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Abstract

A new era of disease is fast emerging in the US. The 21st century model of chronic disease turns the old model upside down. The spotlight has long been on cancer and heart disease, which once were both growing exponentially. Now, among forty fast-growing diseases, the incidence of only three cancers and one cardio-vascular related condition are growing. In their place, four relatively new fast-growing disease groups have emerged: 1) neurological; 2) autoimmune; 3) inflammatory and 4) metabolic disease. A single molecule called peroxynitrite operates at the heart of more than forty fast-growing chronic diseases and conditions in the US. This fast-acting anion creates more than 130 biochemical disruptions in vivo. Among the most troubling is the nitration of L-tryptophan and L-tyrosine, which are precursors to critical neurotransmitters serotonin and dopamine. Peroxynitrite also damages the blood brain barrier (BBB). Such biological markers are hallmarks of neurological diseases like Alzheimer’s, autism, bi-polar disorder and depression. The endogenous culprit – peroxynitrite – is well documented. But what about the exogenous cause? There is now increasing evidence that our modern electrical environment is imposing biological stress on our bodies. Dr. Martin Pall’s voltage-gated ion theory provides evidence to support the connection. He cites two dozen studies that show microwaves from cell phones trigger the internal mechanism that creates an over-production of nitric oxide and peroxynitrite. The connection between the spectacular growth in the use of electronics and wireless technologies and the explosion of chronic disease is more than a simple correlation. Few are aware of the chronic disease epidemic that is going on right now in the US. Fewer still have heard of the peroxynitrite connection. Almost no one recognizes the crucial role that the cell phone in our pocket may be playing with our health. Yet our electrical environment has dramatically changed. And now electrical energy stands as the chief suspect driving this new era of disease in America.
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A New Era of Chronic Disease in America and what’s behind it
Richard Lear, August 2017/2018
All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed.
Third, it is accepted as being self-evident
- Arthur Schopenhauer
There has been a largely unrecognized explosion of chronic disease in the US. More than 170
million Americans are currently suffering from chronic, germless diseases. There is compelling
evidence that these diseases are not caused by bacteria, parasites or viruses. Instead they are
either triggered or accelerated by a single molecule made in the body. This molecule is called
peroxynitrite. Peroxynitrite has been associated with more than 60 chronic diseases. While
thousands of scientists have long recognized the pivotal role of peroxynitrite in disease, few
policy makers and physicians are aware of the connection. And the general public remains
completely in the dark. The scope of the problem is extensive. The annual economic burden
for thirty-six, fast-growing chronic diseases and conditions in the US is more than $2.7 trillion.
The quintessential paper on peroxynitrite was funded by the National Institutes of Health
(NIH). The study, Nitric Oxide and Peroxynitrite in Health and Disease,(1)” identifies more
than 97 biological disruptions caused by peroxynitrite within the body, which, in turn, lead to
dozens of diseases. A paper I published on ResearchGate, “The Root Cause in the Dramatic
Rise in Chronic Disease,(2)” associates peroxynitrite with 40 of the fastest-growing diseases and
medical conditions. 36 more than doubled in a single generation - 1990 to 2015.
Many of these diseases and conditions were relatively unknown until the 1990s. Now most
have become household names like autism, Alzheimer’s, ADHD, fibromyalgia, irritable bowel
syndrome, hypothyroidism, erectile dysfunction, bipolar disorder, just to name a few. Other
more familiar diseases and conditions, including diabetes, hypertension, arthritis, melanoma,
sleep apnea, asthma, depression, and leukemia, have also sky-rocketed in the US.
Four New Categories of Disease
Statistics gathered from US government websites at the CDC, NIH and NCBI confirm the real-
world evidence of the massive toxicity peroxynitrite imposes and the resulting disease impacts
on our society. The growth of so many chronic ailments is evidence of a new era of disease in
the US. The 21st century model of chronic disease turns the old model upside down. The
spotlight has long been on cancer and heart disease, which once were both growing
exponentially. Now, among forty fast-growing diseases, the incidence of only three cancers and
three heart-disease-related conditions are growing. In their place, four relatively new fast-
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growing disease groups have emerged: 1) neurological; 2) autoimmune; 3) inflammatory and
4) metabolic disease.
