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Unrecognized market potentials in personalized medicine
Abstract
Personalized medicine has failed to prove sufficiently disruptive to existing medico-pharma paradigms to yield its true translational potential. The result has been market capture via. addiction of health providers to mandated health insurance. Forthcoming regulatory controls limiting innovation have stymied the full translation of 30 years of research in molecular biology. I provide examples of translational successes that have occurred in spite the limitations of current market paradigms, point to imminent successes. I will then review key reasons for chronic short-falls and identify three emerging areas that will manifest and explode within the next decade-if we accept key data that has been, until today, seen as a threat instead of the largest of opportunities for scientific, technological, medical and ethical advances in medicine in 150 years. The three areas are: personalized aging, personalized neurodevelopment, and the largest of the three opportunities, personalized immunotherapeutics.
Precision medicine (PM), through the integration of omics and environmental data, aims to provide a more precise prevention, diagnosis, and treatment of disease. Currently, PM is one of the emerging approaches in modern healthcare and public health, with wide implications for health care delivery, public health policy making formulation, and entrepreneurial endeavors. In spite of its growing popularity and the buzz surrounding it, PM is still in its nascent phase, facing considerable challenges that need to be addressed and resolved for it to attain the acclaim for which it strives. In this article, we discuss some of the current methodological pitfalls of PM, including the use of big data, and provide a perspective on how these challenges can be overcome by bringing PM closer to evidence-based medicine (EBM). Furthermore, to maximize the potential of PM, we present real-world illustrations of how EBM principles can be integrated into a PM approach.
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