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DRIVE-ABSurveyforsmallandmediumbiopharmaceutical
companies
Thank you for taking approximately 30 minutes to complete this survey.
The data from this survey will be held strictly confidential. Only seven
individuals will have access to the raw data. They are: Enrico Baraldi,
Francesco Ciabuschi, Carl Anderson Kronlid, Olof Lindahl and Christopher
Okhravi (all of Uppsala University) and Jens Plahte and Christine Årdal (of
the Norwegian Institute of Public Health). The anonymous, summarized
results will be published as well as used as inputs into quantitative
simulations to test different incentives. We will send you a copy of the paper
when it is published. No organization will be identifiable within the
published article.
Your participation, of course, is completely voluntary and has no impact on
any interaction with the DRIVE-AB project, its partners, the EU or any
government.
In this survey we often refer to your “lead antibacterial project”. Please
choose one antibacterial project that has to date been one of your company's
primary R&D efforts.
Please start by answering the question below.
1)Canyoupleaseindicatethenameoftheantibacterialcompanyyourepresent?
2)Whatyearwasyourcompanyestablished?
3)Howmanyfull-timeequivalentemployeesdoesyourcompanyemploytoday?
1-5
6-10
11-50
51-100
More than 100
We are a virtual company with zero full-time equivalent employees.
I don't know
4)*Whattypeofantibacterialapproachisyourcompanypursuing?Pleasechooseasmanycategoriesasrelevant:
Small molecule
Antibody
Preventive vaccine
Phage-based
Anti-virulence
Adjunctive therapy
Other
I don't know
5)*Whichofthefollowinghealthapplicationsisyourcompanyfocusingon?
Only human health
Both human and animal health
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Human, animal and environmental health
Other
I don't know
6)In2014whatshareofyourR&Dbudgetwasoutsourcedtootherorganizations?
Less than 25%
26-50%
51-75%
More than 75%
We do not outsource our R&D.
Other
I don't know
7)Whatwastheannualrevenueofyourcompanyin2014?
€ 1 - 99,000
€ 100,000 - 299,000
€ 300,000 - 1 million
More than € 1 million
We do not yet have revenues.
Other
I don't know
8)*Isyourcompanyaspin-offfromauniversityorresearchinstitute?
Yes
No
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Is your company a spin-off from a university or research institute? ”
equals “Yes”
• )
9)Whichuniversityorinstitute(s)?
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Is your company a spin-off from a university or research institute? ”
equals “Yes”
• )
10)DoIP(intellectualproperty)requirementsinrelationtothisuniversity(ies)/institute(s)representanobstacletopursuingyourcompanygoals?
1 - No obstacles
2 - Almost no obstacles
3 - Some obstacles
4 - Major obstacles
5 - Extreme obstacles
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I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Do IP (intellectual property) requirements in relation to this university
(ies)/institute(s) represent an obstacle to pursuing your company goals? ”
equals “2 - Almost no obstacles”
◦ or
◦ If “Do IP (intellectual property) requirements in relation to this university
(ies)/institute(s) represent an obstacle to pursuing your company goals? ”
equals “4 - Major obstacles”
◦ or
◦ If “Do IP (intellectual property) requirements in relation to this university
(ies)/institute(s) represent an obstacle to pursuing your company goals? ”
equals “3 - Some obstacles”
• )
11)InwhichsensedoIPissuesrepresentanobstacle,ifapplicable?
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Is your company a spin-off from a university or research institute? ”
equals “<#na#>I don't know”
◦ or
◦ If “Is your company a spin-off from a university or research institute? ”
equals “No”
• )
12)Isyourcompanyaspin-offfromalarge,multinationalpharmaceuticalcompany?
Yes
No
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Is your company a spin-off from a large, multinational pharmaceutical
company? ” equals “Yes”
• )
13)Whichpharmaceuticalcompany?
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Is your company a spin-off from a large, multinational pharmaceutical
company? ” equals “Yes”
• )
14)DoIP(intellectualproperty)requirementsinrelationtothispharmaceuticalcompanyrepresentanobstacletopursuingyourcompanygoals?
