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Cerebrovascular Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-Technology in Quality-Management of Vascular Dyshemias

Authors:
  • Institute of Mathematik of the National Academy of Sciences of Ukraine, Kyiv
  • Clinic of healthe vessels

Abstract and Figures

Review: Problems of effective correction and radical solving of cardiovascular disorders are not new. However, the statistic indexes of cardiovascular pathology are growing and they are considerably younger [1-6]; this testifies to lack of effective management strategy and tactics in fight against these diseases [7-13]. Today we can make a real estimation of achieved results: for the last 20-30 years many technologies are created for research of vascular system - USD of vessels, МRТ in angiomode; devices for correction of cardiac disorders are widely used - from numerous technologies for estimation of the heart structure to coronarography and coronarshunting; new fields of radical medicine are successfully implemented, such as cardiac surgery, angiosurgery, phlebology [14-16]. And at the same time, regardless of the most up-to-date technologies for vascular diagnostics and angiosurgery cardiovascular diseases gets top ranking regarding morbidity and death rate [6,9,17,18]. It can be explained by the fact that development and introduction in medical practice of modern vascular technologies are behind a steady tendency to progress and cardiovascular diseases strike younger people. This dissonance testifies to insufficient knowledge and analysis at the application of new technological potential of visualization of the cardiovascular system at structural (in vitro and in vivo) and functional level - in vivo [7,9,10,12,17]. Our 20-year-old experience of research of vascular disorders and successful attempts of their correction [19] has shown that 1) There is a huge layer of unexplored hemodynamic parameters, which are important in the personalized treatment processes. However, long neglecting biomechanics in medicine [20] resulted into excessive emphasis on endothelial dysfunction and cellular metamorphosis beneficial for promoting pharmacological business. As a result, doctors are not ready to think logically with categories of circulation mechanics and applied hydro- and hemodynamics [21]. 2) Physicians and medical staff don't have enough knowledge in angiology, hemodynamics, hydrodynamics, analytical angiocorrection, angiotherapy, treatment management on evidential basis. Without understanding the depth of hemodynamic laws and logics of pathological and sanogenic transformations in blood supply for organs and regional reservoirs as closed system of vascular tubes - vascular blood flow, it is impossible to perform personalized adequate treatment and predict positive outcomes [8,10]. 3) There is an urgent need in development of vascular monitoring technologies based on principles of evidential medicine [2,7,8,10]. Monitoring dynamic changes in any medical process management, doctors may correct on time the decline from sanogenic blood restoration in a particular regional reservoir and logic of blood redistribution in different vascular reservoirs in a patient's body. Keywords: Personalized treatment, Hemodynamics, Cardiovascular diseases, Angiocorrection, Hydrodynamic conflicts, Brain edema, Biomarkers, Angiomarkers, Intracranial hypertension, Vascular screening, Angiotherapy
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Open Access Full Text Article
Integrative Clinical Cardiology
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
Review Article
Cerebrovascular Disorders of Arteriovenous Balance in
Psychoneurology: Personalized Medical Process Management and
Analytical Vascular IT-Technology in Quality-Management of
Vascular Dyshemias
Ulyana B Lushchyk1,5*, Viktor V
Novytskyy1,2, Igor P Babii3,5, Nadiya G
Lushchyk4,5, Ivanna I Legka5 and Chika
Onwuka5
1Istyna-Veritas Research Center, Kyiv, Ukraine
2Institute of Mathematics of NAS of Ukraine, Kyiv,
