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Bilateral Vestibular Dysfunction Associated With Chronic Exposure to Military Jet Propellant Type-Eight Jet Fuel


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We describe three patients diagnosed with bilateral vestibular dysfunction associated with the jet propellant type-eight (JP-8) fuel exposure. Chronic exposure to aromatic and aliphatic hydrocarbons, which are the main constituents of JP-8 military aircraft jet fuel, occurred over 3–5 years’ duration while working on or near the flight line. Exposure to toxic hydrocarbons was substantiated by the presence of JP-8 metabolite n-hexane in the blood of one of the cases. The presenting symptoms were dizziness, headache, fatigue, and imbalance. Rotational chair testing confirmed bilateral vestibular dysfunction in all the three patients. Vestibular function improved over time once the exposure was removed. Bilateral vestibular dysfunction has been associated with hydrocarbon exposure in humans, but only recently has emphasis been placed specifically on the detrimental effects of JP-8 jet fuel and its numerous hydrocarbon constituents. Data are limited on the mechanism of JP-8-induced vestibular dysfunction or ototoxicity. Early recognition of JP-8 toxicity risk, cessation of exposure, and customized vestibular therapy offer the best chance for improved balance. Bilateral vestibular impairment is under-recognized in those chronically exposed to all forms of jet fuel.
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May 2018 | Volume 9 | Article 3511
published: 16 May 2018
doi: 10.3389/fneur.2018.00351
Frontiers in Neurology |
Edited by:
Bryan Kevin Ward,
Johns Hopkins University,
United States
Reviewed by:
Pierre-Paul Vidal,
Université Paris Descartes, France
Jorge Kattah,
University of Illinois College of
Medicine, United States
Terry D. Fife
Specialty section:
This article was submitted
to Neuro-Otology,
a section of the journal
Frontiers in Neurology
Received: 06March2018
Accepted: 01May2018
Published: 16May2018
FifeTD, RobbMJA, SteenersonKK
and SahaKC (2018) Bilateral
Vestibular Dysfunction Associated
With Chronic Exposure to Military
Jet Propellant Type-Eight Jet Fuel.
Front. Neurol. 9:351.
doi: 10.3389/fneur.2018.00351
Bilateral Vestibular Dysfunction
Associated With Chronic Exposure
to Military Jet Propellant Type-Eight
Jet Fuel
Terry D. Fife1*, Michael J. A. Robb2, Kristen K. Steenerson3 and Kamala C. Saha1
1 Barrow Neurological Institute, Phoenix, AZ, United States, 2 Robb Oto-Neurology Clinic, Phoenix, AZ,
United States, 3 Stanford University, Palo Alto, CA, United States
We describe three patients diagnosed with bilateral vestibular dysfunction associated
with the jet propellant type-eight (JP-8) fuel exposure. Chronic exposure to aromatic
and aliphatic hydrocarbons, which are the main constituents of JP-8 military aircraft jet
fuel, occurred over 3–5years’ duration while working on or near the ight line. Exposure
to toxic hydrocarbons was substantiated by the presence of JP-8 metabolite n-hexane
in the blood of one of the cases. The presenting symptoms were dizziness, headache,
fatigue, and imbalance. Rotational chair testing conrmed bilateral vestibular dysfunc-
tion in all the three patients. Vestibular function improved over time once the exposure
was removed. Bilateral vestibular dysfunction has been associated with hydrocarbon
exposure in humans, but only recently has emphasis been placed specically on the
detrimental effects of JP-8 jet fuel and its numerous hydrocarbon constituents. Data
are limited on the mechanism of JP-8-induced vestibular dysfunction or ototoxicity.
Early recognition of JP-8 toxicity risk, cessation of exposure, and customized vestibular
therapy offer the best chance for improved balance. Bilateral vestibular impairment is
under-recognized in those chronically exposed to all forms of jet fuel.
Keywords: JP-8, jet propulsion fuel-8, JP-8 jet fuel, bilateral vestibular dysfunction, ototoxicity, vestibulotoxicity,
rotational chair, hydrocarbons
e primary jet fuel used in the United States Air Force and NATO military operations is jet
propellant type-eight (JP-8). JP-8 is a kerosene-based fuel comprised of over 228 aromatic and
aliphatic hydrocarbons (1). During 1992–1996, the Air Force transitioned from using JP-4 to JP-8
due to the improved safety prole of the latter. JP-8 is also used as a multipurpose fuel for ground
vehicles, generators, tent heaters and air conditioners, lamps, and cooking stoves allowing for
an array of exposure opportunities. JP-8 typically contains 18% aromatic hydrocarbons and 82%
aliphatic hydrocarbons, in particular, 9% C8–C9, 65% C10–C14, and 7% C15–C17 (2). JP-8 diers
from commercial airline fuel due to its military additives including static electricity/corrosion/
icing inhibitors, thermal stability enhancers, and antioxidants.
Vestibulotoxicity from JP-8 has been suggested but not well-documented in previous studies.
Several studies indicate an association with impaired balance (3, 4), hearing, and central auditory
processing (58).
We present a case study of three patients who had chronic complaints of dizziness, headache,
fatigue, and imbalance. One patient performed fuel-tank maintenance for the Air National Guard
FIGURE 1 | Example of vestibular hypofunction seen across all frequencies for Case 1. A sinusoidal rotation at 0.04Hz, 60deg/s by rotational chair testing. The
smooth sinusoid is the chair/head rotation at 0.04Hz, and the scatter line represents the slow phases of compensatory nystagmus in response to the sinusoidal
head (and chair) rotations. The abscissa is time measured in seconds. LB, left beating nystagmus; RB, right beating nystagmus. Performed using Micromedical
Technologies (Chatham, IL, USA).
Fife et al. A Potential Cause of Bilateral Vestibulopathy
Frontiers in Neurology | May 2018 | Volume 9 | Article 351
for over a decade, while the other two worked 4–6years in admin-
istrative positions in a small under-ventilated building proximate
to the ight line. Each developed documented-bilateral vestibular
dysfunction most probably related to chronic inhaled JP-8 fumes
over a long period of time.
Case 1: Military Flight Refueler
A 37-year-old woman presented with several years of progres-
sively worsening continuous dizziness, headache, and fatigue.
e dizziness consisted of sensations of spinning, tilting, disequi-
librium, and head fullness. She did not report tinnitus or hearing
loss. She was employed as a military ight refueler and exposed to
JP-8 vapors and exhaust while working full-time on and around
a KC-135E tanker aircra, a plane used for performing in-ight
refueling missions. She worked in a large enclosed hangar that
housed all but the tail section of the tanker aircra. During
inspection and maintenance of the aircra, up to 9,750 gallons of
fuel would be loaded. Jet fuel vapors were always present in the
hangar due to venting, small leaks, and fuel residue. Fuel vapor
concentrations were even greater when engine maintenance
necessitated removal of fuel lters and fuel components, drain-
ing of fuel into buckets, and opening of fuel lines. She worked in
engine maintenance with over 4years of inhalational and dermal
exposure to JP-4 and JP-8.