1 - No obstacles
2 - Almost no obstacles
3 - Some obstacles
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4 - Major obstacles
5 - Extreme obstacles
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Do IP (intellectual property) requirements in relation to this
pharmaceutical company represent an obstacle to pursuing your company
goals? ” equals “4 - Major obstacles”
◦ or
◦ If “Do IP (intellectual property) requirements in relation to this
pharmaceutical company represent an obstacle to pursuing your company
goals? ” equals “3 - Some obstacles”
◦ or
◦ If “Do IP (intellectual property) requirements in relation to this
pharmaceutical company represent an obstacle to pursuing your company
goals? ” equals “2 - Almost no obstacles”
• )
15)InwhichsensedoIPissuesrepresentanobstacle,ifapplicable?
16)*HowmanyantibacterialLEADSisyourcompanycurrentlypursuing?
0
1 - 10
11 - 50
More than 50
Other
I don't know
17)*HowmanyantibacterialPROJECTSisyourcompanycurrentlypursuing?
1
2
3
More than 3
Other
I don't know
18)*Whatisthesourceofyourcompany'sleadantibioticproject?Pleasecheckallthatapply.
Own research
Academic research
Research from a research institute
Research from another pharmaceutical company
Other
I don't know
19)Whatshareofyourcompany'sfinancialresourcesin2014werededicatedtoyourleadantibacterialproject?
Less than 25%
26 - 50%
51 - 75%
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More than 75%
Other
I don't know
20)Isyourcompany'sleadantibacterialprojecttakingabroadoranarrowspectrumapproach?
Broad spectrum (both gram positive AND gram negative)
Narrow spectrum (gram-positive OR gram-negative)
Pathogen specific
Too early to know
Not applicable
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Is your company's lead antibacterial project taking a broad or a narrow
spectrum approach? ” equals “Broad spectrum (both gram positive AND gram
negative)”
• )
21)Pleasespecifytherangeofthisspectrum.
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Is your company's lead antibacterial project taking a broad or a narrow
spectrum approach? ” equals “Narrow spectrum (gram-positive OR gram-
negative)”
◦ or
◦ If “Is your company's lead antibacterial project taking a broad or a narrow
spectrum approach? ” equals “Pathogen specific”
• )
22)Pleasespecifywhichpathogen(s)itistargeting.
23)Whatdegreeofnoveltydoesyourleadantibacterialprojectrepresent?
A novel class
Novel mode of action
Known class
Other
I don't know
24)*Doesthedevelopmentandcommercialevaluationofyourleadantibacterialprojectassumethatarapidpoint-of-carediagnosticwillbeavailableatlaunch?
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Yes
No
Ideally
Other
I don't know
25)Doesyourleadantibacterialprojectfocuson:
Non-resistant bacteria
Resistant bacteria that have not yet reached the level of multi-drug
resistance
Multi-drug resistant bacteria
Other
I don't know
26)*Whichmarketsegmentisyourcompanytargeting?Pleaseselectallthatapply.
Community / General Practitioner
Hospital
Other
I don't know
27)WhatstagedoesyourcompanyAIMtoCOMPLETEbeforeout-licensingorsellingyourleadantibacterialproject?
Lead compound optimization
Preclinical testing
Clinical trials Phase I
Clinical trials Phase II
Clinical trials Phase III
Regulatory approval
We intend to commercialize the product.
Other
I don't know
28)WhichstageshasyourcompanyALREADYcompletedforitsleadantibacterialproject?Pleasecheckallthatapply.
Lead compound identification
Lead compound optimization
Preclinical testing
Clinical trials Phase I
Clinical trials Phase II
Clinical trials Phase III
Regulatory approval
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Lead compound
identification ”
• )
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29)HowlongdidittakeyourcompanytocompleteLeadCompoundIdentificationforyourleadantibacterialproject?
