A multiple treatment reversal design was used to evaluate the effects of three different antecedent-based interventions on the post-use cleaning of gym equipment. Unidentified students, faculty, staff, and community members participated in this study. An announcement, signs, and signs together with increased accessibility to cleaning materials were evaluated. The highest level of post-use cleaning was observed under the signs plus accessibility condition. These results indicate that the use of antecedent-based interventions may be a viable option for increasing cleaning behavior.