Her examination showed moderately impaired equilibrium
to walk only three steps in tandem before taking a sidestep.
Romberg testing revealed more sway during eye closure but no
falling. Her medical and neurological examinations were nor-
mal. ere was no spontaneous, gaze, or positional nystagmus.
Qualitative head impulse test was not performed at that time.
A brain SPECT study at an outside facility revealed mild-
right frontal hypoperfusion that persisted on a repeated study
the following year. Neurocognitive examination showed overall
memory function in the 97th percentile. An MRI brain without
gadolinium and an EEG were normal. An initial hydrocarbon
assay revealed the presence of 3-methylpentane and n-hexane
in the blood at concentrations of 27 and 15.7ng/ml (parts per
billion), respectively (none should be measurable in normal
individuals). Ten months later, 3-methylpentane and n-hexane
remained present although at signicantly lower concentra-
tions. Eighteen months aer presentation, 3-methylpentane
and n-hexane persisted in the blood and had only diminished
an additional 20%. Rotational chair, more so than caloric ves-
tibular testing, demonstrated bilateral vestibular dysfunction
(Figures 1 and 2) with reduced gain values on step velocity
along with a reduced time constant. Gain was also reduced on
all sinusoidal rotations with increase phase lead at 0.01, 0.02,
and 0.04Hz rotations. e patient reported that her headaches,
dizziness, fatigue, and mild unsteadiness improved somewhat
following a transfer to the nance department where no JP-8
exposure existed. ere was a long interval of 15years since her
initial visit when she was lost to follow up. Now, 16years aer
her initial presentation, she reports that the dizziness is mild
but headaches and severe fatigue persist. She has continued
to work but plans to retire earlier than originally anticipated
due to the ongoing symptoms. Recently, cervical and ocular
vestibular-evoked myogenic potential (cVEMP and oVEMP,
respectively) and video head impulst testing for each canal were
performed and all results were normal.
Cases 2 and 3
e following two patients were employees in a small-purchasing
warehouse, located 75feet south of the ight path, which was
separated from the blast and heat emissions from jet aircra
engines by a metal-coated and chain-link fence. Neither air
conditioning vents nor carpet had not been cleaned or replaced
for over a decade. On inspection, the vents were found to be mal-
functioning such that air was able to enter the building but unable
to escape. Subsequent inspection by the U. S. Occupational Safety
and Health Administration (OSHA) conrmed poor ventilation
evidenced by carbon dioxide concentrations >1,500ppm (nor-
mal <1,000 ppm according to the U.S. Department of Labor).
Hydrocarbons discovered in the carpet via an independent
analysis using gas chromatography/mass spectrometry included
FIGURE 2 | The summary of average gain values at frequencies between 0.01 and 0.64Hz sinusoidal rotations. The gain values were below normal for all
frequencies tested for Cases 1 and 2 and were reduced at most frequencies for Case 3.
TABLE 1 | Caloric vestibular test results of each case.
TimingbRCaRWaLCaLWaVR% DP%
Case 1 0 16 12 14 20 9 Right 16 Left
Case 2 0 5 7 6 8 7 Right 0
Case 2 16 Months 19 32 30 21 0 22 Right
Case 3 0 23 17 11 10 31 Left 8 Right
Case 3 7 Months 20 32 20 36 3 Right 3 Left
All studies performed with water caloric irrigation using ICS Chartr VNG, now GN
Otometric (Schaumburg, IL).
aPeak slow phase velocity in degrees/second of caloric-induced nystagmus.
bTime 0=initial presentation. Subsequent studies designated as months subsequent
to presentation.
RC, right cool irrigation, LC, left cool irrigation, RW, right warm irrigation, LW, left warm
irrigation; VR, vestibular response asymmetry as a percentage using Jongkees formula;
DP, directional preponderance which reects the direction (rightward versus leftward) of
the bithermal caloric-induced nystagmus expressed as a percentage using Jongkees
Fife et al. A Potential Cause of Bilateral Vestibulopathy
Frontiers in Neurology | May 2018 | Volume 9 | Article 351
undecane (C11), dodecane (C12), tridecane (C13), tetradecane
(C14), and toluene (C8)—all known JP-8 constituents (2). e
chemicals present in the oce carpet likely reected poor indoor
air quality. Vapor, aerosol, dermal, and eye absorption of JP-8 are
Case 2: Warehouse Employe 1
A 45-year-old female contracting ocer for the National Guard
reported several years of imbalance, headache, fatigue, eye and
skin irritation, coughing, sinus congestion, recurrent urinary
tract infections, chest tightness, irritability, depression, shortness
of breath, palpitations, and numbness. She described her dizzi-
ness as an intermittent oating and a rightward tilting sensation
with imbalance lasting minutes to hours without any particular
pattern. She had a history of asthma and allergies including
reaction to aspirin causing urticaria and airway obstruction. In
1998, she developed syncope and dizziness though no specic
cause was found. She started working in the building in 1994 and
worked there full-time for 5years.
Her examination was normal except that she fell on Romberg
testing and could only walk a few steps in tandem. Brain MRI,
EEG, audiogram, and pulmonary function tests were normal.
Quantitative rotational chair and caloric vestibular tests revealed
bilateral peripheral vestibular dysfunction (Tabl e  1 ; Figure 2).
Her caloric responses improved following removal from the
under-ventilated environment (Table1).
Case 3: Warehouse Employe 2
A 54-year-old female National Guard contract specialist pre-
sented with 2 years of intermittent dizziness, blurred vision,
and occasional palpitations. Dizziness was experienced at least
3days a week. She reported intermittent problems with erratic
heart beats, cough, sneezing, headaches, fatigue, recurrent sinus
infections, upper respiratory tract, and bladder infections. She
worked in the purchasing warehouse full-time for 3years. When
away from the workplace her symptoms were improved. Aer
moving with her colleagues into a new building, the frequency of
dizziness was lessened.
Her medical, neurological, and oto-neurological examina-
tions were normal. Electronystagmography revealed somewhat
reduced caloric vestibular responses for age and a 33% reduced
vestibular response on the le. Rotational testing showed reduced
gain with sinusoidal rotational stimuli at frequencies from 0.02
to 0.16Hz (Figure2). Her caloric responses improved follow-
ing removal from the “sick-building” environment (Tab l e  1).
