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P103: Performance characteristics of the modified Sgarbossa criteria for diagnosis of acute coronary occlusion in emergency department patients with ventricular paced rhythm and symptoms of acute coronary syndrome

Authors:
  • Advocate Christ Medical Center

Abstract

Introduction: The ECG diagnosis of acute coronary occlusion (ACO) in the setting of ventricular paced rhythm (VPR) is purported to be impossible. However, VPR has a similar ECG morphology to LBBB. The validated Smith-modified Sgarbossa criteria (MSC) have high sensitivity (Sens) and specificity (Spec) for ACO in LBBB. MSC consist of 1 of the following in 1 lead: concordant ST Elevation (STE) 1 mm, concordant ST depression 1 mm in V1-V3, or ST/S ratio <−0.25 (in leads with 1 mm STE). We hypothesized that the MSC will have higher Sens for diagnosis of ACO in VPR when compared to the original Sgarbossa criteria. We report preliminary findings of the Paced Electrocardiogram Requiring Fast Emergency Coronary Therapy (PERFECT) study Methods: The PERFECT study is a retrospective, multicenter, international investigation of ED patients from 1/2008 - 12/2016 with VPR on the ECG and symptoms suggestive of acute coronary syndrome (e.g. chest pain or shortness of breath). Data from four sites are presented. Acute myocardial infarction (AMI) was defined by the Third Universal Definition of AMI. A blinded cardiologist adjudicated ACO, defined as thrombolysis in myocardial infarction score 0 or 1 on coronary angiography; a pre-defined subgroup of ACO patients with peak cardiac troponin (cTn) >100 times the 99% upper reference limit (URL) of the cTn assay was also analyzed. Another blinded physician measured all ECGs. Statistics were by Mann Whitney U, Chi-square, and McNemars test. Results: The ACO and No-AMI groups consisted of 15 and 79 encounters, respectively. For the ACO and No-AMI groups, median age was 78 [IQR 72-82] vs. 70 [61-75] and 13 (86%) vs. 48 (61%) patients were male. The median peak cTn ratio (cTn/URL) was 260 [33-663] and 0.5 [0-1.3] for ACO vs. no-AMI. The Sens and Spec for the MSC and the original Sgarbossa criteria were 67% (95%CI 39-87) vs. 46% (22-72; p=0.25) and 99% (92-100) vs. 99% (92-100; p=0.5). In pre-defined subgroup analysis of ACO patients with peak cTn >100 times the URL (n=10), the Sens was 90% (54-100) for the MSC vs. 60% (27- 86) for original Sgarbossa criteria (p=0.25). Conclusion: ACO in VPR is an uncommon condition. The MSC showed good Sens for diagnosis of ACO in the presence of VPR, especially among patients with high peak cTn, and Spec was excellent. These methods and results are consistent with studies that have used the MSC to diagnose ACO in LBBB.
P102
A quality improvement project: identifying and managing latent
safety threats though a zone wide emergency department in-situ
multidiscipline simulation program
L. Mews, MD, D. ODochartaigh, MSc, M. Chan, MD, T. Brown, MD,
A. Robb, MD, W. Ma, MD, MBA, University of Alberta, Edmonton, AB
Introduction: High delity in-situ simulation has been found to detect
system deciencies, equipment failures, and conditions predisposing to
medical errors, also known as latent safety threats (LST). What is not
well reported is whether these LSTs are effectively managed. As a part
of an ongoing quality improvement project, multidisciplinary, in-situ
simulations were conducted across emergency departments (ED) in the
Edmonton zone with the aim to identify LST and subsequently manage
them to improve patient care. Methods: In 2017 simulations were
conducted at EDs in the Edmonton Zone (N =10). Following each
simulation, a cross sectional, survey based assessment tool, was com-
pleted by participants to identify LST. These LST were shared with the
site clinical nurse educator and/or site manager and a management plan
made. Two to six months follow-up was made to track progress. For
reporting, LST were grouped into themes, progress on LST were coded
as either resolved, ongoing, or not managed. Results: A total of 112
LST were identied through 18 separate simulations. The most com-
monly identied LTS were: resuscitation resource required (n 23), lack
of staff training (21), equipment not immediately available (20), IT
resource required (8), medication not immediately available (6), staff
requiring familiarization (5), medication resource required (5), IT issue
(4), large equipment needed (4), small equipment needed (4), lack of
staff resource (3), medication needed, (3), equipment malfunction (2),
Environment cluttered (2), non-appropriate resource removed (2). Site
follow-up identied a total of 52 LST that where resolved, and 60 LST
that had ongoing work to manage them. No occurrences of LST not
being managed were identied. Conclusion: Simulation was used to
effectively identify LST. Creating a structured plan and follow up
allowed many LST to be resolved and effectively managed. In 2018
simulation will reassess if LST remain.
