A Scientific review on clot dissolving activity of cayenne pepper

Abstract

The work of fibrinolysis is to break up fibrin clots. The
a glycoprotein with gram atomic weight (GMW) of 90,000.
plasminogen is changed over to plasmin by tissue plasminogen activator (TPA).
happens on the fibrin surface, in this way restricting proteolytic
location. Tissue plasminogen activator, produced by monoclonal methods, has recently
been made available for limited therapeutic use. As of now
are broadly utilized remedially to enact plasminogen. These
shaped which is free in the circulation as well as bound to fibrin,
proteolysis of circulating plasminogen and clotting components
has demonstrated to be more useful than anticoagulation alone for
and for aspiratory emboli. Herbs and species are natural foods additives that contribute
significantly to the taste and flavor of our food. In some cult
spices have also been used as medicines. Cayenne pepper is one among them
which belongs to the family solanaceae. It is a type of Capsicum annum. It is usually
a hot chili powder that is used to flavor dishes. Th
present in most of the Capsicum species is capsaicin
dissolving potential. This present review focuses on providing the information about the
Capsaicin.
It is usually a
dishes. The word
kynnha which
from the city of
is high in
product2. The
it is Capsaicin
property17.
an anticoagulant
K-dependent
than that of
Taxonomical classification: 17
 Kingdom: Plantae
 Order: Solanales
 Family: Solanaceae
 Genus: Capsicum
 Species: annuum
Fig No 1 Cayenne pepper
Therapeutic uses of Cayenne pepper:
 Boosts metabolism
 Improves Digestive Health
 Lowers Blood Pressure
 Can reduce pain
 Anti-Cancer
 Protects the Heart8
Impact Factor: SJIF: 5.995
; 10572-10574
//2018.10574.1796
and Kavya K
operator of fibrinolysis is plasmin,
Beneath normal conditions,
Actuation
movement to the suitable
. Streptokinase and Urokinase
specialists cause plasmin to be
coming about in
components. Fibrinolytic treatment
profound vein thrombi
cultures, these herbs and
r The main chemical constituent
(48.6%) which has clot
20

Full text

A SCIENTIFIC REVIEW ON CLOT
Sai Sri lakshmi G*.,
Naga varalakshmi T., Sai kiran A., Vindhya G., Sundar Raj I
Sai kiran, D.no:1
A R T I C L E I N F O
INTRODUCTION
Cayenne pepper is a type of Capsicum
annum.
moderate hot chili pepper used to flavor
cayenne is derived from the old tupi
language
means pepper. Cayenne pepper gets its
name
Cayenne in French Guiana.21 Cayenne
pepper
vitamin A. It also contains vitamin B,
vitamin E, vitamin C,
riboflavin, potassium and manganese.16,17,18
Plan Profile
Cayenne pepper is a naturally occurring
plant
main active chemical constituent present
in
which has an anti-coagulant and anti-
inflammatory
While coming to the synthetic Warfarin, it
is
that acts by inhibiting the synthesis
of vitamin K
coagulation factors. Warfarin has more side
effects
Cayenne pepper.18
Synonyms: 16,18
 Capsicum annuum
 Capsicum angulosum
 Capsicum frutescens
 Capsicum minimum
International Journal of Current Advanced Research
ISSN: O: 2319-6475, ISSN: P: 2319-
6505,
Available Online at
www.journalijcar.org
Volume 7; Issue 3(B); March 2018
; Page No.
DOI: http:
//dx.doi.org/10.24327/ijcar.2018
Copyright©2018 Sai Sri lakshmi G et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
*Corresponding author: Sai Sri lakshmi G
Sai kiran, D.no:1-
355,1st Ward, Katapheta, Mangalagiri
Article History:
Received 6th December, 2017
Received in revised form 21st
January, 2018 Accepted 05th February, 2018
Published online 28th March, 2018
Key words:
Cayenne pepper, Capsaicin, Clot dissolving
activity
A SCIENTIFIC REVIEW ON CLOT DISSOLVING ACTIVITY OF CAYENNE PEPPER
Naga varalakshmi T., Sai kiran A., Vindhya G., Sundar Raj I
Sai kiran, D.no:1
-
355,1st Ward, Katapheta, Mangalagiri
A B S T R A C T
The work of fibrinolysis is to break up
fibrin clots. The
a glycoprotein with gram atomic
weight (GMW) of 90,000.
plasminogen is changed over
to plasmin by tissue plasminogen activator (TPA).
happens on the fibrin surface, in this way restricting
proteolytic
location
. Tissue plasminogen activator, produced by monoclonal methods, has recently
been made available for limited therapeutic use.
As of now
are broadly utilized remedially to enact
plasminogen. These
shaped
which is free in the circulation as well as bound to fibrin,
proteolysis of circulating plasminogen and clotting
components
has demonstrated to be more useful
than anticoagulation alone for
and for aspiratory
emboli. Herbs and species are natural foods additives that contribute
significantly to the taste and flavor of our food. In some cult
spices have also been used as medicines. Cayenne pepper is one among them
which belongs to the family solanaceae. It is a type of Capsicum annum. It is usually
a hot chili powder that is used to flavo
r dishes. Th
present in most of the Capsicum species is
capsaicin
dissolving potential. This present review focuses on providing the information about the
Capsaicin.
annum.
It is usually a
dishes. The word
language
kynnha which
name
from the city of
pepper
is high in
vitamin E, vitamin C,
plant
product2. The
in
it is Capsaicin
inflammatory
property17.
is
an anticoagulant
of vitamin K
-dependent
effects
than that of
Taxonomical classification: 17
 Kingdom: Plantae
 Order: Solanales
 Family: Solanaceae
 Genus: Capsicum
 Species: annuum
Fig No 1
Cayenne pepper
Therapeutic uses of Cayenne pepper:
 Boosts metabolism

