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S2 Table

Authors:
Cesar de Cesar Netto at Duke University
Cesar de Cesar Netto
Alexandre Leme Godoy-Santos at University of São Paulo
Alexandre Leme Godoy-Santos
Pedro Augusto Pontin at University of São Paulo
Pedro Augusto Pontin
Renato Natalino at University of São Paulo
Renato Natalino
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Abstract

Complete statistical analysis. (1) Stiffness, (2) Young’s modulus, (3) yield tension, (4) yield stress, (5) ultimate tension, (6) ultimate stress, (7) cross sectional area, (8) histological Bonar score. (DOCX)
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COMPLETE STATISTICAL ANALYSIS
1. Stiffness
Group Week n Mean Std Dev Minimum Median Maximum
Control 16 weeks 7 91.4 23.71 43.67 92.01 113.91
High-Dose
10 weeks 5 43.43 13.61 29.24 41.87 62.42
12 weeks 4 61.02 18.84 33.06 69.21 72.61
16 weeks 4 57.83 16.06 37.36 58.7 76.54
Low-Dose
10 weeks 5 84.27 33.11 54.41 67.5 131.17
12 weeks 4 64.85 5.9 59 64.25 71.89
16 weeks 5 60.34 35.94 24.46 63.71 115.72
Source DF Sum of
Squares
Mean
Square F Value p-value
Model 6 9115.522 1519.254 2.63 0.0388
Group 2 6717.966 3358.983 5.81 0.008 *
Week 2 164.023 82.011 0.14 0.8684
Group*Week 2 2233.534 1116.767 1.93 0.1644
Error 27 15609.920 578.145
Total 33 24725.443
Week Comparison between groups Difference CI (95%)
10
weeks High-Dose - Control -47.97 -76.85 -19.08 *
Low-Dose - Control -7.13 -36.02 21.76
Low-Dose - High-Dose 40.83 9.63 72.04 *
12
weeks High-Dose - Control -30.38 -61.30 0.55
Low-Dose - Control -26.55 -57.48 4.37
Low-Dose - High-Dose 3.83 -31.06 38.71
16
weeks High-Dose - Control -33.58 -64.50 -2.65 *
Low-Dose - Control -31.06 -59.95 -2.17 *
Low-Dose - High-Dose 2.51 -30.58 35.61
Group Comparison between
weeks Difference CI (95%)
Low-Dose 12 weeks - 10 weeks -19.42 -52.52 13.67
16 weeks - 10 weeks -23.93 -55.13 7.27
16 weeks - 12 weeks -4.51 -37.60 28.59
High-Dose 12 weeks - 10 weeks 17.59 -15.51 50.68
16 weeks - 10 weeks 14.39 -18.70 47.49
16 weeks - 12 weeks -3.20 -38.08 31.69
2. Young's Modulus
Group Week n Mean Std Dev Minimum Median Maximum
Control 16 weeks 7 301 116.32 134.84 286.92 512.78
High-Dose
10 weeks 5 75 43.98 31.25 57.02 144.83
12 weeks 4 233.56 87.15 113.07 251.6 317.95
16 weeks 4 191.19 52.54 115.77 207.22 234.54
Low-Dose
10 weeks 5 219.63 135.5 115.28 177.07 456.99
12 weeks 4 130.22 50.17 73.03 135.12 177.59
16 weeks 5 129.46 81.76 23.73 135.34 250.23
Source DF Sum of
Squares
Mean
Square F Value p-value
Model 6196972.83
6
32828.80
63.89 0.0063
Group 2109372.80
5
54686.40
36.48 0.005 *
Week 2 5522.438 2761.219 0.33 0.7236
Group*Week 2 82077.594 41038.79
74.87 0.0157 *
Error 27 227727.95
38434.369
Total 33 424700.78
9
Week Comparison between groups Difference CI (95%)
10
weeks High-Dose - Control -226.00 -336.34 -115.66 *