Keywords: quality improvement and patient safety, simulation, latent
threats
P103
Performance characteristics of the modied Sgarbossa criteria for
diagnosis of acute coronary occlusion in emergency department
patients with ventricular paced rhythm and symptoms of acute
coronary syndrome
G. J. Mitchell, MB, BAO, K. Dodd, MD, D. L. Zvosec, PhD, E. Chen,
MD, M. A. Hart, MD, J. Marshall, MD, A. A. Smith, MD, J. Suna, L.
Cullen, MBBS (Hons) PhD, S. W. Smith, MD, University of Calgary,
Calgary, AB
Introduction: The ECG diagnosis of acute coronary occlusion (ACO)
in the setting of ventricular paced rhythm (VPR) is purported to be
impossible. However, VPR has a similar ECG morphology to LBBB.
The validated Smith-modied Sgarbossa criteria (MSC) have high
sensitivity (Sens) and specicity (Spec) for ACO in LBBB. MSC
consist of 1 of the following in 1 lead: concordant ST Elevation (STE) 1
mm, concordant ST depression 1 mm in V1-V3, or ST/S ratio <0.25
(in leads with 1 mm STE). We hypothesized that the MSC will have
higher Sens for diagnosis of ACO in VPR when compared to the ori-
ginal Sgarbossa criteria. We report preliminary ndings of the Paced
Electrocardiogram Requiring Fast Emergency Coronary Therapy
(PERFECT) study Methods: The PERFECT study is a retrospective,
multicenter, international investigation of ED patients from 1/2008 - 12/
2016 with VPR on the ECG and symptoms suggestive of acute coronary
syndrome (e.g. chest pain or shortness of breath). Data from four sites
are presented. Acute myocardial infarction (AMI) was dened by the
Third Universal Denition of AMI. A blinded cardiologist adjudicated
ACO, dened as thrombolysis in myocardial infarction score 0 or 1 on
coronary angiography; a pre-dened subgroup of ACO patients with
peak cardiac troponin (cTn) >100 times the 99% upper reference limit
(URL) of the cTn assay was also analyzed. Another blinded physician
measured all ECGs. Statistics were by Mann Whitney U, Chi-square,
and McNemars test. Results: The ACO and No-AMI groups consisted of
15 and 79 encounters, respectively. For the ACO and No-AMI groups,
median age was 78 [IQR 72-82] vs. 70 [61-75] and 13 (86%) vs. 48 (61%)
patients were male. The median peak cTn ratio (cTn/URL) was 260 [33-
663] and 0.5 [0-1.3] for ACO vs. no-AMI. The Sens and Spec for the
MSC and the original Sgarbossa criteria were 67% (95% CI 39-87) vs.
46% (22-72; p =0.25) and 99% (92-100) vs. 99% (92-100; p =0.5). In
pre-dened subgroup analysis of ACO patients with peak cTn >100 times
the URL (n =10), the Sens was 90% (54-100) for the MSC vs. 60%
(27- 86) for original Sgarbossa criteria (p=0.25). Conclusion: ACO in
VPR is an uncommon condition. The MSC showed good Sens for
diagnosis of ACO in the presence of VPR, especially among patients with
high peak cTn, and Spec was excellent. These methods and results are
consistent with studies that have used the MSC to diagnose ACO in LBBB.
