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Acupuncture for anxiety in dental patients: Systematic review and meta-analysis

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Abstract

Introduction: Dental anxiety affects an estimated 4% to 30% of the adult population in countries world-wide. The objective of this study was to conduct the first systematic review and meta-analysis of randomised controlled trials of acupuncture to reduce anxiety in dental patients. Methods: Online databases (OVID/AMED, Cochrane Library, CINAHL, OVID/Medline, EMBASE, PROSPERO, PsycINFO, PubMED, as well as databases in Chinese, Portuguese, Spanish and German) were searched up to July 2017 for eligible trials involving dental patients receiving an acupuncture intervention with measured anxiety scores. Comparators were placebo, usual care, or another dental anxiety intervention. Included studies were assessed using the Cochrane Risk of Bias Tool. Results: From 129 trials identified as potentially eligible, six trials with 800 patients were included in this review. Two trials (combined n = 249) were rated as moderate-to-high or high quality, both used auricular acupuncture, and were the only two trials to report continuous post-intervention anxiety scores, both using the (80-point) State-Trait Anxiety Inventory (STAI). A meta-analysis comparing acupuncture with no-intervention controls found a statistically significant and clinically relevant reduction in anxiety of −8.43, 95% CI (−11.90, −5.00). A meta-analysis comparing acupuncture to placebo/sham acupuncture found a clinically irrelevant and non-significant reduction of −1.54, 95% CI (−4.73, 1.64), a contrast that might be explained by context effects. Conclusions: There is limited evidence from two good quality trials that auricular acupuncture can achieve a significant and clinically meaningful reduction of anxiety in dental patients. There is no conclusive effect of acupuncture when compared with a sham/placebo control.

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... It has been shown to provide emotional support and reduce anxiety, improving patients' overall comfort and experience [25]. The placebo effect, which happens when patients believe the treatment is working, can significantly intensify the psychological benefits of acupuncture [26]. ...
... provided ample evidence that supported the effectiveness of acupuncture as an intervention to improve major depressive disorders in pregnancy [20]. In Allan et al.'s meta-analysis, the comparison of acupuncture with a no-intervention control group exhibited significant clinical mitigation in the anxiety level of dental patients, though an insignificant drop was observed when acupuncture was compared with a sham/placebo control [21]. A meta-analysis compared acupuncture and nonacupuncture interventions in the treatment of anxiety, but it did not report any significant difference between A point estimate (the size of the square corresponds to its weight), Combined overall effect of treatment. ...
... Acupuncture has been demonstrated to be a very effective way of controlling anxiety, particularly mental anxiety, 29 and general anxiety. 30 The anxiety involved in undergoing IVF-ET is very similar in nature to mental anxiety; thus, it is expected that this could explain the mechanism of acupuncture's improving the success rate when used with IVF-ET. ...
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Background: Assisted reproductive technology (ART) is the routine treatment for infertility. The success rate for individual sessions is generally not high, and many patients need to undergo several cycles. To increase their chances of success, many patients turn to acupuncture to complement ART. Many clinical trials of acupuncture helping in vitro fertilization (IVF) have focused only on IVF-embryo transfer (ET). In some difficult cases, when even IVF cannot be offered, acupuncture and Chinese herbs can improve the patients' conditions to reach a level at which ART can be successful. Cases: Six cases showed how acupuncture and Traditional Chinese Medicine (TCM), using Chinese herbs, can make IVF possible in difficult cases and how they can also help prevent miscarriage afterward. The cases included patients with amenorrhea, sperm disorders, polycystic ovary syndrome, diminished ovarian reserve (DOR), tubal blockage, premenopause, and premature ovarian insufficiency. Results: Acupuncture and Chinese herbs worked together to help make ART possible or easier. The ART used for these patients included intrauterine insemination, IVF, IVF with a donor egg, and introcytoplasmic sperm injection. In 3 cases, IVF was not initially successful but was successful after TCM treatment. Conclusions: These 6 cases demonstrated the positive effect of a combined approach, using acupuncture and herbs to reduce DOR and regulate hormonal disorders, creating sustainable environments for conceiving and maintaining pregnancy, thus, translating into clinical success. Clinical observation of these cases sheds new light on designing future clinical trials and practice of TCM for practitioners who provide infertility treatments.