Ukraine
3Clinic of Healthy Vessels, Kyiv, Ukraine
4Medical Center “Ukrainian Medical Innovations”,
Ternopil, Ukraine
5Specialized Clinic “Vessels, Brain,
Neurorehabilitation”, Muscat, Oman
*Corresponding author: Ulyana B Lushchyk,
Istyna-Veritas Research Center, Kyiv, Ukraine, E-mail:
u.lushchyk@gmail.com
Abstract
Review: Problems of effective correction and radical solving of cardiovascular disorders
are not new. However, the statistic indexes of cardiovascular pathology are growing and
they are considerably younger [1-6]; this testies to lack of effective management strategy
and tactics in ght against these diseases [7-13].
Today we can make a real estimation of achieved results: for the last 20-30 years
many technologies are created for research of vascular system - USD of vessels, МRТ in
angiomode; devices for correction of cardiac disorders are widely used - from numerous
technologies for estimation of the heart structure to coronarography and coronarshunting;
new elds of radical medicine are successfully implemented, such as cardiac surgery,
angiosurgery, phlebology [14-16].
And at the same time, regardless of the most up-to-date technologies for vascular
diagnostics and angiosurgery cardiovascular diseases gets top ranking regarding morbidity
and death rate [6,9,17,18].
It can be explained by the fact that development and introduction in medical practice of
modern vascular technologies are behind a steady tendency to progress and cardiovascular
diseases strike younger people.
This dissonance testies to insufcient knowledge and analysis at the application of
new technological potential of visualization of the cardiovascular system at structural (in
vitro and in vivo) and functional level - in vivo [7,9,10,12,17].
Our 20-year-old experience of research of vascular disorders and successful attempts
of their correction [19] has shown that
1) There is a huge layer of unexplored hemodynamic parameters, which are important
in the personalized treatment processes. However, long neglecting biomechanics
in medicine [20] resulted into excessive emphasis on endothelial dysfunction
and cellular metamorphosis benecial for promoting pharmacological business.
As a result, doctors are not ready to think logically with categories of circulation
mechanics and applied hydro- and hemodynamics [21].
2) Physicians and medical staff don’t have enough knowledge in angiology,
hemodynamics, hydrodynamics, analytical angiocorrection, angiotherapy,
treatment management on evidential basis. Without understanding the depth of
hemodynamic laws and logics of pathological and sanogenic transformations in
blood supply for organs and regional reservoirs as closed system of vascular tubes
- vascular blood ow, it is impossible to perform personalized adequate treatment
and predict positive outcomes [8,10].
3) There is an urgent need in development of vascular monitoring technologies based
on principles of evidential medicine [2,7,8,10].
Monitoring dynamic changes in any medical process management, doctors may correct
on time the decline from sanogenic blood restoration in a particular regional reservoir and
logic of blood redistribution in different vascular reservoirs in a patient’s body.
Keywords: Personalized treatment, Hemodynamics, Cardiovascular diseases,
Angiocorrection, Hydrodynamic conicts, Brain edema, Biomarkers, Angiomarkers,
Intracranial hypertension, Vascular screening, Angiotherapy
This article was published in the following Scient Open Access Journal:
Integrative Clinical Cardiology
Received August 07, 2017; Accepted August 17, 2017; Published August 22, 2017
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 2 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
The Positive Treatment Result as the
Implementation of Proper Diagnostic and
Predictive Personalized Medical Management at
the Current Level of Vascular Medical Technology
Medicine as a science is constantly evolving. However, the
human body is not yet fully known, and treatment of many
       
