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Trends in Emergency Department Visits for Nonfatal Self-
inflicted Injuries Among Youth Aged 10 to 24 Years in the United
States, 2001–2015
Melissa C. Mercado, PhD, MSc, MA1, Kristin Holland, PhD, MPH1, Ruth W. Leemis, MPH1,
Deborah M. Stone, ScD, MSW, MPH1, and Jing Wang, MD, MPH1
1National Center for Injury Prevention and Control, Centers for Disease Control and Prevention,
Atlanta, Georgia
In the United States, youth have the highest burden of nonfatal self-inflicted injury (ie,
deliberate physical harm against oneself, inclusive of suicidal and nonsuicidal intent)
requiring medical attention.1 One study found that emergency department (ED) visits for
these injuries during the 1993 to 2008 period varied by age group, ranging from 1.1 to 9.6
per 1000 ED visits, with adolescents aged 15 to 19 years exhibiting the highest rates.1 Self-
inflicted injury is one of the strongest risk factors for suicide—the second-leading cause of
death among those aged 10 to 24 years during 2015.2 This study examined trends in nonfatal
self-inflicted injuries treated in hospital EDs among US children, adolescents, and young
adults aged 10 to 24 years (hereafter referred to as youth).
Methods
The National Electronic Injury Surveillance System—All Injury Program (NEISS-AIP)
collects data on all first-time visits for nonfatal injuries treated in 66 US hospital EDs
through stratified probability sampling, allowing for the derivation of national estimates.3
Corresponding Author: Melissa C. Mercado, PhD, MSc, MA, National Center for Injury Prevention and Control, Centers for Disease
Control and Prevention, 4770 Buford Hwy NE, Mailstop F-63, Atlanta, GA 30341-3717 cju8@cdc.gov.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of
Interest and none were reported.
Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the
CDC.
Author Contributions: Dr. Mercado had full access to all of the data in the study and takes responsibility for the integrity of the data
and the accuracy of the data analysis.
Concept and design:
Mercado, Holland, Leemis, Stone.
Acquisition, analysis, or interpretation of data:
Mercado, Holland, Leemis, Wang.
Drafting of the manuscript:
Mercado, Holland, Leemis, Wang.
Critical revision of the manuscript for important intellectual content:
All authors.
Statistical analysis:
Holland, Wang.
Administrative, technical, or material support:
Mercado, Holland, Leemis.
Supervision:
Mercado.
Other - subject matter expertise:
Stone.
Additional Contributions: The data used in this report originated from the National Electronic Injury Surveillance System All Injury
Program, operated by the US Consumer Product Safety Commission and whose data are made available by CDC’s web-based Injury
Statistics Query and Reporting System, supported by CDC’s National Center for Injury Prevention and Control. We thank Tadesse
Haileyesus, MS (CDC’s National Center for Injury Prevention and Control), for providing technical support. He did not receive
compensation for his contribution.
HHS Public Access
Author manuscript
JAMA
. Author manuscript; available in PMC 2018 November 21.
Published in final edited form as:
JAMA
. 2017 November 21; 318(19): 1931–1933. doi:10.1001/jama.2017.13317.
Author Manuscript Author Manuscript Author Manuscript Author Manuscript
Self-inflicted injuries were identified by reviewing injury cause narratives and other coded
data within ED records. This study used publicly available secondary data and was exempted
by the CDC from institutional review board review.
Self-inflicted injury ED visit rates were calculated from 2001 through 2015 by sex, age (10–
14, 15–19, and 20–24 years), along with injury method (poisoning, sharp object, blunt
object), and 95% CIs using US Census population estimates as denominators. Rates were
weighted to obtain nationally representative estimates and age-adjusted to the 2000 US
Census population. Trends in self-inflicted injury ED visit rates were assessed using
joinpoint regression software (Surveillance Research Program, National Cancer Institute),
version 4.3.1.0. The annual percentage change described the rate of change for each linear
segment.
Results
From 2001 to 2015, NEISS-AIP captured 43 138 youth self-inflicted injury ED visits. The
overall weighted age-adjusted rate for this group showed no statistically significant trend
until 2008, increasing 5.7% (95% CI, 3.0%–8.4%) annually thereafter and reaching 303.7
per 100 000 population (95% CI, 254.1–353.3) in 2015 (Table). Age-adjusted trends for
males overall and across age groups remained stable throughout 2001–2015 (Figure, Table).
