Studies for developing Japanese Taila, an Ayurvedic medicated oil

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An Ayurvedic medicated oil, Jatyadi Taila (J), is known to be used in Ayurveda (Indian traditional medicine), especially for anal fistula surgery involving the medicated thread Kshara Sutra. Although this surgical method has been introduced into Japan, the pharmacological efficacy, toxicity and postoperative care for J remain unclear. In this study, we investigated the effects of this oil on production of the chemokine interleukin (IL)-8 as well as cell proliferation in cultured human epidermal keratinocytes. We also attempted to create an oil for Kshara Sutra based on Kampo ointments such as shiunko and chuoko, instead of J. J itself did not affect IL-8 production in keratinocytes co-stimulated with TPA, but showed a strong cytotoxicity toward this cell line. Among the tested oils, oil of turmeric resulted in suppression of not only IL-8 production but also cell growth in cultured keratinocytes. Oil of turmeric and Phellodendri Cortex showed a tendency to suppress IL-8 production under the same condition. The methanol-eluted fractions of J suppressed IL-8 production without any significant cytotoxicity. The methanol fraction of the oil from sesame or Lithospermi Radix significantly enhanced the proliferation of keratinocytes without IL-8 production. These findings indicate that the Ayurvedic oil J may have potential for suppression of skin inflammation through regulation of the keratinocyte inflammatory response. It is further proposed that Japanese Taila based on shiunko and chuoko might be useful for Kshara Sutra surgery in patients. © 2012, Medical and Pharmaceutical Society for WAKAN-YAKU. All rights reserved.

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Kshara Sutraはアーユルヴェーダで痔瘻の治療に用いられる手術糸である。本研究では, Kshara Sutraによる施術を広く日本に導入するため, 日本に生育する植物を使って国産Kshara Sutraの作製を試みた。Kshara Sutraを作製するにあたっては3種類の薬剤が必要である。その一種Snuhi(トウダイグサ科のEuphorbia antiquorum L, またはEuphorbia neliifolia L. )は患部の肉芽形成を促進させ, 糸に薬剤を付着させる役割を担うとされる。しかし, Snuhiは熱帯性の植物で日本に自生せず, 野外での栽培も困難である。そこで, Snuhiの代わりにクワ科のイチジク(Ficus carica L. )の未熟果実から得た乳液とトウガラシチンキ剤を用いてKshara Sutraを作製した。なお, その他の材料として, 我が国に自生するヒナタイノコヅチの全草から製したKshara, 市販のウコン末, および高吸水性糸を使用した。これは我が国初の国産Kshara Sutraであり, 「金沢糸1号」と名付けた。その臨床については現在進行中である。Kshara Sutra is a medicated thread which is used in anal fistura surgical operations in Ayurveda, the Indian traditional Medicine. For the purpose of introducing Kshara Sutra therapy into Japan, which offers a better cure rate than modern surgery in India and Sri Lanka, we attempted the production of alternative Kshara Sutra by using Japanese plants and materials. We established the protocol of Kshara Sutra preparation including the use of the latex of the fig (Ficus carica L.) fruit as a binding agent instead of Snuhi (Euphorbia antiquorum L. or Euphorbia neliifolia L.), and red pepper tincture for induction of healing by granulation. In addition, we made Kshara, an alkali agent, from the plant of Achyranthes bidentata Bl. and used commercial turmeric powder and a suture with high water absorbency. This was the first Kshara Sutra in use in Japan and we named it "Kanazawa Sutra I". and Its clinical examination is under way.