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HIP
ISSN 1120-7000
HIP International
2018, Vol. 28(1) 90 –95
© The Author(s) 2017
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DOI: 10.5301/hipint.5000535
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ORIGINAL RESEARCH ARTICLE
Several factors inuence disease progression, including size
of lesion, age, aeological risk factors, and there are varying
levels of evidence for pharmacological and other nonopera-
ve treatments to modify risk factors (3). Several classicaon
systems are in use but no accepted way of relang the dis-
ease stages between systems (1, 4). Of 76,448 primary hip
replacements undertaken in the UK in 2012, the vast major-
ity (92%) were performed for osteoarthris (5). Only 2% were
performed for ON but this accounted for 24% of all paents
undergoing total hip arthroplasty (THA) under 30 and 19% of
paents under 40 years old (5).
In 2005, McGrory et al (6) conducted a survey of mem-
bers of the American Associaon of Hip and Knee Surgeons
(AAHKS) regarding their current pracce in management of
ON of the femoral head. Of the 403 (54%) acve members
who responded core decompression (CD) was the most com-
mon intervenon for pre-collapse ON, and THA was the most
common for post-collapse ON. The authors recognised a wide
variaon in reported pracce and advocated conducng of
mulcentre prospecve randomised controlled trials to de-
termine best pracce.
To our knowledge, no similar study has been performed in
the UK, and it would be interesng to compare variaons in
Current pracce of BHS members in the
treatment of osteonecrosis of the femoral
head in adults
Henry B. Colaço1, Jerome A. Davidson2, Dominic Davenport3, Mark. C. Norris4, Marcus J.K. Bankes3, Zameer Shah3
1 Trauma and Orthopaedics Department, Royal Free Hospital, London - UK
2 Royal Naonal Orthopaedic Hospital, Stanmore - UK
3 Department of Orthopaedics, Guy’s and St. Thomas’ NHS Foundaon Trust, London - UK
4 Department of Orthopaedics, Darent Valley Hospital, Darord - UK
Introducon
Avascular necrosis of the femoral head (ON) presents
a unique set of challenges to the orthopaedic surgeon. It
is most prevalent in younger individuals in their 3rd and 4th
decades (1). The natural history of the condion is failure of
bone remodeling progressing to subchondral fracture, col-
lapse, and ulmately hip arthris (2). Management of ON of
the femoral head is controversial, and there remains a wide
variaon in pracce worldwide. Marker et al (1) suggested a
treatment algorithm in 2008, but no established guidelines in
the UK exist for this condion.
ABSTRACT
Introducon: The management of osteonecrosis (ON) of the femoral head remains controversial. It is unclear
the extent to which non-arthroplasty procedures are used and there has been no previous report of the trends
in operave management of ON in the UK. Our objecve is to report current trends in management of ON of the
femoral head amongst specialist hip surgeons in the UK.
Methods: A single-stage internet-based survey was e-mailed to 352 eligible members of the Brish Hip Society
(BHS). This consisted of 10 queson stems including 16 hypothecal clinical scenarios with imaging.
Results: 115 acve Consultant members of the BHS completed the survey. For symptomac pre-collapse ON we
found core decompression (CD) was the most common operave intervenon and for post-collapse ON we found
that total hip arthroplasty (THA) was the most common operave intervenon. We found no dierence in the
rate of operave intervenon between 24 and 48-year-old paents at any stage of ON but joint preserving pro-
cedures were more oen selected for the younger paent and arthroplasty for the older paent. Surgeons were
more likely to oer arthroplasty to a 48-year-old paent at an earlier stage of disease.
Conclusions: Our respondents would oer dierent operave intervenons dependent on stage of ON and pa-
ent age. Core decompression (CD) and arthroplasty were common but variaon in treatment opons oered
suggests a lack of consensus amongst UK hip surgeons. We suggest that further research such as a prospecve
RCT is needed to gain consensus on management of this condion.