Computerized dynamic posturography showed falls on conditions
4, 5 and 6 indicating some general impairment of equilibrium and
a predominant vestibular decit pattern. Audiometric tests were
normal except for mild-sensorineural hearing loss in the right ear
from 250 to 8,000Hz and borderline normal le-sided hearing
from 250 to 2,000Hz sloping to a moderate loss between 3,000
and 8,000Hz.
ese case reports describe three women working in close pro-
ximity to JP-8 jet fuel who developed bilateral vestibulopathy
aer 3–5years of exposure. Serum studies in one of the patients
(Case 1) demonstrated JP-8 fuel metabolites 3-methylpentane
Fife et al. A Potential Cause of Bilateral Vestibulopathy
Frontiers in Neurology | May 2018 | Volume 9 | Article 351
and n-hexane (1). ese compounds are not present in human
blood normally. e levels of these metabolites diminish over
time once the individual is removed from repeated exposure.
Quantitative vestibular testing revealed bilateral vestibular
dysfunction in all three patients aer JP-8 exposure. ere was
no other probable identiable explanation for the vestibular
dysfunction. Although causal relationship cannot be deni-
tively proven yet, this collection of data suggests a relationship
between prolonged exposure to JP-8 fuel and development of
bilateral vestibular dysfunction which has not previously been
documented in humans.
The presence of bilateral vestibular dysfunction in these
cases may be due to a process localizing to the vestibular
ner ves, the vestibular end-organs, or a combination of both.
However, the constituent hydrocarbons in JP-8 are lipophilic
and have been shown to aect the CNS so a peripheral vestibu-
lar mechanism is assumed but not assured. Indeed, for Case 1
on whom we have long-term follow up, headaches and severe
fatigue have persisted for years, which are symptoms associated
with CNS hydrocarbon toxicity. A CNS toxicity contribution
might also explain the chronicity of symptoms and lackluster
res ponse to vestibular rehabilitative eorts. e relative
preservation of caloric vestibular responses (Table  1 ) in the
presence of prominent pan-frequency vestibular dysfunction
on rotational chair testing raises the possibility of some degree
of frequency-specic ototoxicity (9). Furthermore, improve-
ment in the caloric responses with removal from continued
exposure implies the possibility of some degree of reversibility
of vestibular dysfunction. Dedicated occupational studies in
humans on the vestibular eects of chronic JP-8 exposure are
limited and data are still sparse on the direct mechanisms of
ototoxicity due to jet fuel.
Human Studies
A study of the eects of low-level exposure to JP-8 fuel vapor in
U.S. Air Force aircra maintenance personnel found a correla-
tion between solvent exposure (benzene, toluene, xylene) and
increased postural sway implying vestibular or proprioceptive
impairment (3). Another study of 37 Air Force personnel with
short-term work day exposure to JP-8 did not identify increases
in postural sway (4). Long-term exposure to jet fuel in a subset
of eight subjects assessed by vestibular testing found minor ves-
tibular abnormalities but those patients actually reported more
cognitive symptoms than vestibular ndings (10).
Liquid hydrocarbon fractions are distilled from petroleum
based on density. Although there may be variations in composi-
tion, these hydrocarbon mixtures have toxic eects on the human
body similar to jet fuels (11). Some organic solvents com monly
used in commercial industries are also hydrocarbon mixtures and
would be expected to have similar toxicities. Indeed, dizziness,
sometimes but not always resulting in vestibular test abnor-
malities, is a common symptom among individuals exposed to
organic solvents (12). Workers exposed chronically to toluene
and ethanol for many years exhibited reduced pursuit tracking
and increased postural sway; and the latter suggests possible
impairment of vestibular function (13). A study of three weld-
ers with short-term exposure to hydrocarbons found vestibular
nystagmus and vestibular abnormalities that persisted for 3–18+
months aer exposure (14).
It has been suggested that aliphatic and aromatic hydrocarbon
toxicity may be associated with bilateral vestibular dysfunction,
dizziness, and abnormal performance on posturography testing
(3, 15). Although, organic solvents may have toxic eects on
peripheral vestibular function or brainstem vestibular pathways
(16), most of the data simply suggest increased sway in those
exposed, which is not necessarily a specic indicator of vestibu-
lar dysfunction. A small study of 18 individuals with exposure
to organic solvents found a signicantly greater number with
abnormal vestibular function including oVEMP and cVEMP,
and caloric testing when compared to unexposed controls. e
authors suggest that organic solvent toxicity may adversely aect
the function of the utricle and saccule to a greater degree than
hearing or semicircular canal function (17).
Animal Studies
Studies in rats exposed to JP-8 vapor for 6h per day, 5days per
week for a total of 1month showed that pure-tone hearing thresh-
olds, outer hair cell function, and hair cell numbers remained
unaected with exposure of 1,500mg/m3. However, when rats
were exposed to JP-8 plus noise, marked decreases in distortion
produce otoacoustic emissions amplitude, increases in pure-
tone auditory threshold along with a small reduction (<1%) in
the number of cochlear outer hair cells were detected (18, 19).
A study of 26 pigmented rats exposed to toluene in a prosptec-
tive cross-over control study found a dose-related reduction in
VOR suppression and reduced VOR gain and time constants
(20). Another study in rats exposed to 1,000mg/m3 of JP-8 found
impaired encoding of stimulus intensity both in rats exposed
only to JP-8 and in those exposed to JP-8 and noise. ere were
no changes in auditory thresholds and no loss of cochlear outer
hair cells; however, there was impaired brainstem encoding of
stimulus intensity indicating dysfunction of central auditory
processing (6, 8).
ere are no studies of the long-term eects of JP-8 specically
on peripheral vestibular function in humans. is may be in part
because many exposed personnel tolerate limited exposure well,
and those that do have symptoms have not been evaluated and
reported in published literature. Bilateral vestibular dysfunction,
regardless of cause, is probably under-recognized in clinical
medicine (21). Hence, the true incidence of vestibulopathy from
jet fuel exposure is unknown.
Human Exposure and Absorption
of Jet Fuel
Military duties such as fuel transportation, aircra fueling and
defueling, aircraft maintenance, cold aircraft engine starts,
main tenance of equipment and machinery, use of tent heaters,
and cleaning or degreasing with fuel may result in jet fuel expo-
sure. Fuel handlers, mechanics, ight line personnel, especially
crew chiefs, and even incidental workers remain at risk for
developing illness secondary to chronic JP-8 fuel exposure in
aerosol, vapor or liquid form. JP-8 is one of the most common
occupational chemical exposures in the US military (1). e Air
Fife et al. A Potential Cause of Bilateral Vestibulopathy
Frontiers in Neurology | May 2018 | Volume 9 | Article 351
Force has set recommended exposure limits for JP-8 at 63ppm
(447mg/m3 as an 8-h time-weighted average) (22).
