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Abstract

Introduction and hypothesisWomen expel various kinds of fluids during sexual activities. These are manifestations of sexual arousal and orgasm or coital incontinence. This study is aimed at suggesting a diagnostic scheme to differentiate among these phenomena. Methods Web of Science and Ovid (MEDLINE) databases were systematically searched from 1950 to 2017 for articles on various fluid expulsion phenomena in women during sexual activities, which contain relevant information on sources and composition of the expelled fluids. ResultsAn ultra-filtrate of blood plasma of variable quantity, which is composed of transvaginal transudate at sexual stimulation, enables vaginal lubrication. Female ejaculation (FE) is the secretion of a few milliliters of thick, milky fluid by the female prostate (Skene’s glands) during orgasm, which contains prostate-specific antigen. Squirting (SQ) is defined as the orgasmic transurethral expulsion of tenths of milliliters of a form of urine containing various concentrations of urea, creatinine, and uric acid. FE and SQ are two phenomena with different mechanisms. Coital incontinence (CI) could be classified into penetration and orgasm forms, which could be associated with stress urinary incontinence or detrusor hyperactivity. Conclusion Squirting, FE, and CI are different phenomena with various mechanisms and could be differentiated according to source, quantity, expulsion mechanism, and subjective feelings during sexual activities.
REVIEW ARTICLE
Differential diagnostics of female Bsexual^fluids: a narrative review
Zlatko Pastor
1,2,3
&Roman Chmel
1
Received: 9 October 2017 /Accepted: 24 November 2017
#The International Urogynecological Association 2017
Abstract
Introduction and hypothesis Women expel various kinds of fluids during sexual activities. These are manifestations of sexual
arousal and orgasm or coital incontinence. This study is aimed at suggesting a diagnostic scheme to differentiate among these
phenomena.
Methods Web of Science and Ovid (MEDLINE) databases were systematically searched from 1950 to 2017 for articles on
various fluid expulsion phenomena in women during sexual activities, which contain relevant information on sources and
composition of the expelled fluids.
Results An ultra-filtrate of blood plasma of variable quantity, which is composed of transvaginal transudate at sexual stimulation,
enables vaginal lubrication. Female ejaculation (FE) is the secretion of a few milliliters of thick, milky fluid by the female prostate
(Skenes glands) during orgasm, which contains prostate-specific antigen. Squirting (SQ) is defined as the orgasmic transurethral
expulsion of tenths of milliliters of a form of urine containing various concentrations of urea, creatinine, and uric acid. FE and SQ
are two phenomena with different mechanisms. Coital incontinence (CI) could be classified into penetration and orgasm forms,
which could be associated with stress urinary incontinence or detrusor hyperactivity.
Conclusion Squirting, FE, and CI are different phenomena with various mechanisms and could be differentiated according to
source, quantity, expulsion mechanism, and subjective feelings during sexual activities.
Keywords Female ejaculation .Squirting .Coital incontinence .Female prostate .Vaginal lubrication
Introduction
Women expel various kinds of fluids during sexual activi-
ties [1]. The prevalence is around 1054% [25], and the
quantity of the fluid ranges from 0.3 to 900 mL [510].
Expulsion may be manifested by the feelings of wetness,
secretion, discharge, or massive fluid emission.
Controversial opinions on the fluidsorigin, quantity, com-
position, and expulsion mechanism exist [11], and discrep-
ancy in terminology, inaccurate characteristics, and unclear
fluidexpulsionmechanismshaveresultedinanincorrect
understanding. Most often, the fluids are described as fe-
male ejaculation because of its similarity to male ejacula-
tion. Previous research reported that Skenes paraurethral
glands (the female prostate) are the source of expulsion
[26,12,13]. Moreover, discrepancy in the amount of
expelled fluid [25,9] and the prevalence of various ex-
pulsions [59] were associated with the erroneous assump-
tion that the fluids expelled were identical and from the
same source. Currently, the expelled fluids could be related
to various phenomena [10,14,15]. A smaller volume of
fluids may be expelled by the female prostate [7,8,10,13,
1621], vagina [22], or Bartholinsglands[23]. A larger
volume could originate from the urinary bladder [6,7,10,
14,15]. Fluid emission could be a common and desirable
manifestation of sexual arousal (vaginal lubrication), a
physiological sexual response (squirting, SQ; female ejac-
ulation, FE), a result of coital incontinence (CI), or a com-
bination of various fluids.
The aim of our review was to identify the sources of
fluids expelled during sexual activities; compare their
volume, biochemical composition, and expulsion
*Zlatko Pastor
pastor.zlatko@volny.cz
1
Obstetrics and Gynecology Department, 2nd Faculty of Medicine,
University Hospital Motol, Charles University, Prague, V Úvalu 84,
Prague 5, Czech Republic
2
National Institute of Mental Health, Klecany, Czech Republic
3
Institute of Sexology, 1st Faculty of Medicine, Charles University,
Prague, Czech Republic
International Urogynecology Journal
https://doi.org/10.1007/s00192-017-3527-9
mechanism; create a scheme based on their characteris-
tics for differential diagnostics of similar but physiolog-
ically different phenomena; and distinguish pathological
conditions from physiological manifestations of sexual
arousal.
Materials and methods
Literature search
We conducted a comprehensive and systematic search of
the international databases Web of Science and Ovid
(MEDLINE). These databases were searched for the peri-
od 1950 to 2017. The search was performed in June 2017
with the following terms: Bfemale ejaculation^AND
Borgasm,^Bfemale ejaculation^AND Bfemale prostate,^
Bsquirting^AND Borgasm,^Bvaginal lubrication^OR
Bsecretion^AND Borgasm,^and Bcoital incontinence^
AND Borgasm.^The search was then refined to Bhuman^
and Bwomen.^In addition, we performed a manual search
and scanned the reference list of selected articles. To ob-
tain appropriate articles related to a comparison between
male and female prostates and their secretion capacity, we
search for Bmale prostate^AND Bsperm^OR Bsemen^
AND BWHO.^
Selection of studies and data analysis
EndNoteOnline(ClarivateAnalytics, Philadelphia, PA,
USA) was used for the preparation of the reference list.
We assessed the quality of the studies; confirmed the eli-
gibility of the titles, abstracts, and full texts; and indepen-
dently selected the titles and abstracts twice. To define the
differential diagnosis of FE and SQ, manuscripts without
exact information about the quantity, composition, and flu-
id expulsion mechanism were excluded. Studies that
assessed the previously mentioned phenomena based on
womens subjective feelings or on research questionnaire
were not included. Only reviews containing a comprehen-
sive analysis were included. In the case of CI, articles
showing no correlations with urine leakage during sexual
activities and in which the type of urinary incontinence
was not verified by urodynamic investigation were exclud-
ed. We read the full text of the articles and made the selec-
tion based on the aforementioned eligibility criteria.