Keywords: Arthroplasty, Avascular necrosis, Conservave hip surgery, Core decompression, Osteonecrosis, Young
adult hip
Accepted: May 10, 2017
Published online: September 5, 2017
Corresponding author:
Dominic Davenport
Department of Orthopaedics
Guy’s Hospital
Great Maze Pond
SE1 9RT, London, UK
dominic.davenport@nhs.net
Colaço et al 91
pracce including use of novel treatments and threshold for
arthroplasty. We hypothesised that despite the development
of novel treatment opons most surgeons would oer CD for
pre-collapse ON and arthroplasty for post-collapse ON. We
hypothesised that joint preserving surgery would be more
commonly used in the younger paent group (24 years), and
the threshold for arthroplasty would be higher than for the
older paent group (48 years).
Methods
An invitaon to complete an on-line electronic survey
was e-mailed by the Brish Hip Society (BHS) to all known
acve Consultant members (n = 352) from the total number
of 447 members (remainder listed as non-Consultant grade).
We sent a single reminder e-mail aer 4 weeks, and the
survey was open for 8 weeks. Demographic data collected
included years of experience, fellowship training, geographi-
cal region and annual arthroplasty volume. The survey was
incenvised to minimise responder bias. All respondents’
details were anonymised to enhance condenality and en-
courage responses.
Our survey is comprised of 10 stems with dierent ques-
on styles including ranking, mulple choice, matrix of choic-
es, and matrix of drop-down menus (Appendix 1, available
online as Supplementary material at www.hip-int.com). The
survey was carefully designed to reduce total survey error,
by minimising the 4 major potenal sources of error: sam-
pling, noncoverage, measurement and nonresponse. The
ease of use of internet surveys can potenally be exploited to
increase the response rate, which is the generally accepted
indicator of nonresponse error. The survey will refer to pro-
gressive stages consistent with the Steinberg classicaon for
the clinical scenario quesons (7). 16 clinical scenarios are
presented: 8 dierent combinaons of Steinberg stage, level
of symptoms, and Kerboul angle in 2 dierent age groups
(24 and 48 years old). Surgeons were asked to select their
preferred treatment opon for 16 hypothecal clinical sce-
narios of paents with ON of the hip.
There were no paent idenable cases used in the sce-
narios and therefore ethical approval was not required. The
quesons have been carefully designed to discriminate be-
tween parcipants’ individual approaches to management.
Data were analysed using Microso® Excel. Descripve sta-
scs and presented, and comparisons analysed using chi-
square test.
Results
Responder demographics
We received responses from 115/352 (33%) BHS mem-
bers. 90 responders chose to indicate their experience, annual
THA operaon volume and fellowship status. 33.3% had more
than 20 years of hip surgery and the majority (83.3%) of the
responders had at least 10 years’ experience. Only 2 (2.2%) of
responders had <5 years’ experience. Parcipants performed
a high volume of THA with the majority (55.4%) performing
over 100 per year while only 14.13% of respondents per-
formed <50 THA per year.
Of our responders 54.4% had UK hip fellowship experi-
ence and 37.8% had a hip fellowship experience abroad, the
majority of which were in USA, Canada and Australia. Only
17.8% had no fellowship experience specic to hip surgery.
This gure was consistent with our nding that 79.1% of re-
spondents described themselves as either ‘hip specialists’
or ‘specialist lower limb arthroplasty’ surgeon. The survey
was completed by a wide geographical spread of surgeons
throughout the UK with similar numbers from NHS District
General Hospital and NHS Teaching Hospital (49.4% and
44.7% respecvely), the remaining 5 (5.9%) operated exclu-
sively in the independent sector.
The use of classicaon systems
The majority (89.1%) used Ficat and Arlet (8) or Ficat (9)
classicaon system to guide their treatment plan and deci-
sion making but 57% were also sased to use a binary (pre-
vs. post-collapse) system. A minority used other classicaons:
Steinberg et al (7), Gardeniers (10) (ARCO), Ohzono et al (11)
and Kerboul et al (12) classicaons were used by 14%, 12%,
7%, and 3%, respecvely.
Modicaon of risk factors
75% of parcipants would advocate treatment for alco-
hol dependency, and 77.8% would stop ongoing steroid use if
appropriate. 60% would oer bisphosphonate therapy to pa-
ents taking steroids, 35% would oer thromboprophylaxis
to paents with hypercoagulability or a stan to paents with
hyperlipidaemia. Other nonoperave treatments such as ex-
tra- corporeal shock wave therapy (3%) or hyperbaric oxygen
therapy (6%) were less frequently oered.