Less than 6 months
6 months – 1 year
1 year – 2 years
2 – 4 years
5 years or more
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Lead compound
identification ”
• )
30)ComparedtoyourcompanyexpectationsatthebeginningofLeadCompoundIdentification,theactualdurationwas:
1 - Much shorter than expected
2 - Slightly shorter than expected
3 - As long as expected
4 - Slightly longer than expected
5 - Much longer than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Lead compound
identification ”
• )
31)HowmuchdiditcostyourcompanytocompleteLeadCompoundIdentificationforyourleadantibacterialproject(notincludingopportunitycostorthecostsofothercandidateproducts)?
Less than € 100,000
€ 100,001 - € 250,000
€ 250,001 - € 500,000
€ 500,001 - € 999,999
More than € 1,000,000
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Lead compound
identification ”
• )
32)ComparedtoyourcompanyexpectationsatthebeginningofLeadCompoundIdentification,theactualcostswere:
1 - Much less than expected
2 - Slightly less than expected
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3 - As much as expected
4 - Slightly more than expected
5 - Much more than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Lead compound
optimization ”
• )
33)HowlongdidittakeyourcompanytocompleteLeadCompoundOptimizationforyourleadantibacterialproject?
Less than 6 months
6 months – 1 year
1 year – 2 years
2 – 4 years
5 years or more
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Lead compound
optimization ”
• )
34)ComparedtoyourcompanyexpectationsatthebeginningofLeadCompoundOptimization,theactualdurationwas:
1 - Much shorter than expected
2 - Slightly shorter than expected
3 - As long as expected
4 - Slightly longer than expected
5 - Much longer than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Lead compound
optimization ”
• )
35)HowmuchdiditcostyourcompanytocompleteLeadCompoundOptimizationforyourleadantibacterialproject(notincludingopportunitycostorthecostsofothercandidateproducts)?
Less than € 1 million
€ 1 million - € 5 million
€ 5 million - € 10 million
€ 10 million - € 15 million
More than € 15 million
Other
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I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Lead compound
optimization ”
• )
36)ComparedtoyourcompanyexpectationsatthebeginningofLeadCompoundOptimization,theactualcostswere:
1 - Much less than expected
2 - Slightly less than expected
3 - As much as expected
4 - Slightly more than expected
5 - Much more than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Preclinical testing ”
• )
37)HowlongdidittakeyourcompanytocompletePreclinicalTestingforyourleadantibacterialproject?
Less than 6 months
6 months – 1 year
1 year – 2 years
2 – 4 years
5 years or more
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Preclinical testing ”
• )
38)ComparedtoyourcompanyexpectationsatthebeginningofPreclinicalTesting,theactualdurationwas:
1 - Much shorter than expected
2 - Slightly shorter than expected
3 - As long as expected
4 - Slightly longer than expected
5 - Much longer than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
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• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Preclinical testing ”
• )
39)HowmuchdiditcostyourcompanytocompletePreclinicalTestingforyourleadantibacterialproject(notincludingopportunitycostorthecostsofothercandidateproducts)?
Less than € 1 million
€ 1 million - € 5 million
€ 5 million - € 10 million
€ 10 million - € 15 million
More than € 15 million
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Preclinical testing ”
• )
40)ComparedtoyourcompanyexpectationsatthebeginningofPreclinicalTesting,theactualcostswere:
1 - Much less than expected
2 - Slightly less than expected
3 - As much as expected
4 - Slightly more than expected
5 - Much more than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
I”
• )
41)HowlongdidittakeyourcompanytocompleteClinicalTrialsPhaseIforyourleadantibacterialproject?
Less than 6 months
6 months – 1 year
1 year – 2 years
2 – 4 years
5 years or more
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
I”
• )
42)ComparedtoyourcompanyexpectationsatthebeginningofClinicalTrialsPhaseI,theactualdurationwas:
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1 - Much shorter than expected
2 - Slightly shorter than expected
3 - As long as expected
4 - Slightly longer than expected
5 - Much longer than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
I”
• )
43)HowmuchdiditcostyourcompanytocompleteClinicalTrialsPhaseIforyourleadantibacterialproject(notincludingopportunitycostorthecostsofothercandidateproducts)?
