency questionnaire (FFQ). DTAC scores were generated using FFQ data, and Healthy Eating Index-2015 (HEI-2015) was used as a diet quality index. The lowest tertile of HEI-2015 and DTAC was considered as the reference category, and logistic regression was used to estimate the relationship between prediabetes with HEI-215 and DTAC.
Results:
Mean age and body mass index of participants were 47.42 ± 15.98 years and 27.90 ± 4.96 kg/m2. Patients with prediabetes had lower DTAC scores when compared to controls (11.86 ± 5.77 and 17.81 ± 12.08, P = 0.01). There was a significant inverse association between the highest tertile of the DTAC score when compared with the lowest tertile in crude (OR = 0.11; 95% CI: 0.03-0.43), age-adjusted (OR = 0.13; 95% CI: 0.03-0.48), and fully adjusted (OR = 0.09; 95% CI: 0.02-0.53) models. In contrast, there was no difference between HEI-2015 in patients with prediabetes when compared to controls (74.41 ± 8.91 and 74.41 ± 9.35, respectively; P = 0.85). Correspondingly, no difference was observed between the highest tertile of the HEI-2015 score when compared with the lowest tertile in crude (OR = 1.23; 95% CI: 0.53-2.86), age-adjusted (OR = 1.17; 95% CI: 0.48-2.82), and fully adjusted (OR = 1.53; 95% CI: 0.56-4.16) models.
Conclusion:
This study demonstrates a clear association between prediabetes with less DTAC, but not with HEI-2015.
... Cinnamon is a commonly used food spice in many countries. As a medicinal herb, cinnamon has also been traditionally used to promote coronary and microcirculation in the extremities, as well as in treating diabetes in several countries [1][2][3]. Human trials have provided evidence supporting the blood glucose lowing effect of cinnamon in patients with type 2 diabetes [4,5]. is effect seems largely attributed to cinnamaldehyde [6]. As such, commercial cinnamon supplements (1-2 g per day) also claim beneficial effects on blood glucose control and cardiovascular health. ...
Objective:
Cinnamon is a cooking spice and a medicinal herb. It is increasingly used as a health supplement due to its perceived benefit to prevent and or manage type 2 diabetes and metabolic disorders. However, it is unclear if regular consumption of this medicinal plant will interfere with normal physiological functions. Therefore, this study investigated the impact of daily cinnamon supplements on glucose and lipid metabolic profiles in healthy rats.
Methods:
Male rats (Sprague Dawley, 8 weeks) were supplied with cinnamon in their diet (equivalent to ∼1 g/day in humans) for two weeks. Blood glucose and lipid levels, as well as metabolic markers in both liver and abdominal white adipose tissue, were measured.
Results:
Cinnamon significantly increased fat mass and blood cholesterol and low-density lipoprotein (LDL) levels, but reduced fasting blood glucose level by 12%. Liver functional enzymes were normal in rats consuming cinnamon. However, several lipid metabolic markers were impaired which may contribute to dyslipidemia, including two main switches for energy metabolism (sirtuin 1 and peroxisome proliferator-activated receptor-gamma coactivator-1α) and the LDL receptor. However, de novo lipid synthesis enzymes and inflammatory markers were also reduced in the liver by cinnamon treatment, which may potentially prevent the development of steatosis. Markers for lipid oxidation were downregulated in fat tissue in cinnamon-treated rats, contributing to increased fat accumulation.
Conclusion:
Daily low-dose cinnamon supplementation seems to promote abdominal adipose tissue accumulation and disturb lipid homeostasis in healthy rats, raising the concerns regarding daily use in healthy people.
... Secondo alcune ricerche scientifiche contribuirebbe a regolare la glicemia postprandiale sia nei pazienti obesi che in quelli normopeso [402] [403] , infatti alcuni articoli mostrerebbero numeri effetti benefici della spezia su pazienti diabeti [404] [405] . ...
during the covid lockdown there was an increased consumption of both natural and synthetic supplements. the aim of this thesis is to analyze the heavy metal amount in spices and plants used to create the supplements
... Studies have also shown that this plant can prevent neurological disorders and cardiovascular diseases, and lower levels of cholesterol and lipid 2,3,4 . Cinnamaldehyde and trans-cinnamaldehyde are organic compounds found in cinnamon bark and are the main active ingredients of cinnamon. ...
Cinnamaldehyde is the aldehyde that gives cinnamon its flavour and odour. It occurs naturally in the bark of cinnamon tree (Cinnamomum zeylanicum), a common Indian spice. The essential oil of cinnamon bark contains about 90% of cinnamaldehyde. It exists as a yellow oily liquid with a cinnamon odor and sweet taste and is traditionally known to have many medicinal properties, although the mechanism of action is not completely understood. Macrophages are one of the most important cells of the immune system and play important role in influencing the inflammation cascade process. The current study aimed towards understanding the role of this medicinal plant product on genes of the inflammatory pathways, especially in the context of macrophages. For this purpose, the effects of Cinnamaldehyde were studied on the macrophage cell line J774A.
... It was reported that cinnamon improved anthropometric parameters, lipid profile, and glycemic indices of type II diabetic patients (Zare et al., 2019). Although the hypoglycemic effect of ginger (Akash et al., 2015;Carvalho et al., 2020) and cinnamon (Sahib, 2016;Santos and da Silva, 2018) administrated separately were frequently studied in both animal and human, the hypoglycemic effect of combined ginger and cinnamon administration was not sufficiently studied. Therefore, this study was designed to evaluate the effect of the combined administration of ginger and cinnamon on the glycemic, antioxidant capacity, and the structure of pancreatic islet cells in an animal model of diabetes mellitus compared to metformin and to explore the mechanism behind this effect. ...
Background: The antioxidant, hypoglycemic, and insulin-enhancing effects of ginger and cinnamon were previously confirmed in experimental and human studies, while the combined effect of ginger and cinnamon was not thoroughly investigated until now.
Objectives: This study was designed to assess the antidiabetic effect of combined administration of ginger (Zingiber officinale Roscoe) and cinnamon (Cinnamomum cassia L.) in streptozotocin (STZ)-induced diabetic rats compared to metformin and to explain the mechanism behind this effect.
Materials and methods: STZ was utilized to induce diabetes mellitus in male Sprague–Dawley rats. Assessments of fasting blood glucose level (BGL), the total antioxidant capacity (TAC), serum insulin, HOMA-IR, and HOMA–β cells were performed. Pancreatic gene expression of β-catenin and p53 was assessed using RT-PCR. Assessment of histopathological alterations of pancreatic islet cells was performed using routine and immunohistochemical techniques.
Results: BGL significantly decreased (p = 0.01), while serum insulin and TAC significantly increased (p < 0.001) in both metformin- and ginger plus cinnamon–treated groups compared to the untreated diabetic group. HOMA–β cell index significantly increased (p = 0.001) in ginger plus cinnamon, indicating their enhancing effect on insulin secretion in diabetic conditions. p53 gene expression was significantly upregulated (p < 0.001), while β-catenin was insignificantly downregulated (p = 0.32) in ginger plus cinnamon–treated groups. Insulin immunoexpression in β cells significantly increased (p = 0.001, p = 0.004) in metformin- and ginger plus cinnamon–treated groups, respectively.
Conclusions: The combined administration of ginger and cinnamon has a significant hypoglycemic and antioxidant effect in STZ-induced diabetes mostly through enhancing repair of islet cells mediated via upregulation of pancreatic p53 expression. Therefore, testing this effect in diabetic patients is recommended.
... trans-Cinnamaldehyde (tCA) is a key bioactive component isolated from the stem bark of Cinnamomum cassia Presl, of the Lauraceae family, which has traditionally been used to treat a variety of diseases such as anxiety, dyspepsia, diabetes, gastritis, ischemia, blood circulation disturbances, arrhythmia and so on. 7,8) Recent studies have shown that tCA has multiple pharmacological properties, including antioxidant, 9,10) anti-inflammatory, 11,12) anti-cancer 9,13) and inhibitory effects against various metabolic cardiovascular and cardiovascular diseases. 14,15) Among them, the antioxidant activity of tCA has been primarily attributed to increased ROS scavenging activity and involves the activation of oxidative stress defense systems such as nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and thioredoxin (Trx) signaling pathways. ...
