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Abstract

After transduction with the DObWT chain, T cells from mice expressing DOb48A react with cells bearing the MHC allele that selected them. CD4 T cells were isolated from individual DOb48A mice and transduced with retorviruses expressing DObWT or DOb48A as described in the Methods section. The cells were vultured with spoleen cells from mice expressing various MHC alleles and responses assessed one day later by measuring the % of cells that bore CD69. Data shown are from individual mice assayed on different days.
Figure 2-source data 2
Stimulating cells
Mouse number None H-2b
1064 -0.9 8.69
1067 -0.79 23.96
1230 -0.44 18.57
Average -0.71 17.07
St Err 0.14 4.48
1115 -2.31 0.23
1142 0.35 5.01
1148 -1.31 6.57
Average -1.09 3.94
St Err 0.78 1.91
1027 -0.36 8.9
1183 -0.98 2.89
1185 -0.28 -0.58
Average -0.54 3.74
St Err 0.22 2.77
Response of cells transfected with DObWT retrovius
minus response of cells transfected with DOb48A
retrovirus
Genotype of transduced T
cells
H2b DOb48A
H2b DOb48A
H2b DOb48A
H2f DOb48A
H2f DOb48A
H2f DOb48A
H2s DOb48A
H2s DOb48A
H2s DOb48A
Figure 2-source data 2
Stimulating cells
H-2f H-2s
0.11 0.14
1.55 0.68
2.13 10.86
1.26 3.89
0.60 3.49
5.17 0.14
20.44 8.99
9.6 7.2
11.74 5.44
4.54 2.70
2.77 3.96
2.84 4.48
-1.92 0.76
1.23 3.07
1.58 1.16
Response of cells transfected with DObWT retrovius
minus response of cells transfected with DOb48A
retrovirus

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