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Clinical and laboratory characteristics of hepatitis d in Republic of Sakha (Yakutia)
Abstract
Objective:
Inrtroduction: The epidemiological situation for hepatitis D has changed significantly. Reduced population authors infection due to a sharp decline in hospitalizations from Central Asia regions, the Caucasus and Moldova, which are known to be endemic for hepatitis D. Currently, the incidence of chronic hepatitis D (HGD) in Russia is 1%, while in the countries of Central Asia, and in particular in Turkmenistan, the share of HGD among chronic viral hepatitis is 8%. The aim of research was to establish the clinical features, depending on the activity of the replication of hepatitis viruses B and D.
Patients and methods:
Materials and Methods: We studied 26 patients with viral hepatitis D with a determined activity replicative virus by PCR (polymerase chain reaction). The age of patients ranged from 28 to 78 years. The patients performed the ELISA (enzyme-linked immunosorbent assay) study for the presence of markers of parenteral viral hepatitis (HBsAg, a-HCV and a-HDV), the standard general clinical biochemical blood tests. of the instrumental methods survey used ultrasonography (ultrasound), EGD (fibrogastroduodenoscopy). Grading the severity of liver cirrhosis established by Child-Pugh (eng. Child-Pugh, Child-Turcotte, Child-Turcotte-Pugh, sometimes Child-Paquet) is designed to assess the severity of cirrhosis. The severity of liver cirrhosis is assessed on a point system, which are calculated from 5 or 6 parameters.
Results:
Results: It is established that most HGD more prevalent among young people bodied (69%) and occurs mainly in severe symptoms and portal hypertension leading to the rapid development of liver cirrhosis (53%). It showed that hyperenzymemia reaches high levels of ALT to 1715 U / L. with a high viral DNA load virus (HBV) 2648226,0 ± 953892,7 copies / ml in the presence of an RNA virus D (HDV +).
Conclusion:
Conclusion: Thus, the main feature of chronic hepatitis D is its predominant tsirrogennost.
... Согласно современным данным исход заболеваемости детей хроническими вирусными гепатитами имеет неопределенный прогноз и во многом определяется конкретным регионом проживания [19]. На территории Российской Федерации отмечается недостаточный объем назначения специализированного лечения хронических вирусных гепатитов в детской популяции. ...
Objective: to present an analysis of the data presented at the present stage in the scientific specialized literature on the main trends in the provision of specialized medical care to children with chronic viral hepatitis В, С and D. Review writing methodology. The study was based on publications in the databases PubMed/Medline, eLibrary under the keywords: "chronic viral hepatitis", "hepatitis B", "hepatitis C", "hepatitis D", "treatment of chronic hepatitis in children", published during the period from 2012 to 2023. We additionally studied international acts and the regulatory framework of the Russian Federation regarding the provision of specialized medical care to the child population with chronic viral hepatitis (total number of sources — 41). Conclusion. At present, the main approach in providing specialized medical care to children with chronic viral hepatitis is the appointment of etiotropic therapy with the possible delayed prescription of specialized drugs in order to reduce the risk of their side effects. Research is being actively carried out on the development of new pharmacotherapeutic agents that are effective against this group of infectious diseases, as well as the possibilities of preventing infection in infants through early diagnosis and treatment of pregnant women.
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