Neurological Disease
Neurological disease may be the most troubling. Thirteen neurological diseases and conditions
have exploded since 1990 and there are now more than 91 million reported cases of these
diseases and conditions in the US. In the past generation alone, autism has grown at 2094%,
Psycho-social - attentional problems - 809%, Alzheimer’s - 299% and bi-polar disorder in
children, has increased by a staggering 10,833%. Four conditions which are typically referred
to as mental health conditions are included in the neurological category. While all four may have
a mental health component, each also shares the same biological markers with the other
neurological conditions. In particular, individuals experiencing neurological conditions listed
here share an imbalance of neurotransmitters, including deficiencies in dopamine and
serotonin. Additionally, pervasive neuron death, a hallmark of neurodegenerative diseases like
Alzheimer’s and ALS, is also a chief characteristic of conditions like depression, bi-polar, ADD
and anxiety. Here is a snapshot of the growth and magnitude of the societal impact from 11
fast-growing, neurological diseases and conditions.
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Autoimmune
Autoimmune disease is also on the rise. The term autoimmunity was barely known to the
general public in 1990. Now it is commonplace and few are not touched by it. Autoimmune
disease is notable for the multiplicity of symptoms associated with the disease. Sufferers report
headaches, digestive problems, cognitive impacts, memory deficits, poor sleep, joint pain and
muscle pain. Many contend that autoimmune disease arises from the immune system attacking
itself. Multiple biological systems seem to be affected including neurological, immune,
digestive, musculoskeletal and skin.
According to the American Autoimmune Related Diseases Association (AARDA), more than
50 million Americans are affected (2015) by 100 different autoimmune conditions (2018).
The spectacular emergence of these diseases has not gone unnoticed by millions of Americans.
There are now more than 679 million instances of just thirty-six fast-growing diseases and
chronic conditions in the US population.
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So far there has been very little media coverage about what appears to be an epidemic of
chronic disease in America. Meanwhile, most still believe the US is the healthiest nation in the
world. Yet, by all accounts the precise opposite may now be the case. The medical community
has been slow to recognize or at least articulate the larger story. Few medical professionals
seem to have made the key connections between so many chronic conditions. Instead medical
research and treatment approaches are being pursued in research silos.
While forty of the fastest growing chronic diseases all share in common high levels of
peroxynitrite plus six identical bio-markers, the medical community and public seem to be
blinded to these scientific insights. At the heart of it, there seems to be a breakdown in
communication between the scientific community and the rest of us. Or it could be that there
is deep skepticism over the pure elegance of there being a single unifying chronic disease state.
It may be that it seems just too good to be true. Yet, who would guess that the underlying
biological conditions for sleep disturbances and Alzheimer’s are similar? Or that obesity,
leukemia and panic disorder all arise from a single molecule and share the same six biological
markers?
External Causes
If peroxynitrite is the internal cause (endogenous) for the dramatic growth of chronic, germless
disease in America, is there a single external trigger (exogenous), or even a group of identifiable
external causes? It turns out that a range of environmental toxins and chemicals are chiefly
suspect. Dr. Stephanie Seneff, a senior research scientist at MIT, postulates one chemical which
has become prolific, called glyphosate, as a chief candidate. This chemical, the toxic active
ingredient in the herbicide, Roundup, has been increasingly added to wheat and other US crops
in the past two decades. There is evidence that it triggers peroxynitrite and the destruction of
aromatic amino acids like tyrosine, tryptophan and phenylalanine. Decreases in these amino
acids lead to shortages in production of dopamine and serotonin and the increased prevalence
of neurological disorders. Dr. Pal Pacher, the lead author on the landmark NIH paper on
peroxynitrite, blames soft drinks and fast food diets, particularly high fructose corn syrup
products. Others point to the growing prevalence of pesticides such as paraquat. This chemical
synergizes with peroxynitrite to create Parkinson’s-like symptoms in mice. All three are likely
suspects.
The Role of Our Intensifying Electrical Environment
Most concerning is the potential threat from our electrical environment. There is growing
scientific evidence that points to our intensifying electrical environment as the strongest link.