Oxidative stress, which is characterized by overproduction of reactive oxygen species (ROS), is considered a major risk factor associated with fibroblast death in severe lung diseases such as idiopathic pulmonary fibrosis. trans-Cinnamaldehyde (tCA), the major phytochemical constituent in cinnamon, is known to possess strong anti-oxidant activity. However, whether tCA can defend lung fibroblasts against oxidative injury remains to be elucidated. Therefore, this study was conducted to investigate the protective effects of tCA on oxidative stress in V79-4 Chinese hamster lung fibroblasts. The current results showed that tCA inhibited hydrogen peroxide (H2O2)-induced cytotoxicity by blocking abnormal accumulation of ROS in V79-4 Chinese hamster lung fibroblasts. tCA attenuated apoptosis by suppressing of mitochondrial dysfunction and cytosolic release of cytochrome c, increasing the rate of Bcl-2/Bax expression and reducing the activity of caspase-9 and caspase-3 in H2O2-stimulated V79-4 cells, suggesting that tCA protected V79-4 cells from the induction of mitochondria-mediated apoptosis by H2O2. Additionally, the activation of nuclear factor-erythroid-2-related factor 2 (Nrf2) was markedly promoted by tCA in the presence of H2O2, which was associated with the enhanced expression of heme oxygenase-1 (HO-1). However, inhibiting the activity of HO-1 by zinc protoporphyrin IX, a potent inhibitor of HO-1, eliminated the ROS scavenging and protective effects of tCA, indicating that tCA was able to protect V79-4 lung fibroblasts from H2O2-induced oxidative stress by activating the Nrf2 signaling pathway. Therefore, it is suggested that tCA may be useful as a candidate for the treatment of oxidative stress-mediated lung injuries in the future.
Graphical Abstract Fullsize Image
... The limited number of primary studies and disparities in age, duration of the intervention, and the number of participants in selected studies are the probable causes of the between-study heterogeneity. Additionally, differences in nationality may have also contributed to the heterogeneity (Santos & da Silva, 2018). ...
Several clinical trials have identified glycemic‐lowering effects of cinnamon, while other studies have reported conflicting findings. A comprehensive systematic search on Embase, PubMed, Scopus, Web of Science, and Cochrane Library was conducted using defined keywords in any language through June 2020. Studies that compared the effect of cinnamon with placebo on insulin resistance (IR) indices, as the primary outcome, in women with polycystic ovary syndrome (PCOS) were considered eligible. Standard Mean difference (SMD) (with 95% confidence intervals) for endpoints were calculated using the random‐effects model. Finally, five RCTs which met the criteria were included in the meta‐analysis. After pooling data, cinnamon supplementation significantly reduced homeostatic model assessment for insulin resistance (HOMA‐IR) scores in women with PCOS (SMD: −0.84, 95% CI: −1.52, −0.16, p = .010). Cinnamon supplementation likely improves certain IR markers in patients with PCOS.
Practical applications
There are controversies reports for cinnamon intake, which animal models have suggested that it decreases IR via promotion of insulin action, stimulating insulin signaling pathways, and enhancing insulin sensitivity. This study provides comprehensive information about the effect of cinnamon on insulin resistance (IR) indices in women with PCOS. In this regard, our results indicated that cinnamon supplementation significantly reduced homeostatic model assessment for insulin resistance (HOMA‐IR) scores in women with PCOS. Therefore, consumption of cinnamon can be safe and this can be a useful recommendation for improving IR and promotion of healthy life which indeed are the potential or actual uses of this research.
... [133][134][135][136] Although in several recent clinical trials, it is shown that cinnamon supplementation resulted in significant reduction in total and LDL-C, 137-139 the results of a previous review indicated that the effects of cinnamon on blood lipids are controversial. 140 The effects of cinnamon on HMGCoAR were investigated in two animal studies. Both of them showed that cinnamon has a significant effect on HMGCoAR reduction. ...
Cardiovascular diseases (CVDs) are one of the most important causes for mortality worldwide. Elevated levels of total cholesterol, and particularly LDL-cholesterol (LDL-C) are the main risk factor for acute myocardial infarction (AMI) and ischemic heart disease. The risk of CVDs could be reduced by decreasing the elevated cholesterol levels. β-hydroxy β-methylglutaryl-CoA reductase (HMGCoAR) is the primary and rate-limiting enzyme in the cholesterol biosynthesis pathway. Recently, the crucial role of nutraceuticals in maintaining normal physiological function was established. Nutraceuticals play an important role in preventing several non-communicable diseases such as obesity, CVDs, cancer, diabetes, and reducing hyperlipidemia. Although the effect of nutraceuticals and herbal medicine on CVDs and dyslipidemia was previously investigated thoroughly, the effect of these natural products on HMGCoAR as one of the important enzymes involved in CVDs etiopathogenesis has not yet been investigated. Therefore, the major aim of this paper was to review the effects of nutraceuticals and medicinal plants on HMGCoAR. Results indicate that different types of natural foods, isolated nutrients, herbal products, and dietary supplements as nutraceuticals decrease the expression and activity of HMGCoAR. This review shows that medicinal plants and nutraceuticals could be used to decrease HMGCoAR activity as accessible and convenient and economical natural compounds to prevent dyslipidemia and CVDs. © 2020 International Union of Biochemistry and Molecular Biology
Background: Diabetes mellitus prevalence in Indonesia tends to be elevated based on glucose measurement. Antidiabetic oral has some serious side effects for long-term use. Several studies explored various types of Cinnamomum extract's effects on antidiabetic activity and potentially became an alternative therapy in Diabetes mellitus patients. Purposes: This study aimed to determine Cinnamomum burmannii extract's effect on body weight and fasting blood glucose level in rats induced Type-2 DM. Methods: This study was conducted at the Laboratory of the Faculty of Pharmacy and Science, University Muhammadiyah of Prof. DR. Hamka. This study design was a true experimental method by administering Cinnamon extract at 30mg/kg, 60mg/kg, 120mg/kg, and 200mg/kg to animal tests. The statistical analysis used a T-test to compare the different results in parameters before and after the administration of Cinnamon extract. Results: This study shows a difference in blood sugar level and body weight before and after the cinnamon extract group administration. The body weight results presented no significant differences between before and after administering Cinnamon extracts at doses of 30mg/kg, 60mg/kg, 120mg/kg, and 200mg/kg. In contrast, the blood sugar level showed significant differences between before and after administration of Cinnamon extract at group doses (p<0.05). Metformin was still more influential in reducing fasting blood sugar than Cinnamomum burmannii extract at 30mg/kg. Conclusion: This study concluded that Cinnamomum burmannii extract with various doses could reduce fasting blood glucose levels and body weight. The highest dose showed a significant difference in fasting blood glucose levels before and after the administration of extracts.
Introduction
Contradictory claims about the efficacy of several medicinal plants to promote glycemic control in patients with type 2 diabetes mellitus (T2DM) have been explained by divergences in the administration form and by extrapolation of data obtained from healthy individuals. It is not known whether the antidiabetic effects of traditional herbal medicines are influenced by gelatin capsules. This randomized crossover trial aimed to evaluate the acute effect of a single dose of raw cinnamon consumed orally either dissolved in water as a beverage or as ordinary hard gelatin capsules on postprandial hyperglycemia (>140 mg/dL; >7.8 mmol/L) in T2DM patients elicited by a nutritionally-balanced meal providing 50 g of complex carbohydrates.
Methods
Fasting T2DM patients (n = 19) randomly ingested a standardized meal in five experimental sessions, one alone (Control) and the other after prior intake of 3 or 6 g of crude cinnamon in the form of hard gelatin capsules or powder dissolved in water. Blood glucose was measured at fasting and at 0.25, 0.5, 0.75, 1, 1.5 and 2 hours postprandially. After each breakfast, its palatability scores for visual appeal, smell and pleasantness of taste were assessed, as well as the taste intensity sweetness, saltiness, bitterness, sourness and creaminess.
Results
The intake of raw cinnamon dissolved in water, independently of the dose, decreased the meal-induced large glucose spike (peak-rise of +87 mg/dL and Δ1-hour glycemia of +79 mg/dL) and the hyperglycemic blood glucose peak. When cinnamon was taken as capsules, these anti-hyperglycemic effects were lost or significantly diminished. Raw cinnamon intake did not change time-to-peak or the 2-h post-meal glycaemia, but flattened the glycemic curve (lower iAUC) without changing the shape that is typical of T2DM patients.
Conclusions
This cinnamon’s antihyperglycemic action confirms its acarbose-like property to inhibit the activities of the carbohydrate-digesting enzymes α-amylases/α-glucosidases, which is in accordance with its exceptionally high content of raw insoluble fiber. The efficacy of using raw cinnamon as a diabetes treatment strategy seems to require its intake at a specific time before/concomitantly the main hyperglycemic daily meals. Trial registration: Registro Brasileiro de Ensaios Clínicos (ReBEC), number RBR-98tx28b.
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The book touches on many topics, from recipes to health tips, from the history of medicinal spices to their modern uses. Additionally, the nutritional properties and health benefits of each spice are examined in detail.
In addition to being a great resource for those seeking health, the book ""Medical Spices"" will be a reference book for anyone who wants to cook delicious and healthy meals in their kitchens. We invite everyone who wants to discover the healing powers offered by nature and take the first step towards a healthy life to read this book!
