Gastroprotective effects of herbal medicines (Roots)

Article (PDF Available)inInternational Journal of Food Properties 21(1):901-919 · January 2018with 76 Reads
DOI: 10.1080/10942912.2018.1473876
Abstract
Herbal medicines are now commonly used all over the world and this has increased global demand. Quality, safety, and efficacy of these drugs have become a serious concern. This review presents the medicinal plants cited in folklore that are used to treat gastrointestinal ulcers. Electronic databases, that is, Web of Science, PubMed, Scopus, and Google Scholar were searched to identify the gastroprotective effects of each plant. Ethnopharmacological studies have reported various botanical products with antiulcer activities, but there has been limited scientific research, presenting clinical data to validate the efficacy and safety of medicinal herbs as gastroprotective agents. Most studies centered on pharmacological properties of medicinal herbs as used animals models. This information has prompted us to compile a list of the medicinal herbs cited in folklore with gastroprotective activity.
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  • Article
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  • Article
    Introduction: Medicinal plants with phenolic compounds have been shown to have antimicrobial and antioxidant activities. The objective of the study was to evaluate the anti-ulcer effects of ethanolic extracts of Plumbaginales namely P. auriculata, P. indica and P. zeylanica and plumbagin in aspirin and ethanol induced gastric ulcer models. Methods: In vivo studies including DPPH scavenging assay, lipid peroxidase inhibition assay, acid neutralizing capacity test, aspirin- and ethanol-induced ulcer models were performed to assess the antioxidant and antiulcer effects of plants. By using the models of Aspirin (200 mg/kg, 1 hour after the administration of last dose of the extract/ranitidine) and ethanol (1 mL/200 g, 90%) induced ulcer, animals were randomly divided into three groups of six animals each. Group I served as positive control, group II acted as standard and received ranitidine (20 mg/kg). The group III was treated with ethanolic extract by oral route in a dose of 300 mg/kg for a period of 5 days. The animals were sacrificed and the stomach was then excised and cut along the greater curvature, washed carefully with 5.0 mL of 0.9% NaCl and ulcers were scored. Results: Both the aspirin- and ethanol-induced models of ulcer with various extracts of Plumbaginales showed significant acid neutralizing and antioxidant properties. Conclusion: This study suggests that root extracts of P. auriculata may have good quality potentials for use in peptic ulcer diseases and that P. auriculata possesses an antiulcer effect.
  • Article
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  • Article
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    Introduction: The present study investigated protective effect of Zataria multiflora essential oil on ethanol-induced gastric ulcer in rats along with its possible mechanism(s). Methods: Eighty male adult rats were randomly allocated into 8 groups as follows: 1: negative control (NC); 2, 3 and 4: positive control (PC, distilled water), vehicle control (VC, corn oil) and comparative control (CC, omeprazole 20 mg/kg in distilled water), respectively; 5, 6, 7 and 8: treated with 100, 200, 400 and 800 μL/kg Z. multiflora essential oil. After 1 hour, gastric ulcer was induced by 4 mL/kg 75% ethanol orally to rats of groups 2-8. One hour later, blood samples were collected and then all rats were sacrificed and their stomachs were immediately removed. Results: In PC and VC groups severe lesions were observed in stomachs where mucosal lesions in CC group as well as groups treated with Z. multiflora essential oil (especially higher doses) were very mild with regard to ulcer area and number. No significant difference was observed in mucosal prostaglandin E2 (PGE2) and serum tumor necrosis factor-α (TNF-α) level among groups, gastric mucosal nitric oxide (NO) content was significantly higher in rats treated with Z. multiflora essential oil at 200, 400 and 800 μL/kg as compared to PC group. Rats in CC, Z. multiflora 400 and Z. multiflora 800 groups showed higher mucosal total antioxidant capacity (TAC) as compared to PC group. Conclusion: Z. multiflora essential oil has a gastro-protective effect against ethanol-induced gastric ulcer in rats which is probably due to its antioxidant and NO production enhancing effect.
  • Article
    Full-text available
    Ashwgandha has long been considered as an excellent rejuvenator, a general health tonic and a cure for a number of health complaints. It is a sedative, diuretic, anti-inflammatory and generally respected for increasing energy, endurance, and acts as an-adaptogen that exerts a strong immunostimulatory and an-anti-stress agent. Ashwagandha is taken for treating cold and coughs,
  • Article
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    Introduction: Butea frondosa has been suggested to be very useful in treating inflammatory diseases but no scientific investigation has been done in such direction. In this study the anti-inflammatory and anti-microbial activities of leaves aqueous extract of B. frondosa were determined in infected and non-infected human whole blood against specific vaccine antigen, HBsAg. Methods: In order to explore the anti-inflammatory and anti-microbial activities of B. frondosa (0.5-0 mg/mL; 50 μl), infected (virally) and non infected (control) human whole blood samples were stimulated with hepatitis B vaccine containing surface antigen (HBsAg, 20 μg/mL;10 μl) in order to determined its blood counts and proliferation assay. Results: Aqueous leaves extract of B. frondosa (10 mg/mL; 50 μl) containing HBsAg inhibited the percentage count of monocytes as well as granulocytes population in both cases. In addition, this aqueous extract also reduced its proliferation rate at higher doses. Conclusion: Aqueous leaves extract of B. frondosa possesses both anti-inflammatory and antimicrobial activities and might be used for these purposes.
  • Chapter
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