Some reflexions and recommendations on how to organize, to structure and to submit a manuscript to an Editor for publication in a main stream journal, such as the ISI and Scielo journals, are presented. Some of the most relevant aspects related to the title of an article, the abstract, the introduction, the body of the paper, the conclusions and the references, are discussed. Some examples on how
... [Show full abstract] to write each of these parts and recommendations on how to solve some common problems found during the preparation of a manuscript, are given. The topics discussed could make a manuscript more attractive to referees and Editors, who get the first impression by the presentation and organization of the manuscript, to go next to the details. It is concluded that it is necessary that authors must be careful in fulfilling some minimum rules of ethics and quality accepted by the international community if they want their papers to have the expected positive impact.