As unsettling as this theory may be to most of us, there is now substantial science, showing that
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electrical pollution created by microwave radiation from wireless devices may be stealthily
stealing our health.
In a recent study (3), Dr. Martin Pall, Ph.D., winner of a 2013 Global Medical Research award,
identifies a bioelectrical mechanism. Pall’s paper outlines the process by which electrical energy
from wireless technologies in the form of microwave signals activates systemic biological
imbalances and unleashes disease. In this process, microwave radiation at frequencies like those
used in cell phones and Wi-Fi disrupts the flow of calcium ion messengers, which, in turn,
triggers other crucial biological changes. The result is increased levels of peroxynitrite, which
then leads to biological chaos and ultimately to one, or more of the fast-growing chronic
conditions.
Not only has at least one biological mechanism, or more aptly, the chain of causation between
electrical fields and high levels of peroxynitrite, been identified, but there is now extensive
theoretical and epidemiological science to back it up. International science connecting
microwaves with biological effects has actually been established for more than forty years. In
1971, a US Navy-commissioned report (4) surveyed the science, much of it culled from outside
the US. The report cites more than 2,300 scientific studies that directly link microwave signals
with 132 biological effects and chronic diseases. Notably, almost all of the biological
underpinnings of the forty fastest-growing diseases and chronic conditions identified in the Root
Cause paper are listed in this seemingly prescient report.
More recently, the 2012 BioInitiative Report (5), a 1,540-page study co-authored by a group of
twenty-nine international scientists, cites more than 2,500 scientific studies that associate low-
level exposures from electromagnetic radiation (EMR) with dozens of diseases and biological
effects in humans such as autism, brain cancer, breast cancer, leukemia, oxidative damage,
biochemical imbalances, blood-brain-barrier damage, and DNA/ chromosome damage. It
should be no surprise that peroxynitrite is associated with every major disease discussed in this
paper.
As the above examples illustrate, the science connecting wireless signals and other forms of
electromagnetic radiation (EMR) with biological effects and disease is substantial. Yet few are
aware of the depth of the science. Despite the fact that just two papers cite more than 4800
scientific studies that link low-levels of EMR with at least 132 biological impacts and more than
two dozen diseases, federal agencies like the FCC and the Food and Drug Administration
(FDA), which regulates cell phones, still contend that the science is ‘inconclusive.
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Humans Are Electrical Beings
The idea that even low levels of electrical energy can affect our health should not be surprising.
It is well established that humans are electrical beings and our biological welfare critically
depends on a delicate balance of electrical activity. Our brains and hearts depend on electrical
impulses to function. Doctors use EKGs to measure the electrical activity of the heart and
EEGs to gauge the electrical activity of the brain. Trillions of cells exchange electrical messages
sent across multiple pathways in our nervous system, and these electrical messages coordinate
and orchestrate our entire body chemistry. Electricity is essential to life.
The key components of these biological communications (neurons, neurotransmitters, ions) all
depend crucially on low-level electrical energy. Even the cells in humans are electrical. When
healthy, each human cell operates at around 25 millivolts. So, given the electrical nature of our
bodies, it should be no surprise that biological disruptions to our bodies like the increased
levels of electrically-charged calcium ions between cells occur.
A New Era of Chronic Disease
Chronic disease statistics culled from the Centers for Disease Control (CDC), the National
Institutes of Health (NIH), NCBI and PubMed are staggering. In the US population of 322
million, the number of instances of just thirty-six, fast-growing chronic diseases and medical
conditions has mushroomed beyond 679 million. That’s an average of more than two diseases
and chronic conditions for each and every American! The accelerated growth of each of these
conditions began around 1990. About the same time, the exponential growth of wireless
devices was just beginning. At that time there were only about 16 million cell phones in the
US. There are now about one billion wireless devices. That represents a growth of over 6150%
in just one generation.
Conclusion
We’re living in a new era of disease. Germs are no longer fully to blame for our poor health.