In addition to exposure by JP-8 vapor inhalation, toxicity may
also occur by absorption through the skin, which is proportional
to the amount of skin exposed and the duration of exposure
(23, 24). In addition to the standard operating procedure and
safety guidelines, double gloving, immediate onsite laundering
of contaminated/soiled jumpsuits, regular washing of safety
goggles and masks, reduced foam handling time, smoking
cessation, adequate cross ventilation, and frequent shi breaks
may reduce the overall risk of JP-8 induced illness (1, 2).
At this time, OSHA has not determined a legal limit for jet fuels
in workroom air. e U.S. National Institute of Occupational
Safety and Health set a recommended limit of 100mg/m3 for
kerosene in air averaged over a 10-h work day. Multi-organ
toxicity has been documented from JP-8 exposure in animal
experiments over the past 15years. More recently, toxicology
researchers are investigating the adverse tissue eects of JP-8 jet
fuel in concentrations well below permissible exposure limits.
Ultimately, the new data may help us to better understand the
emerging genetic, metabolic and inammatory mechanisms
underpinning JP-8 cellular toxicity—including auditory and
vestibular toxicity—and lead to a reassessment of the safe JP-8
exposure limits (25, 26). In the meantime, bedside vestibular
screening for vestibular dysfunction can be performed by
dynamic visual acuity testing or by head impulse testing.
Are there any known JP-8 biomarkers? Yes. Breath, blood,
urine, and microRNA tissue biomarkers have been studied and
aid in conrming JP-8 exposure. Self-reported JP-8 exposure in
the workplace is a reliable indicator and a stronger predictor
of measured exposure than job title (27). Aer controlling for
work shi smoking, measurements of blood volatile organic
compounds (ethylbenzene, toluene, xylene) are higher among
US Air Force personnel self-reporting JP-8 exposure in asso-
ciation with elevated hydrocarbons in the breathing zone (28).
Urinary biomarkers 1- and 2-naphthol, the metabolites of naph-
thalene, are the most sensitive and useful short-term surrogates
of JP-8 exposure due to their strong correlation with breathing
zone naphthalene, greater abundance, and slower elimination
kinetics (29, 30). Blood microRNAs (miRNAs) may be unique
biomarkers for volatile organic compounds and have been com-
pared recently to urinary biomarkers in human dockyard work-
ers found to have toluene, xylene, and ethylbenzene in whole
blood. Fiy subjects underwent miRNA microarray analysis
and 211–695 mRNAs were identied for toluene, xylene, and
ethylbenzene suggesting higher sensitivity, specicity, and accu-
racy than urinary biomarkers (31). e analysis of circulating
miRNAs in the blood of military veterans exposed to JP-8 is
worthy of future research.
Bilateral vestibular dysfunction in these three patients with pro-
longed vapor and dermal JP-8 fuel exposure should raise aware-
ness in people with occupations that expose them to jet fuels,
liquid hydrocarbons, or organic solvents. Dizziness and mild
imbalance may be the main initial symptoms. Early recognition
and limiting further exposure as well as treatment with vestibular
therapy (32) may improve their function and quality of life.
Written informed consent to publish the report was obtained from
each patient. is report was approved by the local Institutional
Review Board at Barrow Neurological Institute/DignityHealth,
Inc., case series tracking number Case Series 18-004.
TF attended to the three patients in oto-neurological consulta-
tion, contributed to project conception, data collection and anal-
ysis, critical revision, and nal approval of the manuscript. MR
contributed to project conception, scientic poster presentation,
data collection and analysis, draing of the article and critical
revision, and nal approval of the manuscript. KriS contributed
to draing of the article and critical revision and nal approval
of the manuscript. KaS contributed to critical revision and nal
approval of the manuscript.
e authors wish to thank Dana L. Day, AuD for obtaining the
vestibular laboratory data; John B. Sullivan, Jr.,; Mark L. Witten,
Laurence D. Fechter, and O’neil W. Guthrie for their personal
explanations and insights on JP-8 research; Terence Risby, at the
University of Arizona Health Sciences Department of Toxicology.
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Conict of Interest Statement:e authors declare that the research was con-
ducted in the absence of any commercial or nancial relationships that could be
construed as a potential conict of interest.
Copyright © 2018 Fife, Robb, Steenerson and Saha. is is an open-access
article distributed under the terms of the Creative Commons Attribution License
(CC BY). e use, distribution or reproduction in other forums is permitted, provided
the original author(s) and the copyright owner are credited and that the original
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... When the bilateral vestibular function of the human body is impaired, patients may exhibit symptoms such as dizziness or hearing loss. In clinical practice, the activity of the inner and outer hair cells is reduced by weakening their excitability, which is conducive to restoring normal hair cell function and enhancing the patient's tinnitus sensation [1][2][3]. ...
... Impaired or damaged vestibular receptor function may lead to hearing loss, tinnitus, and vertigo in the organism [1]. Current clinical treatment focuses on the activation of the auditory efferent nervous system by masking sound, inhibiting the excitability and spontaneous activity of internal and external hair cells, and suppressing the lesioned central auditory nerve pathway to reduce or inhibit the perception of tinnitus [2,3], which can effectively reduce the auditory efferent nervous system and thus achieve therapeutic benefits [4]. However, some patients showed poor compliance with this treatment method [5], and variations in treatment effects are attributed to patient tolerance and compliance. ...
... Exclusion criteria for this study were as follows: (1) patients with psychiatric problems were incapable of communication; (2) patients with other organic diseases; (3) patients were diagnosed as inner auditory tract lesions or middle ear occupational lesions by imaging; and (4) patients with tinnitus symptoms before the onset of sudden deafness. ...