Background: The prevalence of diabetes mellitus has increased over the past few decades, making it a significant public health challenge of the twenty-first century. Cinnamon, as a traditional medicine, has been used in several regions of the world for its anti-diabetic properties. Objectives: The current study was conducted to determine the effect of Cinnamon Zeylanicum extract on blood glucose levels, oxidative stress markers, and antioxidant enzyme gene expression in diabetic rats. Methods: Forty Sprague-Dawley rats were divided into four groups, each containing 10 rats. A single dose of streptozotocin (50 mg/kg, IP) was used to induce diabetes. In this investigation, 40 mg/kg body weight of cinnamon extract was administered orally. After eight weeks, the levels of glucose, malondialdehyde (MDA), and reduced glutathione (GSH) were determined using biochemical methods. Additionally, the expression levels of catalase and glutathione reductase in the rat liver homogenate were evaluated using real-time PCR. The effect of cinnamon extract on histopathological changes in the rats' liver was also investigated. Results: The findings indicated that the administration of cinnamon extract resulted in a considerable reduction in blood glucose (210 ± 29.9 vs. 449 ± 48.4 mg/dL; P < 0.001) and liver MDA levels (2.01 ± 0.35 vs. 3.05 ± 0.47; P < 0.001) in diabetic rats after eight weeks. However, this extract had no significant effect on GSH levels (4.71 ± 0.25 vs. 4.75 ± 0.42; P = 0.79) in diabetic rats compared to diabetic control rats. The mRNA expression of catalase and glutathione reductase genes in the liver of diabetic control rats (0.73 ± 0.23 and 0.90 ± 0.18, respectively) was significantly lower than that of the healthy control group (1.33 ± 0.37 and 1.46 ± 0.54, respectively) (P = 0.001, P = 0.012). Administration of cinnamon extract increased the expression levels of these antioxidant enzyme genes, but these changes were statistically not significant (P = 0.72 and P = 0.48, respectively). Furthermore, the creation of hyperglycemia led to slight hypertrophic degeneration and lymphocyte infiltration in hepatocytes. Notably, the administration of cinnamon extract was unable to reverse these abnormalities. Conclusions: The findings of our study support cinnamon's anti-diabetic and antioxidant properties in diabetic rats. However, the histological abnormalities in the diabetic rats' livers could not be altered by the administration of cinnamon.
Herbal medicines contain chemical compounds which can potentially forestall illnesses and afflictions. Unfortunately, the increasing popularity of herbal drugs worldwide led to the most pervasive misconception that they are perfectly safe and are recommended by patients as self-medication, which frequently brings about unfavourable outcomes and adverse effects. To combat and create awareness of these adverse events, establishing pharmacovigilance (PV) procedures for herbal medications is becoming more widely recognized on several levels. Different ways of using herbal treatments, which might present unique toxicological issues, whether taken separately or in conjunction with other pharmaceuticals, might represent contributing factors to the unpleasant drug response in lifestyle disorders. The chapter contributes to delivering basic knowledge of PV and adverse drug reactions, along with the safe dosage range of phytochemicals in lifestyle diseases, viz. obesity, diabetes, and atherosclerosis. The discussed toxicity and phytovigilance profile of multitudinous natural remedies in enormous lifestyle disorders makes the work unique.
To identify the bioactive compounds in Cinnamomum burmannii and their biological activity. Cinnamonbark originating from Batu Malang, East Java, which was located 700-1300 meters above sea level, wasprocessed into dry extract by maceration method with 96% ethanol solvent. Furthermore, cinnamonethanol extract was analyzed using the GCMS method to look at the content of the bioactive componentfor further testing biological activity with the server Way2Drug PASS. GCMS results showed 40 activecompounds such as trans-cinnamaldehyde, trans-anethole, cinnamyl acetate, calacorene, cadina-1,4-diene, delta-cadinene. Furthermore, of the 40 compounds, the biological activity potential was testedfor 29 bioactive compounds based on PA (probable to be active) values predicted by the Way2DrugPASS server. Cinnamomum was tested against the potential as anti-fungi, anti-bacterial, anti-oxidant,anti-inflammatory, anti-diabetic, anti-neoplastic. Trans-cinnamaldehyde showed PA 0,583 as antiinflammatory, L-limonene PA0,818 as anti neoplastic, Tans-anethole PA 0,614 as anti neoplastic,Cinnamyl acetate PA 0,669 as anti inflammatory, calacorene PA 0,698 as anti inflammatory, DeltacadinenePA 0,651 as anti neoplastic, , Cathechin PA 0,828 as anti oxidant, alpha.-Cubebene PA 0,888 asanti inflammatory and PA 0,837 as anti neoplastic, melilotin PA 0,929 as anti neoplastic, CaryophyllenePA0,915 as anti neoplastic. Cinnamomum burmannii had biological potency based on potential activity(PA) 0,432 (+0,117) as antifungi, PA 0,335 (+0,090) as antibacterial, PA 0,304 (+0,199) as antioxidan,PA 0,561 (+0,190) as anti inflammatory, PA 0,373 (+0,170) as antidiabetic, PA 0,584 (+0,234) asantineoplastic.
Intermittent fasting (IF) regimens have emerged as a dietary tool to improve the glycemic profile, but a critical appraisal of clinical studies assessing the effects of IF regimens in patients with diabetes is needed. Thus, this review encompasses clinical studies examining the impact of different IF regimens on markers of glycemic control in patients with diabetes. Furthermore, clinical nuances relative to pharmacological treatment are also addressed, mainly insulin therapy, to discuss the risk of hypoglycemic events. Only a handful of clinical studies have investigated the effects of IF on patients with diabetes. Overall, IF regimens may elicit modest benefits on glycemic parameters in patients with diabetes, but their effects are not necessarily greater than those of control diets. Last, although IF regimens may be considered safe for patients receiving insulin therapy within interventional and observational research, markers of glycemic control must be constantly monitored in clinical practice to reduce the risk of hypoglycemia and its related complications.
Objective
Managing dietary glycemic index (GI) deserves further attention in the interplay between non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). This study aimed to evaluate the relationship between dietary GI and the odds of NAFLD in patients with T2DM.
Methods
A cross-sectional study was carried out between April 2021 and February 2022, including 200 participants with T2DM aged 18-70 years, of which 133 had NAFLD and 67 were in the non-NAFLD group. Cardiometabolic parameters were analyzed using standard biochemical kits and dietary intake was assessed using a validated food frequency questionnaire. Binary logistic regression was applied to explore odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD according to tertiles of dietary GI.
Results
Highest vs. lowest tertile (< 57 vs. > 60.89) of energy-adjusted GI was not associated with the odds of having NAFLD (OR 1.25, 95% CI = 0.6-2.57; P-trend = 0.54) in the crude model. However, there was an OR of 3.24 (95% CI = 1.03-10.15) accompanied by a significant trend (P-trend = 0.04) after full control for potential confounders (age, gender, smoking status, duration of diabetes, physical activity, waist circumference, HbA1c, triglycerides, total cholesterol, dietary intake of total carbohydrates, simple carbohydrates, fat, and protein).
Conclusion
High dietary GI is associated with increased odds of NAFLD in subjects with T2DM. However, interventional and longitudinal cohort studies are required to confirm these findings.
Cinnamon or cinnamon extract has been widely used as a traditional herbal medicine with medicinal value and has been reported to have various clinical benefits. As for the current research status, the safety evaluation studies of cinnamon or cinnamon extracts are still lacking, and the toxicological studies are not deep enough. Therefore, this paper reviews the potential side effects of cinnamon or cinnamon extracts, toxicology studies, and clinical studies and identifies relevant meta-analyses and systematic reviews of randomized controlled trials on the use of cinnamon or cinnamon extracts in humans by searching PubMed, EMBASE, and the Cochrane Library to provide new directions and ideas for future safety evaluation of cinnamon or cinnamon extracts. This chapter provides new directions and ideas for future safety evaluation of cinnamon or cinnamon extracts.KeywordsCinnamonCinnamon extractSide effectsToxicological assessmentClinical safety studiesSystematic reviewsRandomized clinical trials
Breakfast consumption is generally considered a health-promoting habit for car-diometabolism, particularly with regard to chrononutrition. Glucose uptake is enhanced by proper insulin secretion triggered by the pancreatic clock, averting metabolic dysregulation related to insulin resistance. Breakfast skipping, in turn, is often considered a behaviour detrimental to health, in part due to putative inverse metabolic actions compared to breakfast consumption, such that breakfast skipping may promote circadian desynchrony. However, most ill health concerns about breakfast skipping are inferred from observational research, and recent well-controlled randomized clinical trials have shown benefits of breakfast skipping for cardiovascular risk factors. Accordingly, this review describes the effects of breakfast consumption versus breakfast skipping on cardiovascular risk factors (blood pressure and glycaemic and lipid indices). In addition, the view of breakfast consumption as an opportunity for functional food ingestion is considered to provide further insights into decision-making practice. Collectively, both breakfast consumption and breakfast skipping can be considered viable habits, but they depend on individual preferences, planning, and the specific foods being consumed or omitted. When consumed, breakfast should consist primarily of functional foods typical for this meal (e.g., eggs, dairy products, nuts, fruits, whole grains, coffee, tea, etc.). While breakfast consumption aligns with chrononutrition principles, breakfast skipping can contribute to a calorie deficit over time, which has the potential for widespread cardiometabolic benefits for patients with overweight/obesity. The concepts and practical considerations discussed in the present review may aid health care personnel in personalising breakfast consumption recommendations for diverse patient populations.