Because of the small number of studies and patients and
the studiesheterogeneity, we could not use meta-
analytical methods. Hence, this review was based on a
descriptive analysis of selected articles; our study is pre-
sented as a narrative synthesis of selected studies. We used
semi-quantitative characteristics of the phenomena for
higher variability of the results and better compre
hensibility.
Fig. 1 The selection process
Int Urogynecol J
Characteristics of selected studies
Our search yielded 622 citations, of which 75 studies
were retrieved (in full text). Fifty-three studies published
from 1950 to 2017 were included in the list. Five book
chapters and two reports by the World Health
Organization (WHO) and International Urogynecological
Association (IUGA) were added. Figure 1shows the se-
lection process.
A total of 63 studies with relevantinformation (FE, 27; SQ,
4; female prostate, 15; vaginal lubrication, 15; CI, 13; male
prostate and semen parameters, 7; Table 1)wereincludedin
the review. Some of the studies reported on several topics
simultaneously, and the information overlapped.
Results
Women may expel fluids during sexual activities from the
vagina, urinary bladder, and female prostate (Fig. 2).
Lubrication fluid (LF) originates from the vagina; urinary
bladder is the source of the fluids expelled at SQ or CI.
FE originates from the female prostate; female prostate
secretion may also contaminate other fluids, especially
during SQ.
The fluids differ from each other according to the source,
expulsion mechanism, volume, color, density, chemical com-
position (prostate-specific antigen [PSA], uric acid, urea, cre-
atinine, sodium, potassium, chloride), pH, manifestations, and
womenssubjectivefeelings(Table2).
Vaginal lubrication fluid
Lubrication fluid is an ultra-filtrate of blood plasma. Blood flow
in the genital area is increased during sexual arousal, and LF
from the vaginal venous plexus enters the vaginal lumen
transvaginally [25,32,36]. The vaginal fluid may also contain
peritoneal and follicular fluid, uterine fluid, cervical fluid, and
secretions from BartholinsandSkenesglands[28]. The daily
production is approximately 6 g [32]. LF is characterized by
high potassium and low sodium concentrations compared with
plasma [29] and has an average pH of 4.7 (range, 3.46.4) [27].
The mean vaginal discharge quantity is 1.5 g/8 h (maximum at
mid-cycle, 2.0 g/8 h), although the amount varies significantly
between the different days of the cycle; low mean values may
be observed on days 7 and 26 (1.4 g/8 h) [30]. During sexual
stimulation, LF production is increased to 0.7 mL/15 min [26],
and both sodium and chloride ion concentrations also increase
[29]. Kinsey et al. assumed that vaginal fluid may be forced out
by the contractions of the perivaginal muscles; thus, it resem-
bles fluid expulsion [22].
Female ejaculation and female prostate
ABreal^FE is the secretion of an extremely scanty (few
milliliters), milky fluid by the female prostate [7,10,15],
which was described by de Graaf in 1762 and later de-
scribed as Skenes paraurethral glands [11,38]. The fe-
male prostate is an exocrine organ of variable size and
location and contains cellular equipment for neuroendo-
crine activity [33,39]. According to various authors, it
exists in only two-thirds of women [40], 1 in 2 women
[41], or in 6 out of 7 women [42]. It weighs 2.6 to 5.2 g,
consists of a maximum of one tenth to one quarter of the
male prostate (23.7 g), and consists of glands, ducts, and
musculofibrous tissues. Compared with the male prostate,
it has more musculofibrous tissues and ducts, but substan-
tially fewer glands (Table 3)[33].
The female prostates secretion contains a high concentra-
tion of PSA, prostatic-specific acid phosphatase, fructose, and
glucose (Table 2)[8,19]. It histomorphologically resembles
themaleprostatebeforepuberty[40]. According to Zaviačič
et al., the prostatic (paraurethral) ducts penetrate into the lu-
men of the urethra along its whole length [33]. Dwyer argues
that single or multiple orifices are on the sides of the urethral
meatus [40]. The role of the female prostate is unclear; some
Table 1 Articles according to
topic, character of the collected
information, and the type and
number of publications used for
the review
Original
research
Systematic
review
Case
report
Book
chapter
Laboratory
manual or
international
classification
Total
Female ejaculation 11 14 2 0 0 27
Squirting 2 1 1 0 0 4
Female prostate 11 3 0 1 0 15
Vaginal lubrication 11 1 0 3 0 15
Coital incontinence 10 2 0 0 1 13
Male prostate and semen
parameters
41 011 7
Int Urogynecol J
studies assume that prostate secretions have an antimicrobial
or protective effect against urinary tract infections [49].
Squirting (gushing)
Squirting is the involuntary expulsion of a substantial amount
of urine during sexual activity [14]. Until recently, most or-
gasmic emissions have been erroneously called the FE [10,
14,19,37]. Currently, such massive gushes at orgasm are
referred to as squirting (gushing) [10,14]. The biochemical
composition of this fluid could be identical to urine [14]orits
diluted form [10]. The volume of massive gushes (which
could be recurring) usually ranges from 15 to 110 mL (medi-
an, 60 mL), and the color is most frequently described as
Bclear as water^[7,9,14]. The fluid may be contaminated
by the female prostate secretion and may contain a small con-
centration of PSA [7,10]. Squirting occurs during sexual stim-
ulation of the clitoro-urethro-vaginal complex [10,14].
Women and their partners consider squirting to be a positive
phenomenon that improves their sexual life [9].