   
       

the



      
changed and the body has been recovered, we are
     
      
    
     

       
become a measure of knowledge and skills of a doctor in medical
        

Therefore, only a Cured Patient/a group of
Patients is a True Arbiter for a Particular Theory
in all Scientific Theoretical Considerations
[2,52,56,57] due to Personalized and Preventive
Treatment Measures [56,58,59].
       
       
     
      
         


       

         
        
       
        
body has lost a certain level of health and unable to overcome
certain critical situation, and the doctor and medical institution is

   

         

       
      
          
medical institutions.
Historical Aspect and Urgent Problems in
Management of Vascular Disorders
In critical conditions for correction of the cardiovascular
syst       



      

        
venous system remains unattainable for understanding for many

      

        
  
       


        
       
   
and understanding of changes in the cardiovascular system
         
      
     

    

       
       
         
information about cardiovascular system studied at medical

       


       
    
staff as a dogma.


   

      
        


         

   

on the velocity and

Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 3 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
Hydrodynamic Conflict as an Important
Component in Medical Management of
Cardiovascular Diseases
         
        
       
          

we can remind the words of the famous Russian neurosurgeon
          
    
      

 
around the theme of the swelling and the cerebral edema, but
        

      
      
      
       


management of cardiovascular diseases has showed that there
are almost no smart technologies at the current stage of medical
        

     
     
    


Our Research Results
General characteristics of the examined patients
   


other regional vascular reservoirs.
         
           
      


       

       
found hemodynamic disturbances at the level of cerebral blood

Methods for diagnosis and evidence tool for monitor-
ing angiotherapy process
A       
    

       

          
      
       
   

Microcirculation was studied using the method of smart
     
          


       



Diagram 1: Patients’ arrangement by gender.
Diagram 2: Age range of the investigated patients.
Diagram 3: Proportion of adult patients in terms of age involution .
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 4 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
Nosology 1996- 2000 2001-2005 2006-2010 2011-2015 Total
Dyscirculatory encephalopathy of different genesis (DE)
1st stage 255 358 738 1901 3252
2nd stage 90 189 476 2554 3309
3rd stage 30 54 76 182 342
Apallic syndrome (vegetative status) AS (VS) 37 35 23 44 139
Transient disorders of cerebral circulation (TDoCC) 64 263 362 284 973
Post-traumatic encephalopathy (PTE) 82 342 574 662 1660
Other diseases of the nervous system (NS) 54 43 434 538 1069
Total 612 1284 2683 6165 10744
Table 1: Patients’ structure by nosology.
Diagram 4: Dyscirculatory encephalopathy of different genesis (DE)
The patients with symptoms of DE of 1-2 st. dominated in patient structure, their number gradually increased every year and especially increased since 2011.
Recently DE-3 has increased reecting patients with signicant neurological decits and requesting the effective treatment.
As the Table 1 shows all nosology groups has increasing number of examined and treated patients.
Diagram 5: Patients’ structure by nosology
According to the diagram 3 the largest increase was observed in patients with TDoCC and posttraumatic encephalopathy. It should be emphasized that the
proportion of patients with other diseases of the nervous system (vegetative, inammatory, peripheral and degenerative diseases of the central nervous
system) was also signicant. All patients in this group were diagnosed vascular disorders in blood supply, which clearly inuenced the course of the disease.
This group of patients also received personlized pathogenetic treatment combined with correction of vascular disorders.
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 5 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
Analysis of the vascular dyshemias treatment
         

 
      

        

   
treatment of revealed hemodynamic changes with dynamic
   

          


Figure 1: Sample analysis of changes in hemodynamic parameters in the main arteries and veins of the brain in angiotherapy dynamics.
Figure 2: Evaluation results of microcirculation by means of vascular screening technology.
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 6 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002


          
   
features of systemic reserves of restructuring in the body at

       
      
      

        
 
  
       
     
Nosology
Total
one or periodic
diagnostics without
treatment
one or periodic
diagnostics without
treatment (%)
standard treatment
standard treatment
(%)
periodic out-
patient treatment
лікування
periodic out-
patient treatment
(%)
Periodic intensive
treatment
Periodic intensive
treatment (%)
DE
1 st. 3252 188 5.78% 348 10.70% 351 10.79% 2365 72.72%
2 st. 3309 63 1.90% 297 8.98% 132 3.99% 2817 85.13%
3 st. 342 21 6.14% 61 17.84% 95 27.78% 165 48.25%
AS (VS) 112 43.57% 42 37.50% 7 6.25% 59 52.68%
PBBSD 973 41 4.21% 201 20.66% 198 20.35% 533 54.78%
PTEP 1660 58 3.49% 231 13.92% 143 8.61% 1228 73.98%
Other diseases of NS 1069 34 3.18% 48 4.49% 55 5.14% 932 87.18%
Table 2: Patients’ structure by the algorithm of receiving medical care.
Diagram 6: Patients’ structure by the algorithm of receiving medical care.
Diagram 7: Specic gravity of patients, who got personalized treatment (1996-
2015)
The above-mentioned diagram shows the steady dynamics of increase of
specic gravity of patients, which got personalized treatment in the Clinic of
Healthy Vessels.
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 7 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
      