Background and aims
Dietary regimens are crucial in the management of non-alcoholic fatty liver disease (NAFLD). The effects of intermittent fasting (IF) have gained attention in this regard, but further research is warranted. Thus, we aimed to ascertain the overall effects of the 5:2 IF diet (5 days a week of normal food intake and 2 consecutive fasting days) in patients with NAFLD compared to a control group (usual diet).
Methods and results
A 12-week randomized controlled trial was performed to evaluate the effects of the 5:2 IF diet on anthropometric indices, body composition, liver indices, serum lipids, glucose metabolism, and inflammatory markers in patients with NAFLD. The IF group (n = 21) decreased body weight (86.65 ± 12.57–82.94 ± 11.60 kg), body mass index (30.42 ± 2.27–29.13 ± 1.95 kg/m²), waist circumference (103.52 ± 6.42–100.52 ± 5.64 cm), fat mass (26.64 ± 5.43–23.85 ± 5.85 kg), fibrosis (6.97 ± 1.94–5.58 ± 1.07 kPa), steatosis scores/CAP (313.09 ± 25.45–289.95 ± 22.36 dB/m), alanine aminotransferase (41.42 ± 20.98–28.38 ± 15.21 U/L), aspartate aminotransferase (34.19 ± 10.88–25.95 ± 7.26 U/L), triglycerides (171.23 ± 39.88–128.04 ± 34.88 mg/dl), high-sensitivity C-reactive protein (2.95 ± 0.62 −2.40 ± 0.64 mg/L), and cytokeratin-18 (1.32 ± 0.06–1.19 ± 0.05 ng/ml) values compared to the baseline and the end of the control group (n = 23)—p ≤ 0.05 were considered as significant. However, the intervention did not change the levels of high-density lipoprotein cholesterol, total cholesterol, low-density lipoprotein cholesterol, fasting blood sugar, insulin, HOMA-IR, and total antioxidant capacity.
Conclusion
Adhering to the 5:2 IF diet can reduce weight loss and related parameters (fat mass and anthropometric indicators of obesity), as well as hepatic steatosis, liver enzymes, triglycerides, and inflammatory biomarkers in patients with NAFLD.
Cinnamon is obtained from a plant whose products have been used daily by people all over the world. Cinnamon is a popular culinary spice, and the oil of cinnamon is used in medicine as a carminative, antiseptic, and astringent. Cinnamon has recently become increasingly popular for its benefits in glycemic control. It has been used for the treatment of coronary risk factors, particularly hypertension, diabetes mellitus, and obesity, and for ameliorating dyslipidemia. Its leaf and bark have digestive, blood purifier, astringent, carminative, warming stimulant, antiseptic, antibacterial, antifungal, and antiviral properties and can help to reduce cholesterol and blood sugar levels. Several mechanisms have been described for the action of polyphenols isolated from cinnamon. These compounds seem to modulate multiple steps of the insulin signal transduction pathway, stimulating the glucose uptake and glycogen synthesis. These bioactive compounds of cinnamon have also been shown to have insulin-independent effects on the regulation of gene expression in adipocytes. In brief, this review indicates that cinnamon has potential beneficial effects on blood glucose, body weight, blood lipids, and blood pressures.
Cinnamon is one of the most important tropical spices, which has different types of essential oils, bioactive compounds to help the human health in numerous ways. Cinnamic acid and cinnamaldehyde are the major derivatives present in this spice and possess antioxidants to combat several diseases and their complications. Antioxidants present in cinnamon possess valuable biological activities especially in fighting with the oxidative stress caused by free radicals. Therefore, bioactive compounds extracted from cinnamon could be used in the preparation of different types of traditional medicines and as supplements too. This chapter illustrates an outline of bioactive compounds derived from cinnamon and their potential ameliorative effects to combat the diseases.
Spices have been added to foods for centuries as flavors, preservatives, and colors and have also been used in traditional medicine in various countries to treat many diseases. Spices play an important role in human health and can be considered as the first functional foods. Although the amount of spices consumed is very low compared to many other foods, the role of spices in the daily diet should not be underestimated due to their health properties. Saffron, ginger, cinnamon, and turmeric are four globally common spices that have been widely used owing to well-known medical benefits in different traditional medicine systems, including Ayurveda, traditional Chinese, and Persian medicine since ancient times. Some general or specific health benefits of these spices include anti-inflammatory, antioxidantAntioxidant, antimicrobial, anti-diabetic, and antihypertensive activities, which have potential protective properties against some ailments such as cancer, type 2 diabetesDiabetes, neurodegenerative and cardiovascular diseases. Recent scientific studies on the therapeutic properties of these common spices have been reviewed in this chapter.
This study was conducted to investigate the effect of cinnamon in high- and low carbohydrate diets on the physiology of rainbow trout (Oncorhynchus mykiss (16.12±1.33 g). Six experimental diets including control/LCarb (200 g/kg carbohydrate), LCarb-3C (200 g/kg carbohydrate, 30 g/kg cinnamon), LCarb-5C (200g/kg carbohydrate, 50 g/kg cinnamon), HCarb (300 g/kg carbohydrate), HCarb-3C (300 g/kg carbohydrate, 30 g/kg cinnamon), and HCarb-5C (300 g/kg carbohydrate, 50 g/kg cinnamon) were formulated to feed fish for eight weeks. The results showed that fish fed dietary LCarb-3C (72.64 g) and LCarb-5C (73.17 g) had higher weight gain as compared with treatments without cinnamon (P<0.05). Blood performance in LCarb3C (67.10) was significantly higher than the HCarb-3C group (P<0.05). Fish fed dietary LCarb-3C had the best performance so that cinnamon in this group lowered glucose, total cholesterol, and low-density lipoprotein, improved total protein, and highdensity lipoprotein contents. Supplementation of this herb also improved protease and lipase in LCarb-3C and LCarb-5C groups as compared with control. Individuals fed supplemented diets but not HCarb had a higher superoxide dismutase activity when compared with the control group (P<0.05). Generally, cinnamon improved parameters in this study in fish fed a low-carbohydrate diet rather than a high-carbohydrate diet.
Cinnamon is an herb widely used in cooking and herbal medicine, found in Southern India and Sri Lanka, China, Indonesia, two main types of cinnamon: Ceylon and cassia. Cinnamon health effective is attributed to its characteristic components like cinnamyl alcohol, oil cinnamaldehyde, and cinnamic acid, coumarin. This herb activities including anti-allergy, antiviral, antimicrobial, antioxidant and as well as an influence when they interference with many treatments in heart disease diabetes. Many researches have been performed particularly on the activity of cinnamon in medical treatment of the popularized metabolic syndrome involving diabetes. our review article, describe several recent research has been shown that has proven the curative and preventive potential offered by cinnamon against many diseases related to oxidative stress
The aim of the current study was to determine the effect of a daily intake of three grams of cinnamon over eight weeks on glycemic indicators, advanced glycation end products, and antioxidant status in patients with type 2 diabetes. In a double-blind, randomized, placebo controlled clinical trial study, 44 patients with type 2 diabetes, aged 57 ± 8 years, were randomly assigned to take either a three g/day cinnamon supplement (n = 22) or a placebo (n = 22) for eight weeks. We measured the fasting blood glucose, insulin, hemoglobinbA1c, homeostasis model assessment for insulin resistance (HOMA-IR), carboxymethyl lysine, total antioxidant capacity, and malondialdehyde levels at the beginning and the end of the study. Thirty-nine patients (20 in the intervention group and 19 in the control group) completed the study. After an eight-week intervention, changes in the level of fasting blood glucose, insulin, hemoglobinbA1c, HOMA-IR, carboxymethyl lysine, total antioxidant capacity, and malondialdehyde were not significant in either group, nor were any significant differences between groups observed in these glycemic and inflammatory indicators at the end of the intervention. Our study revealed that cinnamon supplementation had no significant effects on glycemic and inflammatory indicators in patients with type 2 diabetes.
Background
Nutritional modulation remains central to the management of metabolic syndrome. Intervention with cinnamon in individuals with metabolic syndrome remains sparsely researched.
Methods
We investigated the effect of oral cinnamon consumption on body composition and metabolic parameters of Asian Indians with metabolic syndrome. In this 16-week double blind randomized control trial, 116 individuals with metabolic syndrome were randomized to two dietary intervention groups, cinnamon [6 capsules (3 g) daily] or wheat flour [6 capsules (2.5 g) daily]. Body composition, blood pressure and metabolic parameters were assessed.