Less than € 1 million
€ 1 million - € 5 million
€ 5 million - € 10 million
€ 10 million - € 15 million
More than € 15 million
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
I”
• )
44)ComparedtoyourcompanyexpectationsatthebeginningofClinicalTrialsPhaseI,theactualcostswere:
1 - Much less than expected
2 - Slightly less than expected
3 - As much as expected
4 - Slightly more than expected
5 - Much more than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
II”
• )
45)HowlongdidittakeyourcompanytocompleteClinicalTrialsPhaseIIforyourleadantibacterialproject?
Less than 6 months
6 months – 1 year
1 year – 2 years
2 – 4 years
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5 years or more
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
II”
• )
46)ComparedtoyourcompanyexpectationsatthebeginningofClinicalTrialsPhaseII,theactualdurationwas:
1 - Much shorter than expected
2 - Slightly shorter than expected
3 - As long as expected
4 - Slightly longer than expected
5 - Much longer than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
II”
• )
47)HowmuchdiditcostyourcompanytocompleteClinicalTrialsPhaseIIforyourleadantibacterialproject(notincludingopportunitycostorthecostsofothercandidateproducts)?
Less than € 1 million
€ 1 million - € 5 million
€ 5 million - € 10 million
€ 10 million - € 20 million
More than € 20 million
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
II”
• )
48)ComparedtoyourcompanyexpectationsatthebeginningofClinicalTrialsPhaseII,theactualcostswere:
1 - Much less than expected
2 - Slightly less than expected
3 - As much as expected
4 - Slightly more than expected
5 - Much more than expected
Other
I don't know
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Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
III”
• )
49)HowlongdidittakeyourcompanytocompleteClinicalTrialsPhaseIIIforyourleadantibacterialproject?
Less than 6 months
6 months – 1 year
1 year – 2 years
2 – 4 years
5 years or more
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
III”
• )
50)ComparedtoyourcompanyexpectationsatthebeginningofClinicalTrialsPhaseIII,theactualdurationwas:
1 - Much shorter than expected
2 - Slightly shorter than expected
3 - As long as expected
4 - Slightly longer than expected
5 - Much longer than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
III”
• )
51)HowmuchdiditcostyourcompanytocompleteClinicalTrialsPhaseIIIforyourleadantibacterialproject(notincludingopportunitycostorthecostsofothercandidateproducts)?
Less than € 10 million
€ 10 million - € 25 million
€ 25 million - € 50 million
€ 50 million - € 100 million
More than € 100 million
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
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◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Clinical trials Phase
III”
• )
52)ComparedtoyourcompanyexpectationsatthebeginningofClinicalTrialsPhaseIII,theactualcostswere:
1 - Much less than expected
2 - Slightly less than expected
3 - As much as expected
4 - Slightly more than expected
5 - Much more than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Regulatory
approval”
• )
53)HowlongdidittakeyourcompanytocompleteRegulatoryApprovalforyourleadantibacterialproject?
Less than 6 months
6 months – 1 year
1 year – 2 years
2 – 4 years
5 years or more
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Regulatory
approval”
• )
54)ComparedtoyourcompanyexpectationsatthebeginningofRegulatoryApproval,theactualdurationwas:
1 - Much shorter than expected
2 - Slightly shorter than expected
3 - As long as expected
4 - Slightly longer than expected
5 - Much longer than expected
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Regulatory
approval”
• )
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55)HowmuchdiditcostyourcompanytocompleteRegulatoryApprovalforyourleadantibacterialproject(notincludingopportunitycostorthecostsofothercandidateproducts)?
Less than € 1 million
€ 1 million - € 2 million
€ 2 million - € 3 million
€ 3 million - € 4 million
More than € 4 million
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Which stages has your company ALREADY completed for its lead
antibacterial project? Please check all that apply.” equals “Regulatory
approval”
• )
56)ComparedtoyourcompanyexpectationsatthebeginningofRegulatoryApproval,theactualcostswere:
1 - Much less than expected
2 - Slightly less than expected
3 - As much as expected
4 - Slightly more than expected
5 - Much more than expected
Other
I don't know
57)*Whatstageisyourcompanycurrentlyinforyourleadantibacterialproject?