Fig. 2 Sources of fluids expelled during sexual activities
Table2 Summary of fluids compared according to source, expulsion mechanism, volume, density, chemical composition, color, manifestations, and
subjective feelings
Vaginal lubrication Female ejaculation Squirting (gushing) Coital incontinence
Orgasmic
form
Penetration
form
Source [6,7,10,14,15,2437] Vagina Female prostate Urinary bladder Urinary bladder
Expulsion mechanism [7,10,14,15,
2432]
Transvaginal
transudation
Glands secretion Transurethral
expulsion
Voided urine
Vol u m e [7,10,14,15,26,30] +/++ + ++/+++ ++/+++
Density [10,3032] +/++ ++/+++ + +
Prostate-specific antigen [7,10,14,15,33] /+ +++ +/++ /++
Uric acid [10,14]––+/+++ +++
Urea [10,14]––+/+++ +++
Creatinine [10,14]––+/+++ +++
Sodium [10,14,19,24,25,28,29]+ + ++/+++ +++
Potassium [10,14,19,24,25,28,29] +/++ + ++/+++ +++
Chloride [10,14,19,24,25,28,29] + + ++/+++ +++
Glucose [10,33]+++ /+
Fructose [10,33]+++ /+
pH (acidity) [7,27,33]+++ /+ +
Urodynamic examination [19] Normal finding Normal finding Normal finding Signs of stress incontinence
or DOA
Color [7,10,14,15,24,25,2832] Clear, transparent Whitish, milky Clear, yellowish Yellow
Manifestation [7,10,14,15,24,25,
2832]
Lubrication, transparent
discharge
Insignificant amount
of prostate
secretion
Massive expulsion
of transparent fluid
Involuntary leakage of urine
Subjective feelings [19] Sexual arousal,
wetness
Orgasm, satisfaction Orgasm, satisfaction Humiliation, shame,
embarrassment
+++ large quantity, ++ moderate quantity, + small quantity, no presence or no parameters available
Int Urogynecol J
Coital incontinence
Coital incontinence is manifested by an involuntary leakage of
urine during sexual intercourse and could be classified into
penetration and orgasm forms [50]. The prevalence of CI in
women with urinary incontinence (UI) ranges from 10 to 67%
[5155]. Compared with women with detrusor overactivity
(DOA), women with stress urinary incontinence (SUI) more
frequently report CI [53,55]. Women with CI always have
abnormal urodynamic parameters, unlike women with ejacu-
lation orgasm (FE or SQ) without CI [34]. Some studies cor-
relate penetration CI with the diagnosis of SUI and orgasmic
CI with DOA [51,55]; other studies in this regard are rather
ambiguous [5561].
Discussion
Female ejaculation, SQ, and CI are three completely different
phenomena. Understanding their mechanisms may help to
differentiate them according to their manifestations, subjective
feelings, and biochemical composition of the expelled fluid.
Launching Bsquirting^as a term in the scientific literature in
2011 stopped the use of Bfemale ejaculation^as a Buniversal^
label for all kinds of fluids emitted by women during sexual
activity [10,14,15].
Main differential diagnosis criteria for clinical practice
In clinical practice, the diagnosis of emitted fluids is based
mainly on quantity, appearance, and subjective feelings.
Transurethral gushes of tens to hundreds of milliliters of trans-
parent fluid that is not considered by women without UI at
orgasm as urine is SQ [10,14]. These women, who have no
disorder related to urine leakage [34], usually experience in-
tensive sexual arousal and reach orgasm (even repeatedly)
without any problem. At fluid expulsion, they feel substantial
sexual catharsis and consider the fluid different from urine in
smell, taste, and appearance [6]. In women with SUI or DOA,
CI can be observed. During penile penetration or at orgasm,
they experience unwanted leakage of urine. Consequently,
they feel frustrated and the sexual activity is rather unpleasant
for them because of CI. During FE, a small amount of thick
and milky fluid mixed with lubrication fluid is expelled by the
female prostate, which in turn makes differentiation challeng-
ing. BReal^FE often occurs without noticing a leakage of a
larger fluid volume (unlike SQ). FE is perceived mainly as the
feeling of wetness due to increased lubrication during orgasm.
Moreover, a greater quantity of fluid from the vagina may be
forced out by a one-time pulse emission [22]. It may occur
primarily after penis withdrawal or after coitus, and it is most-
ly a discharge (not gush) of accumulated LF, which is possibly
mixed with sperm.
Table 3 Comparison of
morphological and functional
parameters of the mal e and female
prostate
Male prostate Female prostate
Morphological structures [21,33] Prostatic glands (+++)
Musculofibrous tissue (++)
Ducts (+)
Prostatic glands (+)
Musculofibrous tissue (+++)
Ducts (+++)
Average size of the prostate (cm)
[21,33]
Length (3.4)
Width (4.5)
Height (2.9)
Length (3.3)
Width (1.9)
Height (1.0)
Ave rag e weight (g) [21,33]23.7 2.65.2
Average volume prostatic
secretion (mL) [10,4148]
0.22.3 0.89 ± 0.52
Physiological function [4049] Increase in ejaculation semen volume,
facilitation of reproduction
Unclear, antimicrobial
function
Character of the emission [10,46] Expulsion, discharge during orgasm Secretion during orgasm
Localization [21,33,47] Surrounding the prostatic part of the
urethra
Urethral wall
Prostate-specific antigen
[10,19,21,33]
+++ ++
Glucose [21,33] + +++
Fructose [21,33] + +++
Potassium [19]+ +
Sodium [19]+ +
Chloride [19]+ +
+++ large quantity, ++ moderate quantity, + small quantity
Int Urogynecol J
Sources, volume, and mechanism of expelled fluids
The fluid expelled at SQ has a definite origin (the urinary
bladder) [7,10,14], which may accumulate hundreds of mil-
liliters of fluid; the contractions of musculus detrusor vesicae
facilitate the massive expulsions. When we assessed previous
research, we found that most of the orgasmic expulsions,
which are currently most likely referred to as SQ, are de-
scribed as FE [2,6,13,17,20,23]. The authors considered
all female orgasmic expulsions analogous to male ejaculation
[13] and noted that the female prostate is the main source of
the fluids [33]. The female prostate may produce fluid bio-
chemically comparable with the male prostate secretion; how-
ever, the quantity squirted at an orgasm differs [14].
Transurethral expulsion and their origin in the urinary bladder
were confirmed by catheterizing the urinary bladder [7]orby
ultrasound bladder examination before and after SQ [14].
With the bladders capacity (around 500 mL), expulsions
with an average volume of 60 mL during sexual stimulation
may be repeated [9,14]. Schubach assumed that during sexual
excitation (increased blood pressure, faster glomerular filtra-
tion, changes in hormonally conditioned reabsorption mecha-
nisms in the kidneys), the bladder is filled more rapidly with
less concentrated urine [7]. Such a premise could explain why
some authors (Schubach, 8 respondents; Rubio-Casillas and
Jannini, 1 respondent) reported that SQ is composed of diluted
urine, which contains muchless uric acid, urea, and creatinine
[7,10], whereas others claim that the fluid at SQ is identical in
biochemical composition to urine (Salama, 7 women; our un-
published study, 1 woman) [14]. Moreover, Wimpissinger
et al. proved that in two women, using their expelled fluid,
which they considered FE, a high PSA and glucose content
(without volume data), unlike voided urine [19]. Goldberg
et al. showed that the fluid emitted in six patients is chemically
similar to urine [6]. The chemical analysis (prostatic acid
phosphatase [PAP], urea, creatinine, glucose) in a previous
case report involving one patient indicated that the expulsion
fluid was not urine [13]. Neither Goldberg et al. [6]nor
Addiego et al. [13] provided the exact volumes of the emitted
fluid. Nevertheless, most likely, the volume of the bladder
content and urine concentration immediately before initiating
sexual activity and the possible dilution during sexual stimu-
lation play asubstantial rolein the composition of the expelled
fluid at SQ. The concentration of the emitted fluid may be
influenced by other factors, such as water intake, surrounding
temperature, physical activity, metabolic condition, hormonal
activity, overall health condition, and psychogenic aspects.
