Background: Adopted children have been said to be difficult children, scarred by their past experiences in maltreating families or neglecting orphanages, or by genetic or pre- and perinatal problems. Is (domestic or international) adoption an effective intervention in the developmental domains of physical growth, attachment security, cognitive development and school achievement, self-esteem, and beha- viour problems? Method: Through a series of meta-analyses on more than 270 studies that include more than 230,000 adopted and non-adopted children and their parents an adoption catch-up model was tested. Results: Although catch-up with current peers was incomplete in some developmental domains (in particular, physical growth and attachment), adopted children largely outperformed their peers left behind. Adoptions before 12 months of age were associated with more complete catch-up than later adoptions for height, attachment, and school achievement. International adoptions did not lead to lower rates of catch-up than domestic adoptions in most developmental domains. Conclusions: It is concluded that adoption is an effective intervention leading to massive catch-up. Domestic and inter- national adoptions can be justified on ethical grounds if no other solutions are available. Humans are adapted to adopt, and adoption demonstrates the plasticity of child development. Keywords: Adop- tion, meta-analysis, catch-up, developmental plasticity, ethics, growth, attachment, behaviour prob- lems, brain damage, malnutrition, residential care, resilience, self-esteem. Adoption may be defined as the permanent, legal placement of an abandoned, relinquished or or- phaned child within a family of relatives (kinship adoption) or within an unrelated family (non-kinship adoption). Selman (2005) estimated the number of children adopted across the borders of countries (international, mostly non-kinship adoption) to be at least 40,000 in 2003, which is an increase of 100% since the late eighties. The number of adoptions within countries (domestic adoptions) is harder to estimate. In the USA alone, 120,000 children are adopted annually, their total number amounting to