      
       

     
         
        

      
        


        
         

the results of mathematical modeling of the overall status of the
         
        
       
   


and the side effects and critical state almost leveled during
     

     
 




course of intensive medicinal correction of vascular system due

  
syndrome even in the case of the long duration of unconscious
        
         
disorders.

the residual level of blood circulation in the main artery of the
        
        
         
        
         
Nosology Ecacy of treatment (degree of regression
of pathological features) (persons)
20-30% 40-50% 60-80% 90-100%
DE 1st stage 213 476 1063 1500
DE 2nd stage 78 340 915 1976
DE 3rd stage 81 39 218 4
AS(VS) 44 13 50 5
TDoCC 171 92 563 147
PTE 345 280 612 423
NS 176 38 825 30
Total 1108 1278 4246 4085
Table 3: Close and remote results of efciency of the personalised treatment by
nosology units.
Diagram 8: Approximate and remote results of efciency of the personalised
treatment by nosology units.
Nosology Side effects of complex treatment (allergy, musculoskeletal system, digestive tract)
1996-2000 1996-2000 (%) 2001-2005 2001-2005 (%) 2006-2010 2006-2010 (%) 2011-2015 2011-2015 (%) Total
DE 1st 6 40,00% 640,00% 3 20,00% 00,00% 15
DE 2nd st 5 38,46% 538,46% 215,38% 17,69% 13
DE 3rd st 266,67% 133,33% 00,00% 00,00% 3
AS(VS) 3 25,00% 541,67% 3 25,00% 18,33% 12
TDoCC 2 16,67% 7 58,33% 3 25,00% 00,00% 12
PTE 1 25,00% 125,00% 250,00% 00,00% 4
NS 2 33,33% 233,33% 116,67% 116,67% 6
Total 21 32,31% 27 41,54% 14 21,54% 3 4,62% 65
Table 4: Number of integrated treatment of adverse reactions (allergies, musculoskeletal system, digestive tract).
because all the systems of autoregulation in various vascular
       


          
     






    
 

Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 8 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
     

       
 
      
        
         
       
 
    

        
          
      
mechanisms of restoration of the damaged brain by means of
         


dyshemias and secondary state of ischemic and metabolic
disorders.
       
       
hemodynamic and neurodynamic changes in treatment and
re       
        
the last century about the secondary vascular dyshemias at
  


the evidence basis thanks to advanced vascular technologies.
     









       
          

     
and surgical treatment methods of cardiovascular illnesses

Diagram 9: Side effects of complex treatment (allergy, musculoskeletal system, digestive tract).
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 9 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
Results’ Discussion
Theory of blood supply as the basis of logic hemody-
namic alterations at vascular dyshemias
           
        
     

      
       


        
    
arteriovenous bed and histograms from vascular screening
         
        
       
and structural reconstructions of the cardiovascular system,
      

not only the arterial and venous level of cerebral regional reservoirs,
but also take into account the characteristics of hydrodynamic

       
        

         
        
          
        
      
of functional and structural lesions of various segments
in the cardiovascular system, and then moderate various
situations that could lead to sanogenic reconstructions
         
   


  



Applied aspects of hemodynamic laws application in
the personalized angiotherapy
     
        





        
      
in        
monitoring hemodynamic changes and duration study of
      
h and monitoring the hemodynamic changes during
treatment, we were able to trace a number of reconstructions in
 


        
ambulatory treatment according to the classic treatment scheme.