Previous studies with a small number of women with SQ
(16 respondents) had contradictory conclusions and thus
could not establish a clear mechanism of the creation of the
expelled fluid [7,10,14]. The function of the bladder sphinc-
ter, which should be closed during sexual arousal and orgasm,
remains to be clearly identified [11]. However, according to
Khan et al., involuntary bladder contraction and relaxation of
the sphincter during female orgasm are possible [57].
Earlier studies described most fluid expulsions as FE, and
the female prostate was considered to be the main source [62],
releasing 350 mL of fluid (Bullough et al., 312 mL;
Goldberg et al., 315 mL; Zaviačičet al., 15 mL; Heath,
3050 mL; Belzer, 10 mL) [5,6,8,17,20]. The main evi-
dence of the female prostate as the origin of the fluid was the
presence of PSA (or PAP) in the emission. Although PSA is
the main marker of female prostate secretion, PSA may also
be found in lower concentrations in the fluids expelled from
other sources, such as the vagina and urinary bladder, which
could be associated with contamination by the female prostate
secretion during simultaneous expulsions from the other
sources. According to Rubio-Casillas and Jannini, a decreas-
ing PSA concentration is observed in the following: female
ejaculate > urine > squirting > vaginal secretion [10].
However, a previous study demonstrated that the female pros-
tate could not be the source of massive expulsions considering
its size, structure, and secretion capacity. On average, it
weighs 2.6 to 5.2 g and it is four to five times smaller than
the male prostate. Moreover, the glandular and ductal compo-
nents are in reverse ratio tothose of the male prostate [33]. The
average volume of male ejaculate is 3.6 mL (1.27.6), of
which 1530% is from the male prostate; the secretion volume
ofthemaleprostaterangesroughlyfrom0.2to2.3mL
[4346]. The secretion volume of the female prostate is
around 1 mL [10,19]. Hence, the female prostate could not
be the main source of the massive fluid expulsions.
Differential diagnostic criteria of expelled fluid
according to biochemical analysis and examination
using a device
The expelled fluids could be indicatively differentiated ac-
cording to their manifestations; however, the precise diagnosis
is based on a biochemical analysis or examination using a
device (ultrasound, urodynamic examination, magnetic reso-
nance imaging). Biochemical analysis of FE revealed high
concentrations of PSA, glucose, and fructose, whereas the
fluid at SQ, unlike FE, has higher concentrations of uric acid,
urea, creatinine, and sodium; has a substantially lower density;
and contain practically no fructose or glucose [7,9,10].
Biochemical differentiation of expelled fluids during orgasmic
incontinence at CI and orgasm at SQ is more difficult to per-
form. The quantity and appearance of the fluid may be similar.
The exact diagnosis is based on the fact that continent women
with ejaculation orgasm (SQ) show neither high detrusor ac-
tivity nor any other abnormal urodynamic parameters unlike
women with CI, who have urodynamic evidence of SUI or
DOA [34]. Differentiation based on biochemical markers
characteristic of urine (uric acid, urea, creatinine, chloride,
potassium) could be misleading; although some authors
Int Urogynecol J
provided evidence of lower quantity of these markers at SQ
(SQ is a diluted fluid from the urinary bladder) [10], others
found no differences (SQ is voided urine) [14]. Future studies
should investigate whether substantial urine dilution occurs at
SQ, resulting from sexual arousal and increased renal activity,
or whether the fluid at SQ is just urine. Differentiation of
lubrication fluid from other fluids is not usually difficult, as
the former is a desired and common sexual response. Massive
fluid emissions from the vagina are considered discharge of
accumulated LF rather than gushes of fluid. Women with lu-
brication problems are at a disadvantage in terms of sexual
satisfaction, and a prevalence of lubrication disorders of 5.8 to
19.7% among fertile women was reported [63].
Coital incontinence, its forms, and differential
diagnostics
Whether the fluid expelled at FE (or SQ) is from the
female prostate or the urinary bladder and whether it is
urine has been a major topic of dispute. The fluid at SQ
was (inaccurately) attributed to the female prostate based
on the concentrations of PSA and PAP, which were con-
sidered the main markers for differentiation. Moreover,
the detection of PAP in the urine may be complicated,
as the concentration is small and diagnostic kits primarily
serve to determine the level of phosphatase in the blood
and not in the urine [6]. Women with CI experience leak-
age of urine frequently and involuntarily during the day;
thus, there is no problem with the identification of CI.
They were able to recognize that urine is leaked during
sexual activities, unlike women who are capable of
squirting and do not consider the fluid to be urine [6].
CI is initiated by various situations, such as increased
abdominal pressure, penile insertion, deep penetration,
high arousal, orgasm, and clitoral stimulation [58], and
by psychogenic factors as well. Hence, most women
avoid sex or prevent involuntary urine leakage by voiding
before the sexual activity. Determining whether the incon-
tinence is penetration or orgasmic in form is not difficult,
as a woman could identify at which phase of sexual ac-
tivity urine leakage occurs. However, inconsistent opin-
ions are noted for whether penetration incontinence oc-
curs mainly at SUI [51,52,5458,60] owing to increased
mobility of the urethrovesical junction [56]andwhether
orgasmic incontinence is related to DOA [51]. El-Azab
stated that the reason for urine leakage at orgasm is not
definitely DOA, but an incompetent urethral sphincter or
vaginal prolapse [55]. In a differential diagnosis, we
should take into account the possibility that CI might de-
velop in the course of a womanslifeorinawomanwith
the ability to squirt, or that a woman with symptoms of UI
might gain the ability to squirt.
Limitations and deficiencies of the study
In our study, articles on the characteristics and the exact com-
position of expelled fluids during sexual activity among wom-
en were lacking, and the groups of respondents were small;
thus, having a statistically significant analysis was not possi-
ble. Only studies with approximately 10 respondents and a
few individual case reports were included in the assessment
[6,7,9,10,13,14,19]. Other previous studies use different
methodological procedures and inconsistent terminology, and
the characteristic of the examined fluids is mostly based on
only the subjective feelings of the respondents [3,4,12,23,
62]. The term Bsquirting^was only used for the first time in
the scientific literature in 2011 [10]. Currently, fluid expul-
sions during sexual activities would not be immediately re-
ferred to as FE only; the expulsions could also be SQ [49,11,
13,19,20,23]. Moreover, older studies are focused mainly on
the female prostate, its localization, anatomical composition,
and biochemical analysis of its secretion. Although they
looked into the relationship between orgasm and fluid gushes,
an exact biochemical analysis was not performed, and the
volume was not identified.