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Objective: To investigate the effects of intensive gaze stability training (IGST) combined with conventional drug therapy and traditional Chinese medicine (TCM) therapy on hearing recovery and quality of life (QOL) in patients with bilateral vestibular dysfunction. Materials and methods: A total of 120 patients with bilateral vestibular dysfunction admitted to our hospital from January 2019 to January 2020 were recruited and assigned to group A (n = 60) and group B (n = 60) based on the order of admission. Group B received conventional medication and TCM therapy, and group A received IGST plus conventional medication and TCM therapy. The serum biochemical indexes, blood rheology indexes, symptoms disappearance time, hearing recovery time, pure-tone hearing threshold, vestibular symptom index (VSI), and QOL of the two groups were compared. Results: The serum biochemical indexes and blood rheology indexes in group A were lower than those in group B after treatment (P < 0.001). Patients in group A had a shorter time lapse before symptoms disappearance and hearing recovery than those in group B (P < 0.001). Group A had lower results of the pure-tone hearing threshold (P < 0.001) and of VSI (P < 0.05) than group B. Patients in group A had higher QOL scores than those in group B after treatment (P < 0.001). Conclusion: IGST plus conventional drug therapy effectively improves the serum biochemical indexes and blood rheological indexes of patients with bilateral vestibular hypofunction, accelerates their hearing recovery process, and alleviates their clinical symptoms, thereby improving their QOL, which shows good potential in clinical application.
... It should be noted that balance difficulties have also been associated with hydrocarbon exposure in humans, but few studies have specifically examined this effect for jet fuel and its numerous hydrocarbon components on the parts of the ear and brain responsible for balance control. The following studies suggest an association between impaired balance unidentified jet fuels (Odkvist et al., 1987) or JP-8 exposures (Fife et al., 2018;Maule et al., 2013;L. B. Smith et al., 1997). ...
Purpose Several military occupations, particularly those within the U.S. Air Force, require working with or around jet fuels. Jet fuels contain components that are known to affect central nervous function, yet effects of these fuels on auditory function, specifically auditory processing of sound, are not well understood at this time. Animal studies have demonstrated that exposure to jet fuels prior to noise exposure can exacerbate the noise exposure's effects, and service members exposed to jet fuels are at risk of noise exposure within their work environments. The purpose of this article was to give a brief synopsis of the evidence on the ototoxic effects due to jet fuel exposure to aid audiologists in their decision making when providing care for populations who are occupationally exposed to fuels or while during military service. Conclusions Exposure to jet fuels impacts central nervous function and, in combination with noise exposure, may have detrimental auditory effects that research has yet to fully explain. Additional longitudinal research is needed to explain the relationships, which have clinical implications for service members and others exposed to jet fuels. In the meantime, audiologists can gain useful information by screening for chemical exposures when obtaining patient case histories. If jet fuel exposure is suspected, the Lifetime Exposure to Noise and Solvents Questionnaire can be used to estimate a noise exposure ranking and identify other potentiating agents such as jet fuel and industrial chemicals. A history of jet fuel exposure should inform the selection of hearing tests in the audiometric evaluation and when devising the treatment plan.
... JP-8, albeit less toxic and safer than JP-4, contains many ototoxic aromatic hydrocarbons [70]. Environmental exposure to jet fuels has been associated with several health conditions, such as immune system dysfunction, neurobehavioural problems, developmental/reproductive dysfunction and hepatic, pulmonary, renal and vestibular dysfunction [11,68,71,72]. ...
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Jet fuel hydrocarbons is the generic name for aviation fuels used in gas-turbine engine powered aircraft. The Deepwater Horizon oil rig explosion created the largest environmental disaster in U.S. history, and the second largest oil spill in human history with over 800 million liters of hydrocarbons released into the Gulf of Mexico over a period of 3 months. Due to the widespread use of jet fuel hydrocarbons, this compound mixture has been recognized as the single largest chemical exposure for military personnel. Previous animal studies have demonstrated the ability of jet fuel (JP-8) exposure to promote the epigenetic transgenerational inheritance of disease susceptibility in subsequent generations. The diseases observed include late puberty, kidney, obesity and multiple disease pathologies. The current study is distinct and was designed to identify potential sperm DNA methylation biomarkers for specific transgenerational diseases. Observations show disease specific differential DNA methylation regions (DMRs) called epimutations in the transgenerational F3 generation great-grand-offspring male rats ancestrally exposed to jet fuel. The potential epigenetic DMR biomarkers were identified for late puberty, kidney, obesity, and multiple diseases, and found to be predominantly disease specific. These disease specific DMRs have associated genes that were previously shown to be linked with each of these specific diseases. Therefore, the germline (i.e. sperm) has environmentally induced ancestrally derived epimutations that have the potential to transgenerationally transmit disease susceptibilities to subsequent generations. Epigenetic biomarkers for specific diseases could be developed as medical diagnostics to facilitate clinical management of disease, and allow preventative medicine therapeutics.
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Zusammenfassung Die Differenzialdiagnose von Erkrankungen des vestibulären Labyrinths stellt eine grosse Herausforderung dar, da sich hinter dem sehr häufigen Leitsymptom «Schwindel» viele verschiedene und v. a. seltene Erkrankungen verbergen können. Der vorliegende Beitrag gibt einen Überblick über die für den HNO-Arzt wichtigen seltenen Erkrankungen des vestibulären Labyrinths ausgehend von ihrer klinischen Präsentation als akutes (AVS), episodisches (EVS) oder chronisches vestibuläres Syndrom (CVS). Der Schwerpunkt liegt dabei auf den EVS, sortiert nach ihrer Dauer und dem Vorhandensein von Triggern (Sekunden, ohne Trigger: Vestibularisparoxysmie, Tumarkin-Krise; Sekunden, lärm- und druckinduziert: Syndrome des «dritten Fensters»; Sekunden bis Minuten, positionsabhängig: seltene Varianten und Differenzialdiagnosen des benignen paroxysmalen Lagerungsschwindels; Stunden bis Tage, spontan: intralabyrinthäre Schwannome, Tumoren des endolymphatischen Sacks, Autoimmunerkrankungen des Innenohres). Des Weiteren werden seltene Differenzialdiagnosen eines AVS (Neuritis vestibularis inf., Otolithenfunktionsstörungen, vaskuläre Ursachen, akute bilaterale Vestibulopathie) und eines CVS (bilaterale Vestibulopathie) erläutert. Dabei werden insbesondere die entscheidenden diagnostischen Massnahmen für die Identifikation der einzelnen Krankheitsbilder und die Warnzeichen für potentiell gefährliche Ursachen (z. B. Labyrinthinfarkt/-blutung) dargelegt. Somit dient dieser Beitrag dem HNO-Arzt in Klinik und Praxis als eine Art «Vademecum» für die zügige Identifikation und zeitnahe Therapie seltener Erkrankungen des Gleichgewichtsorgans.