Results
Significantly greater decrease [difference between means, (95% CI)] in fasting blood glucose (mmol/L) [0.3 (0.2, 0.5) p = 0.001], glycosylated haemoglobin (mmol/mol) [2.6 (0.4, 4.9) p = 0.023], waist circumference (cm) [4.8 (1.9, 7.7) p = 0.002] and body mass index (kg/m2 ) [1.3 (0.9, 1.5) p = 0.001] was observed in the cinnamon group compared to placebo group. Other parameters which showed significantly greater improvement were: waist-hip ratio, blood pressure, serum total cholesterol, low-density lipoprotein cholesterol, serum triglycerides, and high-density lipoprotein cholesterol. Prevalence of defined metabolic syndrome was significantly reduced in the intervention group (34.5%) vs. the placebo group (5.2%).
Conclusion
A single supplement intervention with 3 g cinnamon for 16 weeks resulted in significant improvements in all components of metabolic syndrome in a sample of Asian Indians in north India.
Trial registration
The clinical trial was retrospectively registered (after the recruitment of the participants) in ClinicalTrial.gov under the identification number: NCT02455778 on 25th May 2015.
Background
The objectives of study were to investigate the effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome (PCOS).
Methods
This double-blind randomized controlled clinical trial was conducted on 84 overweight or obese PCOS patients; aged 20–38 years. Subjects in cinnamon (n = 42) and placebo (n = 42) groups were given 3 cinnamon capsules (each one contained 500 mg cinnamon) or placebo daily for 8 weeks. Fasting blood samples, anthropometric measurements and dietary intake data were gathered at the beginning and at the end of the study. Independent t test, paired t test and analysis of covariance were used to analyze of data.
Results
Cinnamon significantly increased serum total antioxidant capacity (P = 0.005). Malondialdehyde was significantly decreased compared with placebo (P = 0.014). Cinnamon supplementation significantly improved serum level of total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (all P < 0.05). No significant effect was detected on serum triglyceride level.
Conclusions
Cinnamon supplementation improved antioxidant status and serum lipid profile in women with PCOS and may be applicable for reducing PCOS risk factors.
Aim:
To determine the effect of cinnamon on fasting blood glucose, hemoglobin (Hb) A1c, and oxidative stress markers in poorly controlled type 2 diabetes.
Patients and methods:
A total of 25 type 2 diabetic patients of both sexes, aged 49.1 ± 6.0, treated only with hypoglycemic agent sulfonylurea (glibenclamide) were randomly assigned to receive either 1 g of cinnamon or placebo daily for 12 weeks.
Results:
A highly significant (P ≤ 0.001) reduction (10.12%) of fasting blood glucose level after 6 and 12 weeks of treatment 10.12% and 17.4%, respectively, compared to baseline value and to placebo group at corresponding duration. Meanwhile, the value of glycosylated Hb reduced in cinnamon treated group by (2.625%) and (8.25%) after 6 and 12 weeks, respectively, although this reduction was non-significant compared to baseline value. Concerning the oxidative stress markers, the level of serum glutathione showed highly significant (P ≤ 0.001) elevation after 12 weeks as compared to baseline value and placebo group at corresponding duration, malondialdehyde serum level decreased after treatment of diabetic patients with cinnamon resulted in highly significant (P ≤ 0.001) reduction after 6 and 12 weeks compared to placebo group, but when compared to baseline value, there is a (15%) reduction only after 12 weeks of treatment which was considered highly significant (P ≤ 0.001) change, Finally, administration of cinnamon to diabetic patients for 12 weeks resulted in significant (P ≤ 0.05) elevation of superoxide dismutase level.
Conclusion:
Intake of 1 g of cinnamon for 12 weeks reduces fasting blood glucose and glycosylated Hb among poorly controlled type 2 diabetes patients, as well as, there is improvement in the oxidative stress markers, indicating the beneficial effect of adjuvant cinnamon as anti-diabetic and antioxidant along with conventional medications to treat poorly controlled type 2 diabetes mellitus.
Medicinally important genus Ocimum harbors a vast pool of chemically diverse metabolites. Current study aims at identifying anti-diabetic candidate compounds from Ocimum species. Major metabolites in O. kilimandscharicum, O. tenuiflorum, O. gratissimum were purified, characterized and evaluated for anti-glycation activity. In vitro inhibition of advanced glycation end products (AGEs) by eugenol was found to be highest. Preliminary biophysical analysis and blind docking studies to understand eugenol-albumin interaction indicated eugenol to possess strong binding affinity for surface exposed lysines. However, binding of eugenol to bovine serum albumin (BSA) did not result in significant change in secondary structure of protein. In vivo diabetic mice model studies with eugenol showed reduction in blood glucose levels by 38% likely due to inhibition of α-glucosidase while insulin and glycated hemoglobin levels remain unchanged. Western blotting using anti-AGE antibody and mass spectrometry detected notably fewer AGE modified peptides upon eugenol treatment both in vivo and in vitro. Histopathological examination revealed comparatively lesser lesions in eugenol-treated mice. Thus, we propose eugenol has dual mode of action in combating diabetes; it lowers blood glucose by inhibiting α-glucosidase and prevents AGE formation by binding to ε-amine group on lysine, protecting it from glycation, offering potential use in diabetic management.
Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.Objectives
Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed.Methods
In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥25 kg/m2, unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization.ResultsFour-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24±0.50 vs +0.12±0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement.Conclusions
Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes.
Glycaemic control, in particular at postprandial period, has a key role in prevention of different diseases, including diabetes and cardiovascular events. Previous studies suggest that postprandial high blood glucose levels (BGL) can lead to an oxidative stress status, which is associated with metabolic alterations. Cinnamon powder has demonstrated a beneficial effect on postprandial glucose homeostasis in animals and human models. The purpose of this study is to investigate the effect of cinnamon tea (
C. burmannii
) on postprandial capillary blood glucose level on nondiabetic adults. Participants were given oral glucose tolerance test either with or without cinnamon tea in a randomized clinical trial. The data revealed that cinnamon tea administration slightly decreased postprandial BGL. Cinnamon tea ingestion also results in a significantly lower postprandial maximum glucose concentration and variation of maximum glucose concentration (
p
< 0.05). Chemical analysis showed that cinnamon tea has a high antioxidant capacity, which may be due to its polyphenol content. The present study provides evidence that cinnamon tea, obtained from
C. burmannii
, could be beneficial for controlling glucose metabolism in nondiabetic adults during postprandial period.
Cinnamon (肉桂 ròu guì) has in vitro insulin potentiating activity, and proanthocyanidins from cinnamon prevent in vitro formation of advanced glycation end products. Some human studies were equivocal, but several have shown beneficial effects of cinnamon supplementation on circulating glucose, lipids, and/or insulin. This placebo-controlled double-blind trial tested the effects of a dried water extract of cinnamon (Cinnamomum cassia) on circulating glucose, lipids, insulin, and insulin resistance. Men and women from Beijing and Dalian, China, were invited to participate if they had fasting serum glucose >6.1 mmol/L or 2-h glucose >7.8 mmol/L. Participants, (173 were enrolled and 137 completed the study) were randomly assigned to receive either a spray-dried, water extract of cinnamon (CinSulin®), 250 mg/capsule, or a placebo, twice a day for two months. Mean ± SEM age of participants was 61.3 ± 0.8 years, BMI was 25.3 ± 0.3 and M/F ratio was 65/72. After 2 mo, fasting glucose decreased (p < 0.001) in the cinnamon extract-supplemented group (8.85 ± 0.36 to 8.19 ± 0.29 mmol/L) compared with the placebo group (8.57 ± 0.32 to 8.44 ± 0.34 mmol/L, p = 0.45). Glucose 2 h after a 75 g carbohydrate load, fasting insulin, and HOMA-IR also decreased with cinnamon extract compared with placebo. Total and LDL-cholesterol decreased with cinnamon extract and HDL-cholesterol decreased in both the cinnamon-extract and placebo groups. In conclusion, supplementation with 500 mg of water-extract of cinnamon for two months reduced fasting insulin, glucose, total cholesterol, and LDL cholesterol and enhanced insulin sensitivity of subjects with elevated blood glucose.
Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon and is known to be the main agonist of transient receptor potential-ankyrin receptor 1 (TRPA1). Here, expression of TRPA1 in epithelial mouse stomach cells is described. After receiving a single-dose of CIN, mice significantly reduce cumulative food intake and gastric emptying rates. Co-localization of TRPA1 and ghrelin in enteroendocrine cells of the duodenum is observed both in vivo and in the MGN3-1 cell line, a ghrelin secreting cell model, where incubation with CIN up-regulates expression of TRPA1 and Insulin receptor genes. Ghrelin secreted in the culture medium was quantified following CIN stimulation and we observe that octanoyl and total ghrelin are significantly lower than in control conditions. Additionally, obese mice fed for five weeks with CIN-containing diet significantly reduce their cumulative body weight gain and improve glucose tolerance without detectable modification of insulin secretion. Finally, in adipose tissue up-regulation of genes related to fatty acid oxidation was observed. Taken together, the results confirm anti-hyperglycemic and anti-obesity effects of CIN opening a new approach to investigate how certain spice derived compounds regulate endogenous ghrelin release for therapeutic intervention.