Having a larger group of respondents for the study appears
difficult as the topic is extremely sensitive, and full coopera-
tion of women and their partners with the research team is
required.
Importance of further research and its benefit
for clinical practice
Further studies on expelled fluids during sexual activities in
women are warranted to obtain specific knowledge on their
characteristics and biochemical composition. The creation of a
practical algorithm for the differential diagnostics of the phe-
nomena (FE, SQ, CI) for the use of specialists is essential. The
information could be used to prevent erroneous consideration
of FE and SQ as disorder symptoms that require a therapy, as
is required in cases of CI.
Conclusion
We have differentiated among the four types of fluids expelled
during sexual activities in relation to sexual arousal and or-
gasm. Apart from the desired lubrication and involuntary
urine leakage disorder, two different physiological but unusual
phenomena exist: FE and SQ. At FE, a small amount of fluid
is secreted by the female prostate, and at SQ, the fluid similar
to or identical to urine is squirted transurethrally from the
urinary bladder. Further study is necessary considering the
limited number of studies, the small group of respondents,
and the unclear conclusions.
Int Urogynecol J
Compliance with ethical standards
Financial disclaimer/conflict of interest None.
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... The studies, of varying quality and mostly with few participants, have drawn different conclusions: claiming it is a female prostatic fluid, diluted urine, or a fluid identical to urine (Addiego et al., 1981;Filippi et al., 2009;Pastor, 2013;Rubio-Casillas and Jannini, 2011;Salama et al., 2015;Sevely and Bennett, 1978;Wimpissinger et al., 2007). Recently, this has led to attempts to distinguish female ejaculation and squirting as two distinct events with differing content (Pastor, 2013;Pastor and Chmel, 2017;Rubio-Casillas and Jannini, 2011). Squirting is explained as consisting of a larger amount of water-like fluid (15-110 mL) similar, or identical, to urine, expelled from the urethra (Pastor and Chmel, 2017;Salama et al., 2015). ...
... Recently, this has led to attempts to distinguish female ejaculation and squirting as two distinct events with differing content (Pastor, 2013;Pastor and Chmel, 2017;Rubio-Casillas and Jannini, 2011). Squirting is explained as consisting of a larger amount of water-like fluid (15-110 mL) similar, or identical, to urine, expelled from the urethra (Pastor and Chmel, 2017;Salama et al., 2015). Female ejaculation is explained as being a smaller amount, only a few milliliters, of thicker "milky-like" fluid originating from the prostatic glands surrounding the urethra (Pastor and Chmel, 2017). ...
... Squirting is explained as consisting of a larger amount of water-like fluid (15-110 mL) similar, or identical, to urine, expelled from the urethra (Pastor and Chmel, 2017;Salama et al., 2015). Female ejaculation is explained as being a smaller amount, only a few milliliters, of thicker "milky-like" fluid originating from the prostatic glands surrounding the urethra (Pastor and Chmel, 2017). This relatively recent classification of the phenomena makes it hard to interpret earlier studies where the terms female ejaculation and squirting are used synonymously but may instead refer to what is now categorized as squirting. ...
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Squirting, or female ejaculation, is the expulsion of fluid during sexual stimulation. The limited scientific literature has focused primarily on clarifying what this fluid contains, while women’s own voices on the experience have received scant attention. This study explores 28 women’s experiences and applies a thematic analysis. The sensation of squirting is individual and sometimes conflicting. Descriptions range from considering it amazing, a superpower and feminist statement to an unpleasant and/or shameful event. Across the board, there is a wish for nuanced information and for the current taboo and mystification surrounding the subject to be broken.
... This ambiguity caused diagnostic confusion and controversial conclusions (Rubio-Casillas & Jannini, 2011). SQ and FE are considered physiological but uncommon sexual responses and CI is a symptom of a disorder, such as urinary incontinence (Pastor, 2013;Pastor & Chmel, 2018). The fluid outflow during sexual activities usually manifests as wetness, secretion, or gushes (Pastor & Chmel, 2018). ...
... SQ and FE are considered physiological but uncommon sexual responses and CI is a symptom of a disorder, such as urinary incontinence (Pastor, 2013;Pastor & Chmel, 2018). The fluid outflow during sexual activities usually manifests as wetness, secretion, or gushes (Pastor & Chmel, 2018). The uncertainties regarding orgasmic fluid relate particularly to their origin, volume, composition, and expulsion mechanism. ...
... Although the secretion from female prostate can contaminate other fluids secreted during sexual activities (Pastor, 2013;Rubio-Casillas & Jannini, 2011;Salama et al., 2015). While the classification and differential diagnosis for EO have been proposed previously, (Levin et al., 2016;Pastor, 2013;Pastor & Chmel, 2018;Rogers et al., 2018;Rubio-Casillas & Jannini, 2011;Salama et al., 2015) it is rarely used both in practice and in studies. The differences among sexual fluids are known at present (Pastor, 2013;Pastor & Chmel, 2018;Rodriguez et al., 2021;Rubio-Casillas & Jannini, 2011;Salama et al., 2015;Schubach, 2001) However, orgasmic fluid excretion is often universally considered FE, and the fluid itself is considered an ejaculate from female prostate because it contains PSA (Rodriguez et al., 2021). ...
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Introduction: Women expel fluids of various quantities and compositions from the urethra during sexual arousal and orgasm. These are classified as either female ejaculation (FE) or squirting (SQ). The aim of our analysis was to present evidence that FE and SQ are similar but etiologically different phenomena. Materials and methods: A review of studies was performed on fluids expelled from the urogenital tract during female sexual activities using the Web of Knowledge TM (Web of Science Core Collection) and MEDLINE (Ovid) databases from 1946 to 2021. Results: Until 2011, all female orgasmic expulsions of fluids were referred to as FE. The fluid was known to be either from the paraurethral glands or as a result of coital incontinence. At present, SQ is considered as a transurethral expulsion of approximately ten milliliters or more of transparent fluid, while FE is considered as a secretion of a few milliliters of thick fluid. The fluid in SQ is similar to urine and is expelled by the urinary bladder. The secretion in FE originates from the paraurethral glands and contains a high concentration of prostate-specific antigen. Both phenomena can occur simultaneously. Conclusions: The mechanisms underlying SQ and FE are entirely different. SQ is a massive transurethral orgasmic expulsion from the urinary bladder, while FE is the secretion of a very small amount of fluid from the paraurethral glands.