Low-Dose - Control -81.36 -191.70 28.97
Low-Dose - High-Dose 144.64 25.46 263.81 *
12
weeks High-Dose - Control -67.44 -185.55 50.67
Low-Dose - Control -170.78 -288.89 -52.67 *
Low-Dose - High-Dose -103.34 -236.59 29.91
16
weeks High-Dose - Control -109.81 -227.92 8.30
Low-Dose - Control -171.54 -281.88 -61.20 *
Low-Dose - High-Dose -61.73 -188.13 64.68
Group Comparison between
weeks Difference CI (95%)
Low-Dose 12 weeks - 10 weeks -89.42 -215.82 36.99
16 weeks - 10 weeks -90.17 -209.35 29.00
16 weeks - 12 weeks -0.76 -127.16 125.65
High-Dose 12 weeks - 10 weeks 158.56 32.15 284.97 *
16 weeks - 10 weeks 116.19 -10.22 242.60
16 weeks - 12 weeks -42.37 -175.62 90.88
3. Yield Tension
Group Week n Mean Std Dev Minimum Median Maximum
Control 16 weeks 7 215.24 55.88 139.67 202.53 274.45
High-Dose
10 weeks 5 117.56 42.37 68.79 102.79 180.02
12 weeks 4 205.23 46.8 165.73 191.14 272.92
16 weeks 4 164.73 62.68 77.45 183.77 213.93
Low-Dose
10 weeks 5 271.1 87.4 138.01 268.12 366.81
12 weeks 4 251.42 100.81 157.43 231.81 384.64
16 weeks 5 155.34 98.08 65.84 109.25 283.19
Source DF Sum of
Squares
Mean
Square F Value p-value
Model 6 86293.182 14382.19
72.7 0.0348
Group 2 31356.788 15678.39
42.94 0.0697
Week 2 22383.277 11191.639 2.1 0.1418
Group*Week 2 32553.116 16276.55
83.06 0.0636
Error 27 143790.31
95325.567
Total 33 230083.50
1
4. Yield Stress
Group Week n Mean Std Dev Minimum Median Maximum
Control 16 weeks 7 23.46 8.78 11.81 22.42 37.51
High-Dose
10 weeks 5 4.73 2.15 2.11 6.01 6.71
12 weeks 4 20.01 3.31 15.73 20.31 23.7
16 weeks 4 14.47 6.14 5.71 16.13 19.93
Low-Dose
10 weeks 5 17.91 9.93 9.51 14.02 34.82
12 weeks 4 14.06 0.73 13.09 14.16 14.85
16 weeks 5 9.09 6.72 1.38 6.27 16.4
Source DF Sum of
Squares
Mean
Square F Value p-value
Model 6 1348.812 224.802 5.04 0.0014
Group 2 610.096 305.048 6.84 0.004 *
Week 2 181.362 90.681 2.03 0.1504
Group*Week 2 557.355 278.677 6.25 0.0059 *
Error 27 1204.036 44.594
Total 33 2552.848
Week Comparison between groups Difference CI (95%)
10
weeks High-Dose - Control -18.73 -26.75 -10.71 *
Low-Dose - Control -5.55 -13.57 2.48
Low-Dose - High-Dose 13.18 4.52 21.85 *
12
weeks High-Dose - Control -3.44 -12.03 5.14
Low-Dose - Control -9.39 -17.98 -0.81 *
Low-Dose - High-Dose -5.95 -15.64 3.74
16
weeks High-Dose - Control -8.98 -17.57 -0.40 *
Low-Dose - Control -14.36 -22.39 -6.34 *
Low-Dose - High-Dose -5.38 -14.57 3.81
Group Comparison between
weeks Difference CI (95%)
Low-Dose 12 weeks - 10 weeks -3.85 -13.04 5.34
16 weeks - 10 weeks -8.82 -17.48 -0.15 *
16 weeks - 12 weeks -4.97 -14.16 4.22
High-Dose 12 weeks - 10 weeks 15.29 6.10 24.48 *
16 weeks - 10 weeks 9.75 0.56 18.94 *
16 weeks - 12 weeks -5.54 -15.23 4.15
5. Ultimate Tension
Group Week n Mean Std Dev Minimum Median Maximum
Control 16 weeks 7 267.29 50.12 163.03 275.63 311.85
