No full-text available
To read the full-text of this research,
you can request a copy directly from the authors.
Caralluma fimbriata - Pharmacological review
Abstract
Caralluma fimbriata (CF) has been used as an appetite suppressant herb for millennia. It also has antioxidant, antidiabetic, and nootropic actions. It is proved that it is a natural antiobesogenic agent and is widely consumed in India. It's actions like anti-artherosclerotic and analgesic is of high medicinal value. The objective of this article is to highlight various uses of CF along with its use in medical problems.
... Flowers bloom either singly or in groups at the ends of branches on short stalks. Its flowers are 2 cm in diameter, with small petals of purple color marked with golden and hairy borders [19]. Natural bioactive supplements are becoming increasingly popular for weight reduction, and C. fimbriata is currently regarded as one such functional plant that has exhibited potential outcomes [20]. ...
... Supplementation with C. fimbriata can lead to a clinically meaningful reduction in central adiposity, a key component of MS associated with other risk factors such as elevated blood pressure and cardiovascular disease. It contains pregnane glycosides, a class of naturally occurring compounds believed to inhibit the formation of fat [19]. A study revealed that a 14-year-old girl with Prader-Willi syndrome (PWS) was successfully treated for hyperphagia. ...
Metabolic syndrome (MS), commonly known as syndrome X or insulin resistance syndrome, is a collection of risk factors for cardiovascular diseases and type II diabetes. MS is believed to impact over a billion individuals worldwide. It is a medical condition defined by visceral obesity, insulin resistance, high blood pressure, and abnormal cholesterol levels, according to the World Health Organization. The current dietary trends are more focused on the use of functional foods and nutraceuticals that are well known for their preventive and curative role against such pathological disorders. Caralluma fimbriata is one such medicinal plant that is gaining popularity. It is a wild, edible, succulent roadside shrub with cactus-like leaves. Besides its main nutrient contents, various bioactive constituents have been identified and linked with positive health outcomes of appetite-suppressing, hypolipidemic, antioxidant, hepatoprotective, and anticancer potentials. Hence, such properties make C. fimbriata an invaluable plant against MS. The current review compiles recent available literature on C. fimbriata’s nutritional composition, safety parameters, and therapeutic potential for MS. Summarized data in this review reveals that C. fimbriata remains a neglected plant with limited food and therapeutic applications. Yet various studies explored here do prove its positive health-ameliorating outcomes.
... food of India' is used (Bouarab-Chibane et al., 2019;Jayawardena et al., 2021;Gujjala et al., 2017;Asmi et al., 2017;Lakshmi et al., 2014). The present study is performed to screen for the effective phytochemicals present in different extracts (petroleum ether, ethanol and aqueous) of dry and wet samples of C.fimbriata in terms of quantitatively and qualitatively as shown in Fig. 1, where one see both dry and wet C. fimbriata. ...
To compare the phytochemicals and evaluate the antioxidant, antidiabetic and antimicrobial activity of different extracts (petroleum ether, ethanol and aqueous) of dry and wet samples of Caralluma fimbriata (C. fimbriata) is proposed. Phytochemicals are screened in all the extracts by standard methods and total alkaloids, flavonoids, phenols and tannins are quantified by High-Performance Liquid Chromatography (HPLC). The elemental profiling and proximate analysis are carried out to determine the nutritive value of C. fimbriata. Further the evaluation of antioxidant activities by 2, 2-diphenyl-picrylhydrazyl (DPPH), 2, 2-azino-bis-3-ethylenebenzothiozoline-6-sulfonic acid (ABTS) radical scavenging activity, Ferric Reducing Ability of Plasma (FRAP), Super Oxide Dismutase (SOD) assay and antidiabetic activity by α-amylase and α glucosidase inhibition are performed. The antimicrobial activity of the extracts is determined in vitro by MIC (minimum inhibition Concentration). Results revealed that the phytochemical components tested are present in varying concentrations in all the extracts corresponding to differences in their antioxidant, free radical scavenging activities, antidiabetic and antimicrobial activities with high nutritive value. Therefore, one can conclude that there is a significant correlation between the phytochemicals and activities exhibited by C. fimbriata. The comparative study on wet and dry extracts of Caralluma fimbriata for phytochemicals and therapeutic activity evaluation face challenges related to maintaining consistent extraction conditions between wet and dry methods, ensuring accurate quantification of phytochemical compounds, and establishing relevant and reliable therapeutic activity assays. Additionally, variability in the composition of plant material due to environmental factors and batch-to-batch variations could introduce complexity to the study. The challenges of the study include controlling for variability in plant material, optimizing extraction methods for both wet and dry extracts, and establishing reliable methods for phytochemical analysis and therapeutic activity evaluation.
ResearchGate has not been able to resolve any references for this publication.