Keywords: Sgarbossas criteria, acute coronary occlusion, ventricular
paced rhythm
P104
Evaluating the use of the pulmonary embolism rule-out criteria in
the emergency department
S. Sharif, MD, C. Kearon, MB PhD, M. Eventov, BSc, M. Li, MD,
P. Sneath, BSc, R. Jiang, R. Leung, K. de Wit, MBChB, MSc, MD,
Department of Medicine, Division of Emergency Medicine, McMaster
University, Hamilton, ON
Introduction: Diagnosing pulmonary embolism (PE) can be challen-
ging because the signs and symptoms are often non-specic. Studies
have shown that evidence-based algorithms are not always adhered to in
the Emergency Department (ED), which leads to unnecessary CT
scanning. The pulmonary embolism rule-out criteria (PERC) can iden-
tify patients who can be safely discharged from the ED without further
investigation for PE. The purpose of this study is to evaluate the use of
the PERC rule in the ED and to compare the rates of testing for PE if the
PERC rule was used. Methods: This was a health records review of ED
patients investigated for PE at two emergency departments over a two-
year period (April 2013-March 2015). Inclusion criteria were ED phy-
sician ordered CT pulmonary angiogram, ventilation-perfusion scan, or
D-dimer for investigation of PE. Patients under the age of 18 were
excluded. PE was considered to be present during the emergency
department visit if PE was diagnosed on CT or VQ (subsegmental level
or above), or if the patient was subsequently found to have PE or deep
vein thrombosis during the next 30 days. Trained researchers extracted
anonymized data. The rate of CT/VQ imaging and the negative pre-
dictive value was calculated. Results: There were 1,163 patients that
were tested for PE and 1,097 patients were eligible for our analysis. Of
the total, 330/1,097 (30.1%; 95% CI 27.4-32.3%) had CT/VQ imaging
for PE, and 48/1,097 (4.4%; 95% CI 3.3-5.8%) patients were diagnosed
with PE. 806/1,097 (73.5%; 95% CI 70.8-76.0%) were PERC positive,
and of these, 44 patients had a PE (5.5%; 95% CI 4.1-7.3%).
Conversely, 291/1,097 (26.5%; 95% CI 24.0-29.2%) patients
were PERC negative, and of these, 4 patients had a PE (1.4%; 95%
2018 Scientic Abstracts
CJEM JCMU 2018;20 Suppl 1 S93
https://doi.org/10.1017/cem.2018.301
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... They recognize the electrocardiographic use of the original and modified Sgarbossa Criteria (SC) for the diagnosis of myocardial infarction in the setting of a LBBB [1][2][3][4][5]. However, in the case of a right VPR, there are no specific STEMI guidelines endorsing their use for the diagnosis of OMI, largely since there are only a few validating studies [6][7][8][9][10]. Our aim is to review the usefulness of the modified SC in patients with VPR and suspected myocardial infarction by presenting three cases in which the application of such criteria resulted in the successful electrocardiographic diagnosis of OMI as well as in predicting the occluded coronary vessel. ...
... Some experts have suggested the adaptation of the modified SC for OMI recognition in patients with right VPR since the electrocardiographic morphology of a right VPR is very similar to a LBBB, yet there is only a limited number of studies validating their use in this setting [6][7][8][9][10]. Maloy et al. [8] found that STE >5 mm in leads with discordant QRS complexes was very specific (>99%) but not sensitive (10%) for acute myocardial infarction in patients with VPR. ...
... More recently, a retrospective case-control investigation that studied the sensitivity and specificity of the modified SC to the original SC for the diagnosis of OMI in patients with a VPR has shown encouraging findings [9,10]. Fifty-nine subjects who had a right VPR and angiographic evidence of OMI were compared to 90 patients with non-OMI and to 102 subjects without myocardial infarction. ...