Clinical scenarios: management opons
Full results are summarised in Appendix 2A and 2B, avail-
able online as Supplementary material at www.hip-int.com.
Minimal symptoms, normal radiograph but abnormal MRI
(Steinberg Stage IB)
24-year-old: 26 of 94 (28%) responders would oer CD
with 10 (11%) oering single 8-10 mm technique and 16
(17%) a mulple drill hole technique. 66 (70%) would manage
this case nonoperavely. 1 (1%) respondent would oer THA.
48-year-old: 18 of 93 (19%) responders would oer CD
with 8 (9%) oering a single 8-10 mm technique and 10 (11%)
a mulple drill hole technique. 73 (79%) would manage non-
operavely. 1 (1%) respondent would oer THA.
Moderate symptoms, normal radiograph but abnormal MRI
(Steinberg Stage IIB)
24-year-old: 65 of 94 (69%) responders would oer CD
with 39 (42%) oering single 8-10 mm technique and 26
(28%) a mulple drill hole technique. 27 (29%) would manage
nonoperavely. 1 (1%) respondent would oer THA.
48-year-old: 58 of 93 (63%) responders would oer CD
with 38 (41%) oering a single 8-10 mm technique and 20
A focussed survey of hip specialist pracce in the UK
92
(22%) a mulple drill hole technique. 32 (34%) would manage
nonoperavely. 2 (2%) respondents would oer THA.
Minimal symptoms, radiographic evidence of sclerosis and
poroc femoral head (Steinberg Stage IIB)
24-year-old: 11 of 92 (12%) responders would oer CD
with 9 (10%) oering a single 8-10 mm technique, 2 (2%)
a mulple drill hole technique and 1 (1%) would oer an
osteotomy. 79 (86%) would manage nonoperavely. 1 (1%)
respondent would oer THA.
48-year-old: 9 of 91 (10%) responders would oer CD with
7 (8%) oering a single 8-10 mm technique, 2 (2%) a mulple
drill hole technique, 1 (1%) responder would oer CD with
tantalum rod implantaon. 79 (87%) would manage nonop-
eravely. 2 (2%) respondents would oer THA.
Moderate symptoms, radiographic evidence of sclerosis and
poroc femoral head (Steinberg Stage IIB)
24-year-old: 31 of 92 (34%) responders would oer CD
with 20 (22%) oering a single 8-10 mm technique, 11 (12%)
a mulple drill hole technique and 1 (1%) would oer nonvas-
cularised bula gra. 49 (53%) would manage nonoperave-
ly. 7 (8%) respondents would oer THA, 1 (1%) respondent
would oer resurfacing arthroplasty.
48-year-old: 23 of 91 (25%) responders would oer CD
with 14 (15%) oering a single 8-10 mm technique and 9
(10%) a mulple drill hole technique. 53 (58%) would manage
nonoperavely. 14 (15%) respondent would oer THA, 1 (1%)
responder would oer resurfacing arthroplasty.
Radiographic subchondral collapse of the femoral head and
moderate head involvement (Steinberg Stage IIIB), (25%, Ker-
boul angle 100⁰)
24-year-old: 57 of 94 (61%) responders would oer CD
with 32 (34%) oering a single 8-10 mm technique, 24 (26%)
a mulple drill hole technique and 1 (1%) would oer CD and
tantalum rod implantaon. 8 (9%) would oer a vascularised,
4 (4%) would oer nonvascularised bula gra and 2 (2%)
would oer osteotomy. 13 (14%) would manage nonopera-
vely. 6 (6%) respondent would oer THA, and 2 (2%) would
oer resurfacing arthroplasty.
48-year-old: 46 of 92 (50%) responders would oer CD
with 26 (28%) oering a single 8-10 mm technique, 18 (20%)
a mulple drill hole technique, 2 (2%) would oer CD and
tantalum rod implantaon. 1 (1%) would oer a vascular-
ised, 2 (2%) would oer nonvascularised bula gra. 19
(21%) would manage nonoperavely. 20 (22%) respondents
would oer THA, 3 (3%) would oer resurfacing arthroplasty.