Purpose of review: Determining the etiology of disorders that manifest with chronic dizziness can seem a daunting task, but extracting some basic elements of the patient's history can reduce the differential diagnosis significantly. This includes determining initial triggers, timing of symptoms, associated features, and exacerbating factors. This article covers distinct causes of chronic dizziness including persistent postural perceptual dizziness, mal de débarquement syndrome, motion sickness and visually induced motion sickness, bilateral vestibulopathy, and persistent dizziness after mild concussion. Recent findings: To date, none of the disorders above has a cure but are considered chronic syndromes with fluctuations that are both innate and driven by environmental stressors. As such, the mainstay of therapy for chronic disorders of dizziness involves managing factors that exacerbate symptoms and adding vestibular rehabilitation or cognitive-behavioral therapy alone or in combination, as appropriate. These therapies are supplemented by serotonergic antidepressants that modulate sensory gating and reduce anxiety. Besides expectation management, ruling out concurrent disorders and recognizing behavioral and lifestyle factors that affect symptom severity are critical issues in reducing morbidity for each disorder. Summary: Many syndromes of chronic dizziness can be diagnosed by recognition of key features, although many symptoms overlap between these groups. Symptoms may be manageable and improve with time, but they are often incompletely relieved.
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The use of fossil fuels in aircraft over the last few decades has driven several studies on health effects due to occupational exposure. Relatively recently, alternative fuel types have emerged, but their implications on the health of exposed workers have not attracted proportional attention. In our paper, we review both academic and gray literature about the health risks related to exposure to jet and alternative fuels. The literature suggests that, although the health effects on workers exposed to conventional fuels are concerning, there is no universally accepted dose–response relationship. The limited current research with animals on alternative fuels indicates that these fuels have not resulted in a reduction of health risks. Overall, it seems that, while aviation fuels are tested for efficiency and lower emissions, studies on health impacts in an occupational context have not been a priority. As occupational exposure to aviation fuels might increase due to the growth of the aviation industry, it is essential to conduct further research on the effects of exposures to both conventional and alternative aviation fuels and ensure that the latter do not pose the same risks or even greater ones than those of conventional fuels.
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Background Airport personnel are at risk of occupational exposure to jet engine emissions, which similarly to diesel exhaust emissions include volatile organic compounds and particulate matter consisting of an inorganic carbon core with associated polycyclic aromatic hydrocarbons, and metals. Diesel exhaust is classified as carcinogenic and the particulate fraction has in itself been linked to several adverse health effects including cancer. Method In this review, we summarize the available scientific literature covering human health effects of exposure to airport emissions, both in occupational settings and for residents living close to airports. We also report the findings from the limited scientific mechanistic studies of jet engine emissions in animal and cell models. Results Jet engine emissions contain large amounts of nano-sized particles, which are particularly prone to reach the lower airways upon inhalation. Size of particles and emission levels depend on type of aircraft, engine conditions, and fuel type, as well as on operation modes. Exposure to jet engine emissions is reported to be associated with biomarkers of exposure as well as biomarkers of effect among airport personnel, especially in ground-support functions. Proximity to running jet engines or to the airport as such for residential areas is associated with increased exposure and with increased risk of disease, increased hospital admissions and self-reported lung symptoms. Conclusion We conclude that though the literature is scarce and with low consistency in methods and measured biomarkers, there is evidence that jet engine emissions have physicochemical properties similar to diesel exhaust particles, and that exposure to jet engine emissions is associated with similar adverse health effects as exposure to diesel exhaust particles and other traffic emissions.
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Military systems have become more complex, and the development of future advanced materials for defence applications have received much attention. Nanocellulose has been identified as a 'super versatile material' that will become a replacement material for many applications including in the military. Nanocellulose can be synthesized from discarded fibers that are left over from forestry and agricultural waste that can be transformed into high-value products. Thanks to its interesting properties, comprising low thermal expansion coefficient, high aspect ratio, highly crystalline, good mechanical and optical properties, nanocellulose has emerged as a new material class for high end military products such as bulletproof vests, fire-retardant materials, as a component of propellants, filtration material, and in textile, electronic and energy products. Therefore, in this review, current and future applications of nanocellulose in the military are critically discussed. This review is intended to impart to readers some of the excitement that currently surrounds nanocellulose research, it’s fascinating chemical and physical properties and applications in the military.
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Background: Idiopathic bilateral vestibulopathy (IBV) is an acquired bilateral peripheral vestibular dysfunction of unknown etiology, with persistent unsteadiness but without sensorineural hearing loss (SNHL) other than age-related hearing loss (ARHL). Main text: The prevalence of IBV is unknown. The most common symptom is persistent unsteadiness, particularly in darkness and/or on uneven ground. The other main symptom is oscillopsia during head and body movements. IBV is neither associated with SNHL, except for ARHL, nor any other neurological dysfunction that causes balance disorders. The clinical time course of IBV can generally be divided into two main types: progressive type and sequential type. The progressive type involves gradually progressive persistent unsteadiness without episodes of vertigo. The sequential type involves recurrent vertigo attacks accompanied by persistent unsteadiness. Originally, IBV was found to exhibit bilateral dysfunction in the lateral semicircular canals (LSCCs) and the superior vestibular nerve (SVN) system. However, recently, with the development of more sophisticated vestibular function tests of the otolith organs and vertical semicircular canals, it has been revealed that IBV involves peripheral vestibular lesions other than those already identified in the LSCC and the SVN system. Furthermore, novel subtypes of IBV that do not involve bilateral dysfunction of the LSCC and/or the SVN system have been proposed. Therapeutically, exercise-based vestibular rehabilitation in adult bilateral vestibulopathy (BVP) patients has resulted in improved gaze and postural stability moderately. There are several technical approaches for the treatment of BVP such as vestibular implants, sensory substitution devices and noisy galvanic vestibular stimulation. Conclusions: Combined use of various vestibular function tests, including recently developed tests, revealed the diversity of lesion sites in IBV. Further studies are required to determine the therapeutic effects of the technical approaches on IBV.