        

     
        
 
      
     

        



    
     

Some anatomical and functional levels of cardiovascular,
      
        
      

  

        
        

Nosology
Likely rst signs of positive dynamics bypair (sub)
systems of the organism during 1st personalized
intensive angiotherapy course together with
rehabilitation
10 days 20 days 30 days
Multiple sclerosis macrocirculation,
microcirculation
movements,
sensitivity
coordination,
emotions
AS (VS) macrocirculation,
microcirculation
vegetatics,
sensitivity
muscles,
internal organs
Parkinson’s disease macrocirculation,
microcirculation
vegetatics,
psychosphere
movements,
coordination
Cerebral palsy macrocirculation,
microcirculation
vegetatics,
psychosphere
movements,
coordination
Autism macrocirculation,
microcirculation
movements,
attantion
character,
speech
Epilepsy macrocirculation,
microcirculation
convulsions,
vegetatics
emotions,
intelligence
Stroke macrocirculation,
microcirculation
vegetatics,
movements
coordination,
emotions
Table 5: Dynamics of the rst positive changes in the disease
course during 1st course of angiotherapy together with personalized
neurorehabilitation at some less-curable nosology units. Table 5
highlights the role of monitoring (routine diagnosis) of the organism’s
systems at the 1st treatment course nding the most sensitive to
vascular treatment of subsystems (0.75 ±0.2).
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 10 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
       
     

     
        

      


neurologists diagnosed well, but badly treated.
  
        
    


The Personalized Approach in Medical
Management of Vascular Disorders
Vascular blood supply theory as a basis for personalized
and predictive approach to angiocorrection of vascular
disorders
       
      
        
          

of venous blood (suction function of the myocardium of the right

 


     
      
      
system in the moment of treatment beginning and during the





of changes in the structure of the cardiovascular system, taking


         
        
      

       

      
 



       
       
       
   

organs and tissues.
     

    



dynamic treatment at chronic vascular disorders
        f
Table 7: Dynamics of the disease course at different approaches to diagnostics and treatment of the investigated patients
Conceptual therapeutic approaches to the treatment of cardiovascular diseases
Non-conventional medicine (Ayurveda) Under standard protocol Personalized
Nosoogy No effect Average affect Good effect No effect Average affect Good effect No effect Average affect Good effect
DE 1st. 85-90% 10-15% 0% 0% 40-50% 40-50% 0% 0-20% 80-100%
DE 2 st. 100% 0% 0% 0% 40-50% 40-50% 0% 0-20% 80-100%
DE 3 st. 100% 0% 0% 0% 40-50% 40-50% 0% 0-20% 80-100%
AS (VS) 100% 0% 0% 0% 75-80% 20-25% 0% 40-50% 50-60%
PBBSD 100% 0% 0% 80-100% 0-20% 0% 0% 0-10% 90-100%
Stroke 100% 0% 0% 60-80% 20-40% 0% 0% 30-40% 60-70%
Nosology Integrated personalized neurorehabilitation with hemodynamic recovery effect on 60-100%
Duration of 1 course, (days) amount of courses Intercourse period, (days) Next visit
DE
1 st. 25-30 1-2 30-60 1 year
2 st. 30 2 30 1 month-1 year
3 st. 30 3 20-30 Every month
AS (VS) 30-40 30-35 15-20 1 month-2 years
PBBSD 30 2-3 20-30 2 months
Stroke 30 3-5 20-30 1 month-1 year
Table 6: Structure of the treatment course duration and average duration of period of the life quality renewal of patients prior to the secondary visit.
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 11 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
Figure 3: A chart of blind and control (manageable) treatment process-management of medicinal correction of vascular disorders.
       
and the vector of hemodynamic changes in the vascular system.



       
      
       



       
   
    

Personalized treatment management according to
strategy, tactics and quality of achieved results in
treatment of cardiovascular diseases and cerebrovas-
cular pathology
      
bases, it follows conditionally to distinguish certain stages of this

         

 
correction etc.
         
     

          

   

       

in the living organism.
        
  




      


        



        .
       
medicinal and surgical correction and other contiguous areas of
angiology, hydrohemodynamics, clinic of local regional dyshemias
and system disorders in the cardiovascular system.
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 12 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
Figure 5: Pathology.
Figure 4: Norm
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 13 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002

that changes in the vascular bed at the microcirculation level took



managers suggested that early changes occur in the bloodstream
          

        
  

Pathohemodynamic patterns of forming vascular dys-
hemias
 
      
       
dyshemias and were key to imbalance in the whole vascular



arteriolar and venular links of vascular system and state of


in one direction or another.





