Pomelo (Citrus grandis L.), well-known as Chinese grapefruit or shaddock, or chakotra (in Hindi) is belongs to the genus Rutaceae and originated from warm tropical climates in Southeast Asia. The fruit composed of yellowish or greenish skin, white, or pinkish flesh, so commonly classified as white or pink type. It tastes sweet, slight acidic and bitter. Pomelo fruit width ranges in between 10.00 and 30.00 cm and weight range from 1.00 to 2.00 kg dependent on the type of cultivars. The fruit is generally consumed as fruits, juice, as dip with salt mixture, preserved snacks, or used in salad. Major portion of fruit is water, and it is excellent source of amino acid, minerals (like K, P), folic acid, and vitamins like vitamin C, thiamin, riboflavin, and B12, and antioxidants like β-carotene, polyphenols, terpenoids, alkaloids, β-sitosterol, flavonoids (mainly neohesperidin, naringenin, hesperidin, naringin) and essential oils. Citrus fruits, such as Pomelo, have shown enhanced antioxidant capabilities, antimicrobial, anti-inflammatory, hypolipidemic, hypoglycemic, and anticancer effects, additionally, it helps cure skin issues, diabetes, scurvy, and urinary disorders. There is a detailed description of the extraction and application of antioxidant components as well as the health benefits of pomelo juice, peel, and seeds in this section.