Type 2 diabetes mellitus (T2DM) is one of the most important epidemic diseases in the world this century, and accounts for 90% of cases of diabetes globally. Brazil is one of the most important examples of the alarming picture of T2DM in emergent societies, being the country with the fourth largest number of people with diabetes. The aim of this paper is to review the literature on diabetes in Brazil, specifically looking at the epidemiology and management of T2DM. A literature search was conducted using PubMed and LILACS to identify articles containing information on diabetes in Brazil. Official documents from the Brazilian government, World Health Organization, and International Diabetes Federation were also reviewed.
The incidence of type II diabetes is increasing across the world. Dietary modifications help the patients to control blood glucose. Traditional herbs and spices are commonly used for control of glucose among which cinnamon (Ròu Guì; Cinnamomum cassia) has the greatest effect. Research has shown that adding cinnamon to diet can help to lower the glucose level. The aim of this study was to determine the effect of cinnamon on the glucose level in blood. This was a Randomized clinical trial in which 70 Patients with type II diabetes were assigned randomly two groups (35 in cinnamon and 35 in placebo group). The groups were matched in terms of body mass index (BMI), HbAlc and fasting blood sugar (FBS). Patients were treated with cinnamon and the placebo group was treated with placebo in addition to their routine treatment for 60 days. FBG levels and glycosylated hemoglobin of patients on the first day, and 1 and 2 months after treatment were measured. Data were analyzed using t-test and paired t-test in Statistical Package for the Social Sciences (SPSS).16 software. The mean levels of FBS before, and 1 and 2 months after the intervention were 174 ± 59, 169 ± 43 and 177 ± 45; respectively. The levels of HbAlc before and after the intervention in the cinnamon group were (8.9 ± 1.7 and 8.9 ± 1.6). There was no significant difference in FBS and glycosylated hemoglobin levels between the two groups (P = 0.738 and P = 0.87, respectively). Results showed that using certain amount of cinnamon for 60 days did not change the glucose level of diabetic patients. So, using cinnamon to type II diabetes patients cannot be recommended and more studies are needed in future.
We previously demonstrated that cinnamon extract (CE) ameliorates type 1 diabetes induced by streptozotocin in rats through the up-regulation of glucose transporter 4 (GLUT4) translocation in both muscle and adipose tissues. This present study was aimed at clarifying the detailed mechanism(s) with which CE increases the glucose uptake in vivo and in cell culture systems using 3T3-L1 adipocytes and C2C12 myotubes in vitro. Specific inhibitors of key enzymes in insulin signaling and AMP-activated protein kinase (AMPK) signaling pathways, as well as small interference RNA, were used to examine the role of these kinases in the CE-induced glucose uptake. The results showed that CE stimulated the phosphorylation of AMPK and acetyl-CoA carboxylase. An AMPK inhibitor and LKB1 siRNA blocked the CE-induced glucose uptake. We also found for the first time that insulin suppressed AMPK activation in the adipocyte. To investigate the effect of CE on type 2 diabetes in vivo, we further performed oral glucose tolerance tests and insulin tolerance tests in type 2 diabetes model rats administered with CE. The CE improved glucose tolerance in oral glucose tolerance tests, but not insulin sensitivity in insulin tolerance test. In summary, these results indicate that CE ameliorates type 2 diabetes by inducing GLUT4 translocation via the AMPK signaling pathway. We also found insulin antagonistically regulates the activation of AMPK.
Purpose:
Cinnamon has been studied in randomized controlled trials (RCTs) for its glycemic-lowering effects, but studies have been small and show conflicting results. A prior meta-analysis did not show significant results, but several RCTs have been published since then. We conducted an updated systematic review and meta-analysis of RCTs evaluating cinnamon's effect on glycemia and lipid levels.
Methods:
MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched through February 2012. Included RCTs evaluated cinnamon compared with control in patients with type 2 diabetes and reported at least one of the following: glycated hemoglobin (A1c), fasting plasma glucose, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), or triglycerides. Weighted mean differences (with 95% confidence intervals) for endpoints were calculated using random-effects models.
Results:
In a meta-analysis of 10 RCTs (n = 543 patients), cinnamon doses of 120 mg/d to 6 g/d for 4 to 18 weeks reduced levels of fasting plasma glucose (-24.59 mg/dL; 95% CI, -40.52 to -8.67 mg/dL), total cholesterol (-15.60 mg/dL; 95% CI, -29.76 to -1.44 mg/dL), LDL-C (-9.42 mg/dL; 95% CI, -17.21 to -1.63 mg/dL), and triglycerides (-29.59 mg/dL; 95% CI, -48.27 to -10.91 mg/dL). Cinnamon also increased levels of HDL-C (1.66 mg/dL; 95% CI, 1.09 to 2.24 mg/dL). No significant effect on hemoglobin A1c levels (-0.16%; 95%, CI -0.39% to 0.02%) was seen. High degrees of heterogeneity were present for all analyses except HDL-C (I(2) ranging from 66.5% to 94.72%).
Conclusions:
The consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, total cholesterol, LDL-C, and triglyceride levels, and an increase in HDL-C levels; however, no significant effect on hemoglobin A1c was found. The high degree of heterogeneity may limit the ability to apply these results to patient care, because the preferred dose and duration of therapy are unclear.
Type 2 diabetes mellitus (DM) is a chronic metabolic disorder in which prevalence has been increasing steadily all over the world. As a result of this trend, it is fast becoming an epidemic in some countries of the world with the number of people affected expected to double in the next decade due to increase in ageing population, thereby adding to the already existing burden for healthcare providers, especially in poorly developed countries. This review is based on a search of Medline, the Cochrane Database of Systemic Reviews, and citation lists of relevant publications. Subject heading and key words used include type 2 diabetes mellitus, prevalence, current diagnosis, and current treatment. Only articles in English were included. Screening and diagnosis is still based on World Health Organization (WHO) and American Diabetes Association (ADA) criteria which include both clinical and laboratory parameters. No cure has yet been found for the disease; however, treatment modalities include lifestyle modifications, treatment of obesity, oral hypoglycemic agents, and insulin sensitizers like metformin, a biguanide that reduces insulin resistance, is still the recommended first line medication especially for obese patients. Other effective medications include non-sulfonylurea secretagogues, thiazolidinediones, alpha glucosidase inhibitors, and insulin. Recent research into the pathophysiology of type 2 DM has led to the introduction of new medications like glucagon-like peptide 1 analogoues: dipeptidyl peptidase-IV inhibitors, inhibitors of the sodium-glucose cotransporter 2 and 11ß-hydroxysteroid dehydrogenase 1, insulin-releasing glucokinase activators and pancreatic-G-protein-coupled fatty-acid-receptor agonists, glucagon-receptor antagonists, metabolic inhibitors of hepatic glucose output and quick-release bromocriptine. Inhaled insulin was licensed for use in 2006 but has been withdrawn from the market because of low patronage.
Type 2 diabetes is the most common metabolic disorder worldwide. Traditional herbs and spices can be used to control blood glucose concentrations. The objective of this study was to evaluate the effects of the daily intake of three grams cinnamon over eight weeks on glycemic status, lipid profiles and body composition in type 2 diabetic patients.
A double blind, randomized, placebo controlled clinical trial was conducted on 44 patients with type 2 diabetes. Participants were randomly assigned to take either a three g/day cinnamon supplement (n=22) or a placebo (n=22) for eight weeks. Weight, height, body fat mass and systolic and diastolic blood pressure were measured at baseline and after intervention. The fasting blood glucose, insulin, HbA1c, total cholesterol, LDL C, HDL C, Apo lipoprotein A I and B were measured at baseline and endpoint.
From 44 subjects participated in this study 37 completed the study. There were no significant differences in baseline characteristics, dietary intake and physical activity between groups. In the treatment group, the levels of fasting blood glucose, HbA1c, triglyceride, weight, BMI and body fat mass decreased significantly compared to baseline, but not in placebo group. No significant differences were observed in glycemic status indicators, lipid profile and anthropometric indicators between the groups at the end of intervention.
These data suggest that cinnamon may have a moderate effect in improving glycemic status indicators.
Cinnamon has been used as a spice and as traditional herbal medicine for centuries. The available in vitro and animal in vivo evidence suggests that cinnamon has anti-inflammatory, antimicrobial, antioxidant, antitumor, cardiovascular, cholesterol-lowering, and immunomodulatory effects. In vitro studies have demonstrated that cinnamon may act as an insulin mimetic, to potentiate insulin activity or to stimulate cellular glucose metabolism. Furthermore, animal studies have demonstrated strong hypoglycemic properties. However, there are only very few well-controlled clinical studies, a fact that limits the conclusions that can be made about the potential health benefits of cinnamon for free-living humans. The use of cinnamon as an adjunct to the treatment of type 2 diabetes mellitus is the most promising area, but further research is needed before definitive recommendations can be made.