Neurological, autoimmune, inflammatory, and metabolic diseases are growing out of control
and crippling the US economy. The explosion of chronic disease and medical conditions is
imposing more than a $2.7 billion cost on society - every year. Increased health costs and lost
productivity are the direct results. Insurance companies and the medical community are
overwhelmed. The social, psychological and emotional costs to sufferers and families are
incalculable. There are no vaccinations or cures. Chronic diseases are persistent and often last a
lifetime.
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The internal cause is already known. There is agreement among the most elite NIH scientists1
that peroxynitrite sits at the heart of more than 60 major chronic diseases and conditions. Yet,
the public remains in the dark. Ironically, almost no US government-funded research is taking
place. Several external triggers (dietary and environmental toxins) are also known. Some say
chemicals in our diet are to blame, others point to our intensifying electrical environment.
We’ve entered this new era of disease, where electrical energy creates both a benefit and a
cost. Is the electrical energy around us stealthily creating biochemical chaos in our bodies by
increasing levels of a single toxic molecule? If so, we either need to find ways to neutralize the
molecule, or dial back the electrical energy around us. Or do both.
Few are aware of the chronic disease epidemic that is going on in the US right now. Fewer still
have heard of the peroxynitrite connection. Almost no one recognizes the crucial role that the
cell phone in your pocket may be playing with your health.
Until we recognize that we’ve entered a new era of chronic disease, we’re likely to miss the
bigger picture: our own declining health and the emerging pandemic of disease in America is
likely self-imposed.
References:
(1) Pacher P1, Beckman JS, Liaudet L.
Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007 Jan; 87(1):315-424.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248324/
(2) Lear, Richard A
“Root Cause in the Dramatic Rise of Chronic Disease.” ResearchGate, September 2016
https://www.researchgate.net/publication/303673576_The_Root_Cause_in_the_dramatic_rise_of_Chronic_Disease
(3) Pall, Martin L
“Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects.” J Cell
Mol Med. 2013 Aug; 17(8): 958965. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780531/
(4) Glaser, ZR
“Bibliography of Reported Biological Phenomena (Effects) and Clinical Manifestations Attributed to Microwave
and Radio-Frequency Radiation”; Naval Medical Research Institute, October 1971;
http://www.magdahavas.com/wordpress/wp-content/uploads/2010/06/Navy_Radiowave_Brief.pdf
(5) Carpenter DO, Sage C, Behari J, Xu, Lai H, Blank M, Johansson O, Grigoriev Y, Salford L, Carlberg et al CV, et al
“BioInitiative 2012, A Rationale for Biologically-based Exposure Standards for Low-Intensity Electromagnetic Radiation”;
http://www.bioinitiative.org/table-of-contents/
... The connection between electrical energy like that produced by dirty electricity (EMI), peroxynitrite and the 36 fastest growing diseases is outlined in "A New Era of Disease in America and what's behind it." (7) How dirty electricity may lead to disease and chronic conditions ...
Preprint
Full-text available
A dramatic rise in chronic disease, medical conditions and stress symptoms have arisen in the US. Between 1990-2015 Americans experienced a surge of more than 400 million cases of just 36 fast growing germ-less chronic conditions. Environmental factors such as chemicals, pesticides, heavy metals and electromagnetic radiation (EMR) are suspected. One growing form of EMR, dirty electricity, is discussed here and causally-linked to many of the exploding health and stress symptoms. Connections between dirty electricity (also called power-line EMI) are established by both statistical correlation and the identification of a plausible mechanism. This electrical energy acts like an exogenous trigger and is associated with free radical production, proliferations of peroxynitrite and the initiation of a self-sustaining biological system, undermining homeostasis called p-Factor.
Article
Full-text available
There has been a largely unrecognized explosion of chronic disease in the US. More than 170 million Americans are currently suffering from diseases and conditions that can be vastly improved or even reversed by reducing levels of a single molecule called peroxynitrite. Elevated levels of peroxynitrite have been associated with more than 60 chronic diseases, yet can be controlled through moderate changes in lifestyle, reducing exposures to a few environmental toxins, improving diet plus introducing non-prescription supplementation. While thousands of scientists recognize the pivotal role of peroxynitrite in disease, few policy makers and physicians are aware of the opportunity they have to heal a nation suffering from chronic diseases. The annual economic burden of just forty fast-growing chronic diseases tracked in this paper is more than $2.7 trillion. With increased public awareness coupled with enlightened action this cost to society can be reduced to a fraction by simply implementing the knowledge we already have.
