Anatomic and Functional Connectivity Relationship in Autistic Children
, Mauricio Chinchilla
, Yazmina Machado
, Calixto Machado
, Mario Estevez
, Gerry Leisman
Institute of Neurology and Neurosurgery,
Instituto De Neurologia Y Neurocirugia,
The National Institute for
Brain and Rehabiliation Sciences,
Internationl Brain Research Foundation, Inc.
Objective: To determine the relationship between the anatomic (AC) vs. functional (FC) connectivity, considering
short-range and long-range brain networks.
In a recent published paper (Machado et al., 2013), we showed that in autistics studied with video without audio
tasks vs. video without audio tasks, tended to show lower coherence values in the right hemispheres, suggesting
an impairment of visual and auditory sensory integration in autistics.
Design/Methods: Aanatomic connectivity was assessed by the DW-MRI technique and functional connectivity by
EEG coherence calculation, in three experimental conditions: basal, watching a popular cartoon with audio (V-A),
and with muted audio track (VwA).
Results: For short-range connections, basal records, statistical significant correlations for all EEG bands in the
left hemisphere were found, meanwhile in the right hemispheres no significant correlation for fast EEG frequency
bands were noticed. For the V-A condition, significant correlations mainly diminished for the left hemisphere; for
the right hemisphere again no significant correlations for the fast EEG frequency bands were found. For the VwA
condition, significant correlations for the rapid EEG frequencies mainly disappeared for the right hemisphere. For
long-range connections, basal records, similar correlations were found for both hemispheres. For the right
hemisphere significant correlations incremented to all EEG bands for the V-A condition, but these significant
correlations disappeared for the fast EEG frequencies in the VwA condition.
Conclusions: It appears that in a resting- state condition, AC is better associated with functional connectivity for
short-range connections in the left hemisphere. V-A experimental condition enriches AC and FC association for
long-range connections in the right hemisphere. This might be related to an effective connectivity improvement
due to visual and auditory stimulation. An impaired audio-visual interaction in the right hemisphere
Study Supported by: NA