Due to its geographical characteristics such as proximity to the Bay of Bengal and low-lying riverine landscape, Bangladesh is highly susceptible to climate change. The southwestern region of the country is particularly vulnerable to the impacts of various forms of disasters including floods, cyclones, tidal surges, river erosion, and climate change. A growing body of research has examined the impacts of climate change including increasing water salinity, land degradation, low agricultural productivity, and dislocation. However, no research to date has examined the consequences of climate change for interpersonal and intergroup relationships from a sociological perspective in Bangladesh. To address this gap in the literature, a qualitative study was designed to examine the effects of climate change for intergroup, intragroup, and social relationships in the context of climate change in southwestern Bangladesh. Local people’s accounts were captured by applying a combination of qualitative instruments including 12 in-depth interviews (IDI), four focus group discussions (FGD) in which a total of 27 community people participated, and four key informant interviews (KII). Two southwestern unions Kamarkhola and Suterkhali under the Dacope subdistrict located in the Khulna district of Bangladesh were purposively selected as study sites. Analysis reveals that climate change has at least indirectly influenced both intergroup, intragroup, and social relationships. It generated intergroup conflicts and livelihood vulnerabilities, which coupled with other factors such as land degradation, poverty, social marginalization, low agricultural productivity, unemployment, and water salinity, often led to the dislocation of some vulnerable groups. Findings suggest that relationships with neighbors, friends, and relatives deteriorated as the impacts of climate change, in conjunction with other factors, contributed to various forms of social conflict and antisocial behaviors. For instance, the elderly claimed that the younger generation showed less respect to them as the social fabric weakened. On occasion, people reported being less likely to cooperate in a strongly collectivist, kinship-based, and family-oriented Bangladesh society. Taken together, the findings demonstrate that climate change may affect intergroup, intragroup, and social relationships at various levels, disproportionately affecting marginalized groups. This raises questions about environmental justice. Building intergroup solidarity and promoting prosocial behaviors are essential for addressing the impacts of climate change. Therefore, climate mitigation and adaptation strategies need to consider the impacts of climate change on social relationships.