Article

Association of VEGF +936C/T, -634G/C, -2578C/A and -1154G/A polymorphisms with preeclampsia risk in Chinese pregnant women

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Abstract

Our study aimed to investigate the association between preeclampsia and VEGF +936C/T, -634G/C, -2578C/A and -1154G/A polymorphisms and risk of in the Han Chinese pregnant women. A total of 128 PE cases and 128 normal pregnant women as control were enrolled in a Chinese population. Polymerase chain reaction (PCR) amplification of the genes and sequencing methods were used to genotype VEGF SNPs +936C/T, -634G/C, -2578C/A and -1154G/A. The association between VEGF SNPs +936C/T, -634G/C, -2578C/A and -1154G/A and risk of PE was assessed by the single factor and multiple factors logistic regression. We observed that the TT genotype of VEGF +936C/T was associated with an increased risk of PE when compared with the CC genotype (OR=2.49, 95% CI=1.32-4.68). In recessive model, those carrying the TT genotype of VEGF +936C/T had an strong increased risk of PE in comparison to those with CC+CT genotype (OR=2.43, 95% CI=1.32-4.48). We found the VEGF +936C/T had interaction with smoking and drinking in the risk of PE. In conclusion, the TT genotype of VEGF +936C/T polymorphism have an increased risk of PE, and have an interaction with smoking and drinking. VEGF +936C/T polymorphism could be a susceptibility biomarker for PE.

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Article
Maternal and fetal gene variants play important roles in the pathology of pre-eclampsia (PE), but most studies investigating the associations between vascular endothelial growth factor A (VEGF-A) gene variates and PE focusing on maternal genetic effects. The present study firstly used a hybrid case-parent and control-mother study design investigating the both maternal and fetal effects of VEGF-A gene polymorphisms on PE among Han Chinese pregnant women. This study recruited 221 PE patients with their partners and infants and 345 normotensive women with their infants. The current study found that, in both maternal and fetal dominant model (GC + CC/GG), VEGF-A rs2010963 polymorphism was associated with an increased risk of PE (OR = 1.85, 95% CI: 1.25-2.75; OR = 1.90, 95% CI: 1.28-2.83, respectively). In the log-liner model analyses, offspring carrying the genotype of GC or CC in the rs2010963 polymorphism could increase the risk of maternal PE (OR = 1.84, 95%CI: 1.18-2.86; OR = 1.89, 95%CI: 1.02-3.49, respectively) compared to the offspring with GG. Meanwhile, the present study also found that passive smoking had a significant interaction with maternal rs2010963 polymorphism (PLRT = 0.022) on the risk of PE.
Article
Objectives: The aim of this study was to assess the genetic association between vascular endothelial growth factor (VEGF) gene polymorphisms and the risk of pre-eclampsia (PE). Methods: A systematic literature search of several databases (PubMed, Embase, and the China National Knowledge Infrastructure (CNKI)) was conducted for case–control trials comparing VEGF polymorphisms (+936C/T, −634G/C, −2578C/A, and −1154G/A) with the risk of PE. Meta-analysis was performed using the Stata 12.0 software. Results: Twenty-three case–control studies on a total of 2597 PE patients and 3075 controls were included in our meta-analysis. The +936C/T polymorphism was observed to be associated with the risk of PE in the overall population (T vs. C: odds ratios (OR) = 1.434, 95% confidence interval (CI) = 1.120–1.836, P = .004). However, the −634G/C, −2578C/A, and −1154G/A polymorphisms showed no association with the risk of PE. A subgroup analysis based on ethnicity found that the +936C/T polymorphism was associated with the risk of PE in both Europeans and Asians. Furthermore, the −634G/C polymorphism was found to be associated with the risk of PE in Europeans (C vs. G: OR = 1.428, 95% CI = 1.141–1.778, P = .002). The polymorphisms at other loci were not associated with the risk of PE. Conclusion: This meta-analysis suggests that VEGF +936C/T polymorphism, rather than −634G/C, −2578C/A, or −1154G/A polymorphisms, is associated with the risk of PE in the overall study population. However, the −634G/C polymorphism may be associated with the risk of developing PE in Europeans.
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