P-262: Excessive sympathetic hyperactivity in hypertensive patients following acute myocardial infarction

Article · January 2002
DOI: 10.1016/S0895-7061(02)02613-4 · Source: OAI


    Hypertension is an important risk factor for acute myocardial infarction (AMI). The presence of pre-existent hypertension
    following AMI is associated with a higher total mortality and is an independent risk indicator for both reinfarction and death.
    An increase in sympathetic neural discharge is known to occur in both hypertension and AMI, and is by itself a prognostic
    indicator. This study was planned to quantify the magnitude of sympathetic hyperactivity in hypertensive patients following
    AMI. For this purpose, we compared the central sympathetic output in 9 patients with AMI and pre-existent hypertension (HT-AMI)
    to that in 9 patients with hypertension (HT) at stage II/III (JNC-VI classification) and 9 normotensive subjects (NT). The
    three groups were matched (Table) for age and body mass index (BMI). Muscle sympathetic nerve activity (MSNA) was measured by microneurography from the peroneal
    nerve and its mean frequency was expressed as bursts per 100 cardiac beats (b/100b). In the three groups, the data were obtained
    using the same protocol. HT-AMI patients were examined 2–4 days following admission.

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