Most of the Mediterranean islands are heavily dependent on imported fossil fuels and have to deal with specific problems such as small scale generation of electricity, high distribution costs and an underutilization of their Renewable Energy Source (RES) potential. These challenges result in high energy costs and elevated levels of CO2 emissions. In order to promote a shift towards cleaner energy systems, islands have to invest on RES and smart solutions for sustainable energy supply. The present study examines the feasibility of RES introduction in the Maltese energy system through the application of the methodology developed by PRISMI project to the island of Gozo. The research firstly assesses the island's RES potential, the environmental constraints and the energy consumption. Secondly it simulates energy scenarios in order to analyse the feasibility of increasing the RES penetration in the local energy grid. For the simulation of the energy system and feasibility study, HOMER and EnergyPLAN software have been used. The outcomes of the simulated energy scenarios presented in this paper, takes into account different energy mix layouts and the environmental and technical constraints. Lastly, the study analyses the possibility of achieving the ambitious target of 100% RES share.