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Patent EP1910523A4: Modulation of EGFR signalling by modulation of sphingosine kinase signalling-(text from WO2006135967A1)

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Abstract

The present invention relates generally to a method of modulating EGFR-mediated cellular functional activity and agents useful for same. More particularly, the present invention relates to a method of modulating agonist induced EGFR-mediated cellular proliferation by modulating upstream intracellular sphingosine kinase signalling. The method of the invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant EGFR-mediated cellular functioning, in particular aberrant EGFR-mediated cellular proliferation.
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Publication number EP1910523 A4
Publication type Application
Application number EP20060752619
PCT number PCT/AU2006/000865
Publication date May 27, 2009
Filing date Jun 21, 2006
Priority date Jun 21, 2005
Also published as CA2612640A1, EP1910523A1,
WO2006135967A1
Inventors Pu Xia, Olga Sukocheva, Mathew Alexander
Vadas
Applicant Medvet Science Pty Ltd
Export Citation BiBTeX, EndNote, RefMan
Patent Citations (3), Non-Patent Citations (10), Classifications (15),
Legal Events (9)
External Links: Espacenet, EP Register
Modulation of egfr signalling by modulation of
sphingosine kinase signalling
EP 1910523 A4 (text from WO2006135967A1)
ABSTRACT
The present invention relates generally to a method of modulating EGFR-
mediated cellular functional activity and agents useful for same. More
particularly, the present invention relates to a method of modulating agonist
induced EGFR-mediated cellular proliferation by modulating upstream
intracellular sphingosine kinase signalling. The method of the invention is
useful, inter alia, in the treatment and/or prophylaxis of conditions characterised
by aberrant EGFR-mediated cellular functioning, in particular aberrant EGFR-
mediated cellular proliferation.
DESCRIPTION available in
CLAIMS available in
PATENT CITATIONS
Cited Patent Filing date Publication date Applicant Title
WO1999061581A2 * May 25, 1999 Dec 2, 1999 Office Of The Dean Of Research And
Graduate Education
Sphingosine kinase, cloning, expression
and methods of use
WO2001085953A1 * May 11, 2001 Nov 15, 2001 Medvet Science Pty. Ltd. Sphingosine kinase and uses thereof
WO2004046332A2 * Nov 18, 2003 Jun 3, 2004 Amgen Inc. Amplified genes involved in cancer
* Cited by examiner
French
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English
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NON-PATENT CITATIONS
Reference
1 *
DOLL ET AL: "The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line
MCF7", BIOCHIMICA AND BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OFLIPIDS, ELSEVIER, AMSTERDAM, NL, vol. 1738, no.
1-3, 30 December 2005 (2005-12-30), pages 72 - 81, XP005262452, ISSN: 1388-1981
2 * FRENCH KEVIN J ET AL: "Discovery and evaluation of inhibitors of human sphingosine kinase.", CANCER RESEARCH, vol. 63, no. 18, 15
September 2003 (2003-09-15), pages 5962 - 5969, XP002522495, ISSN: 0008-5472
3 *
MACEYKA M ET AL: "Sphingosine kinase, sphingosine-1-phosphate, and apoptosis", BIOCHIMICA AND BIOPHYSICA ACTA. MOLECULAR
AND CELL BIOLOGY OFLIPIDS, ELSEVIER, AMSTERDAM, NL, vol. 1585, no. 2-3, 30 December 2002 (2002-12-30), pages 193 - 201,
XP004402377, ISSN: 1388-1981
4 *
NAVA V E ET AL: "Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells", EXPERIMENTAL
CELL RESEARCH, ACADEMIC PRESS, US, vol. 281, no. 1, 15 November 2002 (2002-11-15), pages 115 - 127, XP002999187, ISSN: 0014-
4827
5 * PYNE S ET AL: "REVIEW ARTICLE SPHINGOSINE 1-PHOSPHATE SIGNALLING IN MAMMALIAN CELLS", BIOCHEMICAL JOURNAL, THE
BIOCHEMICAL SOCIETY, LONDON, vol. 349, 1 January 2000 (2000-01-01), pages 385 - 402, XP000939036, ISSN: 0264-6021
6 *
SARKAR ET AL: "Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells", FEBS
LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 579, no. 24, 10 October 2005 (2005-10-10), pages 5313 - 5317, XP005098804, ISSN: 0014-
5793
7 * See also references of WO2006135967A1
8 *
SUKOCHEVA OLGA A ET AL: "Sphingosine kinase (SphK) mediates transactivation of the epidermal growth factor receptor (EGFR) by
estrogen in breast cancer cells.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol.
47, April 2006 (2006-04-01), & 97TH ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-CANCER-RESEARCH (AACR);
WASHINGTON, DC, USA; APRIL 01 -05, 2006, pages 690, XP002522496, ISSN: 0197-016X
9 * SUKOCHEVA OLGA A ET AL: "Sphingosine kinase transmits estrogen signaling in human breast cancer cells.", MOLECULAR
ENDOCRINOLOGY, vol. 17, no. 10, October 2003 (2003-10-01), pages 2002 - 2012, XP002522494, ISSN: 0888-8809
10 * TAHA TAREK A ET AL: "Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid
levels and the induction of apoptosis", FASEB JOURNAL, vol. 19, no. 14, December 2005 (2005-12-01), XP002522497, ISSN: 0892-6638
* Cited by examiner
CLASSIFICATIONS
International Classification A61P35/00, A61K48/00, C12N9/00, C12N9/99
Cooperative Classification C12N2310/11, C12Y207/01091, C12N15/1137, A61K48/00, C12N2310/3517, C12N2310/14, C12N2310/315, C12N15/1138
European Classification C12Y207/01091, C12N15/113E, C12N15/113D
LEGAL EVENTS
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Nov 5, 2008 RIN1 Inventor (correction)
Inventor name: XIA, PU
Inventor name: SUKOCHEVA, OLGA
Inventor name: VADAS, MATHEW, ALEXANDER
Nov 12, 2008 RIN1 Inventor (correction)
Inventor name: VADAS, MATHEW, ALEXANDER
Inventor name: XIA, PU
Inventor name: SUKOCHEVA, OLGA
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