The purpose of this paper is to review L1 and cultural interference in L2 learning. The author intends to show research in the topic of L1 interference, and also cultural interference. Each type of interference can affect L2 learning, and it is important to address these notions. Evaluations will also be done on how it affects students learning a second language and educators teaching a second language. There is some important contexts of where the L2 is taught, and the author will comment about these contexts. Teaching a second language at the student’s L1 environment or in the environment where L2 is normally used has implications in both kinds of interference and the author will try to discuss this further. After reviewing the research, the author believes more research is needed in researching cultural interference, and researchers need to find a way to substantiate cultural interference.