Article
Full-text available
Electrocardiographic recognition of an acute myocardial infarction in the setting of a right ventricular paced rhythm (VPR) represents a unique diagnostic challenge. The classical ST-segment patterns of myocardial ischemia can become obscured by the abnormal repolarization changes caused by a right VPR. Consequently, longer door-to-balloon reperfusion times and a higher mortality have been reported among these patients mostly due to a delayed diagnosis. In this population, the use of the modified Sgarbossa Criteria (SC) can aid the clinician in the diagnosis of an acute coronary occlusive myocardial infarction (OMI), as an ST-segment elevation myocardial infarction (STEMI) equivalent. However, there are only a few validating studies and no specific guidelines endorsing their use in patients with VPR. We present three cases with right VPR in which the use of the modified SC was diagnostic of OMI, as well as predictive of the occluded coronary vessel. Our review of the current evidence favors that identification of at least one modified SC in patients with right VPR represents an OMI finding with a similar accuracy as when these are used in patients with LBBB.
... Similarly, Armstrong et al. [20] showed that STE >25% of the QRS amplitude can specifically be used for differentiating STE due to ACO from STE due to left ventricular hypertrophy. Modified Sgarbossa criteria (QRS-STE concordance or STE/S wave amplitude ratio >25% when QRS and STE are discordant) were derived, validated, and shown to accurately diagnose ACO in presence of left bundle branch block [21,22] and ventricular paced rhythm [23]. Similar differentiation rules were also published for left ventricular aneurysm and pericarditis [24][25][26]. ...
Article
An important task in emergency cardiology is distinguishing patients with acute coronary occlusion (ACO), who will benefit from emergent reperfusion therapy, from those without ongoing myocyte loss who can be managed with medical therapy and for whom potentially harmful invasive interventions can be deferred. The electrocardiogram (ECG) is critical in this process. Although the ST-segment elevation myocardial infarction (STEMI)/non-STEMI paradigm is well-established, with “STEMI” representing ACO, its evidence base is poor, and this can have dire consequences. The universally recommended STEMI criteria do not accurately diagnose ACO; in fact, they miss more than one-fourth of the patients with ACO, and also result in a substantial burden of unnecessary catheterization laboratory activations. We here discuss why we believe it is time to change the current STEMI/non-STEMI paradigm.
... Внутригоспитальная летальность у таких пациентов также выше, чем у пациентов без ЭКС независимо от размера некроза [42]. В отношении таких пациентов существует два подхода: смена режима ЭКС для регистрации нативных комплексов и использование упомянутых ранее критериев E.B. Sgarbossa в модификации S.W. Smith, чувствительность и специфичность которых для электростимуляции составляет 67 % и 99 % соответственно [43]. Во время ингибирования функции автоматизма нужно иметь в виду изменения ЭКГ, связанные с эффектом сердечной памяти. ...
Article
Full-text available
The 12-lead electrocardiogram (ECG) remains the most immediately accessible and widely used initial diagnostic tool for guiding management in patients with suspected myocardial infarction (MI). While the development of high-sensitivity cardiac troponin (cTn) assayshas improved the rule-in and rule-out and risk stratification of acute MI without ST elevation, the immediate management of the subset of acute MI with acute coronary occlusion depends on integrating clinical presentation and ECG findings. Careful interpretation of the ECG may yield subtle features suggestive of ischemia that may facilitate more rapid triage of patients with subtle acute coronary occlusion or,conversely, in identification of STEMI mimics (pseudo-STEMI patterns). Our goal in this review article is to consider recent advances in the use of the ECG to diagnose coronary occlusion MIs, including the application of rules that allow MI to be diagnosed based on atypical ECG manifestations. Such rules include the Modified Sgarbossa criteria allowing identification of acute MI in left bundle branch block or ventricular pacing, the 3- and 4-variable formula to differentiate normal ST elevation (formerly called Early Repolarization) from subtle ECG signs of left anterior descending coronary artery occlusion, the differentiation of ST Elevation of left ventricular aneurysm from that of acute anterior MI, and the use of lead aVL in the recognition of inferior MI. Improved use of the ECG is essential to improving the diagnosis and appropriate early management of acute coronary occlusion MIs, which will lead to improved outcomes for patients presenting with acute coronary artery disease.
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