Low miR-1, miR-7, miR-17, miR-26a, miR-29a, miR-30a, miR-34a, miR-124, miR-133, miR-143-145, miR-150, miR-378, miR-455, lincRNA-p21, and MEG3 are related to cancer. In contrast, high miR-9, miR-21, miR-130, miR-155, miR-221, HOTAIR, H19, LINC-ROR, MALAT1, MIAT, NEAT1, TUG1, UCA1, XIST, ZFAS1, ANRIL, ciRs-7, and PVT1 are related to cancer. High and low let-7, miR-146a, miR-181, miR-223, and GAS5 are associated with cancer. These non-coding RNA profiles allow a metabolic reprogramming in tumors to retain stemness and epithelial-mesenchymal transition, insulin sensitized state and angiogenesis. It also explains the shift from OXPHOS to glycolysis, the immune escape, and the prevention of apoptosis in tumors.