Lead compound identification
Lead compound optimization
Preclinical testing
Clinical trials Phase I
Clinical trials Phase II
Clinical trials Phase III
Regulatory approval
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Lead compound identification ”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Preclinical testing ”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Lead compound optimization ”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Regulatory approval”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Clinical trials Phase II”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Clinical trials Phase III”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Clinical trials Phase I”
• )
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58)Howlongdoyouexpectthisstagewilltaketocompletefromstarttofinish?
Less than 6 months
6 months – 1 year
1 year – 2 years
2 – 4 years
More than 5 years
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Lead compound optimization ”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Lead compound identification ”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Preclinical testing ”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Regulatory approval”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Clinical trials Phase II”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Clinical trials Phase III”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Clinical trials Phase I”
• )
59)Howmuchdoyouexpectthisstagewillcosttocompletefromstarttofinish?
Less than € 1 million
€ 1 million - € 5 million
€ 5 million - € 10 million
€ 10 million - € 20 million
More than € 20 million
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Lead compound identification ”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Lead compound optimization ”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Clinical trials Phase III”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Clinical trials Phase I”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Clinical trials Phase II”
◦ or
◦ If “What stage is your company currently in for your lead antibacterial
project?” equals “Preclinical testing ”
• )
60)Whatdoyoubelieveisthesuccessratethatyourcompanywilltransitiontothenextphase?
0 - 25 %
26 - 50 %
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51 - 75 %
More than 75 %
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “What do you believe is the success rate that your company will transition
to the next phase? ” equals “26 - 50 %”
◦ or
◦ If “What do you believe is the success rate that your company will transition
to the next phase? ” equals “0 - 25 %”
◦ or
◦ If “What do you believe is the success rate that your company will transition
to the next phase? ” equals “More than 75 %”
◦ or
◦ If “What do you believe is the success rate that your company will transition
to the next phase? ” equals “51 - 75 %”
• )
61)Whatisthebasisforthissuccessrate?Pleasecheckallthatapply.
Previous experience
Industry standard for our current phase
Company standard for our current phase
Analogs from other companies
Other
I don't know
62)HowmuchdoyouexpecttheNEXTstageofdevelopmentwillcosttocompletefromstarttofinish?
Less than € 1 million
€ 1 million - € 5 million
€ 5 million - € 10 million
€ 10 million - € 20 million
More than € 20 million
Other
I don't know
63)Howmuchtotalexternalfinancinghasyourcompanyreceivedtodate?
Less than € 500,000
€ 500,000 - € 1 million
€ 1 million - € 5 million
€ 5 million - € 20 million
€ 20 million - € 50 million
More than € 50 million
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “How much total external financing has your company received to date? ”
equals “Less than € 500,000”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 500,000 - € 1 million”
◦ or
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◦ If “How much total external financing has your company received to date? ”
equals “More than € 50 million”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 5 million - € 20 million”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 20 million - € 50 million”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 1 million - € 5 million”
• )
64)CanyoupleasespecifyhowmuchyourcompanyhasreceivedintheformofGRANTS?
Less than € 500,000
€ 500,000 - € 1 million
€ 1 million - € 5 million
€ 5 million - € 20 million
€ 20 million - € 50 million
More than € 50 million
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “How much total external financing has your company received to date? ”
equals “Less than € 500,000”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 500,000 - € 1 million”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “More than € 50 million”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 5 million - € 20 million”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 20 million - € 50 million”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 1 million - € 5 million”
• )
65)CanyoupleasespecifyhowmuchyourcompanyhasreceivedintheformofLOANS?