Improves Digestive Health

Lowers Blood Pressure
 Can reduce pain
 Anti-Cancer
 Protects the Heart8
International Journal of Current Advanced Research
6505,
Impact Factor: SJIF: 5.995
www.journalijcar.org
; Page No.
10572-10574
//dx.doi.org/10.24327/ijcar.2018
.10574.1796
This is an open access article distributed under the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
355,1st Ward, Katapheta, Mangalagiri
DISSOLVING ACTIVITY OF CAYENNE PEPPER
Naga varalakshmi T., Sai kiran A., Vindhya G., Sundar Raj I
and Kavya K
355,1st Ward, Katapheta, Mangalagiri
fibrin clots. The
operator of fibrinolysis is plasmin,
weight (GMW) of 90,000.
Beneath normal conditions,
to plasmin by tissue plasminogen activator (TPA).
Actuation
proteolytic
movement to the suitable
. Tissue plasminogen activator, produced by monoclonal methods, has recently
As of now
Streptokinase and Urokinase
plasminogen. These
specialists cause plasmin to be
which is free in the circulation as well as bound to fibrin,
coming about in
components
. Fibrinolytic treatment
than anticoagulation alone for
profound vein thrombi
emboli. Herbs and species are natural foods additives that contribute
significantly to the taste and flavor of our food. In some cult
ures, these herbs and
spices have also been used as medicines. Cayenne pepper is one among them
which belongs to the family solanaceae. It is a type of Capsicum annum. It is usually
r dishes. Th
e main chemical constituent
capsaicin
(48.6%) which has clot
dissolving potential. This present review focuses on providing the information about the
Cayenne pepper
Therapeutic uses of Cayenne pepper:
20
Improves Digestive Health
Lowers Blood Pressure
Review Article
This is an open access article distributed under the Creative Commons Attribution License, which permits

International Journal of Current Advanced Research Vol 7, Issue 3(B), pp 10572-10574, March 2018
10573
 Clears congestion
 Weight loss
 Helps Detoxify
 Relieves Joint Pains
 Has Anti-microbial properties
 Improves immunity6
 Can Heal Toothaches
 Improves Skin And Hair Health
Folklore uses: Stimulant, tonic, carminative, pungent, emetic,
antiseptic, antispasmodic, rubefacient, condiment and anti-
rheumatic.19
Mechanism of Cayenne pepper in dissolving the blood clot
They are potent blood anticoagulants from the east, used as a
cooking necessity.1 They prevent the platelets from sticking
together thereby easing the blood flow.3 Cayenne peeper
contains a compound called Capsaicin which ensures proper
blood flow throughout the vessels. It also helps
reduce symptoms of poor blood circulation like pain,
headaches,10 numb hands, cold feet and tingling in legs.9
Fig No 2 Mechanism of Fibrinolysis11,12
Human Polymorphisms Associated With Thrombosis
Table 1 Some examples of human polymorphisms associated
with thrombosis.14,15
Polymorphism Hemostatic phenotype
PAI-1 4G promoter Increased venous thrombosis risk, slightly
increased arterial thrombosis risk, no apparent
increase in stroke risk24
tPA enhancer 7531 C/T Increased arterial thrombosis in select
populations25
TAFI Thr325Ile Increased circulating TAFI, but no increase in
thrombosis15
TAFI Ala147Thr Increased risk for coronary artery disease
14
Disorders of fibrinolysis can be congenital or acquired in
association with numerous medical conditions including
malignancy, liver disease12, and renal failure18.
Hypofibrinolysis is more often associated with thrombosis11,
while hyperfibrinolysis may result in a bleeding
tendency17.Defects in fibrinolytic components have been
associated with non-hematologic manifestations such as
ligneous mucositis. Global assays of fibrinolysis developed to
predict thrombosis should be validated in larger populations,
and further studied for use in bleeding disorder.16
Major drug interaction:1
CONCLUSION
Capsaicin, the dynamic rule of hot peppers of the class
Capsicum, displays expansive bioactivity. It targets neuronal
structures which contain substance P, clinically observed as
gastrointestinal and dermatologic disturbance, bronchospasm
and fibrinolysis. Capsaicin is an agonist of transient receptor
potential vanilloid compose 1 (TRPV1), in which it can go
about as a neuronal stimulant and result in nociception.
Capsaicin likewise influences an assortment of nonneuronal
tissues, in which its instruments of activity are less sure. The
fibrinolytic framework is as convoluted and multifaceted as the
coagulation course, and is similarly significant thrombotic
sickness and dying. Dysregulation of the fibrinolytic
framework is related with various and capricious clinical
phenotypes going from the coagulopathies of liver sickness12
and DIC to uncommon inborn draining issue. Likewise, the
potential part of the fibrinolytic framework in cell flagging
pathways, irritation, and harm stays to be completely
investigated. The fibrinolytic framework speaks to a genuine
boondocks in understanding the intricate communications of
natural frameworks, and, as we pick up a superior
comprehension of its part in science, we will have the capacity
to enhance the care of patients with assorted medicinal
conditions.
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How to cite this article:
Sai Sri lakshmi G et al (2018) 'A Scientific Review on Clot Dissolving Activity of Cayenne Pepper', International Journal of
Current Advanced Research, 07(3), pp. 10572-10574. DOI: http://dx.doi.org/10.24327/ijcar.2018.10574.1796
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