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Dental anxiety causes people to postpone or refuse to go to the dentist, which further negatively impacts their quality of life and public health. Previous research has shown that mindfulness is inversely related to anxiety. However, little is known about the relationship between mindfulness and dental anxiety. The current research aimed to explore the relationship between mindfulness and dental anxiety and investigate the mediating role of rational thinking. Two studies were conducted. In study one, 206 Chinese participants completed questionnaires measuring trait mindfulness and dental anxiety (state, responding to a dental treatment scenario). In study two, 394 participants completed questionnaires measuring trait mindfulness, dental anxiety (trait), and rational thinking. The results for both studies showed that mindfulness is negatively correlated with dental anxiety. In study 1, each facet of mindfulness except Non-judging was negatively correlated with dental anxiety with Acting with Awareness having the strongest correlation, while in study 2, only Acting with Awareness was significantly negatively correlated with dental anxiety. Furthermore, rational thinking mediated the effect of mindfulness on dental anxiety. In conclusion, mindfulness is negatively related to both state and trait dental anxiety, and rational thinking mediates the relationship between mindfulness and dental anxiety. Implications of these findings are discussed.
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The aim was to investigate the efficacy of behavioural interventions as treatment of dental anxiety/phobia in adults, by conducting a systematic review of randomized controlled trials (RCTs). The inclusion criteria were defined according to the Patients, Interventions, Controls, Outcome (PICO) methodology. The study samples had documented dental anxiety, measured using validated scales [the Dental Anxiety Scale (DAS) or the Dental Fear Survey (DFS)], or fulfilled the psychiatric criteria for dental phobia. Behavioural interventions included were based on cognitive behavioural therapy (CBT)/behavioural therapy (BT), and control conditions were defined as information, sedation, general anaesthesia, and placebo/no treatment. The outcome variables were level of dental anxiety, acceptance of conventional dental treatment, dental treatability ratings, quality of life and oral health-related quality of life, and complications. This systematic review identified 10 RCT publications. Cognitive behavioural therapy/behavioural therapy resulted in a significant reduction in dental anxiety, as measured using the DAS (mean difference = -2.7), but the results were based on low quality of evidence. There was also some support that CBT/BT improves the patients' acceptance of dental treatment more than general anaesthesia does (low quality of evidence). Thus, there is evidence that behavioural interventions can help adults with dental anxiety/phobia; however, it is clear that more well-designed studies on the subject are needed.
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Objectives: The aim of this study was to investigate the effect of ear-press needle acupuncture on Yintang point for preoperative anxiety. Design: This was a prospective, randomized, single-blind, controlled study. Settings/location: The study setting was the Department of Anesthesiology in Ankara Training and Research Hospital of Ministry of Health, Ankara, Turkey. Subjects: The study comprised 52 adult surgical patients. Interventions: A single, 20-minute session of single-point acupuncture was applied on Yintang (acupuncture group) or sham point (sham acupuncture group). Outcome measures: The efficacy of acupuncture was evaluated by means of the changes in bispectral index (BIS) and STAI (State-Trait Anxiety Index). Results: BIS values in the acupuncture group were significantly lower than in the sham group in all time intervals (p<0.0042). BIS values were lower than baseline in the study group during the entire study period (p<0.0004) while no such effect has been observed in the sham group (p>0.0004). Mean values of state anxiety (STAI-S) decreased after acupuncture in the study group (p=0,018), while no change was observed in trait anxiety (STAI-T) (p=0.156). Patients of the sham group showed no change in both parameters (p=0.387 and p=0,116). Conclusions: Ear-press needle acupuncture on Yintang point reduces preoperative anxiety in adult surgical patients.
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Objectives: The objective of this study was to analyse whether auricular acupuncture, acupuncture at the outer ear, could reduce state anxiety before dental treatment. Methods: This prospective, randomised patient-blinded study with 182 patients compared anxiety before dental treatment following auricular acupuncture at the relaxation-, tranquillizer- and master cerebral points (auricular acupuncture group) versus acupuncture at sham points (finger-, shoulder- and tonsil points; sham group) and a non-intervention control group. Anxiety was assessed using the Spielberger State Trait Anxiety Inventory (German version) before auricular acupuncture and 20 min thereafter, immediately before dental treatment. Results: Auricular acupuncture reduced state anxiety score more effectively from 54.7 ± 10.8 to 46.9 ± 10.4 (mean ± SD) than sham acupuncture from 51.9 ± 10.2 to 48.4 ± 10.0. In contrast, state anxiety in the control group increased from 51.0 ± 11.7 to 54.0 ± 11.6 (mean increase +3.0; CI +4.7 to +1.2). The decrease in state anxiety in both intervention groups was statistically significant (p < 0.001) when compared to the non-intervention control group. After correcting for group differences in baseline state anxiety, the reduction in anxiety was -7.3 score points (CI -9.0 to -5.6) in the auricular acupuncture group and -3.7 score points (CI -5.4 to -1.9) in the sham group (p = 0.008). Conclusion: Auricular acupuncture, a minimally invasive method, effectively reduces state anxiety before dental treatment. Clinical relevance: Auricular acupuncture could be an option for patients scheduled for dental treatment, who experience an uncomfortable degree of anxiety and request an acute intervention for their anxiety.