Radiographic subchondral collapse of the femoral head and
large area of involvement (Steinberg Stage IIIB), (35%, Ker-
boul angle 230⁰)
24-year-old: 43 of 91 (47%) responders would oer CD
with 20 (22%) oering a single 8-10 mm technique, 21 (23%)
a mulple drill hole technique, 2 (2%) would oer CD and tan-
talum rod implantaon. 11 (12%) would oer a vascularised, 3
(3%) would oer nonvascularised bula gra and 3 (3%) would
oer osteotomy. 10 (10%) would manage nonoperavely. 16
(18%) respondents would oer THA, 1 (1%) would oer resur-
facing arthroplasty.
48-year-old: 36 of 90 (40%) responders would oer CD with
19 (21%) oering a single 8-10 mm technique, 15 (17%) a mul-
ple drill hole technique, 2 (2%) would oer CD and tantalum
rod implantaon. 2 (2%) would oer a vascularised, 2 (2%). 13
(14%) would manage nonoperavely. 33 (37%) respondents
would oer THA, 1 (1%) would oer resurfacing arthroplasty.
Severe symptoms and femoral head aening post collapse
(Steinberg Stage IVB)
24-year-old: 72 of 92 (78%) of respondents would oer
THA, while a further 4 (4%) would oer resurfacing arthro-
plasty. 8 of 92 (9%) respondents would oer an osteotomy, 1
(1%) respondent would oer hemiarthroplasty, 1 (1 %) would
oer vascularised bula gra and 2 (2%) would oer CD. 2
(2%) would manage this nonoperavely.
48-year-old: 85 of 91 (92%) respondents would oer THA,
while a further 4 (4%) would oer resurfacing arthroplasty.
1 (1%) of respondents would oer an osteotomy, and 1 (1%)
would manage this case nonoperavely.
Severe symptoms with radiographic femoral head collapse
and established osteoarthris (Steinberg Stage V)
24-year-old: 89 of 94 (95%) of respondents would oer
THA, while a further 3 (3%) would oer resurfacing arthro-
plasty. 1 (1%) would oer an osteotomy, and 1 (1%) would
oer arthrodesis. No respondents would choose to manage
this paent nonoperavely.
48-year-old: All 93 respondents (100%) would oer ar-
throplasty in this case, with 92 (99%) selecng THA and 1
(1%) respondent would oer resurfacing arthroplasty.
Comparison of pre- vs. post-collapse ON
For symptomac pre-collapse ON in a 24-year-old the
most common intervenon was CD (52%). 41% of responders
would manage this nonoperavely while only 5% would oer
arthroplasty.
For symptomac pre-collapse ON in a 48-year-old the
most common management was nonoperave (46%) fol-
lowed by CD (44%) and THA (9%).
For severe post-collapse ON in a 24-year-old the most
common intervenon was THA (49%) followed by CD (28%)
and other joint preserving surgery (13%). 7% of responders
would manage this paent nonoperavely.
For severe post-collapse ON in a 48-year-old the most
common intervenon was THA (63%) followed by CD (23%)
and other joint preserving surgery (2%). 9% of responders
would manage this paent nonoperavely.
Factors inuencing management decisions
Surgeons were asked to rank various paent factors in
order of importance in inuencing management decisions.
Stage of the disease and symptoms were the most commonly
Colaço et al 93
selected as the single-most important factor both selected
by 39%. Less frequently considered factors were age (11%),
disease progression (7%), size of the lesion (3%), and risk
factors (1%).
Eect of age on choice of intervenon
There was no signicant dierence in decision for op-
erave versus nonoperave intervenon regardless of stage
between the 24-year-old (67.9%) and 48-year-old (63.2%)
paent (p = 0.11 chi2).
When operaons were grouped into either joint preserv-
ing surgery (including CD, osteotomy and bula graing) or
arthroplasty, we found that joint preserving surgeries were
more commonly oered to the 24-year-old paent than the
48-year-old (58.5% vs. 44.2%, p<0.0001), conversely arthro-
plasty was oered more commonly to the 48-year-old (55.6%
vs. 41.3%, p<0.0001).
Eect of symptoms on decision to operate
We found symptoms had a signicant eect on decision to
oer operave intervenon in early disease across both ages
(p<0.0001) (Fig. 1).
At what stage of disease is arthroplasty oered?