Less than € 500,000
€ 500,000 - € 1 million
€ 1 million - € 5 million
€ 5 million - € 20 million
€ 20 million - € 50 million
More than € 50 million
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “How much total external financing has your company received to date? ”
equals “Less than € 500,000”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 500,000 - € 1 million”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “More than € 50 million”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 5 million - € 20 million”
◦ or
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◦ If “How much total external financing has your company received to date? ”
equals “€ 20 million - € 50 million”
◦ or
◦ If “How much total external financing has your company received to date? ”
equals “€ 1 million - € 5 million”
• )
66)CanyoupleasespecifyhowmuchyourcompanyhasreceivedintheformofEQUITY-DILUTINGCAPITAL?
Less than € 500,000
€ 500,000 - € 1 million
€ 1 million - € 5 million
€ 5 million - € 20 million
€ 20 million - € 50 million
More than € 50 million
Other
I don't know
67)Whatshareofequityisstillretainedtodaybythecompany’sfounders?
0 - 25 %
26 - 50 %
51 - 75 %
76 - 99 %
All equity is still retained by the company's founders.
Other
I don't know
68)Howlongwillyourcurrentfinancingsupporttheactivitiesofthecompany?
1 to 6 months
7 months to 1 year
1 to 3 years
More than 3 years
Other
I don't know
69)DoesyourcompanyhaveaspecificNetPresentValue(NPV)target?
Yes
No
Other
I don't know
Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Does your company have a specific Net Present Value (NPV) target? ”
equals “Yes”
• )
70)Whatisyourcompany’stargetforNPV?
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Thisboxisshowninpreviewonly.
The following criteria must be fulfilled for this question to be shown:
• (
◦ If “Does your company have a specific Net Present Value (NPV) target? ”
equals “No”
• )
71)Whatareyourcompany'sreasonsfornotusingaNPVtarget?
72)Howimportanthavethefollowingperformancemetricsbeeninsecuringfinancingforyourcompany?
1 - Totally
unimportant
2 -
Somewhat
unimportant
3 -
Neutral
4 -
Somewhat
important
5 -
Extremely
important
I
don't
know
Profitability
(NPV, ROI or
other similar
indicators)
Time to exit
(either IPO or
acquisition)
Time to
regulatory
approval
73)Whichexitstrategiesareyourcompany’sownersmoststronglypursuing?Pleasecheckallthatapply.
Exit by IPO
Exit by acquisition
Exit by out-licensing
No exit strategy - We plan to commercialize our products.
Other
I don't know
74)Howimportantarecollaborationswiththefollowingpartnersforyourcompany?
1 - Totally
unimportant
2 -
Somewhat
unimportant
3 -
Neutral
4 -
Somewhat
important
5 -
Extremely
important
I
don't
know
Academic labs
or research
institutes
Incubators
Contract
Research
Organizations
(CROs)
Large,
multinational
pharmaceutical
companies
Diagnostic
companies
Hospitals and
clinical centers
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75)Hasyourcompanyevercollaboratedwithanyofthefollowingpartners?Pleasecheckallthatapply.
Academic labs or research institutes
Incubators
Contract Research Organizations (CROs)
Large, multinational pharmaceutical companies
Diagnostic companies
Hospitals and clinical centers
Other
I don't know
76)Whichofthefollowingincentiveswouldmostassistyourcompanyindevelopingnewantibacterialproducts?Pleasechoosethetop3.
A stronger pipeline of antibiotic candidates coming from academia/research
institutes
Significant new grant funding from governments, foundations or patient
advocacy groups
Value-based pricing for antibiotics and antibiotic alternatives
Direct grants for pre-clinical and clinical development from Private-Public
Partnerships (PPPs), such as BARDA
Tax credits for 50% of clinical development costs (fully refundable)
Advance market commitments (AMCs) that guarantee a market for a
specified product
Faster approvals by EMA/FDA
Dramatically lower costs of clinical development
Significant financial prizes upon registration or for specific milestones
Significantly improved reimbursement for new, powerful antibiotics
Post-approval payments to recoup the costs of global registration and
establishing a manufacturing base
5 years of additional exclusivity after patent expiration (i.e., years 21-25)
Patent tolling (extending the patent life to compensate for periods held off
the market until resistance to other products develops)
Other
I don't know
77)Isthereanythingelsethatyouwouldliketotellus?
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