       
   
        
      

        
       

       
 
critical condition.

 
     
      

ete imbalance
       
leverage of autoregulation and chances for self sanogenic
 
  rd       

       


       

        
        
with redistribution of blood volume in different vascular regional
Diagram 10: The dynamics of the course of vascular disorders in top-managers
Thus, personalized angiotherapy with monitoring of changes was the most effective to get the desired result of vascular dyshemia correction and stabilization
of the result to the nearest and remote periods.
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 14 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
Figure 6: Dynamics of development of vascular dyshemias in the patient group, which did not receive treatment
As seen from the histogram, a group of patients in a stage prior to disease - yellow color (i.e. have moderate signs of vascular dyshemias) within a year
without treatment increased in 5 times (from 42 to 246 persons) at the time of treatment they decreased in three times (from 246 to 81 patients).
reser 
      rd degree
       
       



 


      
        
       
       
risks during treatment.
Conclusions
      
        
       
  
       
      
     
treatment of cardiovascular and cerebrovascular diseases
     
       

       
      
technology for analytical diagnosis and treatment of


situations and monitor sanogenic alterations in
     

      
        
      
     
and autoregulation in the baseline and reserve modes of
    
    

 Mortality and morbidity of cardiovascular diseases
       
mathematical models of vascular diagnostics, vascular


       
 
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 15 of 18
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early stages, when abnormalities in the cardiovascular
system are minimal and changes have functional
disregulatory character on the background of the saved

       
are effective technologies of indicative control of
     
       

   
technologies and mathematical models for correction of

       
       

         

 Biomarkers of vascular disorders are an innovative
        
       
human body.
   
      
vascular screening, angiomarker of arterial and venous
        
     
       
     

        


       


Abbreviations

dynamic changes of hemodynamic parameters
norm 1 year 2 year 3 year 4 year 5 year
hemodynamic parameter
norm 30 25 22 15 4 0
deviaon of hemodynamic
prameters from the norm at
vascular dyshemias (norm 30)
2 5 8 15 26 30
chaos ( 1-3 sdegree of CVS
disbalance)
0 1 2 3 3 3
expressed vascular disorders: ( 1-
3 degree of expressiveness)
deciency of blood supply (1-3
degree of deciency)
0 1 1 2 3 3
tonus disorder 1 1 1 2 3 3
elascity disorder 0-1 0-1 1-2 1-3 1-3 1-3
structural changes of
microcirculaon
0-1 1-3 2-3 2-3 3 3
stcutural changes of
macrocirculaon
0 0-1 0-2 1-3 1-3 1-3
peripheric resistance 0 0-1 0-2 0-3 0-3 2-3
hydodynamic conict 0 0-3 0-3 1-3 1-3 1-3
blood viscosity 0 0 1 1 1-2 1-3
capillary distonia 0-1 0-2 0-3 0-3 0-3 0-3
arteriolar spasm 0-1 1 - 2 1 - 2 1-3 2-3 2-3
reacvity of vascular system (-3
to +3 degree of disbalance)
-1 - 0 - +1 -1 - 0 - +2 -2 - 0 - +2 -2 - 0 - +3 -3 - 0 - +2 -3 - 0 - +1
preclinical signs of vascular
dyshemias
Table 8: Pathohemodynamic patterns of forming of cardiovascular disease and vascular dyshemias from norm to hemodynamic crisis.
The rst signs of dyshemias based on disorders of vascular tonus with the gradual forming of serious pathohemodynamic pattern with deviation from norm
of 5 indexes for 2-3 years, then these
Citation: Ulyana B Lushchyk, Viktor V Novytskyy, Igor P Babii, Nadiya G Lushchyk, Ivanna I Legka, Chika Onwuka (2017). Cerebrovascular
Disorders of Arteriovenous Balance in Psychoneurology: Personalized Medical Process Management and Analytical Vascular IT-
Technology in Quality-Management of Vascular Dyshemias Page 16 of 18
www.scientonline.org Integr Clin CardiolVolume 1 • Issue 1 • 002
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