... Its location is typically lateral in the distal half of the urethra, producing secretions to the urethral meatus [12]. ...
... Real female ejaculation is the secretion of an extremely scanty (few milliliters), milky fluid by the female prostate, which was described by de Graaf in 1762 and later described as Skene'sparaurethralglands [12]. ...
... Squirting could be related to high blood pressure, high glomerular filtration, or altered production of aldosterone at sexual arousal [14].The concentration of the emitted fluid may be influenced by other factors, such as water intake, surrounding temperature, physical activity, metabolic condition, hormonal activity, overall health condition, and psychogenic aspects [12]. ...
... The vaginal discharge volume is directly proportional to the estrogen level and inversely proportional to the progesterone level [23]. Furthermore, sexual stimulation enhances the production of vaginal discharge up to 2.8 mL per hour [24]. The discharge origins in the vaginal venous plexus, where it is secreted by the cervical and Bartholin glands through transduction, and is primarily composed of water, 1-2% of mucin and electrolytes including sodium (Na + ) and potassium (K + ) [14,18,19,24]. ...
... Furthermore, sexual stimulation enhances the production of vaginal discharge up to 2.8 mL per hour [24]. The discharge origins in the vaginal venous plexus, where it is secreted by the cervical and Bartholin glands through transduction, and is primarily composed of water, 1-2% of mucin and electrolytes including sodium (Na + ) and potassium (K + ) [14,18,19,24]. Mucin is one the most abundant glycoprotein in the vaginal mucus layer and it is responsible for the gel-like mucus mesh properties formed from negatively charged mucin fibers. Average vaginal discharge pH is between 3.8 to 4.5, however other reports expand the normal pH value of vaginal discharge from 3.4 to 6.4, with an average pH at 4.7 [19]. ...
... bacteria [25]. Vaginal discharge pH may be affected by age, hormonal stimulation during menstruation, menopause, pregnancy, inflammations, composition of vaginal microbiota, presence of pathogenic microorganism and even ethnical origin and race [24,[26][27][28][29][30][31][32]. The presence of vaginal discharge on the mucosal surface, including its quantity and pH, influences the drug dissolution as well as passive and active drug transport through the vaginal membrane [1,33]. ...
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In order to overcome the limitations associated with vaginal administration of drugs, e.g., the short contact time of the drug form with the mucosa or continuous carrier wash-out, the development of new carriers for gynecological use is necessary. Furthermore, high individual anatomical and physiological variability resulting in unsatisfactory therapeutic efficacy of lipophilic active substances requires application of multicompartment drug delivery systems. This manuscript provides an up-to-date comprehensive review of the literature on emulsion-based vaginal dosage forms (EVDF) including macroemulsions, microemulsions, nanoemulsions, multiple emulsions and self-emulsifying drug delivery systems. The first part of the paper discusses (i) the influence of anatomical-physiological conditions on therapeutic efficacy of drug forms after local and systemic administration, (ii) characterization of EVDF components and the manufacturing techniques of these dosage forms and (iii) methods used to evaluate the physicochemical and pharmaceutical properties of emulsion-based vaginal dosage forms. The second part of the paper presents (iv) the results of biological and in vivo studies as well as (v) clinical evaluation of EVDF safety and therapeutic efficacy across different indications.
... This has included the distinction between female ejaculate speculated to be produced by the female prostate, from fluid produced via "squirting"-referring to involuntary fluid expulsion during coitus hypothesized to be diluted urine. 61,62 The phenomenon of female ejaculation originating from stimulation of the female prostate is still a matter of controversy and debate. Contributing to this controversy are reports of some women who experience ejaculation with orgasm from stimulation of other tissues including the clitoris, and others who describe ejaculation without orgasm. ...
Article
Introduction: There is evidence of glandular tissue within the region of the anterior vaginal wall-female periurethral tissue (AVW-FPT) having similar morphology and immunohistochemistry to the prostate in men and having physiological roles in the female sexual response (FSR). Whether this tissue should be called a prostate in women has been debated. Iatrogenic injury to structures of the AVW-FPT, including these glands and the associated neurovasculature, could be a cause of female sexual dysfunction (FSD). Objectives: To consolidate the current knowledge concerning the glandular tissue surrounding the urethra in women, evidence was reviewed to address whether: (i) these glands comprise the prostate in women, (ii) they have specific functions in the FSR, and (iii) injury to the AVW-FPT and prostate has sexual dysfunction as a likely outcome. Methods: A literature review was conducted using keywords including female prostate, Skene’s/paraurethral glands, periurethral tissue, Gr€afenberg (G)-spot, female ejaculation, mid-urethral sling (MUS), and sexual dysfunction. Results: Histological and immunohistochemical studies of the glandular tissue surrounding the urethra support the existence of prostate in women. Evidence suggests this tissue may have physiologically and clinically relevant autonomic and sensory innervation, and during sexual arousal may contribute to secretions involved in ejaculation and orgasm. Gaps in knowledge relating to the functional anatomy, physiological roles, and embryological origins of this tissue have impeded the acceptance of a prostate in women. Injury to the innervation, vasculature, and/or glandular tissue within the surgical field of MUS implantation suggests iatrogenic sexual dysfunction is plausible. Conclusions: Continuing to advance our understanding of the morphology, histochemistry, and physiologic capacity of this glandular tissue will clarify the characterization of this tissue as the “prostate” involved in the FSR, and its role in FSD following surgical injury.
... From limited literature on this subject, there is an evidence that capillary fluid in the submucosa and mucous that is secreted by the cervical and periurethral glands are involved in the vaginal lubrication process. The epithelial tissue is responsible for the transportation and rationing of ions and water molecules and plays an important role as the final gatekeeper of vaginal lubrication (D'Amati et al., 2003;Pastor & Chmel, 2018;Shabsigh et al., 1999). The role of fluid transport in vaginal lubrication, mainly in the transport of small molecules such as water, glycerol, and ions, has been explored in recent studies (Gorodeski, 2005;Sun et al., 2014). ...