A previous study of healthy subjects showed that intake of 6 g cinnamon with rice pudding reduced postprandial blood glucose and the gastric emptying rate (GER) without affecting satiety.
The objective was to study the effect of 1 and 3 g cinnamon on GER, postprandial blood glucose, plasma concentrations of insulin and incretin hormones [glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1)], the ghrelin response, and satiety in healthy subjects.
GER was measured by using real-time ultrasonography after ingestion of rice pudding with and without 1 or 3 g cinnamon. Fifteen healthy subjects were assessed in a crossover trial.
The addition of 1 or 3 g cinnamon had no significant effect on GER, satiety, glucose, GIP, or the ghrelin response. The insulin response at 60 min and the area under the curve (AUC) at 120 min were significantly lower after ingestion of rice pudding with 3 g cinnamon (P = 0.05 and P = 0.036, respectively, after Bonferroni correction). The change in GLP-1 response (DeltaAUC) and the change in the maximum concentration (DeltaC(max)) were both significantly higher after ingestion of rice pudding with 3 g cinnamon (P = 0.0082 and P = 0.0138, respectively, after Bonferroni correction).
Ingestion of 3 g cinnamon reduced postprandial serum insulin and increased GLP-1 concentrations without significantly affecting blood glucose, GIP, the ghrelin concentration, satiety, or GER in healthy subjects. The results indicate a relation between the amount of cinnamon consumed and the decrease in insulin concentration.
The objective of this study was to determine whether cinnamon improves blood glucose, triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol levels in people with type 2 diabetes.
A total of 60 people with type 2 diabetes, 30 men and 30 women aged 52.2 +/- 6.32 years, were divided randomly into six groups. Groups 1, 2, and 3 consumed 1, 3, or 6 g of cinnamon daily, respectively, and groups 4, 5, and 6 were given placebo capsules corresponding to the number of capsules consumed for the three levels of cinnamon. The cinnamon was consumed for 40 days followed by a 20-day washout period.
After 40 days, all three levels of cinnamon reduced the mean fasting serum glucose (18-29%), triglyceride (23-30%), LDL cholesterol (7-27%), and total cholesterol (12-26%) levels; no significant changes were noted in the placebo groups. Changes in HDL cholesterol were not significant.
The results of this study demonstrate that intake of 1, 3, or 6 g of cinnamon per day reduces serum glucose, triglyceride, LDL cholesterol, and total cholesterol in people with type 2 diabetes and suggest that the inclusion of cinnamon in the diet of people with type 2 diabetes will reduce risk factors associated with diabetes and cardiovascular diseases.
Several aspects of body composition, in particular the amount and distribution of body fat and the amount and composition of lean mass, are now understood to be important health outcomes in infants and children. Their measurement is increasingly considered in clinical practice; however, paediatricians are often unsure as to which techniques are appropriate and suitable for application in specific contexts. This article summarises the pros and cons of measurement technologies currently available for paediatric application. Simple techniques are adequate for many purposes, and simple regional data may often be of greater value than "whole body" values obtained by more sophisticated approaches.
Previous studies of patients with type 2 diabetes showed that cinnamon lowers fasting serum glucose, triacylglycerol, and LDL- and total cholesterol concentrations.
We aimed to study the effect of cinnamon on the rate of gastric emptying, the postprandial blood glucose response, and satiety in healthy subjects.
The gastric emptying rate (GER) was measured by using standardized real-time ultrasonography. Fourteen healthy subjects were assessed by using a crossover trial. The subjects were examined after an 8-h fast if they had normal fasting blood glucose concentrations. GER was calculated as the percentage change in the antral cross-sectional area 15-90 min after ingestion of 300 g rice pudding (GER1) or 300 g rice pudding and 6 g cinnamon (GER2).
The median value of GER1 was 37%, and that of GER2 was 34.5%. The addition of cinnamon to the rice pudding significantly delayed gastric emptying and lowered the postprandial glucose response (P < 0.05 for both). The reduction in the postprandial blood glucose concentration was much more noticeable and pronounced than was the lowering of the GER. The effect of cinnamon on satiety was not significant.
The intake of 6 g cinnamon with rice pudding reduces postprandial blood glucose and delays gastric emptying without affecting satiety. Inclusion of cinnamon in the diet lowers the postprandial glucose response, a change that is at least partially explained by a delayed GER.
To perform a meta-analysis of randomized controlled trials of cinnamon to better characterize its impact on glucose and plasma lipids.
A systematic literature search through July 2007 was conducted to identify randomized placebo-controlled trials of cinnamon that reported data on A1C, fasting blood glucose (FBG), or lipid parameters. The mean change in each study end point from baseline was treated as a continuous variable, and the weighted mean difference was calculated as the difference between the mean value in the treatment and control groups. A random-effects model was used.
Five prospective randomized controlled trials (n = 282) were identified. Upon meta-analysis, the use of cinnamon did not significantly alter A1C, FBG, or lipid parameters. Subgroup and sensitivity analyses did not significantly change the results.
Cinnamon does not appear to improve A1C, FBG, or lipid parameters in patients with type 1 or type 2 diabetes.
The purpose of this study was to determine the effects of supplementation with a water-soluble cinnamon extract (Cinnulin PF(R)) on body composition and features of the metabolic syndrome.
Twenty-two subjects with prediabetes and the metabolic syndrome (mean +/- SD: age, BMI, systolic blood pressure [SBP], fasting blood glucose [FBG]: 46.0 +/- 9.7 y; 33.2 +/- 9.3 kg/m2; 133 +/- 17 mm Hg; 114.3 +/- 11.6 mg/dL) were randomly assigned to supplement their diet with either Cinnulin PF(R) (500 mg/d) or a placebo for 12-weeks. Main outcome measures were changes in FBG, SBP, and body composition measured after 12-weeks of supplementation. The primary statistical analyses consisted of two factor (group x time), repeated-measures ANOVA for between group differences over time. In all analyses, an intent-to-treat approach was used and significance was accepted at P < 0.05.
Subjects in the Cinnulin PF(R) group had significant decreases in FBG (-8.4%: 116.3 +/- 12.8 mg/dL [pre] to 106.5 +/- 20.1 mg/dL [post], p < 0.01), SBP (-3.8%: 133 +/- 14 mm Hg [pre] to 128 +/- 18 mm Hg [post], p < 0.001), and increases in lean mass (+1.1%: 53.7 +/- 11.8 kg [pre] to 54.3 +/- 11.8 kg [post], p < 0.002) compared with the placebo group. Additionally, within-group analyses uncovered small, but statistically significant decreases in body fat (-0.7%: 37.9 +/- 9.2% [pre] to 37.2 +/- 8.9% [post], p < 0.02) in the Cinnulin PF(R) group. No significant changes in clinical blood chemistries were observed between groups over time.
These data support the efficacy of Cinnulin PF(R) supplementation on reducing FBG and SBP, and improving body composition in men and women with the metabolic syndrome and suggest that this naturally-occurring spice can reduce risk factors associated with diabetes and cardiovascular diseases.
Background & aims
Multiple studies have evaluated the hypoglycemic effect of cinnamon in patients with diabetes mellitus (DM) type II, with conflicting results. Differences in Baseline Body Mass Index (BMI) of patients may be able to explain the observed differences in the results. This study was designed to evaluate the effect of cinnamon supplementation on anthropometric, glycemic and lipid outcomes of patients with DM type II based on their baseline BMI.
Methods
The study was designed as a triple-blind placebo-controlled randomized clinical trial, using a parallel design. One hundred and forty patients referred to Diabetes Clinic of Yazd University of Medical Sciences with diagnosis of DM type II were randomly assigned in four groups: cinnamon (BMI ≥ 27, BMI < 27) and Placebo (BMI ≥ 27, BMI < 27). Patients received cinnamon bark powder or placebo in 500 mg capsules twice daily for 3 months. Anthropometric, glycemic and lipid outcomes were measured before and after the intervention.
Result
Cinnamon supplementation led to improvement of all anthropometric (BMI, body fat, and visceral fat), glycemic (FPG, 2hpp, HbA1C, Fasting Insulin, and Insulin Resistance), and lipids (Cholesterol Total, LDL-c and HDL-c) outcomes (except for triglycerides level). All observed changes (except for Cholesterol Total and LDL-c) were significantly more prominent in patients with higher baseline BMI (BMI ≥ 27).
Conclusion
Based on the study findings, cinnamon may improve anthropometric parameters, glycemic indices and lipid profile of patients with type II diabetes. These benefits are significantly more prominent in patients with higher baseline BMI (BMI ≥ 27).
The trial protocol was registered in Iranian Registry of Clinical Trials database (registration ID: IRCT2017031133015N1).