Authors’ contributions
       
      
balance in the human cardiovascular system and mathematical
        
  
        

of the cardiovascular system. IB, NL, IL carried out the diagnostics
       
      
         

Competing interests

Acknowledgments


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Importance Midlife vascular risk factors have been associated with late-life dementia. Whether these risk factors directly contribute to brain amyloid deposition is less well understood. Objective To determine if midlife vascular risk factors are associated with late-life brain amyloid deposition, measured using florbetapir positron emission tomography (PET). Design, Setting, and Participants The Atherosclerosis Risk in Communities (ARIC)–PET Amyloid Imaging Study, a prospective cohort study among 346 participants without dementia in 3 US communities (Washington County, Maryland; Forsyth County, North Carolina; and Jackson, Mississippi) who have been evaluated for vascular risk factors and markers since 1987-1989 with florbetapir PET scans in 2011-2013. Positron emission tomography image analysis was completed in 2015. Exposures Vascular risk factors at ARIC baseline (age 45-64 years; risk factors included body mass index ≥30, current smoking, hypertension, diabetes, and total cholesterol ≥200 mg/dL) were evaluated in multivariable models including age, sex, race, APOE genotype, and educational level. Main Outcomes and Measures Standardized uptake value ratios (SUVRs) were calculated from PET scans and a mean global cortical SUVR was calculated. Elevated florbetapir (defined as a SUVR >1.2) was the dependent variable. Results Among 322 participants without dementia and with nonmissing midlife vascular risk factors at baseline (mean age, 52 years; 58% female; 43% black), the SUVR (elevated in 164 [50.9%] participants) was measured more than 20 years later (median follow-up, 23.5 years; interquartile range, 23.0-24.3 years) when participants were between 67 and 88 (mean, 76) years old. Elevated body mass index in midlife was associated with elevated SUVR (odds ratio [OR], 2.06; 95% CI, 1.16-3.65). At baseline, 65 participants had no vascular risk factors, 123 had 1, and 134 had 2 or more; a higher number of midlife risk factors was associated with elevated amyloid SUVR at follow-up (30.8% [n = 20], 50.4% [n = 62], and 61.2% [n = 82], respectively). In adjusted models, compared with 0 midlife vascular risk factors, the OR for elevated SUVR associated with 1 vascular risk factor was 1.88 (95% CI, 0.95-3.72) and for 2 or more vascular risk factors was 2.88 (95% CI, 1.46-5.69). No significant race × risk factor interactions were found. Late-life vascular risk factors were not associated with late-life brain amyloid deposition (for ≥2 late-life vascular risk factors vs 0: OR, 1.66; 95% CI, 0.75-3.69). Conclusions and Relevance An increasing number of midlife vascular risk factors was significantly associated with elevated amyloid SUVR; this association was not significant for late-life risk factors. These findings are consistent with a role of vascular disease in the development of Alzheimer disease.
Article
Intracranial pressure (ICP) refers to the pressure within the skull, which is determined by the volumes of the intracranial contents; blood, brain and cerebrospinal fluid. Monro-Kellie homeostasis stipulates that a change in the total intracranial volume is accompanied by a change in the ICP, which is more precisely described by the intracranial pressure-volume relationship. Maintenance of a relatively constant ICP is essential for maintenance of the cerebral perfusion pressure, which in turn determines global cerebral blood flow. Although the physiological process of autoregulation ensures that cerebral blood flow is tightly maintained over a range of cerebral perfusion pressures, large increases in the ICP can result in severely impaired autoregulation, meaning that cerebral blood flow may be compromised. In this review article we provide an overview of the physiological determinants of the ICP and cerebral blood flow. We go on to illustrate how pathological states can compromise physiological compensatory mechanisms in order to potentially dangerous disturbances of the ICP and cerebral blood flow.