This article aims to explore Russian foreign policy in the Commonwealth of Independent States (CIS) in the framework of Russia's attitude towards the grouping of GUUAM states (Georgia, Ukraine, Uzbekistan, Azerbaijan and Moldova). The central position of Russia and its political tradition provide a rich background for aspirations to dominate and control the post-Soviet space. The creation of ... [Show full abstract] GUUAM reflects an ineffectiveness of Russian policies towards the constituent countries, which have experienced Russian domination and manipulation of their internal vulnerabilities. A poor history of GUUAM-Russian relations and subsequent problematic record of GUUAM itself, indicate a necessity for Russia and the GUUAM countries to reconsider their foreign policy moves towards establishing mutually beneficial relations. Russia's zero-sum attitude towards influence in the post-Soviet space will hardly have a stabilizing impact on the region. The American military presence in Central Asia and activation of international projects increase the chances that global forces will create a web of networks turning Russia and the entire post-Soviet space into an integral part of both the international security and economic systems.