Article
Full-text available
The direct targets of extremely low and microwave frequency range electromagnetic fields (EMFs) in producing non-thermal effects have not been clearly established. However, studies in the literature, reviewed here, provide substantial support for such direct targets. Twenty-three studies have shown that voltage-gated calcium channels (VGCCs) produce these and other EMF effects, such that the L-type or other VGCC blockers block or greatly lower diverse EMF effects. Furthermore, the voltage-gated properties of these channels may provide biophysically plausible mechanisms for EMF biological effects. Downstream responses of such EMF exposures may be mediated through Ca(2+) /calmodulin stimulation of nitric oxide synthesis. Potentially, physiological/therapeutic responses may be largely as a result of nitric oxide-cGMP-protein kinase G pathway stimulation. A well-studied example of such an apparent therapeutic response, EMF stimulation of bone growth, appears to work along this pathway. However, pathophysiological responses to EMFs may be as a result of nitric oxide-peroxynitrite-oxidative stress pathway of action. A single such well-documented example, EMF induction of DNA single-strand breaks in cells, as measured by alkaline comet assays, is reviewed here. Such single-strand breaks are known to be produced through the action of this pathway. Data on the mechanism of EMF induction of such breaks are limited; what data are available support this proposed mechanism. Other Ca(2+) -mediated regulatory changes, independent of nitric oxide, may also have roles. This article reviews, then, a substantially supported set of targets, VGCCs, whose stimulation produces non-thermal EMF responses by humans/higher animals with downstream effects involving Ca(2+) /calmodulin-dependent nitric oxide increases, which may explain therapeutic and pathophysiological effects.
Article
More than 2300 references on the biological responses to radio frequency and microwave radiation, published up to April 1972, are included in this bibliography of the world literature. Particular attention has been paid to the effects on man on non-ionizing radiation at these frequencies. The citations are arranged alphabetically by author, and contain as much information as possible so as to assure effective retrieval of the original documents. Soviet and East European literature is included in detail. An outline of the effects which have been attributed to radio frequency and microwave radiation is included as Chapter 1. The revised report (which supersedes DDC report AD-734 391) is updated with the inclusion of three supplementary listings, and has incorporated many corrections and additions to the original 2100 citations.
Article
The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide (NO) has stimulated an extraordinary impetus for scientific research in all the fields of biology and medicine. Since its early description as an endothelial-derived relaxing factor, NO has emerged as a fundamental signaling device regulating virtually every critical cellular function, as well as a potent mediator of cellular damage in a wide range of conditions. Recent evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynitrite, produced from the diffusion-controlled reaction between NO and another free radical, the superoxide anion. Peroxynitrite interacts with lipids, DNA, and proteins via direct oxidative reactions or via indirect, radical-mediated mechanisms. These reactions trigger cellular responses ranging from subtle modulations of cell signaling to overwhelming oxidative injury, committing cells to necrosis or apoptosis. In vivo, peroxynitrite generation represents a crucial pathogenic mechanism in conditions such as stroke, myocardial infarction, chronic heart failure, diabetes, circulatory shock, chronic inflammatory diseases, cancer, and neurodegenerative disorders. Hence, novel pharmacological strategies aimed at removing peroxynitrite might represent powerful therapeutic tools in the future. Evidence supporting these novel roles of NO and peroxynitrite is presented in detail in this review.
BioInitiative 2012, A Rationale for Biologically-based Exposure Standards for Low-Intensity Electromagnetic Radiation
  • D O Carpenter
  • C Sage
  • J Behari
  • Xu
  • H Lai
  • M Blank
  • O Johansson
  • Y Grigoriev
  • L Salford
  • Carlberg
Carpenter DO, Sage C, Behari J, Xu, Lai H, Blank M, Johansson O, Grigoriev Y, Salford L, Carlberg et al CV, et al "BioInitiative 2012, A Rationale for Biologically-based Exposure Standards for Low-Intensity Electromagnetic Radiation";