No full-text available
To read the full-text of this research,
you can request a copy directly from the authors.
Co-Existence of Motor Coordination Impairments in Semi-Hospitalized Children and Adolescents with Psychiatric Disorders
... Few studies suggest the coexistence of psychiatric symptoms and motor incoordination. Based on that, it is essential to investigate the other challenges faced by motor coordination impairment patients [13]. Myopathies could be linked with statin use according to some evidence-based research [14] besides that, there are no sufficient pieces of evidence available in support [15]. ...
Introduction: An ability to perform a motor task accurately, rapidly, and controlled manner is known as "motor coordination." Neurodegenerative diseases like Parkinson's disease (PD) are characterized by motor incoordination, gait disturbances, and static tremors. Motor control and muscle coordination also decrease with age, and down neuromotor functions reflect other diseases. Pitavastatin and gemfibrozil both cause lipid-lowering effects by different mechanisms of action. Few studies positively report skeletal muscle contraction behavior with statin use. In the drug-repurposing process, hidden therapeutic functions of the drugs are uncovered using different approaches. Aim and Objectives: Present study was done to assess the motor coordination effect of pitavastatin and gemfibrozil in Comparison to diazepam using Balb-c mice in the rotarod behavioral model. Material and Methods: 20 balb/c mice were divided into 4 groups. The rotarod was used to evaluate the motor coordination effect. The fall-off time was compared among 4 groups. Observations were analyzed using paired t-tests, ANOVA, and post hoc Tukey's test. Results: Pitavastatin (30mg/kg) and gemfibrozil (60mg/kg) make a decline in the fall-off time at all periods of time with significant results at 60 and 120 minutes. Conclusion: In the present study we concluded that both pitavastatin and gemfibrozil possess muscle-relaxant properties. Our study fails to conclude any positive effect of pitavastatin and gemfibrozil on motor coordination. However further studies are needed to confirm that hypothesis.
ResearchGate has not been able to resolve any references for this publication.