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Background Animal data suggest that jet fuels such as JP-8 are associated with hearing deficits when combined with noise and that the effect is more pronounced than with noise exposure alone. Some studies suggest peripheral dysfunction while others suggest central auditory dysfunction. Human data are limited in this regard. The aim of this study was to investigate the possible chronic adverse effects of JP-8 combined with noise exposure on the peripheral and central auditory systems in humans. Methods Fifty-seven participants who were current personnel from the Royal Australian Air Force were selected. Based on their levels of exposure to jet fuels, participants were divided into three exposure groups (low, moderate, high). Groups were also categorised based on their noise exposure levels (low, moderate, high). All participants were evaluated by tympanometry, pure-tone audiometry (1–12 kHz), distortion product otoacoustic emissions (DPOAEs), auditory brainstem response (ABR), words-in-noise, compressed speech, dichotic digit test, pitch pattern sequence test, duration pattern sequence test and adaptive test of temporal resolution. All auditory tests were carried out after the participants were away from the Air Force base for a minimum of two weeks, thus two weeks without jet fuel and noise exposure. Results Jet fuel exposure was significantly associated with hearing thresholds at 4 and 8 kHz; average hearing thresholds across frequencies in the better ear; DPOAEs at 2.8, 4 and 6 kHz; ABR wave V latency in the right ear; compressed speech and words-in-noise. Further analyses revealed that participants with low exposure level to jet fuels showed significantly better results for the aforementioned procedures than participants with moderate and high exposure levels. All results were controlled for the covariates of age and noise exposure levels. Conclusions The results suggest that jet fuel exposure, when combined with noise exposure, has an adverse effect on audibility in humans. Taking all the test results into consideration, jet fuel exposure combined with noise exposure specifically seems to affect the peripheral hearing system in humans.
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Background: Uncompensated vestibular hypofunction results in postural instability, visual blurring with head movement, and subjective complaints of dizziness and/or imbalance. We sought to answer the question, "Is vestibular exercise effective at enhancing recovery of function in people with peripheral (unilateral or bilateral) vestibular hypofunction?" Methods: A systematic review of the literature was performed in 5 databases published after 1985 and 5 additional sources for relevant publications were searched. Article types included meta-analyses, systematic reviews, randomized controlled trials, cohort studies, case control series, and case series for human subjects, published in English. One hundred thirty-five articles were identified as relevant to this clinical practice guideline. Results/discussion: Based on strong evidence and a preponderance of benefit over harm, clinicians should offer vestibular rehabilitation to persons with unilateral and bilateral vestibular hypofunction with impairments and functional limitations related to the vestibular deficit. Based on strong evidence and a preponderance of harm over benefit, clinicians should not include voluntary saccadic or smooth-pursuit eye movements in isolation (ie, without head movement) as specific exercises for gaze stability. Based on moderate evidence, clinicians may offer specific exercise techniques to target identified impairments or functional limitations. Based on moderate evidence and in consideration of patient preference, clinicians may provide supervised vestibular rehabilitation. Based on expert opinion extrapolated from the evidence, clinicians may prescribe a minimum of 3 times per day for the performance of gaze stability exercises as 1 component of a home exercise program. Based on expert opinion extrapolated from the evidence (range of supervised visits: 2-38 weeks, mean = 10 weeks), clinicians may consider providing adequate supervised vestibular rehabilitation sessions for the patient to understand the goals of the program and how to manage and progress themselves independently. As a general guide, persons without significant comorbidities that affect mobility and with acute or subacute unilateral vestibular hypofunction may need once a week supervised sessions for 2 to 3 weeks; persons with chronic unilateral vestibular hypofunction may need once a week sessions for 4 to 6 weeks; and persons with bilateral vestibular hypofunction may need once a week sessions for 8 to 12 weeks. In addition to supervised sessions, patients are provided a daily home exercise program. Disclaimer: These recommendations are intended as a guide for physical therapists and clinicians to optimize rehabilitation outcomes for persons with peripheral vestibular hypofunction undergoing vestibular rehabilitation.Video abstract available for more insights from the author (see Video, Supplemental Digital Content 1,
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Occupational exposure to complex blends of organic solvents is believed to alter brain functions among workers. However, work environments that contain organic solvents are also polluted with background noise which raises the issue of whether or not the noise contributed to brain alterations. The purpose of the current study was to determine whether or not repeated exposure to low intensity noise with and without exposure to a complex blend of organic solvents would alter brain activity. Female Fischer344 rats served as subjects in these experiments. Asynchronous volume conductance between the midbrain and cortex was evaluated with a slow vertex recording technique. Subtoxic solvent exposure, by itself, had no statistically significant effects. However, background noise significantly suppressed brain activity and this suppression was exacerbated with solvent exposure. Furthermore, combined exposure produced significantly slow neurotransmission. These abnormal neurophysiologic findings occurred in the absence of hearing loss and detectable damage to sensory cells. The observations from the current experiment raise concern for all occupations where workers are repeatedly exposed to background noise or noise combined with organic solvents. Noise levels and solvent concentrations that are currently considered safe may not actually be safe and existing safety regulations have failed to recognize the neurotoxic potential of combined exposures.
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Objective: This study aimed to evaluate blood volatile organic compound (VOC) levels as biomarkers of occupational jet propulsion fuel 8 (JP-8) exposure while controlling for smoking. Methods: Among 69 Air Force personnel, post-shift blood samples were analyzed for components of JP-8, including ethylbenzene, toluene, o-xylene, and m/p-xylene, and for the smoking biomarker, 2,5-dimethylfuran. JP-8 exposure was characterized based on self-report and measured work shift levels of total hydrocarbons in personal air. Multivariate regression was used to evaluate the relationship between JP-8 exposure and post-shift blood VOCs while controlling for potential confounding from smoking. Results: Blood VOC concentrations were higher among US Air Force personnel who reported JP-8 exposure and work shift smoking. Breathing zone total hydrocarbons was a significant predictor of VOC blood levels, after controlling for smoking. Conclusions: These findings support the use of blood VOCs as a biomarker of occupational JP-8 exposure.
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Bilateral vestibular hypofunction (BVH) probably represents a heterogeneous disorder with different types of clinical pictures, with and without vertigo. In spite of increasingly sophisticated electrophysiological testing, still many challenges are met when establishing a diagnosis of BVH. Here, we review the main challenges, which are a reflection of its often difficult clinical presentation and the lack of diagnostic standards regarding the implementation and interpretation of vestibular tests. These challenges show that there is an urgent need for standardization. The resulting decisions should be used for the development of uniform diagnostic criteria for BVH, which are, at present, not yet available.
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Prompted by the continued prevalence of hearing related disabilities accepted as eligible for compensation and treatment under Australian Department of Veterans' Affairs legislation, a review of recent literature regarding possible causation mechanisms and thus, possible prevention strategies, is timely. The emerging thoughts on the effects of a combination of jet fuel and noise exposure on the central auditory nervous system (CANS) have relevance in the military aviation context because of the high exposures to solvents (including fuels) and unique noise hazards related to weapons systems and military aircraft. This literature review aimed to identify and analyze the current knowledge base of the effects of combined exposure to JP-8 jet fuel (or its aromatic solvent components) and noise on the CANS in human populations. We reviewed articles examining electrophysiological and behavioral measurement of the CANS following combined exposures to jet fuel (or its aromatic constituents) and noise. A total of 6 articles met the inclusion criteria for the review and their results are summarized. The articles considered in this review indicate that assessment of the CANS should be undertaken as part of a comprehensive test battery for military members exposed to both noise and solvents in the workplace. Reprint & Copyright © 2015 Association of Military Surgeons of the U.S.