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Background Vaginal lubrication is a crucial physiological response that occurs at the beginning of sexual arousal. However, research on lubrication disorders (LD) is still in its infancy, and the role of long non-coding RNAs (lncRNAs) in LD remains unclear. This study aimed to explore the function of lncRNAs in the pathogenesis of vaginal LD. Methods The expression profiles of LD and normal control (NC) lncRNAs were examined using next-generation sequencing (NGS), and eight selected differentially expressed lncRNAs were verified by quantitative real-time PCR. We conducted GO annotation and KEGG pathway enrichment analyses to determine the principal functions of significantly deregulated genes. LncRNA-mRNA co-expression and protein-protein interaction (PPI) networks were constructed and the lncRNA transcription factors (TFs) were predicted. Results From the results, we identified 181,631 lncRNAs and 145,224 mRNAs in vaginal epithelial tissue. Subsequently, our preliminary judgment revealed a total of 499 up-regulated and 337 down-regulated lncRNAs in LD. The top three enriched GO items of the dysregulated lncRNAs included the following significant terms: “contractile fiber part,” “actin filament-based process,” and “contractile fiber”. The most enriched pathways were “cell-extracellular matrix interactions,” “muscle contraction,” “cell-cell communication,” and “cGMP-PKG signaling pathway”. Our results also showed that the lncRNA-mRNA co-expression network was a powerful platform for predicting lncRNA functions. We determined the three hub genes, ADCY5, CXCL12, and NMU, using PPI network construction and analysis. A total of 231 TFs were predicted with RHOXF1, SNAI2, ZNF354C and TBX15 were suspected to be involved in the mechanism of LD. Conclusion In this study, we constructed the lncRNA-mRNA co-expression network, predicted the lncRNA TFs, and comprehensively analyzed lncRNA expression profiles in LD, providing a basis for future studies on LD clinical biomarkers and therapeutic targets. Further research is also needed to fully determine lncRNA’s role in LD development.
... Finally, since squirting, female ejaculation and coital incontinence are different phenomena with various mechanisms and could be easily differentiated according to source, quantity, expulsion mechanism, role in the erotic physiology, and subjective feelings during sexual activities [64], the existence of true female ejaculation in some women could be considered an indirect biomarker of the presence and physiological role of the CUV in the female erotic response. ...
Article
Full-text available
In the field of female sexuality, the existence of the so-called “G-spot” represents a topic still anchored to anecdotes and opinions and explained using non-scientific points, as well as being overused for commercial and mediatic purposes. Purpose of Review The scope of this review is to give an update on the current state of information regarding the G-spot and suggesting potential future directions in the research field of this interesting, albeit controversial, aspect of human sexual physiology. Recent Findings From evolutionary, anatomical, and functional points of view, new evidence has rebutted the original conceptualization of the G-spot, abandoning the idea of a specific anatomical point able to produce exceptional orgasmic experiences through the stimulation of the anterior vaginal wall, the site where the G-spot is assumed to be. From a psychological perspective, only few findings to date are able to describe the psychological, behavioral, and social correlates of the pleasure experience by G-spot-induced or, better, vaginally induced orgasm (VAO). Summary Recent literature suggests the existence of a G-spot but specifies that, since it is not a spot, neither anatomically nor functionally, it cannot be called G, nor spot, anymore. It is indeed a functional, dynamic, and hormone-dependent area (called clitorourethrovaginal, CUV, complex), extremely individual in its development and action due to the combined influence of biological and psychological aspects, which may trigger VAO and in some particular cases also female ejaculation (FE).
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Background: The prostate gland remains unresected during gender-affirming surgery (GAS) for transgender women (TGW), and may develop malignancies in later life. We sought to evaluate prostate cancer awareness (PCA) among post-GAS TGW. Methods: The investigators implemented a cross-sectional study and enrolled a sample of Thai post-GAS TGW without medical background. Predictor variables were categorized as demographic, clinical, operative, or postoperative. The outcome variable was PCA (yes/no). Appropriate statistics were computed, and a p-value ≤ 0.05 was considered statistically significant. Results: The sample consisted of 100 Thai post-GAS TGW (4% bisexual, 12% bachelor [or higher] graduates, 51% service workers, 64% had monthly net income <40,000 TB [or ca. 1050 Euro], 92% operated by plastic surgeons) with a mean age of 26.2 ± 5.4 years (range: 18-45). On bivariate analysis, PCA was significantly associated with educational level (p = 0.007; adjusted odd ratio [ORadj. ]: 5.85; 95% confidence interval [95% CI]: 1.65-20.69), being operated ≥ 10 years (p = 0.01; ORadj. : 0.16; 95% CI: 0.04-0.76), self-recognition of the remaining prostate gland (p = 0.0001; ORadj. : 0.02; 95% CI: 0-0.12), and emphasis on PCA by the GAS operator (p = 0.01; ORadj. : 0.07; 95% CI: 0.01-0.63). Multiple linear regression analysis revealed a statistically significant, positive correlation (r = 0.78; p = 0.0001) among these four predictors, and continued to confirm the positive effect on PCA in TGW with high education and realization of the prostate gland (r = 0.56; p = 0.04) or information on PCA by the operator (r = 0.68; p = 0.003). Conclusion: The GSA operator should intensively inform TGW about the remnant prostate and the risk of PC, especially those with low and middle levels of education attained.
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This study examined U.S. adolescents’ pornography consumption, pornography dependency, and belief in a variety of notions contradicted by basic sexological science. Data were from 595 youth aged 14–18 who participated in a population-based probability survey. Consistent with the sexual script acquisition, activation, application model (3AM) of sexual media socialization, adolescents who had viewed pornography were more likely to hold erroneous sexual beliefs than adolescents who had not viewed pornography. Also consistent with the 3AM, more frequent pornography consumption and higher levels of pornography dependency were independently associated with holding erroneous beliefs about sex among pornography consumers. Counter to theoretical expectations, frequency of pornography consumption did not interact with pornography dependency in the prediction of erroneous sexual beliefs.
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The vagina is an excellent site for topical passive immunization, as access is relatively easy, and it is an enclosed space that has been shown to retain bioactive antibodies for several hours. A number of sexually transmitted infections could potentially be prevented by delivery of specific monoclonal antibodies to the vagina. Furthermore, our group is developing antisperm antibodies for vaginally delivered on-demand topical contraception. In this article, we describe physical features of the vagina that could play a role in antibody deployment, and antibody modifications that could affect mAb retention and function in the female reproductive tract. We also review results of recent Phase 1 clinical trials of vaginal passive immunization with antibodies against sexually transmitted pathogens, and describe our current studies on the use of anti-sperm mAbs for contraception.
