Author and Affiliations-Purpose: Yoga is well known for improving oxygenation to the biological system and combating oxidative stress which is responsible for numerous lifestyle diseases which includes type 2 diabetes and hypertension. Therefore, the present study was conducted to evaluate the effects of yoga in modifying and improving the quality of life in type II diabetic with hypertension patients. Methods: An interventional, prospective and open labeled study was done involving 30 patients of type 2 diabetes along with hypertension. Patients received yoga therapy for 45 days along with the standard treatment. Oxidative stress markers such as changes in RBC morphology (crenated edges and Heinz bodies), malondialdehyde levels along with fasting blood glucose levels, systolic & diastolic blood pressure, body mass index and symptoms associated with type 2 diabetes were evaluated before and at the end of the yoga therapy. Results: Abnormal RBCs were markedly reduced as according to the severity ranking assessed after 45 days of yoga therapy. Significant reduction in the levels of malondialdehyde (P<0.01), blood glucose (P<0.05), Systolic blood pressure (P<0.01) body mass index (P<0.001) and improvement in the unpleasant symptoms were observed after yoga therapy when compared to same patients before starting yoga therapy. Conclusion: These findings suggest that yoga intervention has therapeutic values in patients having type 2 diabetes with hypertension. This may have direct impact on the dose minimization of hypoglycemic drugs of the patient which requires further study in this area. © 2018, Association of Physiologists and Pharmacologists of India. All rights reserved.