Overall age-adjusted rates for females demonstrated no statistically significant trend before
2009, yet increased 8.4% (95% CI, 5.6%–11.2%) yearly from 2009 to 2015. After 2009,
rates among females aged 10 to 14 years increased 18.8% (95% CI, 12.1%–25.8%) per year
—from 109.8 (95% CI, 69.9–149.7) in 2009 to 317.7 (95% CI, 230.3–405.1) per 100 000
population in 2015. Rates among females aged 15 to 19 years showed a 7.2% (95% CI,
3.8%–10.8%) increase per year during 2008–2015. Rates among females aged 20 to 24
years exhibited a 2.0% (95% CI, 0.8%–3.1%) increase per year throughout 2001–2015
(Figure, Table).
Trends for all self-inflicted injury methods were stable for males. Poisoning was the most
common method of self-inflicted injury for females, with rates remaining stable until 2007
and increasing 5.3% (95% CI, 0.5%–10.4%) annually thereafter. Female rates for self-
inflicted injuries by sharp object increased 7.1% (95% CI, 5.2%–8.9%) annually throughout
2001–2015; female rates for blunt object injuries were stable during 2006–2015 (Table).
Discussion
Youth self-inflicted injury ED visit rates were relatively stable before 2008. However, rates
among females significantly increased thereafter—particularly among females aged 10 to 14
years, who experienced an 18.8% annual increase from 2009 to 2015. This study only
included ED cases; thus, rates were underestimated. Also, limited statistical power could
have resulted in some trends not showing statistical significance. Findings are consistent
with previously reported upward trends in youth suicide rates during 1999–2014, in which
rates increased most notably after 2006 with females aged 10 to 14 years experiencing the
greatest increase.4 Findings also coincide with increased reports of depression among youth,
Mercado et al. Page 2
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especially young girls.5 Other potential underlying reasons for the observed increasing
trends, particularly among young females, warrant further study.
These findings underscore the need for the implementation of evidence-based,
comprehensive suicide and self-harm prevention strategies within health systems and
communities. These strategies include strengthening access to and delivery of care for
suicidal youth within health systems and creating protective environments, promoting youth
connectedness, teaching coping and problem-solving skills, and identifying and supporting
at-risk youth within communities.6
Acknowledgments
Funding/Support: This secondary data analysis study was conducted as part of the regular roles and
responsibilities of all coauthors at the Centers for Disease Control and Prevention (CDC).
Role of the Funder/Sponsor: The CDC was involved in the design and conduct of the study; management,
analysis, and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit
the manuscript for publication. Data was secondarily analyzed by the CDC, who was not involved in the data
collection process.
References
1. Ting SA, Sullivan AF, Boudreaux ED, Miller I, Camargo CA Jr. Trends in US emergency
department visits for attempted suicide and self-inflicted injury, 1993–2008. Gen Hosp Psychiatry.
2012; 34(5):557–565. [PubMed: 22554432]
2. Centers for Disease Control and Prevention. [Accessed December 22, 2016] About underlying cause
of death 1999–2015. https://wonder.cdc.gov/ucd-icd10.html
3. Schroeder, T., Ault, K. The NEISS Sample (Design and Implementation) 1997 to Present.
Washington, DC: Consumer Product Safety Commission; 2001.
4. Curtin, SC., Warner, M., Hedegaard, H. Increase in suicide in the United States, 1999–2014.
Hyattsville, MD: National Center for Health Statistics; 2016.
5. Mojtabai R, Olfson M, Han B. National trends in the prevalence and treatment of depression in
adolescents and young adults. Pediatrics. 2016; 138(6):e20161878. [PubMed: 27940701]
6. Stone, DM., Holland, KM., Bartholow, BN., Crosby, AE., Jack, SPD., Wilkins, N. Preventing
Suicide: A Technical Package of Policies, Programs, and Practices. Atlanta, GA: National Center
for Injury Prevention and Control, Centers for Disease Control and Prevention; 2017.
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Figure. Non-fatal Self-Inflicted Injury Emergency Department Visits among Youth aged 10–24
Years — United States, 2001–2015
APC=Annual Percentage Change; CI=Confidence Intervals
Dotted lines indicate observed rates and solid lines indicate modeled rates. The error bars
represent the standard errors of the observed rates. Only the significant trends were labeled
with APC.
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Mercado et al. Page 5
Table
Trends in Non-fatal Self-Inflicted Injury Emergency Department Visit Rates (per 100,000) among Youth aged 10–24 years — United States, 2001–2015
a
2001 2015 Segment 1 Segment 2 Segment 3
Unweighted
Nonfatal
Self-Inflicted
Injury ED
Visits, No.
Weighted
Rate (95%
CI)
Unweighted
Nonfatal
Self-Inflicted
Injury ED
Visits, No.