We found that for both age groups decision to oer
arthroplasty increased with stage of disease and for the
48-year-old paent responders were signicantly more likely
to oer arthroplasty at an earlier stage (Stage III) of disease
when compared to 24-year paent (Fig. 2).
What type of arthroplasty is oered?
Arthroplasty was oered in 41.3% of all operave inter-
venons for the 24-year-old paent. Most (94%) were THA,
followed by resurfacing (5.4%) and hemiarthroplasty (0.5%).
Arthroplasty was selected for 55.6% of cases for the 48-year-
old paent with a similar trend in type (96.1% THA, 3.9%
resurfacing, 0 hemiarthroplasty). Further analysis of the THA
oered showed the most popular choice was uncemented
THA (58.6% in 24-year-old, 55.2% in 48-year-old), followed
by hybrid (30%, 30.7%) and cemented THA (11.4%, 14.1%).
However, we found no signicant dierence between types
of THA between age groups.
Conclusion
There has been no previous report of the trends in opera-
ve management of ON in the UK, and there are no estab-
lished guidelines for management of this condion. We used
this survey to evaluate the approach to diagnosis and man-
agement of hip ON in acve consultant hip surgeon members
of the Brish Hip Society. Of the 115 respondents, 83% had
at least 10 years of surgical pracce as a consultant, 82% had
undertaken a specialist hip fellowship and the majority (75%)
of our respondents describe themselves as either lower limb
arthroplasty or hip specialists.
Like the trends found by the AAHKS our respondents were
likely to recommend cessaon of alcohol or steroid use in pa-
ents with ON, however our respondents were more likely
to oer medical therapy compared to the AAHKS study (6).
60% in our survey would oer a bisphosphonate to paents
on steroids, 35% would oer thromboprophylaxis for paents
with coagulaon disorders and 35% would oer a stan to
paents with hyperlipidemia, compared to the 3%, 6% and
10% respecvely found by McGrory et al (6). There have been
several studies on pharmacological treatments for early ON
of the femoral head (13-15), which may account for their
popularity amongst UK surgeons.
Our survey established that 2 key criteria aid our respon-
dents’ evaluaon; the severity of symptoms and stage of dis-
ease. This was supported by the responses with signicantly
higher operave intervenon rate when symptoms were
moderate rather than minimal. Only 11% of our responders
stated that age was an important factor, which is consistent
with our nding that for all stages of ON rate of operave ver-
sus nonoperave management was not signicantly dierent
regardless of age.
Intervenon in early ON remains controversial. When spe-
cically isolang the responses to the scenario of a paent
Fig. 1 - Rate of operave intervenon in scenarios of mild vs. moder-
ate symptoms for pre-collapse osteonecrosis in a 24- and 48-year-
old paent.
Fig. 2 - Rate of arthroplasty in each stage of osteonecrosis in a 24-
and 48-year-old paent.
A focussed survey of hip specialist pracce in the UK
94
with minimal symptoms and pre-collapse ON most would
manage nonoperavely (70% and 79% for the 24- and 48-year-
old respecvely) however even in this early stage there are re-
spondents who would oer CD (27% for the 24-year-old, 18%
for the 48-year-old) which may reect the evidence that it can
delay disease progression despite lack of symptoms (16). Sim-
ilar results were also seen in the AAHKS study (2).
In the context of symptomac pre-collapse ON joint pre-
serving surgery including CD was the most common interven-
on oered to the 24-year-old paent, whereas nonoperave
management was more commonly oered to the 48-year-old
paent. Arthroplasty was infrequently oered in 4% and 9%
for either age group. This may reect the successful results of
joint preserving surgery in pre-collapse ON in the recent liter-
ature. A meta-analysis of 2025 hips found sasfactory clinical
results in 63.5% of hips managed by CD compared with only
22.7% of hips managed nonoperavely for all stages of ON
(17) and 71% versus 34.5% sasfactory clinic results in pre-
collapse ON in parcular (17). In a long-term study of CD in 34
paents (54 hips) with Ficat stage I-III, Bozic et al (18) report-
ed 48% sasfactory clinical outcomes and 37% radiographic
survival however they observed a 100% failure in 8 Stage III
hips. Consistent with this we found the greatest variaon in
response appears in the corresponding scenario of a paent
Stage III ON.