Objective: This study adopted an inner ear test battery comprising audiometry, and ocular vestibular-evoked myogenic potential (oVEMP), cervical VEMP (cVEMP) and caloric tests to assess inner ear function in patients with long term exposure to organic solvents. Methods: Eighteen patients exposed to organic solvents and another 18 non-exposed controls from the same environment were enrolled in this study. Each subject underwent an inner ear test battery. Results: The percentages of abnormalities identified by the oVEMP test, cVEMP test, audiometry and caloric test for the exposed group were 85%, 54%, 50% and 33%, respectively, which showed significant differences when compared with the respective 8%, 8%, 6% and 0 for the non-exposed group. Additionally, a significantly declining trend of inner ear deficits from the utricle to the saccule, cochlea, and semicircular canals was noted in the exposed group, but not in the non-exposed group. Conclusion: Ototoxicity was identified in those exposed to organic solvents, with the sequence of abnormal inner ear function from the utricle to the saccule, cochlea, and semicircular canals.
More than 800 million L/d of hydrocarbon fuels is used to power cars, boats, and jet airplanes. The weekly consumption of these fuels necessarily puts the public at risk for repeated inhalation exposure. Recent studies showed that exposure to hydrocarbon jet fuel produces lethality in presynaptic sensory cells, leading to hearing loss, especially in the presence of noise. However, the effects of hydrocarbon jet fuel on the central auditory nervous system (CANS) have not received much attention. It is important to investigate the effects of hydrocarbons on the CANS in order to complete current knowledge regarding the ototoxic profile of such exposures. The objective of the current study was to determine whether inhalation exposure to hydrocarbon jet fuel might affect the functions of the CANS. Male Fischer 344 rats were randomly divided into four groups (control, noise, fuel, and fuel + noise). The structural and functional integrity of presynaptic sensory cells was determined in each group. Neurotransmission in both peripheral and central auditory pathways was simultaneously evaluated in order to identify and differentiate between peripheral and central dysfunctions. There were no detectable effects on pre- and postsynaptic peripheral functions. However, the responsiveness of the brain was significantly depressed and neural transmission time was markedly delayed. The development of CANS dysfunctions in the general public and the military due to cumulative exposure to hydrocarbon fuels may represent a significant but currently unrecognized public health issue.
To date, there is still shortage of highly sensitive and specific minimally invasive biomarkers for assessment of environmental toxicants exposure. Because of the significance of microRNA (miRNA) in various diseases, circulating miRNAs in blood may be unique biomarkers for minimally invasive prediction of toxicants exposure. We identified and validated characteristic miRNA expression profiles of human whole blood in workers exposed to volatile organic compounds (VOCs) and compared the usefulness of miRNA indicator of VOCs with the effectiveness of the already used urinary biomarkers of occupational exposure. Using a microarray based approach we screened and detected deregulated miRNAs in their expression in workers exposed to VOCs (toluene [TOL], xylene [XYL] and ethylbenzene [EBZ]). Total 169 workers from four dockyards were enrolled in current study, and 50 subjects of them were used for miRNA microarray analysis. We identified 467 miRNAs for TOL, 211 miRNAs for XYL, and 695 miRNAs for XYL as characteristic discernible exposure indicator, which could discerned each VOC from the control group with higher accuracy, sensitivity, and specificity than urinary biomarkers. Current observations from this study point out that the altered levels of circulating miRNAs can be a reliable novel, minimally invasive biological indicator of occupational exposure to VOCs. Copyright © 2015 Elsevier GmbH. All rights reserved.
JP-8 jet fuel is handled extensively by personnel in the military and commercial airlines, despite the paucity of information regarding its potential human health effects. JP-8 is a complex mixture primarily consisting of kerosene plus aliphatic and aromatic hydrocarbons. Recent reports indicate that acute JP-8 exposure via inhalation or dermal routes can overtly and persistently impair immune function in mice. Data from preliminary studies in this laboratory assessing the immunotoxicity of JP-8 indicated that oral JP-8 exposure caused an increase in liver weight, a decrease in thymus weight, and a decrease in the PFC response. As these results were similar to classic effects elicited by TCDD, a strong AhR ligand, it was hypothesized that JP-8 may exert immunosuppression via a similar mechanism. To test this hypothesis, an Ah-responsive mouse strain (B6C3F1) and a classically non-responsive mouse strain (DBA/2) bearing a lower affinity AhR were gavaged with JP-8 for 7 days. The results suggest that both mouse strains were equally sensitive to JP-8's toxicity at several endpoints including thymus weight and cellularity, liver weight, and specific IgM antibody responses. Furthermore, JP-8 did not induce CYP1A1 or promote down regulation of the AhR when evaluated by Western blot in either B6C3F1 or DBA/2 mice. In vitro studies corroborated these findings as JP-8 did not induce CYP1A1, promote down regulation of the AhR, or activate an XRE-driven reporter gene in murine Hepa-1 cells. These results suggest that JP-8 may exert its toxicity via an AhR-independent mechanism.
Jet propulsion fuel-8 (JP-8) is a kerosene-based fuel that is used in military jets. The U.S. Armed Services and North Atlantic Treaty Organization countries adopted JP-8 as a standard fuel source and the U.S. military alone consumes more than 2.5 billion gallons annually. Preliminary epidemiologic data suggested that JP-8 may interact with noise to induce hearing loss, and animal studies revealed damage to presynaptic sensory cells in the cochlea. In the current study, Long-Evans rats were divided into four experimental groups: control, noise only, JP-8 only, and JP-8 + noise. A subototoxic level of JP-8 was used alone or in combination with a nondamaging level of noise. Functional and structural assays of the presynaptic sensory cells combined with neurophysiologic studies of the cochlear nerve revealed that peripheral auditory function was not affected by individual exposures and there was no effect when the exposures were combined. However, the central auditory nervous system exhibited impaired brainstem encoding of stimulus intensity. These findings may represent important and major shifts in the theoretical framework that governs current understanding of jet fuel and/or jet fuel + noise-induced ototoxicity. From an epidemiologic perspective, results indicate that jet fuel exposure may exert consequences on auditory function that may be more widespread and insidious than what was previously shown. It is possible that a large population of military personnel who are suffering from the effects of jet fuel exposure may be misidentified because they would exhibit normal hearing thresholds but harbor a "hidden" brainstem dysfunction.