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Background Coital incontinence is an under-reported disorder among women with urinary incontinence. Women seldom voluntarily report this condition, and as such, related data remains limited and is at times conflicting. Aims and objectives To investigate the incidence and quality of life in women with coital incontinence and to determine associated predictors. Methods This observational study involved 505 sexually active women attending the urogynecologic clinic for symptomatic urinary incontinence at a tertiary medical center. All of the patients were consulted about the experience of coital incontinence and completed evaluations including urodynamics, and valid questionnaires including the short form of the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire, the Urogenital Distress Inventory and the Incontinence Impact Questionnaire. Results Of these women, 281 (56%) had coital incontinence, while 224 (44%) did not. Among women with coital incontinence, 181 (64%) had urodynamic-proven stress incontinence, 29 (10%) had mixed incontinence, and 15 (5%) had detrusor overactivity. Only 25 (9%) sought consultation for this disorder before direct questioning. Fifty percent (84/281) of the women rarely or sometimes had incontinence during coitus, while 33% (92/281) often had incontinence, and 17% (48/281) always had incontinence. The frequency of coital incontinence was not different regarding the types of incontinence (p = 0.153). Women with mixed incontinence had the worst sexual quality of life and incontinence-related symptom distress. Based on univariate analysis, higher body mass index (OR 2.47, p = 0.027), and lower maximal urethral closure pressure (≤ 30 cmH2O) (OR 4.56, p = 0.007) were possible predictors for coital incontinence. Multivariate analysis showed lower MUCP was independently significant predictors (OR3.93, p = 0.042) Conclusions The prevalence of coital intercourse in urinary incontinence women was high. Coital incontinence in these women was associated with abnormal urodynamic diagnosis and urethral dysfunction.
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The article consist of six sections written by separate authors that review female genital anatomy, the physiology of female sexual function, the pathophysiology of female sexual dysfunction but excluding hormonal aspects. Aim: To review the physiology of female sexual function and the pathophysiology of female sexual dysfunction especially since 2010 and to make specific recommendations accordng to the Oxford Centre for evidence based medicine (2009) "levels of evidence" wherever relevant. Conclusion: Recommendations were made for particular studies to be undertaken especially in controversial aspects in all six sections of the reviewed topics. Despite numerous laboratory assessments of female sexual function, genital assessments alone appear insufficient to characterise fully the complete sexual response.
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The female prostate was first described by Reijnier de Graaf in 1672, and even after several years this gland is still a matter of controversy. Part of this is because the biological function of this female gland is unclear. Moreover, when compared with the male prostate, the existence of this organ in females does not make sense, mainly when we consider that the major function of this gland is to produce a secretion that is responsible for guarantee the sperm survival and assure the reproductive success. However, even under a controversy field, we now have a lot of scientific information which enhances our knowledge of several important biological aspects of this gland. It is clear that this gland is found in some female mammals including humans, rodents, rabbits, bats and dogs. Several studies with rodents showed that the female prostate is homologue of the male prostate, showing strong macroscopic and microscopic similarities with the ventral lobe of males. Besides these aspects, there are several studies reporting that diseases such as cysts, hyperplasia, and carcinoma may affect the female prostate. Therefore, although diseases involving the female prostate are rare, the susceptibility of this organ to develop lesions must be considered, especially in our recent years in which the exposure to endocrine-disrupting chemicals has greatly increased. Finally, further studies will be necessary to enhance our understanding about this gland, mainly of the developmental, evolutionary, and biological functions.
Article
The low-molecular weight organic constituents of human vaginal secretions from normally cycling subjects were analyzed both before and after sexual stimulation. Gas chromatography and combined gas chromatography-mass spectrometry were employed in the analyses of the secretions. Consistent increases were noted for a number of the lipid constituents of the secretions, suggesting that they are derived at least in part from the plasma and transude into the vaginal lumen during arousal. In addition, the increases in the concentrations of glycerol and stearic acid with respect to baseline levels were significant (P ≤ 0.05). Compounds which are produced intravaginally appear to decrease in concentration during the arousal interval because of dilution by the transudate. No consistent qualitative changes were noted in the secretion.
Article
Introduction The article consists of six sections written by separate authors that review female genital anatomy, the physiology of female sexual function, and the pathophysiology of female sexual dysfunction but excluding hormonal aspects. Aim To review the physiology of female sexual function and the pathophysiology of female sexual dysfunction especially since 2010 and to make specific recommendations according to the Oxford Centre for evidence based medicine (2009) “levels of evidence” wherever relevant. Conclusion Recommendations were made for particular studies to be undertaken especially in controversial aspects in all six sections of the reviewed topics. Despite numerous laboratory assessments of female sexual function, genital assessments alone appear insufficient to characterise fully the complete sexual response.
Article
A major area of continued controversy and debate among sex researchers, gynecologists and sex therapists has been and continues to be the question of the phenomenon known as "female ejaculation." The current study was an exploratory research experiment designed to provide information about this issue by catheterizing seven women, who reported that they regularly expelled fluid during sensual and/or sexual arousal. Evidence from various studies of live subjects, involving in total less than fifty women, has shown, at least in these subjects, that what was being considered was a urethral expulsion. However, with the total number of women studied being so small, it was impossible to rule out the possibility that some woman somewhere is expelling fluid other than through the urethra. While the current experiment, based upon a review of previous studies, focused on the nature, composition and source of female urethral expulsions during sensual arousal, this researcher was certainly open to observing, capturing and analyzing any expulsions other than from the urethra. With catheterization, the bladder could be isolated from the urethra so that it could be reliably determined which fluids came from which area. The fluids obtained could then be analyzed for their individual composition, having lessened the possibility that they had been mixed in the urethra. The entire experiment was videotaped with a medical doctor and/or a registered nurse present at all times. The overall environment was designed to be as comfortable and natural as possible for the women subjects in order to increase the probability that there would be fluid to be collected. The primary conclusion from the experiment was that almost all the fluid expelled from these seven women unquestionably came from their bladders. Even though their bladders had been drained, they still expelled from 50 ml to 900 ml of fluid through the tube and into the catheter bag. The only reasonable conclusion would be that the fluid came from a combination of residual moisture in the walls of the bladder and from post draining kidney output. There was also a consistency of results that showed a greatly reduced concentration of the two primary components of urine, urea and creatinine, in the expelled fluid. A review of previous literature leads to an inference that it is possible that the expelled fluid is an altered form of urine and that there may be a chemical process that goes on during sexual stimulation and excitement that changes the composition of urine. On four occasions the research team saw evidence of milky-white, mucous-like emissions from the urethra outside of the catheter tube. Although three of those emissions were recorded by the video cameras, the research team was only able to capture a small portion of the fluid for laboratory analysis. An objective reading of the previous literature indicated the possibility of such an emission from the urethral glands and ducts. In the past, the assumption has been that female urethral expulsions during sensual and/or sexual activity originated either in the bladder or from the urethral glands and ducts. The current study, which documented expulsions originating in the bladder, also indicated the possibility that, in some women, there may also be an emission from the urethral glands and ducts. That possibility seems promising enough to encourage future researchers to employ methodology similar to this study to resolve this age old controversy.