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Health Benefits Of Manuka Honey As An Essential Constituent For Tissue Regeneration

Authors:
Kamal Niaz at Louisiana State University
Kamal Niaz
Faheem Maqbool at The University of Queensland
Faheem Maqbool
Haji Bahadar at Tehran University of Medical Sciences
Haji Bahadar
Mohammad Abdollahi at Tehran University of Medical Sciences
Mohammad Abdollahi
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Abstract

Background: Honey is known for its therapeutic properties from ancient civilizations. Recently, the mechanism of action of Manuka honey in wound healing, epithelial regeneration, and ulcer treatments has been revealed. Objective: In the current review, the health perspectives of honey, its chemical composition with special reference to flavonoids, polyphenol, and other bioactive trace compounds used in tissue regeneration have been discussed in detail. Methods: We undertook a structured search using wide spectrum sources like Google Scholar, PubMed, and Scopus. Results: The included papers showed that Manuka honey can inhibit the process of carcinogenesis by controlling different molecular processes, and progression of cancer cells. Manuka honey has been found to have various biological activities, including antioxidant, antimicrobial and anti-proliferative capacities. Scientists try to use Manuka honey in the area of tissue engineering to design a template for regeneration. Naturally derived antibacterial agents of Manuka honey are numerous mixtures of different compounds, which can influence antibacterial capacity. The non-peroxide bacteriostatic properties of Manuka honey are associated with the presence of methylglyoxal (MGO). Conclusion: In addition to bacterial growth inhibition, glyoxal (GO) and MGO from Manuka honey can enhance wound healing and tissue regeneration by their immunomodulatory property. Further studies are needed to provide detailed information about active components of Manuka honey and their potential efficacy in different diseases.
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Curr Drug Metab. 2017;18(10):881-892. doi: 10.2174/1389200218666170911152240.
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Health Benefits of Manuka Honey as
an Essential Constituent for Tissue
Regeneration
Kamal Niaz 1, Faheem Maqbool 1, Haji Bahadar 2, Mohammad Abdollahi 1
1. International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran. Iran.
2. Institute of Paramedical Sciences, Khyber Medical University, Peshawar. Pakistan.
ABSTRACT
Background: Honey is known for its therapeutic properties from ancient civilizations. Recently,
the mechanism of action of Manuka honey in wound healing, epithelial regeneration, and ulcer
treatments has been revealed.
Objective: In the current review, the health perspectives of honey, its chemical composition with
special reference to flavonoids, polyphenol, and other bioactive trace compounds used in tissue
regeneration have been discussed in detail.
Methods: We undertook a structured search using wide spectrum sources like Google Scholar,
PubMed, and Scopus.
Results: The included papers showed that Manuka honey can inhibit the process of
carcinogenesis by controlling different molecular processes, and progression of cancer cells.
Manuka honey has been found to have various biological activities, including antioxidant,
antimicrobial and anti-proliferative capacities. Scientists try to use Manuka honey in the area of
tissue engineering to design a template for regeneration. Naturally derived antibacterial agents of
Manuka honey are numerous mixtures of different compounds, which can influence antibacterial
capacity. The non-peroxide bacteriostatic properties of Manuka honey are associated with the
presence of methylglyoxal (MGO).
Conclusion: In addition to bacterial growth inhibition, glyoxal (GO) and MGO from Manuka
honey can enhance wound healing and tissue regeneration by their immunomodulatory property.
Further studies are needed to provide detailed information about active components of Manuka
honey and their potential efficacy in different diseases.
Keywords: Honey; Leptospermum scoparium; Manuka honey; antimicrobial; methyl-glyoxal;
polyphenols; review; tissue regeneration.
... Moreover, manuka honey can alleviate the pain by providing soothing effect. Presence of methylglyoxal, and glyoxal can fasten the tissue regeneration and healing by enhancing immunomodulation (Niaz et al., 2017). ...
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... Clinically-approved MH wound dressings have been documented to be considerably effective in post-surgical recovery, as well as in the healing of burns, ulcers, and other skin-associated conditions (Willix et al., 1992). Its range of unique antibacterial and anti-inflammatory components promotes the processes of wound healing and renewal through macrophage stimulation, rapid infection clearance, maintenance of wound sterility, and even stimulating healthy tissue regeneration (Visavadia et al., 2008;Niaz et al., 2017). The review of global clinical trial repositories found 43 studies, categorizing MH applications based on both the types of the applications, and the involvement of infectious agents. ...
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... Additionally, Manuka honey has been found to have anti-infammatory properties, making it a potential treatment option for conditions such as infammatory bowel disease and arthritis. When applied topically, Manuka honey has been shown to have woundhealing properties, making it a popular choice for treating burns, cuts, and other skin conditions [23,24]. ...
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