High-Dose
10 weeks 5 168.17 59.6 100.62 202.42 216.25
12 weeks 4 248 50.45 203.53 240.74 306.99
16 weeks 4 253.67 95.32 110.82 299.46 304.94
Low-Dose
10 weeks 5 389.14 105.68 222.28 388.75 503.38
12 weeks 4 335.53 83.78 260.72 333.16 415.1
16 weeks 5 213.84 127.13 111.49 129.06 384.93
Source DF Sum of
Squares
Mean
Square F Value p-value
Model 6158503.20
8
26417.20
13.67 0.0086
Group 2 57275.577 28637.78
93.97 0.0307 *
Week 2 21047.272 10523.63
61.46 0.2499
Group*Week 2 80180.359 40090.17
95.56 0.0095 *
Error 27 194549.17
97205.525
Total 33 353052.38
8
Week Comparison between groups Difference CI (95%)
10
weeks High-Dose - Control -99.12 -201.10 2.87
Low-Dose - Control 121.86 19.87 223.84 *
Low-Dose - High-Dose 220.97 110.82 331.13 *
12
weeks High-Dose - Control -19.29 -128.46 89.88
Low-Dose - Control 68.24 -40.92 177.41
Low-Dose - High-Dose 87.54 -35.62 210.69
16
weeks High-Dose - Control -13.62 -122.79 95.55
Low-Dose - Control -53.45 -155.43 48.54
Low-Dose - High-Dose -39.83 -156.66 77.01
Group Comparison between
weeks Difference CI (95%)
Low-Dose 12 weeks - 10 weeks -53.61 -170.45 63.23
16 weeks - 10 weeks -175.30 -285.46 -65.15 *
16 weeks - 12 weeks -121.69 -238.53 -4.86 *
High-Dose 12 weeks - 10 weeks 79.83 -37.01 196.66
16 weeks - 10 weeks 85.50 -31.34 202.33
16 weeks - 12 weeks 5.67 -117.49 128.83
6. Ultimate Stress
Group Week n Mean Std Dev Minimum Median Maximum
Control 16 weeks 7 28.86 8.13 13.79 29.84 41.3
High-Dose
10 weeks 5 7.13 4.16 2.87 8.04 12.64
12 weeks 4 24.59 6.33 17.53 23.94 32.93
16 weeks 4 22.4 9.61 8.18 26.25 28.9
Low-Dose
10 weeks 5 25.08 10.59 15.32 21.09 42.73
12 weeks 4 19.67 3.58 15.23 19.74 23.96
16 weeks 5 12.43 8.93 2.33 9.88 21.87
Source DF Sum of
Squares
Mean
Square F Value p-value
Model 6 1896.612 316.102 5.11 0.0013
Group 2 661.208 330.604 5.35 0.0111 *
Week 2 185.604 92.802 1.5 0.241
Group*Week 2 1049.801 524.901 8.49 0.0014 *
Error 27 1669.662 61.839
Total 33 3566.274
Week Comparison between groups Difference CI (95%)
10
weeks High-Dose - Control -21.73 -31.18 -12.28 *
Low-Dose - Control -3.78 -13.23 5.67
Low-Dose - High-Dose 17.95 7.75 28.15 *
12
weeks High-Dose - Control -4.28 -14.39 5.84
Low-Dose - Control -9.20 -19.31 0.92
Low-Dose - High-Dose -4.92 -16.33 6.49
16
weeks High-Dose - Control -6.47 -16.58 3.65
Low-Dose - Control -16.43 -25.88 -6.99 *
Low-Dose - High-Dose -9.97 -20.79 0.86
Group Comparison between
weeks Difference CI (95%)
Low-Dose 12 weeks - 10 weeks -5.42 -16.24 5.41
16 weeks - 10 weeks -12.65 -22.86 -2.45 *
16 weeks - 12 weeks -7.24 -18.06 3.59
High-Dose 12 weeks - 10 weeks 17.45 6.63 28.27 *
16 weeks - 10 weeks 15.26 4.44 26.08 *
16 weeks - 12 weeks -2.19 -13.60 9.22
7. Cross-Sectional Area
Group Week n Mean Std Dev Minimum Median Maximum
Control 16 weeks 7 9.59 1.48 6.98 9.89 11.82
High-Dose
