No full-text available
To read the full-text of this research,
you can request a copy directly from the authors.
Angle between first and second polar bodies is significantly associated with clinical outcome
... The position of PB2 extrusion determines the oocyte polar axis. Failure of the polar and PN longitudinal axes to align ( Fig. 2A) may increase the rates of developmental arrest, abnormal cleavage, (Gianaroli et al., 2003;Zhang et al., 2016;Regueira et al., 2018). ...
Fertilization underpins the vital transition from gametic meiosis to embryonic mitosis. For decades, in human IVF, microscopic observation at a single time point has limited our appreciation of the morphokinetic complexity of this process. More recently, the introduction of time lapse technology—also enhanced by combination with artificial intelligence—has revealed the finest morphokinetic details of the beginning of human development. Overall, a picture has finally emerged in which the precise timing, morphology and geometry of several fertilization events offer clues to predict the fate of the embryo—a key aspect of assisted reproduction. In this scenario, correct unfolding of intra- and interpronuclear rearrangements emerge as a crucial factor to create a platform able to preserve genetic and cellular integrity at the first mitotic cleavage.
ResearchGate has not been able to resolve any references for this publication.