The protection of food against contamination from pests is a key prerequisite within a good manufacturing practice (GMP) system. The most effective contribution towards infestation control is maintaining good housekeeping standards, for example controlling accumulations of food and paper debris, keeping gangways and passages clear, removing redundant equipment and materials from the manufacturing areas, and ensuring good stock rotation. The Prevention of Damage by Pests Act 1949 requires an occupier of any land or buildings to notify the local authority of rodent infestation. The Food Safety Act 1990 made it an offence to sell food that is unfit for human consumption or contains foreign bodies, for example pests, parts of pests or droppings. This chapter outlines the steps that a pest control programme should address, including criteria assessment, pest control protocol, implementation; and evaluation. The quality control manager and their nominated deputy must be responsible for the implementation of the pest control programme.