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Noninvasive methods advocated by some clinicians are not very successful in dealing with patient gagging, while sedation approaches run the risk of the patient aspirating foreign bodies. The P-6 Neikuan acupuncture point, located on the wrist, has been used in the Far East for thousands of years for its anti-nausea and anti-anxiety properties. In the West, it is the acupuncture point most studied. Only recently has interest been shown in the P-6 point for its possible anti-gagging effect. The anti-gagging effect of P-6 stimulation is documented in this article. The P-6 point has remarkable anti-gagging effects if stimulation is applied correctly. Clinicians may apply thumb pressure at the P-6 point to achieve some effect, although this is not as effective as acupuncture. Nevertheless, a substantial percentage of gagging patients would be able to go through dental procedures without gagging when the P-6 point is stimulated.
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Implications: Ear acupuncture can decrease preoperative anxiety in adults undergoing outpatient surgery.
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Auricular acupuncture can be an effective treatment for acute anxiety, but there is a lack of direct comparisons of acupuncture to proven standard drug treatments. In this study we compared the efficacy of auricular acupuncture with intranasal midazolam, placebo acupuncture, and no treatment for reducing dental anxiety. Patients having dental extractions (n = 67) were randomized to (i) auricular acupuncture, (ii) placebo acupuncture, and (iii) intranasal midazolam and compared with a no treatment group. Anxiety was assessed before the interventions, at 30 min, and after the dental extraction. Physiological variables were assessed continuously. With the no treatment group as control, the auricular acupuncture group, and the midazolam group were significantly less anxious at 30 min as compared with patients in the placebo acupuncture group (Spielberger Stait-Trait Anxiety Inventory X1, P = 0.012 and <0.001, respectively). In addition, patient compliance assessed by the dentist was significantly improved if auricular acupuncture or application of intranasal midazolam had been performed (P = 0.032 and 0.049, respectively). In conclusion, both, auricular acupuncture and intranasal midazolam were similarly effective for the treatment of dental anxiety.
Article
The data presented in this article was collected after reviewing clinical findings gathered from using various anxiety control methods on apprehensive patients. We examined clinical applications of the eye movement (EM) component of Eye Movement Desensitization (EMD) on fearful dental patients who have histories of traumatic dental experiences. We also used Bi-Digital O-Ring Test (BDORT) to select the proper dosage of sedative to minimize the adverse side effects. For patients who did not respond well to EM, we used BDORT to select the proper sedative medication and its dosage. In certain difficult cases, we supplemented these techniques with acupuncture to augment the sedative effects. Findings were based on the clinical impressions and assessments of both the patients and the operating team. Results showed that EM, although effective in enabling patients to undergo non-invasive dental procedures such as clinical examination and simple prophylaxis, had only limited beneficial effect with invasive procedures such as extraction, drilling, and injections, etc. We also found that BDORT greatly reduced adverse side effects of sedatives such as hypertension, hypotension, hypoxia, tachycardia, bradycardia, nausea, and vomiting. For most apprehensive patients, we found that EMD and acupuncture combined with BDORT predetermined dosage for the submucosal sedation enabled these patients to undergo the complete dental treatment. The authors try to explain the mechanism of BDORT and EM in terms of visual awareness (or consciousness) and preferred patterns, where neurons in the brain respond to the actions and/or direction of movement. The authors believe that BDORT and EM could have better results if the persons performing BDORT have visual awareness and are focused on the task; whereas in EM, the patient's eye on the therapist's hand movements. A more focused approach via visual pathway will result in more favorable results in EM. Likewise, performing BDORT absentmindedly could lead to false results if visual awareness (or consciousness) is absent. "Preferred pattern" will arouse neurons in the brain to cause conscientiousness, and performing BDORT with 'open eyes' arouse the necessary visual awareness that is necessary for the successful performance of BDORT tasks.
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