For scenarios involving post-collapse ON, arthroplasty
was the most popular management in both ages groups and
indeed THA has been shown to be a reliable opon for the
management of post-collapse hip ON (19); a systemac re-
view of 67 studies represenng 3,277 THRs in 2593 paents
reported a survivorship of 97% at a mean of 6 years follow up
(20). Interesngly, we found that while arthroplasty was of-
fered to both the 24- and 48-year-old paent, in subchondral
collapse (Steinberg stage III) it was signicantly more oen
oered to the 48-year-old paent – an outcome not observed
in other scenarios suggesng surgeons are more inclined to
oer arthroplasty at an earlier stage of disease to the 48-year-
old paent. Whilst advances in implant design and bearing
surface technology may have reduced the high incidence of
wear and rate of asepc loosening following arthroplasty in
younger paents, we believe our results indicate that many
surgeons are sll reluctant to oer arthroplasty to younger
paents with early ON.
THA was the most common choice of arthroplasty at ev-
ery stage regardless of age with very few surgeons choosing
resurfacing or hemiarthroplasty reecng a wider trend in
the wake of reported high revision rates (21) despite poten-
ally being a good opon for younger male paents (22).
Uncemented THA was the most popular, followed by hybrid
and cemented THR (54.0%, 28.5%, 12.5% respecvely). Our
gures dier from those reected in the Naonal Joint Reg-
istry (NJR) records for 2012 (5) where the proporon of un-
cemented THA is lower (44%) (5) which we believe reects
the increasing preference of metaphyseal press t stems in
younger paents amongst specialist hip surgeons.
This study has limitaons common to survey-based meth-
odology: respondents were disclosing their opinions based
on hypothecal scenarios rather than real-life paents. We
recognise that in clinical pracce other variables may inu-
ence individual paent management decisions, which are
beyond the scope of this study. However, we believe that
the hypothecal scenarios cover a broad spectrum of clinical
presentaons. The methodology used in the quesonnaire
was designed to minimise sampling, noncoverage, measure-
ment and nonresponse bias. We recognise that our respond-
ers reected a self-selected group of specialist hip surgeons,
but will not include all praccing hip surgeons in the UK. It
is possible that the management in these scenarios would
dier between BHS members and non-BHS member hip sur-
geons. Sampling error was minimised by inving all eligible
members of the BHS to parcipate, and including all respons-
es from parcipants who meet the inclusion criteria in the
analysis. Noncoverage error was minimised by approaching a
self-selected subgroup of praccing hip surgeons, but will not
include currently praccing UK-based hip surgeons who are
non-members of the BHS. Nonresponse error stems from fail-
ure to respond to the e-mailed invitaon, and can potenally
skew the result if responders share dierent characteriscs
to responders and despite targeng this specialist group we
only received responses from 33% of the total cohort. Several
strategies were used to increase response rate: providing in-
formaon about the survey, appealing to parcipant’s sense
of being part of a scienc community, and obligaon to
support the BHS, making the quesons varied and engaging,
and liming the survey to 10 queson stems in total. In ad-
dion, an incenve was oered for one parcipant selected
at random at the end of the study, which has been shown to
reduce nonresponse error. Measurement error refers to the
discrepancy of parcipants’ beliefs and the survey responses.
This is addressed by applying the ‘leverage-saliency’ theory of
survey response, and can be minimised by asking a relevant,
topical queson to encourage eecve interacon and valid
answers that reect parcipants’ true beliefs, in addion to
careful visual layout and queson design.
This study is relevant to the orthopaedic community in the
UK, as currently there are no established guidelines for man-
agement of ON of the femoral head. Our study found that
CD and other joint preserving surgeries are the most popular
operave intervenons for pre-collapse ON in both 24- and
48-year-old paents. THA, parcularly uncemented, is the most
popular intervenon for post-collapse ON in both ages group.
We found surgeons more likely to oer THA to the 48-year-old
paent at an earlier disease stage than the 24-year-old.
There remain many unanswered quesons which is
reected in the variaon of responses both in our study and
the previous survey by McGrory et al (6) for the AAHKS. The
use of registry data and further mulcentre clinical studies
are required to enhance our understanding of outcomes in
ON of the femoral head to provide guidelines and improve
decision making in the future management of the condion.
Disclosures
Financial support: None.
Conict of interest: None.
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