Weighted
Rate (95%
CI)
Period APC (95% CI) Period APC (95% CI) Period APC (95% CI)
Male
Age group, y
10–14 93 33.9 (21.4 to
46.4) 180 44.1 (22.9 to
65.3) 2001–2015 1.0 (−2.0 to 4.1)
15–19 387 213.7 (150.4
to 277.0) 531 256.5 (176.9
to 336.1) 2001–2015 0.5 (−0.9 to 1.8)
20–24 350 240.7 (165.6
to 315.8) 407 243.8 (181.7
to 305.9) 2001–2015 −0.1 (−1.3 to 1.2)
Injury Type
b
Poisoning 460 89.5 (69.9 to
109.1) 359 74.1 (55.2 to
93) 2001–2008 −6.3 (−10.4 to
−2.1) 2008–2011 10.6 (−19.4 to
51.9) 2011–2015 −4.3 (−14.0 to
6.4)
Sharp object 228 45.2 (33.4 to
57.1) 347 50.7 (38.5 to
62.8) 2001–2015 1.1 (−0.3 to 2.5)
Blunt object 35 6.0 (3.1 to
8.9) 101 11.8 (7.3 to
16.3) 2001–2015 1.3 (−2.5 to 5.2)
Overall Trend 830 160.8 (114.9
to 206.7) 1118 184.3 (135.1
to 233.5) 2001–2015 0.5 (−0.5 to 1.6)
Age-adjusted Overall Trend 830 160.2 (127.9
to 192.5) 1118 179.2 (144.9
to 213.5) 2001–2015 0.3 (−0.7 to 1.4)
Female
Age group, y
10–14 286 119.4 (78.4
to 160.4) 1033 317.7 (230.3
to 405.1) 2001–2004 9.7 (−8.1 to 30.9) 2004–2009 −4.3 (−13.1 to
5.4) 2009–2015 18.8 (12.1 to
25.8)
15–19 725 389.3 (271.7
to 506.9) 1356 632.5 (465.9
to 799.1) 2001–2004 11.0 (−2.8 to
26.7) 2004–2008 −4.6 (−14.1 to
5.9) 2008–2015 7.2 (3.8 to 10.8)
20–24 355 228.0 (150.4
to 305.6) 556 346.2 (253.1
to 439.3) 2001–2015 2.0 (0.8 to 3.1)
Injury Type
b
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2001 2015 Segment 1 Segment 2 Segment 3
Unweighted
Nonfatal
Self-Inflicted
Injury ED
Visits, No.
Weighted
Rate (95%
CI)
Unweighted
Nonfatal
Self-Inflicted
Injury ED
Visits, No.
Weighted
Rate (95%
CI)
Period APC (95% CI) Period APC (95% CI) Period APC (95% CI)
Poisoning 988 170.9 (135
to 206.8) 987 203.3 (167.1
to 239.5) 2001–2007 −6.4 (−13.0 to
0.8) 2007–2015 5.3 (0.5 to 10.4)
Sharp object 261 54.1 (40.5 to
67.7) 1021 136.3 (103.5
to 169) 2001–2015 7.1 (5.2 to 8.9)
Blunt object 19 2.5 (0.5 to
4.5) 104 11.2 (7.3 to
15.0) 2001–2006 36.1 (15.7 to 60.0) 2006–2015 −0.7 (−4.9 to
3.6)
Overall Trend 1366 244.3 (171.8
to 316.8) 2945 430.8 (325.5
to 536.1) 2001–2004 9.1 (0.2 to 18.8) 2004–2009 −1.6 (−5.7 to
2.8) 2009–2015 7.9 (5.0 to 10.8)
Age-adjusted Overall Trend 1366 245.5 (196.5
to 294.5) 2945 434.0 (363.2
to 504.8) 2001–2004 9.0 (0 to 18.8) 2004–2009 −1.9 (−6.2 to
2.5) 2009–2015 8.4 (5.6 to 11.2)
Overall
Age-adjusted overall trend 201.6 (163.8
to 239.4) 303.7 (254.1
to 353.3) 2001–2004 7.9 (−2.4 to 19.4) 2004–2008 −3.7 (−11.0 to
4.1) 2008–2015 5.7 (3.0 to 8.4)
Abbreviation: APC, annual percentage change.
a
Joinpoint regression was used to determine nonfatal self-inflicted injury emergency department visit rate trends overall and by sex or age-group. Trends are presented as linear segments connected at the
joinpoints (ie, at the years when the slope of each trend changed significantly). The number and location of joinpoints for each trend is determined statistically. Therefore, the time periods for each linear
segment within each trend may vary. If no joinpoint was identified for a trend, then that trend remained linear for the entire 2001–2015 period; in those instances, the APC is presented in Segment 1 only
and left blank for all other segments.
b
Insufficient sample size to analyze the trends for other types of self-inflicted injury. Blunt object-related injuries include “Injuries resulting from being struck by (hit) or crushed by a human, animal, or
inanimate object or force other than a vehicle or machinery.” This does not include falls from heights, such as buildings and bridges.
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