This article contributes to the literature on the politicization of appointments to increase political control over public bureaucracies with often substantial managerial and policy autonomy. Using data from a large-scale executive survey from central government ministries and agencies in 18 European countries, the article provides a comprehensive cross-national and cross-organizational analysis of the autonomy-politicization conundrum and the drivers of the politicization of senior-level appointments. We find that national patterns of politicization correspond fairly well to country families as defined by administrative traditions, with some traditions being more coherent than others. At the organizational level, we find no evidence of efforts by politicians to compensate for extended autonomy by politicizing senior-level appointments, yet we provide evidence of differential effects of both formal and informal organizational characteristics on patterns of politicization. Our analyses show that politicization of senior appointments is lower in organizations with agency status, higher organizational social capital, higher financial autonomy and more extensive use of management tools. The article thereby not only offers comprehensive evidence of cross-country differences in politicization; it also adds to the literature on sub-national variation, by fleshing out an organizational perspective to the study of politicized appointments in the European context.