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ACKNOWLEDGEMENTS Study funded by Galderma R&D; poster/editorial support provided by Galderma Laboratories, L.P.
INTRODUCTION
Cleansing skin is an important component of maintaining healthy skin
as it removes dirt, oil, make up, and helps prepare the skin for topical
prescription treatments. However, it can also damage the skin by stripping
out natural moisturizing factors and degrading skin barrier function. For
patients with rosacea, this is of particular concern due to underlying skin
barrier disruption and increased skin sensitivity to many ingredients found
in cleansing products. A foaming cleanser has been specifically developed
for redness-prone skin (Cetaphil Foaming Face Wash [CFFW]). This formula
contains caffeine, allantoin, and glycerin to help preserve the skin barier. The
results of 2 clinical studies that assessed the performance and tolerability of
CFFW are presented in this poster.
SUBJECTS and METHODS
Study 1: Hydration and Skin Barrier Function
• Men and women with dry volar forearms
• Product massaged onto pre moistened skin and left for 1 minute
• Product was rinsed with 50 mL of warm water and blotted dry
- Control had same rinsing and drying procedures
• Corneometer and transepidermal water loss (TEWL) assessed at baseline
and 2, 4, 8, and 24 hourss
Study 2: In Use Efficacy and Tolerability
• Men or women with rosacea and mild to moderate non-transient erythema
• Product used BID for 3 weeks
• Assessments made on day 1, day 1 30 minutes after first use and days 8
and 22 before product use
- Chromameter, investigator, and subject assessment of redness
- Investigator and subject tolerability (dermatologic and ophthalmologic)
assessments
· Redness and tolerability assessments made on a 5 point scale of 0
(none), 0.5 (very slight), 1 (slight), 2 (moderate) and 3 (strong)
- Subject satisfaction
AN EFFECTIVE YET GENTLE FOAMING FACIAL CLEANSER SPECIFICALLY DESIGNED FOR REDNESS-PRONE SKIN Matthew H Meckfessel, PhD1; Sandrine Teissedre, MSc2; Nadege Lachmann3; Francine Santoro, MD3
1Galderma Laboratories, L.P., Fort Worth, Texas; 2Galderma R&D, Sophia Antipolis, France; 3Galderma R&D, Egerkingen, Switzerland
CET.P-RD105309-01
SUMMARY
CFFW provides effective, yet gentle cleansing, and is
an ideal facial cleanser for patients with rosacea
Mean Score (a.u.)
Chromameter
Baseline Day 1, 30 Minutes Day 8 Day 22
0
10
5
15
20
25
*
*
P
< .05 vs baseline
Figure 4. Chromameter Assessment
Disagree Neutral Agree
Percent of Subjects
Overall, I like the product
very much
Is suitable for sensitive skin
Washes away face make up and
skin impurities
Rinses easily to leave skin soft
and clean
0 50 6010 20 30 40 70 80 90 100
24.2
69.7
66.7
3.0
3.0
3.0
3.0
21.2
9.1
15.2
78.8
90.9
P
< .05 for Agree vs
Disagree for all
Figure 5. Subject Satisfaction
RESULTS
There were no significant changes to skin hydration or skin barrier function
during the 24 hour period showing CFFW did not disrupt the skin barrier
(Figures 1 and 2). For the in use study, 33 women enrolled with a mean age
of 52.1 years. There was no significant change during the study as assessed
by investigators and subjects (Figure 3). There was a significant worsening
as assessed by chromameter at day 8 (Figure 4). However, this change
in erythema is likely not clinically relevant as they were not noted by the
investigator or subjects. The product was well tolerated with mean scores
for all parameters less than mild for both dermatologic and ophthalmologic
assessments (data not shown). Subjects demonstrated high satisfaction
with the product (Figure 5). Three adverse events were reported and were
not considered related by the investigator: toothache, suspicion of nervous
breakdown, and edema of both lower lids.
Mean Corneometer (a.u.)
CCFW
Control Area
Hour
0
20
22
24
26
28
30
32
34
36
38
40
4 8 12 16 20 24
No significant differences between control and CFFW
Mean TEWL (g/m2h)
CCFW
Control Area
Hour
0
0
2
4
6
8
10
4 8 12 16 20 24
No significant differences between control and CFFW
Mean Score
Investigator
Subject
Baseline Day 1, 30 Minutes Day 8 Day 22
0
1
2
3
No significant differences from baseline.
Figure 2. TEWL Assessments
Figure 1. Corneometry Assessments Figure 3. Skin Redness Assessments