Our aim is to assess the effect of cinnamon powder capsules on insulin resistance, anthropometric measurements, glucose and lipid profiles, and androgens of women with polycystic ovarian syndrome (PCOS). Out of 80 women that were diagnosed as PCOS by Rotterdam Criteria, 66 were enrolled in this randomized double-blind placebo-controlled clinical trial. All of the PCOS women were taking medroxy progesterone acetate 10 mg/day for the last 10 days of their menstrual cycles. The cases were randomly allocated to 2 groups. The women in the first group were treated by cinnamon powder capsules 1.5 g/day in 3 divided doses for 12 weeks and the second group by similar placebo capsules. Anthropometric measurements, fasting blood sugar, fasting insulin, blood glucose 2 hr after taking 75 g oral glucose, HbA1c, testosterone, dehydroepiandrosterone sulphate, homeostatic model assessment for insulin resistance, triglyceride, and cholesterol (low-density lipoprotein, high-density lipoprotein, and total) before and after the intervention were evaluated and compared as outcome measures. Fasting insulin (p = .024) and homeostatic model assessment for insulin resistance (p = .014) were reduced after 12 weeks in the cinnamon group compared with the placebo. There was also a significant decrease in low-density lipoprotein in cinnamon group (p = .004) as compared with baseline that caused significant difference with placebo (p = .049). However, changes in other outcome measurements did not lead to statistically significant difference with placebo. The present results suggest that complementary supplementation of cinnamon significantly reduced fasting insulin and insulin resistance in women with PCOS.
Cinnamon (Cinnamomum sp) has been suggested to help patients with type 2 diabetes mellitus (T2DM) achieve better glycemic control, although conclusions from meta-analyses are mixed. To evaluate whether the use of cinnamon dietary supplements by adults with T2DM had clinically meaningful effects on glycemic control, as measured by changes in fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c), a comprehensive PubMed literature search was performed. Eleven randomized controlled trials were identified that met our inclusion criteria that enrolled 694 adults with T2DM receiving hypoglycemic medications or not. In 10 of the studies, participants continued to take their hypoglycemic medications during the cinnamon intervention period. Studies ranged from 4 to 16 weeks in duration; seven studies were double-blind. Cinnamon doses ranged from 120 to 6,000 mg/day. The species of cinnamon used varied: seven used Cinnamomum cassia or Cinnamomum aromaticum, one used Cinnamomum zeylanicum, and three did not disclose the species. Because of the heterogeneity of the studies, a meta-analysis was not conducted. All 11 of the studies reported some reductions in FPG during the cinnamon intervention, and of the studies measuring HbA1c very modest decreases were also apparent with cinnamon, whereas changes in the placebo groups were minimal. However, only four studies achieved the American Diabetes Association treatment goals (FPG <7.2 mmol/L [130 mg/dL] and/or HbAlc <7.0). We conclude that cinnamon supplements added to standard hypoglycemic medications and other lifestyle therapies had modest effects on FPG and HbA1c. Until larger and more rigorous studies are available, registered dietitian nutritionists and other health care professionals should recommend that patients continue to follow existing recommendations of authoritative bodies for diet, lifestyle changes, and hypoglycemic drugs.
In vitro and in vivo animal studies have reported strong insulin-like or insulin-potentiating effects after cinnamon administration. Recently, a human intervention study showed that cinnamon supplementation (1 g/d) strongly reduced fasting blood glucose concentration (30%) and improved the blood lipid profile in patients with type 2 diabetes. The objective of this study was to investigate the effects of cinnamon supplementation on insulin sensitivity and/or glucose tolerance and blood lipid profile in patients with type 2 diabetes. Therefore, a total of 25 postmenopausal patients with type 2 diabetes (aged 62.9 +/- 1.5 y, BMI 30.4 +/- 0.9 kg/m(2)) participated in a 6-wk intervention during which they were supplemented with either cinnamon (Cinnamomum cassia, 1.5 g/d) or a placebo. Before and after 2 and 6 wk of supplementation, arterialized blood samples were obtained and oral glucose tolerance tests were performed. Blood lipid profiles and multiple indices of whole-body insulin sensitivity were determined. There were no time X treatment interactions for whole-body insulin sensitivity or oral glucose tolerance. The blood lipid profile of fasting subjects did not change after cinnamon supplementation. We conclude that cinnamon supplementation (1.5 g/d) does not improve whole-body insulin sensitivity or oral glucose tolerance and does not modulate blood lipid profile in postmenopausal patients with type 2 diabetes. More research on the proposed health benefits of cinnamon supplementation is warranted before health claims should be made.
Cassia cinnamon has been suggested to lower blood glucose (BG) and serum insulin (SI) due to an improvement in insulin resistance (IR) and sensitivity (IS). This study compared the effects Cassia cinnamon had on calculated IR and IS values and BG and SI in response to an oral glucose tolerance test (OGTT) in young, sedentary, and obese women. On three separate days, 10 women had a fasted venous blood sample obtained. Participants were given 5 g of encapsulated placebo (PLC) or 5 g of encapsulated Cassia cinnamon bark (CASS). Three hours after the initial blood sample, another blood sample was obtained to calculate values for IS and IR. The participants then completed an OGTT by consuming a 75 g glucose solution. Blood was obtained 30, 60, 90, and 120 min following glucose ingestion. IS and IR were not significantly different between placebo and Cassia (p > .05). The peak BG concentration in response to the OGTT was significantly lower at the 30 min time point for CASS, as compared to PLC (140 ± 5.8 and 156 ± 5.2 mg/dL, p = .025); however, there was no significant difference between treatments for SI (p > .05). The area-under-the-curve responses for BG and SI were not significantly different between PLC and CASS (p > .05). This study suggests that a 5 g dose of Cassia cinnamon may reduce the peak BG response and improve glucose tolerance following an OGTT, but with no improvement in IS and IR in young, sedentary, obese women.
Brown adipose tissue (BAT) is a site of adaptive non-shivering thermogenesis after cold exposure, and is involved in the regulation of energy expenditure and body fatness. BAT can be activated and recruited by not only cold exposure but also by various food ingredients including capsaicin in chili pepper and catechins in green tea, which would be easily and safely applicable to our daily life for preventing obesity.
Objectives:
Type 2 diabetes (T2D) may be caused by elevated oxidative stress, inflammation, and hyperglycemia. The phytochemicals in several herbal medicines are reported to effectively improve diabetes and to ameliorate diabetic complications. The aim of the present study was to determine the effects of cinnamon, cardamom, saffron, and ginger as supplementary remedies in T2D.
Methods:
This randomized controlled, clinical trial included 204 T2D patients. The participants were randomly assigned to four intervention groups receiving 3 glasses of black tea and either 3 g cardamom, or cinnamon, or ginger, or 1 g saffron and one control group which consumed only 3 tea glasses without any herbal medicine for 8 weeks. Markers of inflammation, oxidative stress, fasting blood sugar, lipid profile, and anthropometric measures were evaluated at baseline and after 8 weeks of intervention.
Results:
After 8 weeks of intervention, cinnamon, cardamom, ginger, and saffron consumption had significant effects on total cholesterol, LDL, and HDL levels (p < 0.05) compared with controls. However, the herbal products did not have significant effects on measures of glycemic control, anthropometry, inflammation, and oxidative stress. In within-group comparisons only, cinnamon intake significantly decreased fasting blood sugar (FBS).
Conclusions:
The herbal remedies examined had significantly beneficial effects on cholesterol, but not on measures of glycemic control, oxidative stress, and inflammation. Based on the contradictory results reported in the literature, the effects of herbal medicine in diabetic patients should undergo further detailed investigation.
Background
Alternative medicine is common in patients with diabetes mellitus. The primary objective of the study was to determine the effects of cinnamon and whortleberry on blood glucose control, lipid profile and body mass index in type 2 diabetes (T2DM) patients.Methods
In this randomized, triple–blinded clinical trial 105 patients with type 2 diabetes were recruited and randomly divided into 3 groups: placebo, cinnamon and whortleberry supplementations (1 g daily for 90 days). Some biochemical indexes including, fasting blood glucose, serum insulin, lipid profiles and HbA1c were measured before and after the study as Primary outcome.ResultsThere was no significant difference in baseline characteristics between three groups. Fasting blood glucose, two hour blood glucose and Homeostasis Model assessment (HOMA) score were significantly reduced in patients in whortleberry group, whereas they were not changed in placebo group. There was a significant difference between cinnamon and control groups in body mass index (P = 0.02). In cinnamon and whortleberry groups there was no significant difference in any variables (P > 0.05). Although all glucose control indexes decreased after intervention (P < 0.05).Conclusions
There was no significant difference in blood glucose level, insulin sensitivity and lipid profile between 3 groups. However, using cinnamon and whortleberry is recommended for adjusting weight and blood glucose respecting along with medical treatment.The significant finding(s) of the studyCinnamon and Caucasian whortleberry lead to significant reduction in some biochemical variables in type 2 diabetic mellitus such