10 weeks 5 27.17 7.88 17.11 26.84 36.87
12 weeks 4 10.29 1.69 8.42 10.42 11.9
16 weeks 4 11.75 1.42 10.5 11.47 13.55
Low-Dose
10 weeks 5 16.6 5.4 10.53 14.87 24.99
12 weeks 4 18.01 7.45 11.09 16.84 27.26
16 weeks 5 22.61 14.36 13.06 17.77 47.83
Group Group2 n Mean Std Dev Minimum Median Maximum
Control 16 weeks 7 2.25 0.16 1.94 2.29 2.47
High-Dose
10 weeks 5 3.27 0.3 2.84 3.29 3.61
12 weeks 4 2.32 0.17 2.13 2.34 2.48
16 weeks 4 2.46 0.12 2.35 2.44 2.61
Low-Dose
10 weeks 5 2.77 0.32 2.35 2.7 3.22
12 weeks 4 2.83 0.42 2.41 2.8 3.31
16 weeks 5 3 0.52 2.57 2.88 3.87
Source DF Sum of
Squares
Mean
Square F Value p-value
Model 6 4.349 0.725 7.41 <.0001
Group 2 1.809 0.904 9.24 0.0009 *
Week 2 0.906 0.453 4.63 0.0187 *
Group*Week 2 1.635 0.817 8.36 0.0015 *
Error 27 2.641 0.098
Total 33 6.991
Week Comparison between groups Difference CI (95%)
10
weeks High-Dose - Control 1.02 0.64 1.39 *
Low-Dose - Control 0.52 0.14 0.89 *
Low-Dose - High-Dose -0.50 -0.90 -0.09 *
12
weeks High-Dose - Control 0.07 -0.33 0.47
Low-Dose - Control 0.58 0.17 0.98 *
Low-Dose - High-Dose 0.50 0.05 0.96 *
16
weeks High-Dose - Control 0.21 -0.19 0.61
Low-Dose - Control 0.75 0.37 1.12 *
Low-Dose - High-Dose 0.54 0.11 0.97 *
Group Comparison between
weeks Difference CI (95%)
Low-Dose 12 weeks - 10 weeks 0.06 -0.37 0.49
16 weeks - 10 weeks 0.23 -0.18 0.63
16 weeks - 12 weeks 0.17 -0.26 0.60
High-Dose 12 weeks - 10 weeks -0.95 -1.38 -0.51 *
16 weeks - 10 weeks -0.81 -1.24 -0.38 *
16 weeks - 12 weeks 0.14 -0.32 0.59
8. Histological Bonar Score
Group Time-
Point n Mean Std Dev Minimum Median Maximum
Control 16 weeks 8 2 0.82 1 2 3
High-Dose
10 weeks 5 12.8 0.84 12 13 14
12 weeks 4 4.5 1.91 2 5 6
16 weeks 5 5.6 2.51 2 5 8
Low-Dose
10 weeks 5 11.6 0.55 11 12 12
12 weeks 6 8 2.1 6 7.5 11
16 weeks 5 11.8 2.28 8 12 14
Source DF Sum of
Squares
Mean
Square
F
Value p-value
Model 6 580.676 96.779 33.37 <.0001
Group 2 336.524 168.262 58.02 <.0001 *
Week 2 174.080 87.040 30.01 <.0001 *
Group*Week 2 70.072 35.036 12.08 0.0001 *
Error 30 87.000 2.900
Total 36 667.676
Week Comparison between groups Difference CI (95%)
10
weeks High-Dose - Control 10.80 8.76 12.84 *
Low-Dose - Control 9.60 7.56 11.64 *
Low-Dose - High-Dose -1.20 -3.40 1.00
12
weeks High-Dose - Control 2.50 0.32 4.68 *
Low-Dose - Control 6.00 4.07 7.93 *
Low-Dose - High-Dose 3.50 1.26 5.74 *
16
weeks High-Dose - Control 3.60 1.56 5.64 *
Low-Dose - Control 9.80 7.76 11.84 *
Low-Dose - High-Dose 6.20 4.00 8.40 *
Group Comparison between weeks Difference CI (95%)
Low-Dose 12 weeks - 10 weeks -3.60 -5.71 -1.49 *
16 weeks - 10 weeks 0.20 -2.00 2.40
16 weeks - 12 weeks 3.80 1.69 5.91 *
High-Dose 12 weeks - 10 weeks -8.30 -10.63 -5.97 *
16 weeks - 10 weeks -7.20 -9.40 -5.00 *
16 weeks - 12 weeks 1.10 -1.23 3.43

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